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17.221 Aktuelle Fachpublikationen zum Thema Addition

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Hyaluronan synthase assembles chitin oligomers with -GlcNAc({alpha}1->)UDP at the reducing end

01.06.2015 | Paul H Weigel; Christopher M West; Peng Zhao; Lance Wells; Bruce A Baggenstoss; Jennifer L Washburn, Glycobiology , 2015

Class I hyaluronan synthases (HASs) assemble a polysaccharide containing the repeating disaccharide [GlcNAc(β1,4)GlcUA(β1,3)]n-UDP and vertebrate HASs also assemble (GlcNAc-β1,4)n homo-oligomers (chitin) in the absence of GlcUA-UDP. This multi-membrane domain CAZy GT2 family glycosyltransferase, ...

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Biallelic mutations in CAD, impair de novo pyrimidine biosynthesis and decrease glycosylation precursors

01.06.2015 | Bobby G. Ng; Lynne A. Wolfe; Mie Ichikawa; Thomas Markello; Miao He; Cynthia J. Tifft; William A. Gahl; Hudson H. Freeze, Human Molecular Genetics, 2015

In mitochondria, carbamoyl-phosphate synthetase 1 activity produces carbamoyl phosphate for urea synthesis, and deficiency results in hyperammonemia. Cytoplasmic carbamoyl-phosphate synthetase 2, however, is part of a tri-functional enzyme encoded by CAD; no human disease has been attributed to ...

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Molecular Mechanism Behind the Synergistic Activity of Diphenylmethyl Selenocyanate and Cisplatin Against Murine Tumor Model

20.05.2015 | Chakraborty, Pramita; Singha Roy, Somnath; Bhattacharya, Sudin, Anti-Cancer Agents in Medicinal Chemistry , 2015

Abstract: Various preclinical, clinical and epidemiological studies have already well established the cancer chemopreventive and chemoprotective potential of selenium compounds. In addition to its protective efficacy, recent studies have also proved the abilities of selenium compounds to ...

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Berberine Exhibits Antitumor Effects in Human Ovarian Cancer Cells

20.05.2015 | Jin, Ping; Zhang, Chunjie; Li, Na, Anti-Cancer Agents in Medicinal Chemistry , 2015

Abstract: Background: Berberine is an extract of a traditional Chinese herbal medicine and has been shown to inhibit the proliferation and induce apoptosis in a wide variety of tumour cells. However, the effects of Berberine in ovarian cancer cells are unknown. Aims: To investigate the ...

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The similarity question for biologicals and non-biological complex drugs

17.05.2015 | Author(s): Daan J.A. Crommelin , Vinod P. Shah , Imre Klebovich , Scott E. McNeil , Vera Weinstein , Beat Flüh ..., European Journal of Pharmaceutical Science, 2015

Publication date: 30 August 2015 Source:European Journal of Pharmaceutical Sciences, Volume 76 Author(s): Daan J.A. Crommelin , Vinod P. Shah , Imre Klebovich , Scott E. McNeil , Vera Weinstein , Beat Flühmann , Stefan Mühlebach , Jon S.B. de Vlieger For small – low molecular weight ...

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Modulation of cell morphogenesis by Tousled‐like kinase in the Drosophila follicle cell

16.05.2015 | Tsung‐Han Yeh, Shu‐Yu Huang, Wan‐Yu Lan, Gwo‐Jen Liaw, Jenn‐Yah Yu, Developmental Dynamics, 2015

Abstract Background: Tousled‐like kinase (Tlk) is a conserved Serine/Threonine kinase regulating DNA replication, chromatin assembly, and DNA repair. Previous studies have suggested that Tlk is involved in cell morphogenesis in vitro. In addition, tlk genetically interact with Rho1, which ...

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Hydrodynamic Effects on Drug Dissolution and Deaggregation in the Small Intestine—A Study with Felodipine as a Model Drug

16.05.2015 | Lennart Lindfors, Malin Jonsson, Emelie Weibull, James G. Brasseur, Bertil Abrahamsson, Journal of Pharmaceutical Sciences, 2015

The aim of this study was to understand and predict the influence of hydrodynamic effects in the small intestine on dissolution of primary and aggregated drug particles. Dissolution tests of suspensions with a low‐solubility drug, felodipine, were performed in a Couette cell under hydrodynamic ...

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Pasta Fortified with Potato Juice: Structure, Quality, and Consumer Acceptance

16.05.2015 | Przemysław Kowalczewski, Grażyna Lewandowicz, Agnieszka Makowska, Ismena Knoll, Wioletta Błaszczak, Wojciech Białas, ..., Journal of Food Science, 2015

Abstract The potential of potato juice in relieving gastrointestinal disorders has already been proven. Work continues on implementation of this active component into products that are widely consumed. In this article, results of an attempt to fortify pasta with potato juice are presented and ...

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Prenatal Diagnosis of Pierre Robin Sequence: accuracy and ability to predict phenotype and functional severity

15.05.2015 | Katia Lind, Marie‐Cécile Aubry, Nadia Belarbi, Christel Chalouhi, Gérard Couly, Alexandra Benachi, Stanislas Lyonnet ..., Prenatal Diagnosis, 2015

Abstract Objective To assess the outcome of fetuses who had sonographic features suggestive of Pierre Robin Sequence (PRS). Method All prenatal ultrasounds that mentioned “posterior cleft palate”, or “micro or retrognathia” or “PRS” over 13 and 20 years respectively at 2 obstetrical ...

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Metabolic syndrome in female migraine patients is associated with medication overuse headache: a clinic‐based study in China

15.05.2015 | Z. He, L. Dong, Y. Zhang, Q. Kong, G. Tan, J. Zhou, European Journal of Neurology, 2015

Background and purpose Migraine and metabolic syndrome have been reported to coexist to a marked degree, especially in women migraine patients, but the relationship between these two conditions is still unclear. This study was performed to evaluate the association of headache characteristics ...

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