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18.413 Aktuelle Fachpublikationen zum Thema Addition

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Impact of sulfation pattern on the conformation and dynamics of sulfated fucan oligosaccharides as revealed by NMR and MD

01.05.2015 | Ismael NL Queiroz; Xiaocong Wang; John N Glushka; Gustavo RC Santos; Ana P Valente; James H Prestegard; Robert J Woo ..., Glycobiology , 2015

Sulfated fucans from sea urchin egg jelly express well-defined chemical structures that vary with species. This species specificity regulates the sperm acrosome reaction, a critical step to assure intra-specific fertilization. In addition, these polysaccharides are involved in other biological ...


SRD: a Staphylococcus regulatory RNA database [ARTICLES]

01.05.2015 | Mohamed Sassi; Yoann Augagneur; Tony Mauro; Lorraine Ivain; Svetlana Chabelskaya; Marc Hallier; Olivier Sallou; Bric ..., RNA, 2015

An overflow of regulatory RNAs (sRNAs) was identified in a wide range of bacteria. We designed and implemented a new resource for the hundreds of sRNAs identified in Staphylococci, with primary focus on the human pathogen Staphylococcus aureus. The "Staphylococcal Regulatory RNA Database" (SRD, ...


Using the Morris Water Maze to Assess Spatial Learning and Memory in Weanling Mice

17.04.2015 | Christopher D. Barnhart et al., PLoS ONE, 2015

by Christopher D. Barnhart, Dongren Yang, Pamela J. Lein Mouse models have been indispensable for elucidating normal and pathological processes that influence learning and memory. A widely used method for assessing these cognitive processes in mice is the Morris water maze, a classic test for ...


Transcript Dynamics at Early Stages of Molecular Interactions of MYMIV with Resistant and Susceptible Genotypes of the Leguminous Host, Vigna mungo

17.04.2015 | Anirban Kundu et al., PLoS ONE, 2015

by Anirban Kundu, Anju Patel, Sujay Paul, Amita Pal Initial phases of the MYMIV- Vigna mungo interaction is crucial in determining the infection phenotype upon challenging with the virus. During incompatible interaction, the plant deploys multiple stratagems that include extensive ...


SOBIR1 requires the GxxxG dimerization motif in its transmembrane domain to form constitutive complexes with receptor‐like proteins

16.04.2015 | Guozhi Bi, Thomas W. H. Liebrand, Ruby R. Bye, Jelle Postma, Aranka M. Burgh, Silke Robatzek, Xiangyang Xu, Matthieu ..., Molecular Plant Pathology, 2015

Summary Receptor‐like proteins (RLPs), forming an important group of transmembrane receptors in plants, play roles in development and immunity. RLPs contain extracellular leucine‐rich repeats (LRRs) and, in contrast to receptor‐like kinases (RLKs), lack a cytoplasmic kinase required for ...


The lactate receptor, G‐protein‐coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain

16.04.2015 | Cecilie Morland, Knut Husø Lauritzen, Maja Puchades, Signe Holm‐Hansen, Krister Andersson, Albert Gjedde, Håvard Att ..., Journal of Neuroscience Research, 2015

We have proposed that lactate is a “volume transmitter” in the brain and underpinned this by showing that the lactate receptor, G‐protein‐coupled receptor 81 (GPR81, also known as HCA1 or HCAR1), which promotes lipid storage in adipocytes, is also active in the mammalian brain. This includes the ...


Improved Escherichia coli Bactofection and Cytotoxicity by Heterologous Expression of Bacteriophage ΦX174 Lysis Gene E

16.04.2015 | Tai-Chun Chung; Charles H. Jones; Akhila Gollakota; Mahmoud Kamal Ahmadi; Snehal Rane; Guojian Zhang; Blaine A. Pfeifer, Molecular Pharmaceutics, 2015

Bactofection offers a gene delivery option particularly useful in the context of immune modulation. The bacterial host naturally attracts recognition and cellular uptake by antigen presenting cells (APCs) as the initial step in triggering an immune response. Moreover, depending on the bacterial ...


Promotion of Pro‐Apoptotic Signals by Lysosomal Photodamage

15.04.2015 | David Kessel, John J. Reiners, Photochemistry and Photobiology, 2015

Abstract We previously reported that low level lysosomal photodamage enhanced the efficacy of subsequent mitochondrial photodamage, resulting in a substantial promotion of apoptotic cell death. We now extend our analysis of the sequential PDT protocol to include two additional ...


Comparison and integration of deleteriousness prediction methods for nonsynonymous SNVs in whole exome sequencing studies

15.04.2015 | Chengliang Dong; Peng Wei; Xueqiu Jian; Richard Gibbs; Eric Boerwinkle; Kai Wang; Xiaoming Liu, Human Molecular Genetics, 2015

Accurate deleteriousness prediction for nonsynonymous variants is crucial for distinguishing pathogenic mutations from background polymorphisms in whole exome sequencing (WES) studies. Although many deleteriousness prediction methods have been developed, their prediction results are sometimes ...


Structural basis for misfolding in myocilin-associated glaucoma

15.04.2015 | Rebecca K. Donegan; Shannon E. Hill; Dana M. Freeman; Elaine Nguyen; Susan D. Orwig; Katherine C. Turnage; Raquel L. ..., Human Molecular Genetics, 2015

Olfactomedin (OLF) domain-containing proteins play roles in fundamental cellular processes and have been implicated in disorders ranging from glaucoma, cancers and inflammatory bowel disorder, to attention deficit disorder and childhood obesity. We solved crystal structures of the OLF domain of ...


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