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1.632 Aktuelle Fachpublikationen zum Thema Addition

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Antitumor properties of a new non-anticoagulant heparin analog from the mollusk Nodipecten nodosus: Effect on P-selectin, heparanase, metastasis and cellular recruitment

01.04.2015 | Angélica Maciel Gomes; Eliene Oliveira Kozlowski; Lubor Borsig; Felipe C O B Teixeira; Israel Vlodavsky; Mauro S G Pavão, Glycobiology , 2015

Inflammation and cancer are related pathologies acting synergistically to promote tumor progression. In both, hematogenous metastasis and inflammation, P-selectin participates in interactions involving tumor cells, platelets, leukocytes and endothelium. Heparin has been shown to inhibit ...

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Conserved ion and amino acid transporters identified as phosphorylcholine-modified N-glycoproteins by metabolic labeling with propargylcholine in Caenorhabditis elegans cells

01.04.2015 | Casey J Snodgrass; Amanda R Burnham-Marusich; John C Meteer; Patricia M Berninsone, Glycobiology , 2015

Phosphorylcholine (PC) modification of proteins by pathogens has been implicated in mediating host–pathogen interactions. Parasitic nematodes synthesize PC-modified biomolecules that can modulate the host's antibody and cytokine production to favor nematode survival, contributing to long-term ...

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Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci

15.03.2015 | Meian He; Min Xu; Ben Zhang; Jun Liang; Peng Chen; Jong-Young Lee; Todd A. Johnson; Huaixing Li; Xiaobo Yang; Junche ..., Human Molecular Genetics, 2015

Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A ...

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Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs

15.03.2015 | Hiroaki Suzuki; Yoshio Shibagaki; Seisuke Hattori; Masaaki Matsuoka, Human Molecular Genetics, 2015

Dysregulation of transactive response DNA-binding protein-43 (TDP-43) is thought to be linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). TDP-43 normally localizes in the nucleus but its main localization shifts to the cytoplasm in most ...

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The differential characterization of GPR55 receptor in human peripheral blood reveals a distinctive expression in monocytes and NK cells and a proinflammatory role in these innate cells

01.03.2015 | Valerio Chiurchiù; Mirko Lanuti; Marco De Bardi; Luca Battistini; Mauro Maccarrone, International Immunology, 2015

G protein-coupled receptor 55 (GPR55) is activated by endogenous, plant-derived and synthetic cannabinoids. Recent studies reported a broad tissue distribution for GPR55 and found prominent roles for this receptor in inflammatory pain, gut and bone physiology, as well as cancer. However, little ...

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Disease origin and progression in amyotrophic lateral sclerosis: an immunology perspective

01.03.2015 | Andrea Malaspina; Fabiola Puentes; Sandra Amor, International Immunology, 2015

The immune system is inextricably linked with many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), a devastating neuromuscular disorder affecting motor cell function with an average survival of 3 years from symptoms onset. In ALS, there is a dynamic interplay between the ...

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A founder CEP120 mutation in Jeune asphyxiating thoracic dystrophy expands the role of centriolar proteins in skeletal ciliopathies

01.03.2015 | Ranad Shaheen; Miriam Schmidts; Eissa Faqeih; Amal Hashem; Ekkehart Lausch; Isabel Holder; Andrea Superti-Furga; UK1 ..., Human Molecular Genetics, 2015

Jeune asphyxiating thoracic dystrophy (JATD) is a skeletal dysplasia characterized by a small thoracic cage and a range of skeletal and extra-skeletal anomalies. JATD is genetically heterogeneous with at least nine genes identified, all encoding ciliary proteins, hence the classification of JATD ...

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Expression inactivation of SMARCA4 by microRNAs in lung tumors

01.03.2015 | Isabel F. Coira; Eva E. Rufino-Palomares; Octavio A. Romero; Paola Peinado; Chanatip Metheetrairut; Laura Boyero-Cor ..., Human Molecular Genetics, 2015

SMARCA4 is the catalytic subunit of the SWI/SNF chromatin-remodeling complex, which alters the interactions between DNA and histones and modifies the availability of the DNA for transcription. The latest deep sequencing of tumor genomes has reinforced the important and ubiquitous tumor suppressor ...

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Genomic Signatures Reveal New Evidences for Selection of Important Traits in Domestic Cattle

01.03.2015 | Lingyang Xu; Derek M. Bickhart; John B. Cole; Steven G. Schroeder; Jiuzhou Song; Curtis P. Van Tassell; Tad S. Sonst ..., Molecular Biology and Evolution, 2015

We investigated diverse genomic selections using high-density single nucleotide polymorphism data of five distinct cattle breeds. Based on allele frequency differences, we detected hundreds of candidate regions under positive selection across Holstein, Angus, Charolais, Brahman, and N'Dama. In ...

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Functional Conservation of Both CDS- and 3′-UTR-Located MicroRNA Binding Sites between Species

01.03.2015 | Guojing Liu; Rui Zhang; Jin Xu; Chung-I Wu; Xuemei Lu, Molecular Biology and Evolution, 2015

MicroRNAs (miRNAs) mediate gene regulation posttranscriptionally through pairing of their seed (2–7 nt) to 3'-untranslated regions (3'-UTRs) or coding regions (coding sequences [CDSs]) of their target genes. CDS target sites generally show weaker repression effects than 3'-UTR sites. However, ...

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