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175 Aktuelle Fachpublikationen zum Thema Addition

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Protective Effects and Mechanisms of G5 PAMAM Dendrimers against Acute Pancreatitis Induced by Caerulein in Mice

16.12.2014 | Yin Tang; Yingchun Han; Lu Liu; Wenwen Shen; Huayu Zhang; Yunan Wang; Xin Cui; Yuhui Wang; George Liu; Rong Qi, Biomacromolecules, 2014

In this study, generation 5 (G5) polyamidoamine (PAMAM) dendrimers with two different surface groups, G4.5-COOH and G5-OH, were investigated for their protective effects on pancreas injury in a caerulein-induced acute pancreatitis (AP) mouse model. Both dendrimers significantly decreased ...


Effects of Synthetic Biomacromolecule Addition on the Flow Behavior of Concentrated Mesenchymal Cell Suspensions

12.12.2014 | Benoît G. C. Maisonneuve; Denis C. D. Roux; Peter Thorn; Justin J. Cooper-White, Biomacromolecules, 2014

In the fields of tissue engineering and regenerative medicine, many researchers and companies alike are investigating the utility of concentrated mesenchymal stem cell suspensions as therapeutic injectables, with the hope of regenerating the damaged tissue site. These cells are seldom used alone, ...


Advances in Combination Therapies Based on Nanoparticles for Efficacious Cancer Treatment: An Analytical Report

11.12.2014 | Serge Mignani; Maria Bryszewska; Barbara Klajnert-Maculewicz; Maria Zablocka; Jean-Pierre Majoral, Biomacromolecules, 2014

The main objective of nanomedicine research is the development of nanoparticles as drug delivery systems or drugs per se to tackle diseases as cancer, which are a leading cause of death with developed nations. Targeted treatments against solid tumors generally lead to dramatic regressions, but, ...


Tuning the Properties of Mucin via Layer-by-Layer Assembly

04.12.2014 | Jiyoung Ahn; Thomas Crouzier; Katharina Ribbeck; Michael F. Rubner; Robert E. Cohen, Biomacromolecules, 2014

Multilayer films consisting of bovine submaxillary mucin (BSM) and poly(allylamine hydrochloride) (PAH) were prepared on various substrates using layer-by-layer assembly. The effects of both the assembly pH and ionic strength on multilayer characteristics were investigated by assessing film ...


Adhesion Properties of Catechol-Based Biodegradable Amino Acid-Based Poly(ester urea) Copolymers Inspired from Mussel Proteins

26.11.2014 | Jinjun Zhou; Adrian P. Defante; Fei Lin; Ying Xu; Jiayi Yu; Yaohua Gao; Erin Childers; Ali Dhinojwala; Matthew L. Becker, Biomacromolecules, 2014

Amino acid-based poly(ester urea) (PEU) copolymers functionalized with pendant catechol groups that address the need for strongly adhesive yet degradable biomaterials have been developed. Lap-shear tests with aluminum adherends demonstrated that these polymers have lap-shear adhesion strengths ...


Influence of Amino Acids, Buffers, and pH on the γ-Irradiation-Induced Degradation of Alginates

20.11.2014 | Ann-Sissel T. Ulset; Hideki Mori; Marianne Ø. Dalheim; Masayuki Hara; Bjørn E. Christensen, Biomacromolecules, 2014

Alginate-based biomaterials and medical devices are commonly subjected to γ-irradiation as a means of sterilization, either in the dry state or the gel (hydrated) state. In this process the alginate chains degrade randomly in a dose-dependent manner, altering alginates’ material properties. The ...


“Green” Synthesis of Unnatural Poly(Amino Acid)s with Zwitterionic Character and pH-Responsive Solution Behavior, Mediated by Linear–Dendritic Laccase Complexes

28.10.2014 | Ivan Gitsov; Lili Wang; Nikolay Vladimirov; Arsen Simonyan; David J. Kiemle; Andri Schutz, Biomacromolecules, 2014

This article describes the enzyme-catalyzed “green” synthesis of an unnatural poly(amino acid). dl-Tyrosine was polymerized under environmentally friendly conditions using linear–dendritic laccase complexes as initiators and water as solvent. The influence of the dendron generation in the ...


Poly(ε-caprolactone) Nanowebs Functionalized with α- and γ-Cyclodextrins

23.10.2014 | Ganesh Narayanan; Bhupender S. Gupta; Alan E. Tonelli, Biomacromolecules, 2014

The effects of alpha- and gamma-cyclodextrins (α- and γ-CDs) on the thermal and crystal nucleation behavior of electrospun poly(ε-caprolactone) (PCL) nanofibers have been investigated. PCL/CD composite nanofibers were obtained for the first time by electrospinning the mixture from ...


Thermoresponsive Nanostructured Surfaces Generated by the Langmuir–Schaefer Method Are Suitable for Cell Sheet Fabrication

21.10.2014 | Morito Sakuma; Yoshikazu Kumashiro; Masamichi Nakayama; Nobuyuki Tanaka; Kazuo Umemura; Masayuki Yamato; Teruo Okano, Biomacromolecules, 2014

Thermoresponsive poly(N-isopropylacrylamide) (PIPAAm)-immobilized surfaces for controlling cell adhesion and detachment were fabricated by the Langmuir–Schaefer method. Block copolymers composed of polystyrene and PIPAAm (St-IPAAms) having various chain lengths and compositions were synthesized ...


Polyion Complex Micelle Based on Albumin–Polymer Conjugates: Multifunctional Oligonucleotide Transfection Vectors for Anticancer Chemotherapeutics

16.10.2014 | Yanyan Jiang; Hongxu Lu; Yee Yee Khine; Aydan Dag; Martina H. Stenzel, Biomacromolecules, 2014

Novel biocompatible polyion complex micelles, containing bovine serum albumin (BSA), polymer, and oligonucleotide, were synthesized as a generation of vectors for the gene transfection. Maleimide-terminated poly((N,N-dimethyl amino) ethyl methacrylate) (PDMAEMA) was prepared via reversible ...


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