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17.351 Aktuelle Fachpublikationen zum Thema Addition

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Antitumor properties of a new non-anticoagulant heparin analog from the mollusk Nodipecten nodosus: Effect on P-selectin, heparanase, metastasis and cellular recruitment

01.04.2015 | Angélica Maciel Gomes; Eliene Oliveira Kozlowski; Lubor Borsig; Felipe C O B Teixeira; Israel Vlodavsky; Mauro S G Pavão, Glycobiology , 2015

Inflammation and cancer are related pathologies acting synergistically to promote tumor progression. In both, hematogenous metastasis and inflammation, P-selectin participates in interactions involving tumor cells, platelets, leukocytes and endothelium. Heparin has been shown to inhibit ...

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Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

15.03.2015 | Meian He; Min Xu; Ben Zhang; Jun Liang; Peng Chen; Jong-Young Lee; Todd A. Johnson; Huaixing Li; Xiaobo Yang; Junche ..., Human Molecular Genetics, 2015

Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A ...

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p16INK4A inhibits the pro‐metastatic potentials of osteosarcoma cells through targeting the ERK pathway and TGF‐β1

01.03.2015 | Gabriela Silva, Abdelilah Aboussekhra, Molecular Carcinogenesis, 2015

Extracellular signal‐regulated kinase (ERK) is a downstream component of the evolutionarily conserved mitogen‐activated protein kinase‐signaling pathway, which controls the expression of a plethora of genes implicated in various physiological processes. This pathway is often hyper‐activated by ...

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3D-printed hierarchical scaffold for localized isoniazid/rifampin drug delivery and osteoarticular tuberculosis therapy

01.03.2015 | Author(s): Min Zhu , Kun Li , Yufang Zhu , Jianhua Zhang , Xiaojian Ye, Acta Biomaterialia, 2015

Publication date: 1 April 2015 Source:Acta Biomaterialia, Volume 16 Author(s): Min Zhu , Kun Li , Yufang Zhu , Jianhua Zhang , Xiaojian Ye After surgical treatment of osteoarticular tuberculosis (TB), it is necessary to fill the surgical defect with an implant, which combines the ...

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Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA [ARTICLES]

01.03.2015 | Ambrosius P. Snijders; Guillaume M. Hautbergue; Alex Bloom; James C. Williamson; Thomas C. Minshull; Helen L. Philli ..., RNA, 2015

Splicing factor proline- and glutamine-rich (SFPQ) also commonly known as polypyrimidine tract-binding protein-associated-splicing factor (PSF) and its binding partner non-POU domain-containing octamer-binding protein (NONO/p54nrb), are highly abundant, multifunctional nuclear proteins. However, ...

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The differential characterization of GPR55 receptor in human peripheral blood reveals a distinctive expression in monocytes and NK cells and a proinflammatory role in these innate cells

01.03.2015 | Valerio Chiurchiù; Mirko Lanuti; Marco De Bardi; Luca Battistini; Mauro Maccarrone, International Immunology, 2015

G protein-coupled receptor 55 (GPR55) is activated by endogenous, plant-derived and synthetic cannabinoids. Recent studies reported a broad tissue distribution for GPR55 and found prominent roles for this receptor in inflammatory pain, gut and bone physiology, as well as cancer. However, little ...

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A deeply conserved, noncanonical miRNA hosted by ribosomal DNA [ARTICLES]

01.03.2015 | Li-Ling Chak; Jaaved Mohammed; Eric C. Lai; Greg Tucker-Kellogg; Katsutomo Okamura, RNA, 2015

Advances in small RNA sequencing technologies and comparative genomics have fueled comprehensive microRNA (miRNA) gene annotations in humans and model organisms. Although new miRNAs continue to be discovered in recent years, these have universally been lowly expressed, recently evolved, and of ...

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atBRX1-1 and atBRX1-2 are involved in an alternative rRNA processing pathway in Arabidopsis thaliana [ARTICLES]

01.03.2015 | Benjamin L. Weis; Denise Palm; Sandra Missbach; Markus T. Bohnsack; Enrico Schleiff, RNA, 2015

Ribosome biogenesis is an essential process in all organisms. In eukaryotes, multiple ribosome biogenesis factors (RBFs) act in the processing of ribosomal (r)RNAs, assembly of ribosomal subunits and their export to the cytoplasm. We characterized two genes in Arabidopsis thaliana coding for ...

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Disease origin and progression in amyotrophic lateral sclerosis: an immunology perspective

01.03.2015 | Andrea Malaspina; Fabiola Puentes; Sandra Amor, International Immunology, 2015

The immune system is inextricably linked with many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), a devastating neuromuscular disorder affecting motor cell function with an average survival of 3 years from symptoms onset. In ALS, there is a dynamic interplay between the ...

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A founder CEP120 mutation in Jeune asphyxiating thoracic dystrophy expands the role of centriolar proteins in skeletal ciliopathies

01.03.2015 | Ranad Shaheen; Miriam Schmidts; Eissa Faqeih; Amal Hashem; Ekkehart Lausch; Isabel Holder; Andrea Superti-Furga; UK1 ..., Human Molecular Genetics, 2015

Jeune asphyxiating thoracic dystrophy (JATD) is a skeletal dysplasia characterized by a small thoracic cage and a range of skeletal and extra-skeletal anomalies. JATD is genetically heterogeneous with at least nine genes identified, all encoding ciliary proteins, hence the classification of JATD ...

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