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17.018 Aktuelle Fachpublikationen zum Thema Addition

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Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA [ARTICLES]

01.03.2015 | Ambrosius P. Snijders; Guillaume M. Hautbergue; Alex Bloom; James C. Williamson; Thomas C. Minshull; Helen L. Philli ..., RNA, 2015

Splicing factor proline- and glutamine-rich (SFPQ) also commonly known as polypyrimidine tract-binding protein-associated-splicing factor (PSF) and its binding partner non-POU domain-containing octamer-binding protein (NONO/p54nrb), are highly abundant, multifunctional nuclear proteins. However, ...

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The differential characterization of GPR55 receptor in human peripheral blood reveals a distinctive expression in monocytes and NK cells and a proinflammatory role in these innate cells

01.03.2015 | Valerio Chiurchiù; Mirko Lanuti; Marco De Bardi; Luca Battistini; Mauro Maccarrone, International Immunology, 2015

G protein-coupled receptor 55 (GPR55) is activated by endogenous, plant-derived and synthetic cannabinoids. Recent studies reported a broad tissue distribution for GPR55 and found prominent roles for this receptor in inflammatory pain, gut and bone physiology, as well as cancer. However, little ...

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A deeply conserved, noncanonical miRNA hosted by ribosomal DNA [ARTICLES]

01.03.2015 | Li-Ling Chak; Jaaved Mohammed; Eric C. Lai; Greg Tucker-Kellogg; Katsutomo Okamura, RNA, 2015

Advances in small RNA sequencing technologies and comparative genomics have fueled comprehensive microRNA (miRNA) gene annotations in humans and model organisms. Although new miRNAs continue to be discovered in recent years, these have universally been lowly expressed, recently evolved, and of ...

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atBRX1-1 and atBRX1-2 are involved in an alternative rRNA processing pathway in Arabidopsis thaliana [ARTICLES]

01.03.2015 | Benjamin L. Weis; Denise Palm; Sandra Missbach; Markus T. Bohnsack; Enrico Schleiff, RNA, 2015

Ribosome biogenesis is an essential process in all organisms. In eukaryotes, multiple ribosome biogenesis factors (RBFs) act in the processing of ribosomal (r)RNAs, assembly of ribosomal subunits and their export to the cytoplasm. We characterized two genes in Arabidopsis thaliana coding for ...

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Disease origin and progression in amyotrophic lateral sclerosis: an immunology perspective

01.03.2015 | Andrea Malaspina; Fabiola Puentes; Sandra Amor, International Immunology, 2015

The immune system is inextricably linked with many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), a devastating neuromuscular disorder affecting motor cell function with an average survival of 3 years from symptoms onset. In ALS, there is a dynamic interplay between the ...

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A founder CEP120 mutation in Jeune asphyxiating thoracic dystrophy expands the role of centriolar proteins in skeletal ciliopathies

01.03.2015 | Ranad Shaheen; Miriam Schmidts; Eissa Faqeih; Amal Hashem; Ekkehart Lausch; Isabel Holder; Andrea Superti-Furga; UK1 ..., Human Molecular Genetics, 2015

Jeune asphyxiating thoracic dystrophy (JATD) is a skeletal dysplasia characterized by a small thoracic cage and a range of skeletal and extra-skeletal anomalies. JATD is genetically heterogeneous with at least nine genes identified, all encoding ciliary proteins, hence the classification of JATD ...

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Genomic Signatures Reveal New Evidences for Selection of Important Traits in Domestic Cattle

01.03.2015 | Lingyang Xu; Derek M. Bickhart; John B. Cole; Steven G. Schroeder; Jiuzhou Song; Curtis P. Van Tassell; Tad S. Sonst ..., Molecular Biology and Evolution, 2015

We investigated diverse genomic selections using high-density single nucleotide polymorphism data of five distinct cattle breeds. Based on allele frequency differences, we detected hundreds of candidate regions under positive selection across Holstein, Angus, Charolais, Brahman, and N'Dama. In ...

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Functional Conservation of Both CDS- and 3′-UTR-Located MicroRNA Binding Sites between Species

01.03.2015 | Guojing Liu; Rui Zhang; Jin Xu; Chung-I Wu; Xuemei Lu, Molecular Biology and Evolution, 2015

MicroRNAs (miRNAs) mediate gene regulation posttranscriptionally through pairing of their seed (2–7 nt) to 3'-untranslated regions (3'-UTRs) or coding regions (coding sequences [CDSs]) of their target genes. CDS target sites generally show weaker repression effects than 3'-UTR sites. However, ...

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Control of homeostatic and pathogenic balance in adipose tissue by ganglioside GM3

01.03.2015 | Masakazu Nagafuku; Takashige Sato; Saya Sato; Kyoko Shimizu; Toshio Taira; Jin-Ichi Inokuchi, Glycobiology , 2015

Ganglioside GM3 (Siaα2-3Galβ1-4Glcβ1-1Cer) has been known to participate in insulin signaling by regulating the association of the insulin receptor in caveolae microdomains (lipid rafts), which is essential for the execution of the complete insulin metabolic signaling in adipocytes. ...

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Threatened species impact assessments: survey effort requirements based on criteria for cumulative impacts

23.02.2015 | Gurutzeta Guillera‐Arroita, José J. Lahoz‐Monfort, Michael A. McCarthy, Brendan A. Wintle, Diversity and Distributions, 2015

Abstract Aim Environmental impact assessments (EIAs) often involve establishing whether a species of concern is present at the site considered for development. When surveys falsely conclude that sites are unoccupied, species prevalence in the region is cumulatively reduced. We argue that ...

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