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17.158 Aktuelle Fachpublikationen zum Thema Addition

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Mice expressing reduced levels of hepatic glucose-6-phosphatase-{alpha} activity do not develop age-related insulin resistance or obesity

15.09.2015 | Goo-Young Kim; Young Mok Lee; Jun-Ho Cho; Chi-Jiunn Pan; Hyun Sik Jun; Danielle A. Springer; Brian C. Mansfield; Jan ..., Human Molecular Genetics, 2015

Glycogen storage disease type-Ia (GSD-Ia) is caused by a lack of glucose-6-phosphatase-α (G6Pase-α or G6PC) activity. We have shown that gene therapy mediated by a recombinant adeno-associated virus (rAAV) vector expressing human G6Pase-α normalizes blood glucose homeostasis in the global G6pc ...

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Destabilization of microRNAs in human cells by 3′ deadenylation mediated by PARN and CUGBP1

03.09.2015 | Takayuki Katoh; Hiroaki Hojo; Tsutomu Suzuki, Nucleic Acids Research, 2015

MicroRNA-122 (miR-122), which is expressed at high levels in hepatocytes, is selectively stabilized by 3'-adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2. Here, we report that poly(A)-specific ribonuclease (PARN) is responsible for the deadenylation and destabilization of ...

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Convenient analysis of protein modification by chemical blotting with fluorogenic “click” reagents

02.09.2015 | Jun Ohata; Farrukh Vohidov; Zachary Thomas Ball, Molecular BioSystems, 2015

Direct visualization of bioorthogonal alkyne or azide handles using fluorogenic azide-alkyne cycloaddition conducted on the surface of a blot membrane. The method eliminates the need for separation steps to remove excess small molecule reagents before attachment of antigen molecules or other ...

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Human sialic acid acetyl esterase: Towards a better understanding of a puzzling enzyme

01.09.2015 | Flavia Orizio; Eufemia Damiati; Edoardo Giacopuzzi; Giuliana Benaglia; Stefano Pianta; Roland Schauer; Reinhard Schw ..., Glycobiology , 2015

Sialic acid acetyl esterase (SIAE) removes acetyl moieties from the hydroxyl groups in position 9 and 4 of sialic acid. Recently, a dispute has been opened on its association to autoimmunity. In order to get new insights on human SIAE biology and to clarify its seemingly contradictory molecular ...

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Glycosaminoglycans affect heparanase location in CHO cell lines

01.09.2015 | Maria BR Piva; Eloah R Suarez; Carina M Melo; Renan P Cavalheiro; Helena B Nader; Maria AS Pinhal, Glycobiology , 2015

Glycosaminoglycans (GAG) play a ubiquitous role in tissues and cells. In eukaryotic cells, heparan sulfate (HS) is initially degraded by an endo-β-glucuronidase called heparanase-1 (HPSE). HS oligosaccharides generated by the action of HPSE intensify the activity of signaling molecules, ...

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Crystal structure of a symbiosis-related lectin from octocoral

01.09.2015 | Akiko Kita; Mitsuru Jimbo; Ryuichi Sakai; Yukio Morimoto; Kunio Miki, Glycobiology , 2015

D-Galactose-binding lectin from the octocoral, Sinularia lochmodes (SLL-2), distributes densely on the cell surface of microalgae, Symbiodinium sp., an endosymbiotic dinoflagellate of the coral, and is also shown to be a chemical cue that transforms dinoflagellate into a non-motile (coccoid) ...

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I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3{beta} signaling pathway

01.09.2015 | Etsuro Ohta; Tomoko Nihira; Akiko Uchino; Yoichi Imaizumi; Yohei Okada; Wado Akamatsu; Kayoko Takahashi; Hideki Haya ..., Human Molecular Genetics, 2015

Leucine-rich repeat kinase 2 (LRRK2) is the causative molecule of the autosomal dominant hereditary form of Parkinson's disease (PD), PARK8, which was originally defined in a study of a Japanese family (the Sagamihara family) harboring the I2020T mutation in the kinase domain. Although a number ...

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Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation

01.09.2015 | Andrés Miguez; Gerardo García-Díaz Barriga; Verónica Brito; Marco Straccia; Albert Giralt; Silvia Ginés; Josep M. Ca ..., Human Molecular Genetics, 2015

Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by motor and cognitive impairments, involving striatum, cortex and hippocampus. Synaptic and memory dysfunction in HD mouse models have been related to low levels of brain-derived neurotrophic factor (BDNF) and ...

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DICER/AGO-dependent epigenetic silencing of D4Z4 repeats enhanced by exogenous siRNA suggests mechanisms and therapies for FSHD

01.09.2015 | Jong-Won Lim; Lauren Snider; Zizhen Yao; Rabi Tawil; Silvère M. Van Der Maarel; Frank Rigo; C. Frank Bennett; Galina ..., Human Molecular Genetics, 2015

Facioscapulohumeral muscular dystrophy (FSHD) is caused by the aberrant expression of the DUX4 transcription factor in skeletal muscle. The DUX4 retrogene is encoded in the D4Z4 macrosatellite repeat array, and smaller array size or a mutation in the SMCHD1 gene results in inefficient epigenetic ...

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Cytotoxicity and genotoxicity of urban particulate matter in mammalian cells

01.09.2015 | Audrey F. Dumax-Vorzet; M. Tate; Richard Walmsley; Rhod H. Elder; Andrew C. Povey, Mutagenesis, 2015

Ambient air particulate matter (PM)-associated reactive oxygen species (ROS) have been linked to a variety of altered cellular outcomes. In this study, three different PM samples from diesel exhaust particles (DEPs), urban dust standard reference material SRM1649a and air collected in Manchester ...

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