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CDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death

15.08.2015 | Arezu Jahani-Asl; En Huang; Isabella Irrcher; Juliet Rashidian; Naotada Ishihara; Diane C. Lagace; Ruth S. Slack; Da ..., Human Molecular Genetics, 2015

Defects in mitochondrial fission and cyclin dependent kinase 5 (CDK5) activation are early events that precede neuronal loss following NMDA-induced neuronal death. Here, we report that the cytoplasmic CDK5 tightly regulates mitochondrial morphology defects associated with NMDA-induced neuronal ...


X chromosome-linked intellectual disability protein PQBP1 associates with and regulates the translation of specific mRNAs

15.08.2015 | Didi Wan; Zi Chao Zhang; Xiaoyan Zhang; Qian Li; Junhai Han, Human Molecular Genetics, 2015

X chromosome-linked intellectual disability is a common developmental disorder, and mutations of the polyglutamine-binding protein 1 (PQBP1) gene have been linked to this disease. In addition to existing in the nucleus as a splicing factor, PQBP1 is also found in cytoplasmic RNA granules, where ...


Expression of stage-specific embryonic antigen-4 (SSEA-4) defines spontaneous loss of epithelial phenotype in human solid tumor cells

01.08.2015 | Kavitha Sivasubramaniyan; Abhishek Harichandan; Karin Schilbach; Andreas F Mack; Jens Bedke; Arnulf Stenzl; Lothar K ..., Glycobiology , 2015

Stage-specific embryonic antigen-4 (SSEA-4) is a glycosphingolipid, which is overexpressed in some cancers and has been linked to disease progression. However, little is known about the functions of SSEA-4 and the characteristics of SSEA-4 expressing tumor cells. Our studies identified SSEA-4 ...


4-Methylumbelliferone inhibits hepatocellular carcinoma growth by decreasing IL-6 production and angiogenesis

01.08.2015 | Flavia Piccioni; Esteban Fiore; Juan Bayo; Catalina Atorrasagasti; Estanislao Peixoto; Manglio Rizzo; Mariana Malvic ..., Glycobiology , 2015

Cirrhosis is characterized by an excessive accumulation of extracellular matrix components including hyaluronic acid (HA) and is widely considered a preneoplastic condition for hepatocellular carcinoma (HCC). 4-Methylumbelliferone (4MU) is an inhibitor of HA synthesis and has anticancer activity ...


Seipin is necessary for normal brain development and spermatogenesis in addition to adipogenesis

01.08.2015 | Chihiro Ebihara; Ken Ebihara; Megumi Aizawa-Abe; Tomoji Mashimo; Tsutomu Tomita; Mingming Zhao; Valentino Gumbilai; ..., Human Molecular Genetics, 2015

Seipin, encoded by BSCL2 gene, is a protein whose physiological functions remain unclear. Mutations of BSCL2 cause the most-severe form of congenital generalized lipodystrophy (CGL). BSCL2 mRNA is highly expressed in the brain and testis in addition to the adipose tissue in human, suggesting ...


How much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse

01.08.2015 | Caroline Godfrey; Sofia Muses; Graham McClorey; Kim E. Wells; Thibault Coursindel; Rebecca L. Terry; Corinne Betts; ..., Human Molecular Genetics, 2015

Splice modulation therapy has shown great clinical promise in Duchenne muscular dystrophy, resulting in the production of dystrophin protein. Despite this, the relationship between restoring dystrophin to established dystrophic muscle and its ability to induce clinically relevant changes in ...


Measurements of Neuronal Soma Size and Estimated Peptide Concentrations in Addition to Cell Abundance Offer a Higher Resolution of Seasonal and Reproductive Influences of GnRH-I and GnIH in European Starlings

01.08.2015 | Nelson Amorin; Rebecca M. Calisi, Integrative and Comparative Biology, 2015

Hypothalamic neuropeptides involved in vertebrate reproduction, gonadotropin releasing hormone (GnRH-I) and gonadotropin-inhibitory hormone (GnIH), can vary in the abundance of immunoreactive cells as a function of the reproductive status and nest box occupation of European starlings (Sturnus ...


Dissecting Molecular Evolution in the Highly Diverse Plant Clade Caryophyllales Using Transcriptome Sequencing

01.08.2015 | Ya Yang; Michael J. Moore; Samuel F. Brockington; Douglas E. Soltis; Gane Ka-Shu Wong; Eric J. Carpenter; Yong Zhang ..., Molecular Biology and Evolution, 2015

Many phylogenomic studies based on transcriptomes have been limited to "single-copy" genes due to methodological challenges in homology and orthology inferences. Only a relatively small number of studies have explored analyses beyond reconstructing species relationships. We sampled 69 ...


DEOD: uncovering dominant effects of cancer-driver genes based on a partial covariance selection method

01.08.2015 | Bayarbaatar Amgalan; Hyunju Lee, Bioinformatics, 2015

Motivation: The generation of a large volume of cancer genomes has allowed us to identify disease-related alterations more accurately, which is expected to enhance our understanding regarding the mechanism of cancer development. With genomic alterations detected, one challenge is to pinpoint ...


PRROC: computing and visualizing precision-recall and receiver operating characteristic curves in R

01.08.2015 | Jan Grau; Ivo Grosse; Jens Keilwagen, Bioinformatics, 2015

Summary: Precision-recall (PR) and receiver operating characteristic (ROC) curves are valuable measures of classifier performance. Here, we present the R-package PRROC, which allows for computing and visualizing both PR and ROC curves. In contrast to available R-packages, PRROC allows for ...


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