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17.279 Aktuelle Fachpublikationen zum Thema Addition

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Arginine methylation and citrullination of splicing factor proline- and glutamine-rich (SFPQ/PSF) regulates its association with mRNA [ARTICLES]

01.03.2015 | Ambrosius P. Snijders; Guillaume M. Hautbergue; Alex Bloom; James C. Williamson; Thomas C. Minshull; Helen L. Philli ..., RNA, 2015

Splicing factor proline- and glutamine-rich (SFPQ) also commonly known as polypyrimidine tract-binding protein-associated-splicing factor (PSF) and its binding partner non-POU domain-containing octamer-binding protein (NONO/p54nrb), are highly abundant, multifunctional nuclear proteins. However, ...

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The differential characterization of GPR55 receptor in human peripheral blood reveals a distinctive expression in monocytes and NK cells and a proinflammatory role in these innate cells

01.03.2015 | Valerio Chiurchiù; Mirko Lanuti; Marco De Bardi; Luca Battistini; Mauro Maccarrone, International Immunology, 2015

G protein-coupled receptor 55 (GPR55) is activated by endogenous, plant-derived and synthetic cannabinoids. Recent studies reported a broad tissue distribution for GPR55 and found prominent roles for this receptor in inflammatory pain, gut and bone physiology, as well as cancer. However, little ...

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A deeply conserved, noncanonical miRNA hosted by ribosomal DNA [ARTICLES]

01.03.2015 | Li-Ling Chak; Jaaved Mohammed; Eric C. Lai; Greg Tucker-Kellogg; Katsutomo Okamura, RNA, 2015

Advances in small RNA sequencing technologies and comparative genomics have fueled comprehensive microRNA (miRNA) gene annotations in humans and model organisms. Although new miRNAs continue to be discovered in recent years, these have universally been lowly expressed, recently evolved, and of ...

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atBRX1-1 and atBRX1-2 are involved in an alternative rRNA processing pathway in Arabidopsis thaliana [ARTICLES]

01.03.2015 | Benjamin L. Weis; Denise Palm; Sandra Missbach; Markus T. Bohnsack; Enrico Schleiff, RNA, 2015

Ribosome biogenesis is an essential process in all organisms. In eukaryotes, multiple ribosome biogenesis factors (RBFs) act in the processing of ribosomal (r)RNAs, assembly of ribosomal subunits and their export to the cytoplasm. We characterized two genes in Arabidopsis thaliana coding for ...

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Disease origin and progression in amyotrophic lateral sclerosis: an immunology perspective

01.03.2015 | Andrea Malaspina; Fabiola Puentes; Sandra Amor, International Immunology, 2015

The immune system is inextricably linked with many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), a devastating neuromuscular disorder affecting motor cell function with an average survival of 3 years from symptoms onset. In ALS, there is a dynamic interplay between the ...

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A founder CEP120 mutation in Jeune asphyxiating thoracic dystrophy expands the role of centriolar proteins in skeletal ciliopathies

01.03.2015 | Ranad Shaheen; Miriam Schmidts; Eissa Faqeih; Amal Hashem; Ekkehart Lausch; Isabel Holder; Andrea Superti-Furga; UK1 ..., Human Molecular Genetics, 2015

Jeune asphyxiating thoracic dystrophy (JATD) is a skeletal dysplasia characterized by a small thoracic cage and a range of skeletal and extra-skeletal anomalies. JATD is genetically heterogeneous with at least nine genes identified, all encoding ciliary proteins, hence the classification of JATD ...

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Expression inactivation of SMARCA4 by microRNAs in lung tumors

01.03.2015 | Isabel F. Coira; Eva E. Rufino-Palomares; Octavio A. Romero; Paola Peinado; Chanatip Metheetrairut; Laura Boyero-Cor ..., Human Molecular Genetics, 2015

SMARCA4 is the catalytic subunit of the SWI/SNF chromatin-remodeling complex, which alters the interactions between DNA and histones and modifies the availability of the DNA for transcription. The latest deep sequencing of tumor genomes has reinforced the important and ubiquitous tumor suppressor ...

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Genomic Signatures Reveal New Evidences for Selection of Important Traits in Domestic Cattle

01.03.2015 | Lingyang Xu; Derek M. Bickhart; John B. Cole; Steven G. Schroeder; Jiuzhou Song; Curtis P. Van Tassell; Tad S. Sonst ..., Molecular Biology and Evolution, 2015

We investigated diverse genomic selections using high-density single nucleotide polymorphism data of five distinct cattle breeds. Based on allele frequency differences, we detected hundreds of candidate regions under positive selection across Holstein, Angus, Charolais, Brahman, and N'Dama. In ...

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Functional Conservation of Both CDS- and 3′-UTR-Located MicroRNA Binding Sites between Species

01.03.2015 | Guojing Liu; Rui Zhang; Jin Xu; Chung-I Wu; Xuemei Lu, Molecular Biology and Evolution, 2015

MicroRNAs (miRNAs) mediate gene regulation posttranscriptionally through pairing of their seed (2–7 nt) to 3'-untranslated regions (3'-UTRs) or coding regions (coding sequences [CDSs]) of their target genes. CDS target sites generally show weaker repression effects than 3'-UTR sites. However, ...

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Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells

01.03.2015 | Timothy N. Perkins; Paul M. Peeters; Arti Shukla; Ingrid Arijs; Julie Dragon; Emiel F.M. Wouters; Niki L. Reynaert; ..., Human Molecular Genetics, 2015

Occupational and environmental exposures to airborne asbestos and silica are associated with the development of lung fibrosis in the forms of asbestosis and silicosis, respectively. However, both diseases display distinct pathologic presentations, likely associated with differences in gene ...

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