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14 Aktuelle Fachpublikationen zum Thema Addition

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[Feature] Runners-up

19.12.2014 | Science , 2014

In addition to its Breakthrough of the Year, Science named nine runners-up as significant scientific achievements of 2014.

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[Feature] Areas to watch in 2015

19.12.2014 | Science , 2014

Science is a moving target. In addition to looking back on achievements of the previous year, the Breakthrough staff also hazards a few informed guesses about developments likely to make news in months to come.

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[Special Issue Review] The melanoma revolution: From UV carcinogenesis to a new era in therapeutics

21.11.2014 | Jennifer A. Lo; David E. Fisher, Science , 2014

Melanoma, the deadliest form of skin cancer, is an aggressive disease that is rising in incidence. Although melanoma is a historically treatment-resistant malignancy, in recent years unprecedented breakthroughs in targeted therapies and immunotherapies have revolutionized the standard of care for ...

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[Special Issue Review] Antibodies in HIV-1 Vaccine Development and Therapy

13.09.2013 | Florian Klein; Hugo Mouquet; Pia Dosenovic; Johannes F. Scheid; Louise Scharf; Michel C. Nussenzweig, Science , 2013

Despite 30 years of study, there is no HIV-1 vaccine and, until recently, there was little hope for a protective immunization. Renewed optimism in this area of research comes in part from the results of a recent vaccine trial and the use of single-cell antibody-cloning techniques that uncovered ...

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[Report] Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

19.03.2013 | Issam Ben-Sahra, Jessica J. Howell, John M. Asara, Brendan D. Manning, Science , 2013

In addition to its role in stimulating protein and lipid synthesis, the kinase mammalian target of rapamycin stimulates nucleotide biosynthesis.

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[Report] Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

19.03.2013 | Aaron M. Robitaille, Stefan Christen, Mitsugu Shimobayashi, Marion Cornu, Luca L. Fava, Suzette Moes, Cristina Presc ..., Science , 2013

In addition to its role in stimulating protein and lipid synthesis, the kinase mammalian target of rapamycin stimulates nucleotide biosynthesis.

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[Book Review] Genetics: Similarities Despite Separation

13.07.2012 | Dorret I. Boomsma, Science , 2012

In addition to charting the history of the Minnesota Study of Twins Reared Apart, Segal reviews the project's conclusions and their impact.

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[Research Article] Growing Microtubules Push the Oocyte Nucleus to Polarize the Drosophila Dorsal-Ventral Axis

30.05.2012 | Tongtong Zhao, Owen S. Graham, Alexandre Raposo, Daniel St Johnston, Science , 2012

The addition of tubulin monomers to microtubules provides the force to relocate the oocyte nucleus.

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[Report] Interplay of Intra- and Intermolecular H-Bonding in a Progressively Solvated Macrocyclic Peptide

24.04.2012 | Natalia S. Nagornova, Thomas R. Rizzo, Oleg V. Boyarkin, Science , 2012

The main conformational changes associated with the hydration of a peptide ring ensue upon the addition of just two water molecules.

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[Report] Extending the Carbon Chain: Hydrocarbon Formation Catalyzed by Vanadium/Molybdenum Nitrogenases

20.09.2011 | Yilin Hu, Chi Chung Lee, Markus W. Ribbe, Science , 2011

The molybdenum nitrogenase enzyme can reduce carbon monoxide, albeit inefficiently, in addition to its native substrate, nitrogen.

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