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20.398 Aktuelle Fachpublikationen zum Thema Addition

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The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6−/− shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand

15.02.2016 | Daniele Conte; Giulia Garaffo; Nadia Lo Iacono; Stefano Mantero; Stefano Piccolo; Michelangelo Cordenonsi; David Per ..., Human Molecular Genetics, 2016

The congenital malformation split hand/foot (SHFM) is characterized by missing central fingers and dysmorphology or fusion of the remaining ones. Type-1 SHFM is linked to deletions/rearrangements of the DLX5–DLX6 locus and point mutations in the DLX5 gene. The ectrodactyly phenotype is reproduced ...

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MT-HESS: an efficient Bayesian approach for simultaneous association detection in OMICS datasets, with application to eQTL mapping in multiple tissues

15.02.2016 | Alex Lewin; Habib Saadi; James E. Peters; Aida Moreno-Moral; James C. Lee; Kenneth G. C. Smith; Enrico Petretto; Leo ..., Bioinformatics, 2016

Motivation: Analysing the joint association between a large set of responses and predictors is a fundamental statistical task in integrative genomics, exemplified by numerous expression Quantitative Trait Loci (eQTL) studies. Of particular interest are the so-called ‘hotspots’, important genetic ...

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Efficient synthesis and biological evaluation of a novel series of 1,5‐benzodiazepine derivatives as potential antimicrobial agents

06.02.2016 | Ying‐shuang An, Zhen‐fang Hao, Xiu‐jun Zhang, Lan‐zhi Wang, Chemical Biology & Drug Design, 2016

Abstract A series of novel 1,5‐benzodiazepine derivatives were rationally designed and synthesized following the principle of the superposition of bioactive substructures by the combination of 1,5‐benzodiazepine, pyridine (phenyl) and an ester group. The structures of the target compounds were ...

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Characterization of functionally active interleukin‐18/eGFP fusion protein expression during cell cycle phases in recombinant chicken DF1 cells

06.02.2016 | Hsing Chieh Wu, Yu San Chen, Jui Hung Shien, Pin Chun Shen, Long Huw Lee, Biotechnology Progress, 2016

Abstract The dependence of foreign gene expression on cell cycle phases in mammalian cells has been described. In this study, we constructed a DF1/chIL‐18a cell line that stably expresses the fusion protein chIL‐18 and the enhanced green fluorescence protein connected through a (G4S)3 linker ...

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Modeling bond correlations in denatured proteins and polypeptides

06.02.2016 | Marcos R. Betancourt, Biopolymers, 2016

Abstract Bond‐orientational correlations for finite‐length homopolypeptides and a selected group of denatured proteins are obtained by numerical simulations using a polypeptide model with a potential of mean force. These correlations characterize the stiffness of the polypeptide backbone and ...

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Delayed astrocytic contact with cerebral blood vessels in FGF‐2 deficient mice does not compromise permeability properties at the developing blood‐brain barrier

06.02.2016 | Norman R. Saunders, Katarzyna M. Dziegielewska, Klaus Unsicker, C. Joakim Ek, Developmental Neurobiology, 2016

Abstract The brain functions within a specialised environment tightly controlled by brain barrier mechanisms. Understanding the regulation of barrier formation is important for understanding brain development and may also lead to finding new ways to deliver pharmacotherapies to the brain; ...

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Y‐chromosome identification in circulating cell‐free fetal DNA using surface plasmon resonance

06.02.2016 | Giulia Breveglieri, Elisabetta Bassi, Silvia Carlassara, Lucia Carmela Cosenza, Patrizia Pellegatti, Giovanni Guerra ..., Prenatal Diagnosis, 2016

Abstract Objective Since the discovery of cell‐free fetal DNA (cffDNA) in maternal plasma, diagnostic non‐invasive prenatal methods have been developed or optimized for fetal sex determination and identification of genetic diseases. As far as fetal sex determination, this might be important ...

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Optimization of large‐ring cyclodextrin production from starch by amylomaltase from Corynebacterium glutamicum and effect of organic solvent on product size

05.02.2016 | Teerawit Vongpichayapaiboon, Piamsook Pongsawasdi, Kuakarun Krusong, Journal of Applied Microbiology, 2016

Abstract Aims To increase yield of starch conversion to large‐ring cyclodextrins (LR‐CDs) by amylomaltase from Corynebacterium glutamicum (CgAM). Methods and Results In this work, LR‐CDs produced from pea, tapioca, corn, potato, rice and glutinous rice starch by the recombinant CgAM ...

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Atherogenesis: hyperhomocysteinemia interactions with LDL, macrophage function, paraoxonase 1, and exercise

05.02.2016 | Ilya Chernyavskiy, Sudhakar Veeranki, Utpal Sen, Suresh C. Tyagi, Annals of the New York Academy of Sciences, 2016

Despite great strides in understanding the atherogenesis process, the mechanisms are not entirely known. In addition to diet, cigarette smoking, genetic predisposition, and hypertension, hyperhomocysteinemia (HHcy), an accumulation of the noncoding sulfur‐containing amino acid homocysteine ...

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Standardization of cryopreserved peripheral blood mononuclear cells through a resting process for clinical immunomonitoring—Development of an algorithm

05.02.2016 | Lei Wang, Angela Hückelhoven, Jian Hong, Nan Jin, Jiju Mani, Bao‐an Chen, Michael Schmitt, Anita Schmitt, Cytometry Part A, 2016

Abstract Flow cytometry, as a powerful tool for immunomonitoring and quality control of peripheral blood mononuclear cells (PBMCs), is routinely used in clinical studies. However, flow cytometry based assays for cryopreserved peripheral blood mononuclear cells (cPBMCs) constitute a challenge. ...

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