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19.703 Aktuelle Fachpublikationen zum Thema Addition

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The multiple roles of epidermal growth factor repeat O-glycans in animal development

01.10.2015 | Amanda R Haltom; Hamed Jafar-Nejad, Glycobiology , 2015

The epidermal growth factor (EGF)-like repeat is a common, evolutionarily conserved motif found in secreted proteins and the extracellular domain of transmembrane proteins. EGF repeats harbor six cysteine residues which form three disulfide bonds and help generate the three-dimensional structure ...

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Protective effects of polysialic acid on proteolytic cleavage of FGF2 and proBDNF/BDNF

01.10.2015 | Masaya Hane; Shuhei Matsuoka; Sayaka Ono; Shinji Miyata; Ken Kitajima; Chihiro Sato, Glycobiology , 2015

Polysialic acid (polySia) is a linear polymer of sialic acid that modifies neural cell adhesion molecule (NCAM) in the vertebrate brain. PolySia is a large and exclusive molecule that functions as a negative regulator of cell–cell interactions. Recently, we demonstrated that polySia can ...

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Mice expressing reduced levels of hepatic glucose-6-phosphatase-{alpha} activity do not develop age-related insulin resistance or obesity

15.09.2015 | Goo-Young Kim; Young Mok Lee; Jun-Ho Cho; Chi-Jiunn Pan; Hyun Sik Jun; Danielle A. Springer; Brian C. Mansfield; Jan ..., Human Molecular Genetics, 2015

Glycogen storage disease type-Ia (GSD-Ia) is caused by a lack of glucose-6-phosphatase-α (G6Pase-α or G6PC) activity. We have shown that gene therapy mediated by a recombinant adeno-associated virus (rAAV) vector expressing human G6Pase-α normalizes blood glucose homeostasis in the global G6pc ...

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Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region

15.09.2015 | Zhenfei Ning; Andrew S. McLellan; Melanie Ball; Freda Wynne; Cora O'Neill; Walter Mills; John P. Quinn; Dirk A. Klei ..., Human Molecular Genetics, 2015

Sprouty proteins are regulators of cell growth and branching morphogenesis. Unlike mouse Spry3, which is X-linked, human SPRY3 maps to the pseudoautosomal region 2; however, the human Y-linked allele is not expressed due to epigenetic silencing by an unknown mechanism. SPRY3 maps adjacent to ...

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Destabilization of microRNAs in human cells by 3′ deadenylation mediated by PARN and CUGBP1

03.09.2015 | Takayuki Katoh; Hiroaki Hojo; Tsutomu Suzuki, Nucleic Acids Research, 2015

MicroRNA-122 (miR-122), which is expressed at high levels in hepatocytes, is selectively stabilized by 3'-adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2. Here, we report that poly(A)-specific ribonuclease (PARN) is responsible for the deadenylation and destabilization of ...

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Transcription yield of fully 2′-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants

03.09.2015 | Adam J. Meyer; Daniel J. Garry; Bradley Hall; Michelle M. Byrom; Hannah G. McDonald; Xu Yang; Y. Whitney Yin; Andrew ..., Nucleic Acids Research, 2015

On average, mutations are deleterious to proteins. Mutations conferring new function to a protein often come at the expense of protein folding or stability, reducing overall activity. Over the years, a panel of T7 RNA polymerases have been designed or evolved to accept nucleotides with modified ...

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Accurate placement of substrate RNA by Gar1 in H/ACA RNA-guided pseudouridylation

03.09.2015 | Peng Wang; Lijiang Yang; Yi Qin Gao; Xin Sheng Zhao, Nucleic Acids Research, 2015

H/ACA RNA-guided ribonucleoprotein particle (RNP), the most complicated RNA pseudouridylase so far known, uses H/ACA guide RNA for substrate capture and four proteins (Cbf5, Nop10, L7Ae and Gar1) for pseudouridylation. Although it was shown that Gar1 not only facilitates the product release, but ...

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Human sialic acid acetyl esterase: Towards a better understanding of a puzzling enzyme

01.09.2015 | Flavia Orizio; Eufemia Damiati; Edoardo Giacopuzzi; Giuliana Benaglia; Stefano Pianta; Roland Schauer; Reinhard Schw ..., Glycobiology , 2015

Sialic acid acetyl esterase (SIAE) removes acetyl moieties from the hydroxyl groups in position 9 and 4 of sialic acid. Recently, a dispute has been opened on its association to autoimmunity. In order to get new insights on human SIAE biology and to clarify its seemingly contradictory molecular ...

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Glycosaminoglycans affect heparanase location in CHO cell lines

01.09.2015 | Maria BR Piva; Eloah R Suarez; Carina M Melo; Renan P Cavalheiro; Helena B Nader; Maria AS Pinhal, Glycobiology , 2015

Glycosaminoglycans (GAG) play a ubiquitous role in tissues and cells. In eukaryotic cells, heparan sulfate (HS) is initially degraded by an endo-β-glucuronidase called heparanase-1 (HPSE). HS oligosaccharides generated by the action of HPSE intensify the activity of signaling molecules, ...

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Crystal structure of a symbiosis-related lectin from octocoral

01.09.2015 | Akiko Kita; Mitsuru Jimbo; Ryuichi Sakai; Yukio Morimoto; Kunio Miki, Glycobiology , 2015

D-Galactose-binding lectin from the octocoral, Sinularia lochmodes (SLL-2), distributes densely on the cell surface of microalgae, Symbiodinium sp., an endosymbiotic dinoflagellate of the coral, and is also shown to be a chemical cue that transforms dinoflagellate into a non-motile (coccoid) ...

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