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18.363 Aktuelle Fachpublikationen zum Thema Addition

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An updated evolutionary study of Flaviviridae NS3 helicase and NS5 RNA-dependent RNA polymerase, reveals novel invariable motifs as potential pharmacological targets.

03.02.2016 | Louis Papageorgiou; Styliani Loukatou; Sofia Kossida; Dimitris Maroulis; Dimitrios Vlachakis, Molecular BioSystems, 2016

The rate of Flaviviridae family viruses infections worldwide has increased dramatically in the last few years. In addition, infections caused by arthropod vectors viruses including Hepatitis C, West Nile, Dengue fever, Yellow fever and Japanese encephalitis are emerging throughout the world. ...


Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells [ARTICLE]

01.02.2016 | Chun-Yu Cho; Jhy-Shrian Huang; Shine-Gwo Shiah; Shih-Ying Chung; Jong-Ding Lay; Ya-Yu Yang; Gi-Ming Lai; Ann-Lii Che ..., RNA, 2016

The AXL receptor tyrosine kinase is frequently overexpressed in cancers and is important in cancer invasion/metastasis and chemoresistance. Here, we demonstrate a regulatory feedback loop between AXL and microRNA (miRNA) at the post-transcriptional level. Both the GAS6-binding domain and the ...


Sequencing of lariat termini in S. cerevisiae reveals 5' splice sites, branch points, and novel splicing events [ARTICLE]

01.02.2016 | Daoming Qin; Lei Huang; Alissa Wlodaver; Jorge Andrade; Jonathan P. Staley, RNA, 2016

Pre-mRNA splicing is a central step in the shaping of the eukaryotic transcriptome and in the regulation of gene expression. Yet, due to a focus on fully processed mRNA, common approaches for defining pre-mRNA splicing genome-wide are suboptimal—especially with respect to defining the branch ...


Changes in gene expression and histological injuries as a result of exposure of Crassostrea gigas to the toxic dinoflagellate Gymnodinium catenatum

01.02.2016 | Norma García-Lagunas; Reyna de Jesús Romero-Geraldo; Norma Yolanda Hernández-Saavedra, Journal of Molluscan Studies, 2016

The harmful alga Gymnodinium catenatum is one of the species that produces the neurotoxic, hydrophilic, tetrahydropurine derivatives known as paralytic shellfish toxins (PST). Studies have shown that several classes of marine toxins have genotoxic effects on bivalves. However, there are few ...


SHV-129: A Gateway to Global Suppressors in the SHV {beta}-Lactamase Family?

01.02.2016 | Marisa L. Winkler; Robert A. Bonomo, Molecular Biology and Evolution, 2016

Enzymes are continually evolving in response to environmental pressures. In order to increase enzyme fitness, amino acid substitutions can occur leading to a changing function or an increased stability. These evolutionary drivers determine the activity of an enzyme and its success in future ...


Genetic Determinism and Evolutionary Reconstruction of a Host Jump in a Plant Virus

01.02.2016 | Nikon Vassilakos; Vincent Simon; Aliki Tzima; Elisabeth Johansen; Benoît Moury, Molecular Biology and Evolution, 2016

In spite of their widespread occurrence, only few host jumps by plant viruses have been evidenced and the molecular bases of even fewer have been determined. A combination of three independent approaches, 1) experimental evolution followed by reverse genetics analysis, 2) positive selection ...


Stepwise Functional Evolution in a Fungal Sugar Transporter Family

01.02.2016 | Carla Gonçalves; Marco A. Coelho; Madalena Salema-Oom; Paula Gonçalves, Molecular Biology and Evolution, 2016

Sugar transport is of the utmost importance for most cells and is central to a wide range of applied fields. However, despite the straightforward in silico assignment of many novel transporters, including sugar porters, to existing families, their exact biological role and evolutionary trajectory ...


Determinants of the Usage of Splice-Associated cis-Motifs Predict the Distribution of Human Pathogenic SNPs

01.02.2016 | XianMing Wu; Laurence D. Hurst, Molecular Biology and Evolution, 2016

Where in genes do pathogenic mutations tend to occur and does this provide clues as to the possible underlying mechanisms by which single nucleotide polymorphisms (SNPs) cause disease? As splice-disrupting mutations tend to occur predominantly at exon ends, known also to be hot spots of ...


Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways

01.02.2016 | Shoko Akasaki; Kazufumi Matsushita; Yukinori Kato; Ayumi Fukuoka; Naruhito Iwasaki; Masakiyo Nakahira; Shigeharu Fuj ..., International Immunology, 2016

Thymic stromal lymphopoietin (TSLP) and IL-33 are epithelium-derived proallergic cytokines that contribute to allergic diseases. Although the involvement of TSLP in allergic rhinitis (AR) is suggested, the exact role of TSLP in AR is poorly understood. Furthermore, the relative contribution of ...


Natriuretic Peptides as Cardiovascular Safety Biomarkers in Rats: Comparison With Blood Pressure, Heart Rate, and Heart Weight

01.02.2016 | Steven K. Engle; David E. Watson, Toxicological Sciences, 2016

Cardiovascular (CV) toxicity is an important cause of failure during drug development. Blood-based biomarkers can be used to detect CV toxicity during preclinical development and prioritize compounds at lower risk of causing such toxicities. Evidence of myocardial degeneration can be detected by ...


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