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15.315 Aktuelle Fachpublikationen zum Thema Addition

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sPARTA: a parallelized pipeline for integrated analysis of plant miRNA and cleaved mRNA data sets, including new miRNA target-identification software

01.02.2015 | Atul Kakrana; Reza Hammond; Parth Patel; Mayumi Nakano; Blake C. Meyers, Nucleic Acids Research, 2015

Parallel analysis of RNA ends (PARE) is a technique utilizing high-throughput sequencing to profile uncapped, mRNA cleavage or decay products on a genome-wide basis. Tools currently available to validate miRNA targets using PARE data employ only annotated genes, whereas important targets may be ...

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Absolute and relative quantification of RNA modifications via biosynthetic isotopomers

01.02.2015 | Stefanie Kellner; Antonia Ochel; Kathrin Thüring; Felix Spenkuch; Jennifer Neumann; Sunny Sharma; Karl-Dieter Entian ..., Nucleic Acids Research, 2015

In the resurging field of RNA modifications, quantification is a bottleneck blocking many exciting avenues. With currently over 150 known nucleoside alterations, detection and quantification methods must encompass multiple modifications for a comprehensive profile. LC–MS/MS approaches offer a ...

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Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4)

01.02.2015 | James E. Thornton; Peng Du; Lili Jing; Ljiljana Sjekloca; Shuibin Lin; Elena Grossi; Piotr Sliz; Leonard I. Zon; Ric ..., Nucleic Acids Research, 2015

Recent small RNA sequencing data has uncovered 3' end modification of mature microRNAs (miRNAs). This non-templated nucleotide addition can impact miRNA gene regulatory networks through the control of miRNA stability or by interfering with the repression of target mRNAs. The miRNA modifying ...

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A high-resolution network model for global gene regulation in Mycobacterium tuberculosis

01.02.2015 | Eliza J.R. Peterson; David J. Reiss; Serdar Turkarslan; Kyle J. Minch; Tige Rustad; Christopher L. Plaisier; William ..., Nucleic Acids Research, 2015

The resilience of Mycobacterium tuberculosis (MTB) is largely due to its ability to effectively counteract and even take advantage of the hostile environments of a host. In order to accelerate the discovery and characterization of these adaptive mechanisms, we have mined a compendium of 2325 ...

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Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae

01.02.2015 | Xin Deng; Haihua Liang; Kai Chen; Chuan He; Lefu Lan; Xiaoyan Tang, Nucleic Acids Research, 2015

Pseudomonas syringae uses the two-component system RhpRS to regulate the expression of type III secretion system (T3SS) genes and bacterial virulence. However, the molecular mechanisms and the regulons of RhpRS have yet to be fully elucidated. Here, we show that RhpS functions as a kinase and a ...

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Molecular characterization of a new N-acetylneuraminate synthase (NeuB1) from Idiomarina loihiensis

01.01.2015 | María Inmaculada García García; Kam Lau; Mark von Itzstein; Francisco García Carmona; Álvaro Sánchez Ferrer, Glycobiology , 2015

N-Acetylneuraminate lyase synthase (NeuB; E.C. 2.5.1.56) is a key enzyme in pathogenic microorganisms for producing N-acetylneuraminic acid through the irreversible condensation of N-acetylmannosamine (ManNAc) and phosphoenolpyruvate (PEP). However, nothing is known about this enzyme in ...

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Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus

01.01.2015 | Yan Zhang; Jing Zhang; Jing Yang; Yongfei Wang; Lu Zhang; Xianbo Zuo; Liangdan Sun; Hai-Feng Pan; Nattiya Hirankarn; ..., Human Molecular Genetics, 2015

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease that affects mainly females. What role the X chromosome plays in the disease has always been an intriguing question. In this study, we examined the genetic variants on the X chromosome through meta-analysis of two genome-wide ...

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A murine model of neurofibromatosis type 2 that accurately phenocopies human schwannoma formation

01.01.2015 | Jeffrey R. Gehlhausen; Su-Jung Park; Ann E. Hickox; Matthew Shew; Karl Staser; Steven D. Rhodes; Keshav Menon; Jacqu ..., Human Molecular Genetics, 2015

Neurofibromatosis type 2 (NF2) is an autosomal dominant genetic disorder resulting from germline mutations in the NF2 gene. Bilateral vestibular schwannomas, tumors on cranial nerve VIII, are pathognomonic for NF2 disease. Furthermore, schwannomas also commonly develop in other cranial nerves, ...

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Rare mutations associating with serum creatinine and chronic kidney disease

20.12.2014 | Gardar Sveinbjornsson; Evgenia Mikaelsdottir; Runolfur Palsson; Olafur S. Indridason; Hilma Holm; Aslaug Jonasdottir ..., Human Molecular Genetics, 2014

Chronic kidney disease (CKD) is a complex disorder with a strong genetic component. A number of common sequence variants have been found to associate with serum creatinine (SCr), estimated glomerular filtration rate (eGFR) and/or CKD. We imputed 24 million single-nucleotide polymorphisms and ...

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Deactivation of TBP contributes to SCA17 pathogenesis

20.12.2014 | Tun-Chieh Hsu; Cheng-Kuang Wang; Chun-Yen Yang; Li-Ching Lee; Hsiu-Mei Hsieh-Li; Long-Sun Ro; Chiung-Mei Chen; Guey- ..., Human Molecular Genetics, 2014

Spinocerebellar ataxia type 17 (SCA17) is an autosomal dominant cerebellar ataxia caused by the expansion of polyglutamine (polyQ) within the TATA box-binding protein (TBP). Previous studies have shown that polyQ-expanded TBP forms neurotoxic aggregates and alters downstream genes. However, how ...

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