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2.050 Aktuelle Fachpublikationen zum Thema Addition

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The apical ectodermal ridge of the mouse model of ectrodactyly Dlx5;Dlx6−/− shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand

15.02.2016 | Daniele Conte; Giulia Garaffo; Nadia Lo Iacono; Stefano Mantero; Stefano Piccolo; Michelangelo Cordenonsi; David Per ..., Human Molecular Genetics, 2016

The congenital malformation split hand/foot (SHFM) is characterized by missing central fingers and dysmorphology or fusion of the remaining ones. Type-1 SHFM is linked to deletions/rearrangements of the DLX5–DLX6 locus and point mutations in the DLX5 gene. The ectrodactyly phenotype is reproduced ...

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MT-HESS: an efficient Bayesian approach for simultaneous association detection in OMICS datasets, with application to eQTL mapping in multiple tissues

15.02.2016 | Alex Lewin; Habib Saadi; James E. Peters; Aida Moreno-Moral; James C. Lee; Kenneth G. C. Smith; Enrico Petretto; Leo ..., Bioinformatics, 2016

Motivation: Analysing the joint association between a large set of responses and predictors is a fundamental statistical task in integrative genomics, exemplified by numerous expression Quantitative Trait Loci (eQTL) studies. Of particular interest are the so-called ‘hotspots’, important genetic ...

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Changes in gene expression and histological injuries as a result of exposure of Crassostrea gigas to the toxic dinoflagellate Gymnodinium catenatum

01.02.2016 | Norma García-Lagunas; Reyna de Jesús Romero-Geraldo; Norma Yolanda Hernández-Saavedra, Journal of Molluscan Studies, 2016

The harmful alga Gymnodinium catenatum is one of the species that produces the neurotoxic, hydrophilic, tetrahydropurine derivatives known as paralytic shellfish toxins (PST). Studies have shown that several classes of marine toxins have genotoxic effects on bivalves. However, there are few ...

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Disentangling Sources of Selection on Exonic Transcriptional Enhancers

01.02.2016 | Rachel M. Agoglia; Hunter B. Fraser, Molecular Biology and Evolution, 2016

In addition to coding for proteins, exons can also impact transcription by encoding regulatory elements such as enhancers. It has been debated whether such features confer heightened selective constraint, or evolve neutrally. We have addressed this question by developing a new approach to ...

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SHV-129: A Gateway to Global Suppressors in the SHV {beta}-Lactamase Family?

01.02.2016 | Marisa L. Winkler; Robert A. Bonomo, Molecular Biology and Evolution, 2016

Enzymes are continually evolving in response to environmental pressures. In order to increase enzyme fitness, amino acid substitutions can occur leading to a changing function or an increased stability. These evolutionary drivers determine the activity of an enzyme and its success in future ...

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Genetic Determinism and Evolutionary Reconstruction of a Host Jump in a Plant Virus

01.02.2016 | Nikon Vassilakos; Vincent Simon; Aliki Tzima; Elisabeth Johansen; Benoît Moury, Molecular Biology and Evolution, 2016

In spite of their widespread occurrence, only few host jumps by plant viruses have been evidenced and the molecular bases of even fewer have been determined. A combination of three independent approaches, 1) experimental evolution followed by reverse genetics analysis, 2) positive selection ...

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Stepwise Functional Evolution in a Fungal Sugar Transporter Family

01.02.2016 | Carla Gonçalves; Marco A. Coelho; Madalena Salema-Oom; Paula Gonçalves, Molecular Biology and Evolution, 2016

Sugar transport is of the utmost importance for most cells and is central to a wide range of applied fields. However, despite the straightforward in silico assignment of many novel transporters, including sugar porters, to existing families, their exact biological role and evolutionary trajectory ...

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Determinants of the Usage of Splice-Associated cis-Motifs Predict the Distribution of Human Pathogenic SNPs

01.02.2016 | XianMing Wu; Laurence D. Hurst, Molecular Biology and Evolution, 2016

Where in genes do pathogenic mutations tend to occur and does this provide clues as to the possible underlying mechanisms by which single nucleotide polymorphisms (SNPs) cause disease? As splice-disrupting mutations tend to occur predominantly at exon ends, known also to be hot spots of ...

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Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways

01.02.2016 | Shoko Akasaki; Kazufumi Matsushita; Yukinori Kato; Ayumi Fukuoka; Naruhito Iwasaki; Masakiyo Nakahira; Shigeharu Fuj ..., International Immunology, 2016

Thymic stromal lymphopoietin (TSLP) and IL-33 are epithelium-derived proallergic cytokines that contribute to allergic diseases. Although the involvement of TSLP in allergic rhinitis (AR) is suggested, the exact role of TSLP in AR is poorly understood. Furthermore, the relative contribution of ...

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Natriuretic Peptides as Cardiovascular Safety Biomarkers in Rats: Comparison With Blood Pressure, Heart Rate, and Heart Weight

01.02.2016 | Steven K. Engle; David E. Watson, Toxicological Sciences, 2016

Cardiovascular (CV) toxicity is an important cause of failure during drug development. Blood-based biomarkers can be used to detect CV toxicity during preclinical development and prioritize compounds at lower risk of causing such toxicities. Evidence of myocardial degeneration can be detected by ...

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