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50 Aktuelle Fachpublikationen zum Thema Addition

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[Perspective] Dengue vaccines at a crossroad

06.11.2015 | Annelies Wilder-Smith; Duane J. Gubler, Science , 2015

The era when most vaccines provided efficacy well beyond 90% is over. Many of the more recently developed vaccines only provide partial efficacy. Although vaccines are typically licensed on the basis of demonstrated efficacy, the ultimate goal of vaccination goes far beyond efficacy. In addition ...


[Research Article] Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions

30.10.2015 | Jiansen Jiang; Henry Chan; Darian D. Cash; Edward J. Miracco; Rachel R. Ogorzalek Loo; Heather E. Upton; Duilio Casc ..., Science , 2015

Telomerase helps maintain telomeres by processive synthesis of telomere repeat DNA at their 3′-ends, using an integral telomerase RNA (TER) and telomerase reverse transcriptase (TERT). We report the cryo–electron microscopy structure of Tetrahymena telomerase at ~9 angstrom resolution. In ...


[Perspective] Restoring the sense of touch

16.10.2015 | Polina Anikeeva; Ryan A. Koppes, Science , 2015

Amputation of damaged tissue is one of the oldest surgical techniques, reaching prevalence in the 16th century (1). Improved emergency medicine has allowed more individuals to survive traumatic injuries as amputees, but prosthetic limbs remain the only means to restore any degree of function to ...


[Report] Identification of active sites in CO oxidation and water-gas shift over supported Pt catalysts

09.10.2015 | Kunlun Ding; Ahmet Gulec; Alexis M. Johnson; Neil M. Schweitzer; Galen D. Stucky; Laurence D. Marks; Peter C. Stair, Science , 2015

Identification and characterization of catalytic active sites are the prerequisites for an atomic-level understanding of the catalytic mechanism and rational design of high-performance heterogeneous catalysts. Indirect evidence in recent reports suggests that platinum (Pt) single atoms are ...


[Report] Deterministic generation of multiparticle entanglement by quantum Zeno dynamics

18.09.2015 | Giovanni Barontini; Leander Hohmann; Florian Haas; Jérôme Estève; Jakob Reichel, Science , 2015

Multiparticle entangled quantum states, a key resource in quantum-enhanced metrology and computing, are usually generated by coherent operations exclusively. However, unusual forms of quantum dynamics can be obtained when environment coupling is used as part of the state generation. In this work, ...


[Report] Coherent manipulation of Andreev states in superconducting atomic contacts

11.09.2015 | C. Janvier; L. Tosi; L. Bretheau; Ç. Ö. Girit; M. Stern; P. Bertet; P. Joyez; D. Vion; D. Esteve; M. F. Goffman; H. ..., Science , 2015

Coherent control of quantum states has been demonstrated in a variety of superconducting devices. In all of these devices, the variables that are manipulated are collective electromagnetic degrees of freedom: charge, superconducting phase, or flux. Here we demonstrate the coherent manipulation of ...


[Report] RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

04.09.2015 | Brian J. Liddicoat; Robert Piskol; Alistair M. Chalk; Gokul Ramaswami; Miyoko Higuchi; Jochen C. Hartner; Jin Billy ..., Science , 2015

Adenosine-to-inosine (A-to-I) editing is a highly prevalent posttranscriptional modification of RNA, mediated by ADAR (adenosine deaminase acting on RNA) enzymes. In addition to RNA editing, additional functions have been proposed for ADAR1. To determine the specific role of RNA editing by ADAR1, ...


[In Depth] Many psychology papers fail replication test

28.08.2015 | John Bohannon, Science , 2015

The largest effort yet to replicate psychology studies has yielded both good and bad news. On the down side, of the 100 prominent papers analyzed, only 39% could be replicated unambiguously, as a group of 270 researchers describes on page 943. On the up side, despite the sobering results, the ...


[Report] Irrationality in mate choice revealed by túngara frogs

28.08.2015 | Amanda M. Lea; Michael J. Ryan, Science , 2015

Mate choice models derive from traditional microeconomic decision theory and assume that individuals maximize their Darwinian fitness by making economically rational decisions. Rational choices exhibit regularity, whereby the relative strength of preferences between options remains stable when ...


[Perspective] As simple as [2+2]

28.08.2015 | Myles W. Smith; Phil S. Baran, Science , 2015

Olefin cycloadditions, pericyclic reactions in which the relatively weak π bonds of these unsaturated species are swapped out for stronger σ bonds, are among the most widely exploited transformations in organic synthesis (1). Indeed, the Diels-Alder reaction—a [4π+2π] cycloaddition (a [4+2] ...


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