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1.328 Aktuelle Fachpublikationen zum Thema Addition

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Deficiency of {alpha}-glucosidase I alters glycoprotein glycosylation and lifespan in Caenorhabditis elegans

01.10.2013 | Toshihiko Katoh; Juri Takase; Yasushi Tani; Ryuta Amamoto; Naofumi Aoshima; Michael Tiemeyer; Kenji Yamamoto; Hisash ..., Glycobiology , 2013

Endoplasmic reticulum (ER) α-glucosidase I is an enzyme that trims the distal α1,2-linked glucose (Glc) residue from the Glc3Man9GlcNAc2 oligosaccharide following its addition to nascent glycoproteins in the initial step of processing. This reaction is critical to the subsequent processing of ...

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Fucosyltransferase VII improves the function of selectin ligands on cord blood hematopoietic stem cells

01.10.2013 | Xiang Wan; Hidetaka Sato; Hiromasa Miyaji; J Michael McDaniel; Yuesi Wang; Etsuji Kaneko; BreeAnna Gibson; Padmaja M ..., Glycobiology , 2013

Selectins and their carbohydrate ligands mediate the homing of hematopoietic stem/progenitor cells (HSPCs) to the bone marrow. We have previously shown that ex vivo fucosylation of selectin ligands on HSPCs by α1,3 fucosyltransferase VI (FUT6) leads to improved human cord blood (CB)-HSPC ...

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Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD

01.10.2013 | Danielle C. Diaper; Yoshitsugu Adachi; Luke Lazarou; Max Greenstein; Fabio A. Simoes; Angelique Di Domenico; Daniel ..., Human Molecular Genetics, 2013

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative disorders that are characterized by cytoplasmic aggregates and nuclear clearance of TAR DNA-binding protein 43 (TDP-43). Studies in Drosophila, zebrafish and mouse demonstrate that the neuronal ...

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Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography

15.09.2013 | Airong Li; Osman O. Ahsen; Jonathan J. Liu; Chuang Du; Mary L. McKee; Yan Yang; Wilma Wasco; Christopher H. Newton-C ..., Human Molecular Genetics, 2013

The SRY-related HMG-box 5 (SOX5) gene encodes a member of the SOX family of transcription factors. Recently, genome-wide association studies have implicated SOX5 as a candidate gene for susceptibility to four cardiac-related endophenotypes: higher resting heart rate (HR), the electrocardiographic ...

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Enrichment of processed pseudogene transcripts in L1-ribonucleoprotein particles

15.09.2013 | Prabhat K. Mandal; Adam D. Ewing; Dustin C. Hancks; Haig H. Kazazian, Jr, Human Molecular Genetics, 2013

Long INterspersed Elements (LINE-1s, L1s) are responsible for over one million retrotransposon insertions and 8000 processed pseudogenes (PPs) in the human genome. An active L1 encodes two proteins (ORF1p and ORF2p) that bind with L1 RNA and form L1-ribonucleoprotein particles (RNPs). Although it ...

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An integrated toolkit for accurate prediction and analysis of cis-regulatory motifs at a genome scale

15.09.2013 | Qin Ma; Bingqiang Liu; Chuan Zhou; Yanbin Yin; Guojun Li; Ying Xu, Bioinformatics, 2013

Motivation: We present an integrated toolkit, BoBro2.0, for prediction and analysis of cis-regulatory motifs. This toolkit can (i) reliably identify statistically significant cis-regulatory motifs at a genome scale; (ii) accurately scan for all motif instances of a query motif in specified ...

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pyRMSD: a Python package for efficient pairwise RMSD matrix calculation and handling

15.09.2013 | Víctor A. Gil; Víctor Guallar, Bioinformatics, 2013

Summary: We introduce pyRMSD, an open source standalone Python package that aims at offering an integrative and efficient way of performing Root Mean Square Deviation (RMSD)-related calculations of large sets of structures. It is specially tuned to do fast collective RMSD calculations, as ...

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Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice

01.09.2013 | Michael G. Poulos; Ranjan Batra; Moyi Li; Yuan Yuan; Chaolin Zhang; Robert B. Darnell; Maurice S. Swanson, Human Molecular Genetics, 2013

The muscleblind-like (MBNL) genes encode alternative splicing factors that are essential for the postnatal development of multiple tissues, and the inhibition of MBNL activity by toxic C(C)UG repeat RNAs is a major pathogenic feature of the neuromuscular disease myotonic dystrophy. While MBNL1 ...

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Genotoxicity biomarkers associated with exposure to traffic and near-road atmospheres: a review

01.09.2013 | David M. DeMarini, Mutagenesis, 2013

Diesel and gasoline emissions, which are the primary components of traffic exhaust, are known or possible human carcinogens, respectively, and working or living near high-traffic roads is associated with various health effects, including cancer. To help understand the mechanistic basis for this ...

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The influence on DNA damage of glycaemic parameters, oral antidiabetic drugs and polymorphisms of genes involved in the DNA repair system

01.09.2013 | Bruna Santos da Silva; Diego Luiz Rovaris; Rafaela Milan Bonotto; Jéssica Brasil Figueiredo Meyer; Ramona Elisa Groh ..., Mutagenesis, 2013

The hyperglycaemia seen in type 2 diabetes mellitus (DM2) is associated with increased oxidative stress and production of reactive oxygen species, both of which are factors that can provoke DNA damage. Notwithstanding, other factors, including medications and individual susceptibility, can also ...

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