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17.702 Aktuelle Fachpublikationen zum Thema Addition

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Impact of sulfation pattern on the conformation and dynamics of sulfated fucan oligosaccharides as revealed by NMR and MD

01.05.2015 | Ismael NL Queiroz; Xiaocong Wang; John N Glushka; Gustavo RC Santos; Ana P Valente; James H Prestegard; Robert J Woo ..., Glycobiology , 2015

Sulfated fucans from sea urchin egg jelly express well-defined chemical structures that vary with species. This species specificity regulates the sperm acrosome reaction, a critical step to assure intra-specific fertilization. In addition, these polysaccharides are involved in other biological ...

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Comparison and integration of deleteriousness prediction methods for nonsynonymous SNVs in whole exome sequencing studies

15.04.2015 | Chengliang Dong; Peng Wei; Xueqiu Jian; Richard Gibbs; Eric Boerwinkle; Kai Wang; Xiaoming Liu, Human Molecular Genetics, 2015

Accurate deleteriousness prediction for nonsynonymous variants is crucial for distinguishing pathogenic mutations from background polymorphisms in whole exome sequencing (WES) studies. Although many deleteriousness prediction methods have been developed, their prediction results are sometimes ...

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Identifying cancer-related microRNAs based on gene expression data

15.04.2015 | Xing-Ming Zhao; Ke-Qin Liu; Guanghui Zhu; Feng He; Béatrice Duval; Jean-Michel Richer; De-Shuang Huang; Chang-Jun Ji ..., Bioinformatics, 2015

Motivation: MicroRNAs (miRNAs) are short non-coding RNAs that play important roles in post-transcriptional regulations as well as other important biological processes. Recently, accumulating evidences indicate that miRNAs are extensively involved in cancer. However, it is a big challenge to ...

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Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal {alpha}-dystroglycan O-mannosylation, independent from sialic acid

15.04.2015 | Moniek Riemersma; Julia Sandrock; Thomas J. Boltje; Christian Büll; Torben Heise; Angel Ashikov; Gosse J. Adema; Han ..., Human Molecular Genetics, 2015

Binding of cellular α-dystroglycan (α-DG) to its extracellular matrix ligands is fully dependent on a unique O-mannose-linked glycan. Disrupted O-mannosylation is the hallmark of the muscular dystrophy-dystroglycanopathy (MDDG) syndromes. SLC35A1, encoding the transporter of cytidine ...

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SMARTS: reconstructing disease response networks from multiple individuals using time series gene expression data

15.04.2015 | Aaron Wise; Ziv Bar-Joseph, Bioinformatics, 2015

Motivation: Current methods for reconstructing dynamic regulatory networks are focused on modeling a single response network using model organisms or cell lines. Unlike these models or cell lines, humans differ in their background expression profiles due to age, genetics and life factors. In ...

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Use of precisely sculptured thin film (STF) substrates with generalized ellipsometry to determine spatial distribution of adsorbed fibronectin to nanostructured columnar topographies and effect on cell adhesion

12.04.2015 | Author(s): Tadas Kasputis , Alex Pieper , Keith Brian Rodenhausen , Daniel Schmidt , Derek Sekora , Charles Ri ..., Acta Biomaterialia, 2015

Publication date: May 2015 Source:Acta Biomaterialia, Volume 18 Author(s): Tadas Kasputis , Alex Pieper , Keith Brian Rodenhausen , Daniel Schmidt , Derek Sekora , Charles Rice , Eva Schubert , Mathias Schubert , Angela K. Pannier Sculptured thin film (STF) substrates consist of ...

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In vivo study of magnesium plate and screw degradation and bone fracture healing

12.04.2015 | Author(s): Amy Chaya , Sayuri Yoshizawa , Kostas Verdelis , Nicole Myers , Bernard J. Costello , Da-Tren Chou ..., Acta Biomaterialia, 2015

Publication date: May 2015 Source:Acta Biomaterialia, Volume 18 Author(s): Amy Chaya , Sayuri Yoshizawa , Kostas Verdelis , Nicole Myers , Bernard J. Costello , Da-Tren Chou , Siladitya Pal , Spandan Maiti , Prashant N. Kumta , Charles Sfeir Each year, millions of Americans suffer ...

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Cisplatin-loaded polymeric nanoparticles: Characterization and potential exploitation for the treatment of non-small cell lung carcinoma

12.04.2015 | Author(s): Chunshan Shi , Haiyang Yu , Dejun Sun , Lili Ma , Zhaohui Tang , Qiusheng Xiao , Xuesi Chen, Acta Biomaterialia, 2015

Publication date: May 2015 Source:Acta Biomaterialia, Volume 18 Author(s): Chunshan Shi , Haiyang Yu , Dejun Sun , Lili Ma , Zhaohui Tang , Qiusheng Xiao , Xuesi Chen Cisplatin-loaded poly(l-glutamic acid)-g-methoxy poly(ethylene glycol 5K) nanoparticles (CDDP-NPs) were characterized ...

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Characterization of antimicrobial activity and mechanisms of low amphipathic peptides with different α-helical propensity

12.04.2015 | Author(s): Xin Zhu , Licong Zhang , Jue Wang , Zhi Ma , Wei Xu , Jianping Li , Anshan Shan, Acta Biomaterialia, 2015

Publication date: May 2015 Source:Acta Biomaterialia, Volume 18 Author(s): Xin Zhu , Licong Zhang , Jue Wang , Zhi Ma , Wei Xu , Jianping Li , Anshan Shan Antimicrobial peptides (AMPs) serve as a defense mechanism within multicellular organisms and are attracting increasing attention ...

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Looking back and moving forward: Recent advances in understanding of cardiovascular development by imaging of zebrafish

10.04.2015 | Shigetomo Fukuhara, Hajime Fukui, Yuki Wakayama, Koji Ando, Hiroyuki Nakajima, Naoki Mochizuki, Development, Growth & Differentiation, 2015

Development requires cell proliferation, migration, differentiation, apoptosis, and many kinds of cell responses. Cells prepare intracellular conditions to respond to extracellular cues from neighboring cells. We have studied the development of the cardiovascular system (CVS) by visualizing ...

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