Meine Merkliste  

19.016 Aktuelle Fachpublikationen zum Thema Addition

mit folgenden Suchkriterien:

The multiple roles of epidermal growth factor repeat O-glycans in animal development

01.10.2015 | Amanda R Haltom; Hamed Jafar-Nejad, Glycobiology , 2015

The epidermal growth factor (EGF)-like repeat is a common, evolutionarily conserved motif found in secreted proteins and the extracellular domain of transmembrane proteins. EGF repeats harbor six cysteine residues which form three disulfide bonds and help generate the three-dimensional structure ...


Protective effects of polysialic acid on proteolytic cleavage of FGF2 and proBDNF/BDNF

01.10.2015 | Masaya Hane; Shuhei Matsuoka; Sayaka Ono; Shinji Miyata; Ken Kitajima; Chihiro Sato, Glycobiology , 2015

Polysialic acid (polySia) is a linear polymer of sialic acid that modifies neural cell adhesion molecule (NCAM) in the vertebrate brain. PolySia is a large and exclusive molecule that functions as a negative regulator of cell–cell interactions. Recently, we demonstrated that polySia can ...


Mice expressing reduced levels of hepatic glucose-6-phosphatase-{alpha} activity do not develop age-related insulin resistance or obesity

15.09.2015 | Goo-Young Kim; Young Mok Lee; Jun-Ho Cho; Chi-Jiunn Pan; Hyun Sik Jun; Danielle A. Springer; Brian C. Mansfield; Jan ..., Human Molecular Genetics, 2015

Glycogen storage disease type-Ia (GSD-Ia) is caused by a lack of glucose-6-phosphatase-α (G6Pase-α or G6PC) activity. We have shown that gene therapy mediated by a recombinant adeno-associated virus (rAAV) vector expressing human G6Pase-α normalizes blood glucose homeostasis in the global G6pc ...


Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region

15.09.2015 | Zhenfei Ning; Andrew S. McLellan; Melanie Ball; Freda Wynne; Cora O'Neill; Walter Mills; John P. Quinn; Dirk A. Klei ..., Human Molecular Genetics, 2015

Sprouty proteins are regulators of cell growth and branching morphogenesis. Unlike mouse Spry3, which is X-linked, human SPRY3 maps to the pseudoautosomal region 2; however, the human Y-linked allele is not expressed due to epigenetic silencing by an unknown mechanism. SPRY3 maps adjacent to ...


Destabilization of microRNAs in human cells by 3′ deadenylation mediated by PARN and CUGBP1

03.09.2015 | Takayuki Katoh; Hiroaki Hojo; Tsutomu Suzuki, Nucleic Acids Research, 2015

MicroRNA-122 (miR-122), which is expressed at high levels in hepatocytes, is selectively stabilized by 3'-adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2. Here, we report that poly(A)-specific ribonuclease (PARN) is responsible for the deadenylation and destabilization of ...


Transcription yield of fully 2′-modified RNA can be increased by the addition of thermostabilizing mutations to T7 RNA polymerase mutants

03.09.2015 | Adam J. Meyer; Daniel J. Garry; Bradley Hall; Michelle M. Byrom; Hannah G. McDonald; Xu Yang; Y. Whitney Yin; Andrew ..., Nucleic Acids Research, 2015

On average, mutations are deleterious to proteins. Mutations conferring new function to a protein often come at the expense of protein folding or stability, reducing overall activity. Over the years, a panel of T7 RNA polymerases have been designed or evolved to accept nucleotides with modified ...


Accurate placement of substrate RNA by Gar1 in H/ACA RNA-guided pseudouridylation

03.09.2015 | Peng Wang; Lijiang Yang; Yi Qin Gao; Xin Sheng Zhao, Nucleic Acids Research, 2015

H/ACA RNA-guided ribonucleoprotein particle (RNP), the most complicated RNA pseudouridylase so far known, uses H/ACA guide RNA for substrate capture and four proteins (Cbf5, Nop10, L7Ae and Gar1) for pseudouridylation. Although it was shown that Gar1 not only facilitates the product release, but ...


Convenient analysis of protein modification by chemical blotting with fluorogenic “click” reagents

02.09.2015 | Jun Ohata; Farrukh Vohidov; Zachary Thomas Ball, Molecular BioSystems, 2015

Direct visualization of bioorthogonal alkyne or azide handles using fluorogenic azide-alkyne cycloaddition conducted on the surface of a blot membrane. The method eliminates the need for separation steps to remove excess small molecule reagents before attachment of antigen molecules or other ...


Human sialic acid acetyl esterase: Towards a better understanding of a puzzling enzyme

01.09.2015 | Flavia Orizio; Eufemia Damiati; Edoardo Giacopuzzi; Giuliana Benaglia; Stefano Pianta; Roland Schauer; Reinhard Schw ..., Glycobiology , 2015

Sialic acid acetyl esterase (SIAE) removes acetyl moieties from the hydroxyl groups in position 9 and 4 of sialic acid. Recently, a dispute has been opened on its association to autoimmunity. In order to get new insights on human SIAE biology and to clarify its seemingly contradictory molecular ...


Glycosaminoglycans affect heparanase location in CHO cell lines

01.09.2015 | Maria BR Piva; Eloah R Suarez; Carina M Melo; Renan P Cavalheiro; Helena B Nader; Maria AS Pinhal, Glycobiology , 2015

Glycosaminoglycans (GAG) play a ubiquitous role in tissues and cells. In eukaryotic cells, heparan sulfate (HS) is initially degraded by an endo-β-glucuronidase called heparanase-1 (HPSE). HS oligosaccharides generated by the action of HPSE intensify the activity of signaling molecules, ...


Seite 1 von 1902
Suche per e-Mail abonnieren

Sie erhalten passend zu Ihrer Suche die neusten Suchergebnisse per E-Mail. Dieser Service ist für Sie kostenlos und kann jederzeit abbestellt werden.

Ihr Bowser ist nicht aktuell. Microsoft Internet Explorer 6.0 unterstützt einige Funktionen auf Chemie.DE nicht.