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20.304 Aktuelle Fachpublikationen zum Thema Addition

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MT-HESS: an efficient Bayesian approach for simultaneous association detection in OMICS datasets, with application to eQTL mapping in multiple tissues

15.02.2016 | Alex Lewin; Habib Saadi; James E. Peters; Aida Moreno-Moral; James C. Lee; Kenneth G. C. Smith; Enrico Petretto; Leo ..., Bioinformatics, 2016

Motivation: Analysing the joint association between a large set of responses and predictors is a fundamental statistical task in integrative genomics, exemplified by numerous expression Quantitative Trait Loci (eQTL) studies. Of particular interest are the so-called ‘hotspots’, important genetic ...


Delayed astrocytic contact with cerebral blood vessels in FGF‐2 deficient mice does not compromise permeability properties at the developing blood‐brain barrier

06.02.2016 | Norman R. Saunders, Katarzyna M. Dziegielewska, Klaus Unsicker, C. Joakim Ek, Developmental Neurobiology, 2016

Abstract The brain functions within a specialised environment tightly controlled by brain barrier mechanisms. Understanding the regulation of barrier formation is important for understanding brain development and may also lead to finding new ways to deliver pharmacotherapies to the brain; ...


Flow cytometry as an improved method for the titration of Chlamydiaceae and other intracellular bacteria

05.02.2016 | T. Käser, J. A. Pasternak, G. Hamonic, M. Rieder, K. Lai, M. Delgado‐Ortega, V. Gerdts, F. Meurens, Cytometry Part A, 2016

Abstract Chlamydiaceae is a family of intracellular bacteria causing a range of diverse pathological outcomes. The most devastating human diseases are ocular infections with C. trachomatis leading to blindness and genital infections causing pelvic inflammatory disease with long‐term sequelae ...


A Stable Pyrophosphoserine Analog for Incorporation into Peptides and Proteins

05.02.2016 | Lisa M. Yates; Dorothea Fiedler, ACS Chemical Biology, 2016

Protein pyrophosphorylation is a covalent modification of proteins, mediated by the inositol pyrophosphate messengers. Although the inositol pyrophosphates have been linked to a range of cellular processes, the role of protein pyrophosphorylation remains minimally characterized in vivo. The ...


Interpretation of Ocular Melanin Drug Binding Assays. Alternatives to the Model of Multiple Classes of Independent Sites

05.02.2016 | José A. Manzanares; Anna-Kaisa Rimpelä; Arto Urtti, Molecular Pharmaceutics, 2016

Melanin has a high binding affinity for a wide range of drugs. The determination of the melanin binding capacity and its binding affinity are important, e.g., in the determination of the ocular drug distribution, the prediction of drug effects in the eye, and the trans-scleral drug delivery. The ...


Viruses, Vol. 8, Pages 44: A KDEL Retrieval System for ER-Golgi Transport of Japanese Encephalitis Viral Particles

05.02.2016 | Wang, Robert YL; Wu, Yu-Jen ; Chen, Han-Shan ; Chen, Chih-Jung, Viruses, 2016

Evidence has emerged that RNA viruses utilize the host secretory pathway for processing and trafficking mature viral particles and for exiting the infected cells. Upon completing the complex assembly process, the viral particles take advantage of the cellular secretory trafficking machinery for ...


Marine Drugs, Vol. 14, Pages 35: Potential Anti-Atherosclerotic Properties of Astaxanthin

05.02.2016 | Kishimoto, Yoshimi ; Yoshida, Hiroshi ; Kondo, Kazuo, Marine Drugs, 2016

Astaxanthin is a naturally occurring red carotenoid pigment classified as a xanthophyll, found in microalgae and seafood such as salmon, trout, and shrimp. This review focuses on astaxanthin as a bioactive compound and outlines the evidence associated with its potential role in the prevention of ...


Sirtuins 1 and 2 Are Universal Histone Deacetylases

05.02.2016 | Willie W. Hsu; Bo Wu; Wenshe R. Liu, ACS Chemical Biology, 2016

Lysine acetylation serves as an epigenetic marker for myriad cellular processes, such as signaling, differentiation, DNA repair, angiogenesis, and the like. Sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) are NAD+-dependent histone deacetylases that operate as post-translational regulators for the ...


GAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders

05.02.2016 | Kasey N. Davis et al., PLoS ONE, 2016

by Kasey N. Davis, Ran Tao, Chao Li, Yuan Gao, Marjorie C. Gondré-Lewis, Barbara K. Lipska, Joo Heon Shin, Bin Xie, Tianzhang Ye, Daniel R. Weinberger, Joel E. Kleinman, Thomas M. Hyde Genetic variation and early adverse environmental events work together to increase risk for schizophrenia. ...


Xenobiotic Compounds Degradation by Heterologous Expression of a Trametes sanguineus Laccase in Trichoderma atroviride

05.02.2016 | Edgar Balcázar-López et al., PLoS ONE, 2016

by Edgar Balcázar-López, Luz Helena Méndez-Lorenzo, Ramón Alberto Batista-García, Ulises Esquivel-Naranjo, Marcela Ayala, Vaidyanathan Vinoth Kumar, Olivier Savary, Hubert Cabana, Alfredo Herrera-Estrella, Jorge Luis Folch-Mallol Fungal laccases are enzymes that have been studied because of ...


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