01.06.2013 | Mélisande Blein-Nicolas; Warren Albertin; Benoît Valot; Philippe Marullo; Delphine Sicard; Christophe Giraud; Sylvie ..., Molecular Biology and Evolution, 2013

Saccharomyces cerevisiae and S. uvarum are two domesticated species of the Saccharomyces sensu stricto clade that diverged around 100 Ma after whole-genome duplication. Both have retained many duplicated genes associated with glucose fermentation and are characterized by the ability to ...

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01.06.2013 | Zhang Wang; Martin Wu, Molecular Biology and Evolution, 2013

Large-scale, genome-level molecular phylogenetic analyses present both opportunities and challenges for bacterial evolutionary and ecological studies. We constructed a phylum-level bacterial phylogenetic marker database by surveying all complete bacterial genomes and identifying single-copy ...

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01.06.2013 | Manuel Gil; Marcelo Serrano Zanetti; Stefan Zoller; Maria Anisimova, Molecular Biology and Evolution, 2013

Markov models of codon substitution naturally incorporate the structure of the genetic code and the selection intensity at the protein level, providing a more realistic representation of protein-coding sequences compared with nucleotide or amino acid models. Thus, for protein-coding genes, ...

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01.06.2013 | Masahiko Yabu; Hiroaki Korekane; Koji Hatano; Yasufumi Kaneda; Norio Nonomura; Chihiro Sato; Ken Kitajima; Yasuhide ..., Glycobiology , 2013

We previously reported on the accumulation of a substantial amount of free N-acetylneuraminic acid (Neu5Ac)-containing complex-type N-glycans in human pancreatic cancer cells (Yabu M, Korekane H, Takahashi H, Ohigashi H, Ishikawa O, Miyamoto Y. 2013. Accumulation of free Neu5Ac-containing ...

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15.05.2013 | Zafar Iqbal; Geert Vandeweyer; Monique van der Voet; Ali Muhammad Waryah; Muhammad Yasir Zahoor; Judith A. Besseling ..., Human Molecular Genetics, 2013

AnkyrinG, encoded by the ANK3 gene, is involved in neuronal development and signaling. It has previously been implicated in bipolar disorder and schizophrenia by association studies. Most recently, de novo missense mutations in this gene were identified in autistic patients. However, the ...

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15.05.2013 | Samantha Zongaro; Renate Hukema; Simona D'Antoni; Laetitia Davidovic; Pascal Barbry; Maria Vincenza Catania; Rob Wil ..., Human Molecular Genetics, 2013

While FMR1 is silenced in Fragile X syndrome (FXS) patients carrying the full mutation, its expression is elevated (2–8 fold) in premutated individuals. These people may develop the Fragile X-associated Tremor/Ataxia syndrome (FXTAS), a late onset neurodegenerative disorder characterized by ...

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15.05.2013 | Mardi J. Sutherland; Shuyun Wang; Malgorzata E. Quinn; Allison Haaning; Stephanie M. Ware, Human Molecular Genetics, 2013

In humans, loss-of-function mutations in ZIC3 cause isolated cardiovascular malformations and X-linked heterotaxy, a disorder with abnormal left–right asymmetry of organs. Zic3 null mice recapitulate the human heterotaxy phenotype but also have early gastrulation defects, axial patterning ...

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13.05.2013 | Author(s): Yevgen O. Posokhov , Alexander Kyrychenko, Computational Biology and Chemistry, 2013

Publication date: Available online 7 May 2013 Source:Computational Biology and Chemistry Author(s): Yevgen O. Posokhov , Alexander Kyrychenko The modulation of the properties and function of cell membranes by small volatile substances is important for many biomedical applications. ...

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12.05.2013 | Author(s): Jiri Gallo , Stuart B. Goodman , Yrjö T. Konttinen , Markus A. Wimmer , Martin Holinka, Acta Biomaterialia, 2013

Publication date: Available online 10 May 2013 Source:Acta Biomaterialia Author(s): Jiri Gallo , Stuart B. Goodman , Yrjö T. Konttinen , Markus A. Wimmer , Martin Holinka Aseptic loosening and other wear-related complications are one of the most frequent late reasons for revision ...

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12.05.2013 | Author(s): Xin Liu , Mohamed N. Rahaman , Gregory E. Hilmas , B. Sonny Bal, Acta Biomaterialia, 2013

Publication date: June 2013 Source:Acta Biomaterialia, Volume 9, Issue 6 Author(s): Xin Liu , Mohamed N. Rahaman , Gregory E. Hilmas , B. Sonny Bal There is a need to develop synthetic scaffolds to repair large defects in load-bearing bones. Bioactive glasses have attractive ...

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