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33 Aktuelle Fachpublikationen zum Thema Addition

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[Research Article] Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts

26.06.2015 | Rajan Jain; Deqiang Li; Mudit Gupta; Lauren J. Manderfield; Jamie L. Ifkovits; Qiaohong Wang; Feiyan Liu; Ying Liu; ..., Science , 2015

Cardiac progenitor cells are multipotent and give rise to cardiac endothelium, smooth muscle, and cardiomyocytes. Here, we define and characterize the cardiomyoblast intermediate that is committed to the cardiomyocyte fate, and we characterize the niche signals that regulate commitment. ...

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[Report] Recruitment of RNA polymerase II by the pioneer transcription factor PHA-4

19.06.2015 | H.‐T. Hsu; H.‐M. Chen; Z. Yang; J. Wang; N. K. Lee; A. Burger; K. Zaret; T. Liu; E. Levine; S. E. Mango, Science , 2015

Pioneer transcription factors initiate cell-fate changes by binding to silent target genes. They are among the first factors to bind key regulatory sites and facilitate chromatin opening. Here, we identify an additional role for pioneer factors. In early Caenorhabditis elegans foregut ...

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[Perspective] Slippery when dry

05.06.2015 | James Hone; Robert W. Carpick, Science , 2015

Friction and wear account for massive amounts of wasted energy annually (estimates run in the hundreds of billions of dollars in the United States), in addition to unwanted and even unsafe failures of vehicles, machines, and devices (1). For example, nearly one-third of a vehicle's fuel energy is ...

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[Review] Function-led design of new porous materials

29.05.2015 | Anna G. Slater; Andrew I. Cooper, Science , 2015

Porous solids are important as membranes, adsorbents, catalysts, and in other chemical applications. But for these materials to find greater use at an industrial scale, it is necessary to optimize multiple functions in addition to pore structure and surface area, such as stability, sorption ...

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[In Depth] Leaf bacteria fertilize trees, researchers claim

22.05.2015 | Elizabeth Pennisi, Science , 2015

One of the fastest growing trees, poplars, may rely on tiny microbes in their leaves to fuel their growth. For more than a decade, a lone researcher has been building a case for nitrogen fixation by bacteria living in poplar leaves. There have been many claims of nitrogen fixation in plants ...

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[Perspective] More than just bugs in spit

08.05.2015 | Clifton Barry, Science , 2015

The development of new drugs for tuberculosis (TB) is not for the faint of heart. In addition to all the typical hurdles to developing a new anti-infective, additional complications result from the complex pathology induced by the disease. Because the bacillus is surrounded by a thick, waxy coat, ...

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[Report] Creating and probing electron whispering-gallery modes in graphene

08.05.2015 | Yue Zhao; Jonathan Wyrick; Fabian D. Natterer; Joaquin F. Rodriguez-Nieva; Cyprian Lewandowski; Kenji Watanabe; Taka ..., Science , 2015

The design of high-finesse resonant cavities for electronic waves faces challenges due to short electron coherence lengths in solids. Complementing previous approaches to confine electronic waves by carefully positioned adatoms at clean metallic surfaces, we demonstrate an approach inspired by ...

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[Report] Adhesion and friction in mesoscopic graphite contacts

08.05.2015 | Elad Koren; Emanuel Lörtscher; Colin Rawlings; Armin W. Knoll; Urs Duerig, Science , 2015

The weak interlayer binding in two-dimensional layered materials such as graphite gives rise to poorly understood low-friction characteristics. Accurate measurements of the adhesion forces governing the overall mechanical stability have also remained elusive. We report on the direct mechanical ...

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[Technical Response] Response to Comment on “Local reorganization of xanthophores fine-tunes and colors the striped pattern of zebrafish”

17.04.2015 | Ajeet Pratap Singh; Hans-Georg Frohnhöfer; Uwe Irion; Christiane Nüsslein-Volhard, Science , 2015

Watanabe and Kondo question our conclusion that the current Turing-type model of color patterning in zebrafish requires modification. In addition to xanthophores and melanophores, iridophores are essential for stripe formation in the body, although not in the fins. A model of predictive value ...

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[Report] Mutation rate and genotype variation of Ebola virus from Mali case sequences

03.04.2015 | T. Hoenen; D. Safronetz; A. Groseth; K. R. Wollenberg; O. A. Koita; B. Diarra; I. S. Fall; F. C. Haidara; F. Diallo; ..., Science , 2015

The occurrence of Ebola virus (EBOV) in West Africa during 2013–2015 is unprecedented. Early reports suggested that in this outbreak EBOV is mutating twice as fast as previously observed, which indicates the potential for changes in transmissibility and virulence and could render current ...

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