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15.619 Aktuelle Fachpublikationen zum Thema Addition

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The differential characterization of GPR55 receptor in human peripheral blood reveals a distinctive expression in monocytes and NK cells and a proinflammatory role in these innate cells

01.03.2015 | Valerio Chiurchiù; Mirko Lanuti; Marco De Bardi; Luca Battistini; Mauro Maccarrone, International Immunology, 2015

G protein-coupled receptor 55 (GPR55) is activated by endogenous, plant-derived and synthetic cannabinoids. Recent studies reported a broad tissue distribution for GPR55 and found prominent roles for this receptor in inflammatory pain, gut and bone physiology, as well as cancer. However, little ...

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A deeply conserved, noncanonical miRNA hosted by ribosomal DNA [ARTICLES]

01.03.2015 | Li-Ling Chak; Jaaved Mohammed; Eric C. Lai; Greg Tucker-Kellogg; Katsutomo Okamura, RNA, 2015

Advances in small RNA sequencing technologies and comparative genomics have fueled comprehensive microRNA (miRNA) gene annotations in humans and model organisms. Although new miRNAs continue to be discovered in recent years, these have universally been lowly expressed, recently evolved, and of ...

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Disease origin and progression in amyotrophic lateral sclerosis: an immunology perspective

01.03.2015 | Andrea Malaspina; Fabiola Puentes; Sandra Amor, International Immunology, 2015

The immune system is inextricably linked with many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), a devastating neuromuscular disorder affecting motor cell function with an average survival of 3 years from symptoms onset. In ALS, there is a dynamic interplay between the ...

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Expression inactivation of SMARCA4 by microRNAs in lung tumors

01.03.2015 | Isabel F. Coira; Eva E. Rufino-Palomares; Octavio A. Romero; Paola Peinado; Chanatip Metheetrairut; Laura Boyero-Cor ..., Human Molecular Genetics, 2015

SMARCA4 is the catalytic subunit of the SWI/SNF chromatin-remodeling complex, which alters the interactions between DNA and histones and modifies the availability of the DNA for transcription. The latest deep sequencing of tumor genomes has reinforced the important and ubiquitous tumor suppressor ...

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Genomic Signatures Reveal New Evidences for Selection of Important Traits in Domestic Cattle

01.03.2015 | Lingyang Xu; Derek M. Bickhart; John B. Cole; Steven G. Schroeder; Jiuzhou Song; Curtis P. Van Tassell; Tad S. Sonst ..., Molecular Biology and Evolution, 2015

We investigated diverse genomic selections using high-density single nucleotide polymorphism data of five distinct cattle breeds. Based on allele frequency differences, we detected hundreds of candidate regions under positive selection across Holstein, Angus, Charolais, Brahman, and N'Dama. In ...

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Functional Conservation of Both CDS- and 3′-UTR-Located MicroRNA Binding Sites between Species

01.03.2015 | Guojing Liu; Rui Zhang; Jin Xu; Chung-I Wu; Xuemei Lu, Molecular Biology and Evolution, 2015

MicroRNAs (miRNAs) mediate gene regulation posttranscriptionally through pairing of their seed (2–7 nt) to 3'-untranslated regions (3'-UTRs) or coding regions (coding sequences [CDSs]) of their target genes. CDS target sites generally show weaker repression effects than 3'-UTR sites. However, ...

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Venom-Related Transcripts from Bothrops jararaca Tissues Provide Novel Molecular Insights into the Production and Evolution of Snake Venom

01.03.2015 | Inácio L.M. Junqueira-de-Azevedo; Carolina Mancini Val Bastos; Paulo Lee Ho; Milene Schmidt Luna; Norma Yamanouye; N ..., Molecular Biology and Evolution, 2015

Attempts to reconstruct the evolutionary history of snake toxins in the context of their co-option to the venom gland rarely account for nonvenom snake genes that are paralogous to toxins, and which therefore represent important connectors to ancestral genes. In order to reevaluate this process, ...

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Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells

01.03.2015 | Timothy N. Perkins; Paul M. Peeters; Arti Shukla; Ingrid Arijs; Julie Dragon; Emiel F.M. Wouters; Niki L. Reynaert; ..., Human Molecular Genetics, 2015

Occupational and environmental exposures to airborne asbestos and silica are associated with the development of lung fibrosis in the forms of asbestosis and silicosis, respectively. However, both diseases display distinct pathologic presentations, likely associated with differences in gene ...

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Expression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior

01.03.2015 | Jean-Ha Baek; Eva Schmidt; Nikenza Viceconte; Charlotte Strandgren; Karin Pernold; Thibaud J. C. Richard; Fred W. Va ..., Human Molecular Genetics, 2015

Hutchinson–Gilford progeria syndrome (HGPS) is a segmental progeroid syndrome with multiple features suggestive of premature accelerated aging. Accumulation of progerin is thought to underlie the pathophysiology of HGPS. However, despite ubiquitous expression of lamin A in all differentiated ...

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Control of homeostatic and pathogenic balance in adipose tissue by ganglioside GM3

01.03.2015 | Masakazu Nagafuku; Takashige Sato; Saya Sato; Kyoko Shimizu; Toshio Taira; Jin-Ichi Inokuchi, Glycobiology , 2015

Ganglioside GM3 (Siaα2-3Galβ1-4Glcβ1-1Cer) has been known to participate in insulin signaling by regulating the association of the insulin receptor in caveolae microdomains (lipid rafts), which is essential for the execution of the complete insulin metabolic signaling in adipocytes. ...

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