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1.328 Aktuelle Fachpublikationen zum Thema Addition

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Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD

01.10.2013 | Danielle C. Diaper; Yoshitsugu Adachi; Luke Lazarou; Max Greenstein; Fabio A. Simoes; Angelique Di Domenico; Daniel ..., Human Molecular Genetics, 2013

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative disorders that are characterized by cytoplasmic aggregates and nuclear clearance of TAR DNA-binding protein 43 (TDP-43). Studies in Drosophila, zebrafish and mouse demonstrate that the neuronal ...

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Fucosyltransferase VII improves the function of selectin ligands on cord blood hematopoietic stem cells

01.10.2013 | Xiang Wan; Hidetaka Sato; Hiromasa Miyaji; J Michael McDaniel; Yuesi Wang; Etsuji Kaneko; BreeAnna Gibson; Padmaja M ..., Glycobiology , 2013

Selectins and their carbohydrate ligands mediate the homing of hematopoietic stem/progenitor cells (HSPCs) to the bone marrow. We have previously shown that ex vivo fucosylation of selectin ligands on HSPCs by α1,3 fucosyltransferase VI (FUT6) leads to improved human cord blood (CB)-HSPC ...

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Deficiency of {alpha}-glucosidase I alters glycoprotein glycosylation and lifespan in Caenorhabditis elegans

01.10.2013 | Toshihiko Katoh; Juri Takase; Yasushi Tani; Ryuta Amamoto; Naofumi Aoshima; Michael Tiemeyer; Kenji Yamamoto; Hisash ..., Glycobiology , 2013

Endoplasmic reticulum (ER) α-glucosidase I is an enzyme that trims the distal α1,2-linked glucose (Glc) residue from the Glc3Man9GlcNAc2 oligosaccharide following its addition to nascent glycoproteins in the initial step of processing. This reaction is critical to the subsequent processing of ...

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pyRMSD: a Python package for efficient pairwise RMSD matrix calculation and handling

15.09.2013 | Víctor A. Gil; Víctor Guallar, Bioinformatics, 2013

Summary: We introduce pyRMSD, an open source standalone Python package that aims at offering an integrative and efficient way of performing Root Mean Square Deviation (RMSD)-related calculations of large sets of structures. It is specially tuned to do fast collective RMSD calculations, as ...

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An integrated toolkit for accurate prediction and analysis of cis-regulatory motifs at a genome scale

15.09.2013 | Qin Ma; Bingqiang Liu; Chuan Zhou; Yanbin Yin; Guojun Li; Ying Xu, Bioinformatics, 2013

Motivation: We present an integrated toolkit, BoBro2.0, for prediction and analysis of cis-regulatory motifs. This toolkit can (i) reliably identify statistically significant cis-regulatory motifs at a genome scale; (ii) accurately scan for all motif instances of a query motif in specified ...

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Enrichment of processed pseudogene transcripts in L1-ribonucleoprotein particles

15.09.2013 | Prabhat K. Mandal; Adam D. Ewing; Dustin C. Hancks; Haig H. Kazazian, Jr, Human Molecular Genetics, 2013

Long INterspersed Elements (LINE-1s, L1s) are responsible for over one million retrotransposon insertions and 8000 processed pseudogenes (PPs) in the human genome. An active L1 encodes two proteins (ORF1p and ORF2p) that bind with L1 RNA and form L1-ribonucleoprotein particles (RNPs). Although it ...

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Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography

15.09.2013 | Airong Li; Osman O. Ahsen; Jonathan J. Liu; Chuang Du; Mary L. McKee; Yan Yang; Wilma Wasco; Christopher H. Newton-C ..., Human Molecular Genetics, 2013

The SRY-related HMG-box 5 (SOX5) gene encodes a member of the SOX family of transcription factors. Recently, genome-wide association studies have implicated SOX5 as a candidate gene for susceptibility to four cardiac-related endophenotypes: higher resting heart rate (HR), the electrocardiographic ...

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Silencing subtelomeric VSGs by Trypanosoma brucei RAP1 at the insect stage involves chromatin structure changes

01.09.2013 | Unnati M. Pandya; Ranjodh Sandhu; Bibo Li, Nucleic Acids Research, 2013

Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen variant surface glycoprotein (VSG) to evade mammalian host immune responses at the bloodstream form (BF) stage. Monoallelic expression of BF Expression Site (BES)-linked VSGs and silencing of ...

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Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA

01.09.2013 | Lakshminarayan M. Iyer; Dapeng Zhang; A. Maxwell Burroughs; L. Aravind, Nucleic Acids Research, 2013

Discovery of the TET/JBP family of dioxygenases that modify bases in DNA has sparked considerable interest in novel DNA base modifications and their biological roles. Using sensitive sequence and structure analyses combined with contextual information from comparative genomics, we computationally ...

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Aneuploidy facilitates oncogenic transformation via specific genetic alterations, including Twist2 upregulation

01.09.2013 | Gunilla Högnäs; Saara Hämälistö; Kirsi Rilla; Jukka O. Laine; Vesa Vilkki; Astrid Murumägi; Henrik Edgren; Olli Kall ..., Carcinogenesis , 2013

Aneuploidy, deviation from the normal chromosome number, and other chromosomal aberrations are commonly observed in cancer. Integrin-mediated adhesion and dynamic turnover of adhesion sites are required for successful cytokinesis of normal adherent cells and impaired cell division can lead to the ...

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