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15.436 Aktuelle Fachpublikationen zum Thema Addition

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sPARTA: a parallelized pipeline for integrated analysis of plant miRNA and cleaved mRNA data sets, including new miRNA target-identification software

01.02.2015 | Atul Kakrana; Reza Hammond; Parth Patel; Mayumi Nakano; Blake C. Meyers, Nucleic Acids Research, 2015

Parallel analysis of RNA ends (PARE) is a technique utilizing high-throughput sequencing to profile uncapped, mRNA cleavage or decay products on a genome-wide basis. Tools currently available to validate miRNA targets using PARE data employ only annotated genes, whereas important targets may be ...

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Absolute and relative quantification of RNA modifications via biosynthetic isotopomers

01.02.2015 | Stefanie Kellner; Antonia Ochel; Kathrin Thüring; Felix Spenkuch; Jennifer Neumann; Sunny Sharma; Karl-Dieter Entian ..., Nucleic Acids Research, 2015

In the resurging field of RNA modifications, quantification is a bottleneck blocking many exciting avenues. With currently over 150 known nucleoside alterations, detection and quantification methods must encompass multiple modifications for a comprehensive profile. LC–MS/MS approaches offer a ...

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Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4)

01.02.2015 | James E. Thornton; Peng Du; Lili Jing; Ljiljana Sjekloca; Shuibin Lin; Elena Grossi; Piotr Sliz; Leonard I. Zon; Ric ..., Nucleic Acids Research, 2015

Recent small RNA sequencing data has uncovered 3' end modification of mature microRNAs (miRNAs). This non-templated nucleotide addition can impact miRNA gene regulatory networks through the control of miRNA stability or by interfering with the repression of target mRNAs. The miRNA modifying ...

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A high-resolution network model for global gene regulation in Mycobacterium tuberculosis

01.02.2015 | Eliza J.R. Peterson; David J. Reiss; Serdar Turkarslan; Kyle J. Minch; Tige Rustad; Christopher L. Plaisier; William ..., Nucleic Acids Research, 2015

The resilience of Mycobacterium tuberculosis (MTB) is largely due to its ability to effectively counteract and even take advantage of the hostile environments of a host. In order to accelerate the discovery and characterization of these adaptive mechanisms, we have mined a compendium of 2325 ...

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Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae

01.02.2015 | Xin Deng; Haihua Liang; Kai Chen; Chuan He; Lefu Lan; Xiaoyan Tang, Nucleic Acids Research, 2015

Pseudomonas syringae uses the two-component system RhpRS to regulate the expression of type III secretion system (T3SS) genes and bacterial virulence. However, the molecular mechanisms and the regulons of RhpRS have yet to be fully elucidated. Here, we show that RhpS functions as a kinase and a ...

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Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism

01.02.2015 | Anas M Abdel Rahman; Michael Ryczko; Miyako Nakano; Judy Pawling; Tania Rodrigues; Anita Johswich; Naoyuki Taniguchi ..., Glycobiology , 2015

Nutrient transporters are critical gate-keepers of extracellular metabolite entry into the cell. As integral membrane proteins, most transporters are N-glycosylated, and the N-glycans are remodeled in the Golgi apparatus. The Golgi branching enzymes N-acetylglucosaminyltransferases I, II, IV, V ...

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Interactions of human galectins with Trypanosoma cruzi: Binding profile correlate with genetic clustering of lineages

01.02.2015 | M A Pineda; L Corvo; M Soto; M Fresno; P Bonay, Glycobiology , 2015

We report here the specific interaction between several members of the human galectin family with the three developmental stages of several genetic lineages of the protozoan parasite Trypanosoma cruzi. We provide data of specific and differential binding of human galectin (gal)-1, -3, -4, -7 and ...

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The IRF5–TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share

15.01.2015 | Leah C. Kottyan; Erin E. Zoller; Jessica Bene; Xiaoming Lu; Jennifer A. Kelly; Andrew M. Rupert; Christopher J. Less ..., Human Molecular Genetics, 2015

Exploiting genotyping, DNA sequencing, imputation and trans-ancestral mapping, we used Bayesian and frequentist approaches to model the IRF5–TNPO3 locus association, now implicated in two immunotherapies and seven autoimmune diseases. Specifically, in systemic lupus erythematosus (SLE), we ...

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Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia

15.01.2015 | Noriko Funato; Masataka Nakamura; James A. Richardson; Deepak Srivastava; Hiromi Yanagisawa, Human Molecular Genetics, 2015

T-box transcription factor, TBX1, is the major candidate gene for 22q11.2 deletion syndrome (DiGeorge/ Velo-cardio-facial syndrome) characterized by facial defects, thymus hypoplasia, cardiovascular anomalies and cleft palates. Here, we report that the loss of Tbx1 in mouse (Tbx1–/–) results in ...

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A novel bile acid biosynthesis defect due to a deficiency of peroxisomal ABCD3

15.01.2015 | Sacha Ferdinandusse; Gerardo Jimenez-Sanchez; Janet Koster; Simone Denis; Carlo W. Van Roermund; Irma Silva-Zol ..., Human Molecular Genetics, 2015

ABCD3 is one of three ATP-binding cassette (ABC) transporters present in the peroxisomal membrane catalyzing ATP-dependent transport of substrates for metabolic pathways localized in peroxisomes. So far, the precise function of ABCD3 is not known. Here, we report the identification of the first ...

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