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192 Aktuelle Fachpublikationen zum Thema Addition

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Dendritic Polyglycerol Sulfate Inhibits Microglial Activation and Reduces Hippocampal CA1 Dendritic Spine Morphology Deficits

12.08.2015 | Dusica Maysinger; Dominic Gröger; Andrew Lake; Kai Licha; Marie Weinhart; Philip K.-Y. Chang; Rose Mulvey; Rainer Ha ..., Biomacromolecules, 2015

Hyperactivity of microglia and loss of functional circuitry is a common feature of many neurological disorders including those induced or exacerbated by inflammation. Herein, we investigate the response of microglia and changes in hippocampal dendritic postsynaptic spines by dendritic ...

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Synthesis of Hemoglobin Conjugated Polymeric Micelle: A ZnPc Carrier with Oxygen Self-Compensating Ability for Photodynamic Therapy

07.08.2015 | Shasha Wang; Fang Yuan; Kui Chen; Gaojian Chen; Kehua Tu; Hongjun Wang; Li-Qun Wang, Biomacromolecules, 2015

Photodynamic therapy (PDT) is a promising singlet oxygen (1O2) mediated clinical treatment for many tumors. As the source of 1O2, oxygen plays an important role in the curative effect of PDT. However, the facts of photochemical depletion of oxygen and the intrinsic hypoxic microenvironment of ...

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Biotin-Containing Reduced Graphene Oxide-Based Nanosystem as a Multieffect Anticancer Agent: Combining Hyperthermia with Targeted Chemotherapy

05.08.2015 | Nicolò Mauro; Cinzia Scialabba; Gennara Cavallaro; Mariano Licciardi; Gaetano Giammona, Biomacromolecules, 2015

Among the relevant properties of graphene derivatives, their ability of acting as an energy-converting device so as to produce heat (i.e., thermoablation and hyperthermia) was more recently taken into account for the treatment of solid tumors. In this pioneering study, for the first time, the in ...

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In Situ Synthesis of Magnetic Field-Responsive Hemicellulose Hydrogels for Drug Delivery

30.07.2015 | Weifeng Zhao; Karin Odelius; Ulrica Edlund; Changsheng Zhao; Ann-Christine Albertsson, Biomacromolecules, 2015

A one-pot synthetic methodology for fabricating stimuli-responsive hemicellulose-based hydrogels was developed that consists of the in situ formation of magnetic iron oxide (Fe3O4) nanoparticles during the covalent cross-linking of O-acetyl-galactoglucomannan (AcGGM). The Fe3O4 nanoparticle ...

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Exploiting Oligo(amido amine) Backbones for the Multivalent Presentation of Coiled-Coil Peptides

16.07.2015 | Ulla I. M. Gerling-Driessen; Nina Mujkic-Ninnemann; Daniela Ponader; Daniel Schöne; Laura Hartmann; Beate Koksch; U. ..., Biomacromolecules, 2015

The investigation of coiled coil formation for one mono- and two divalent peptide–polymer conjugates is presented. Through the assembly of the full conjugates on solid support, monodisperse sequence-defined conjugates are obtained with defined positions and distances between the peptide side ...

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Photodegradable Gelatin-Based Hydrogels Prepared by Bioorthogonal Click Chemistry for Cell Encapsulation and Release

24.06.2015 | Vinh X. Truong; Kelly M. Tsang; George P. Simon; Richard L. Boyd; Richard A. Evans; Helmut Thissen; John S. Forsythe, Biomacromolecules, 2015

In this study, we present a method for the fabrication of in situ forming gelatin and poly(ethylene glycol)-based hydrogels utilizing bioorthogonal, strain-promoted alkyne–azide cycloaddition as the cross-linking reaction. By incorporating nitrobenzyl moieties within the network structure, these ...

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Alkaline Phosphatase-Mimicking Peptide Nanofibers for Osteogenic Differentiation

16.06.2015 | Gulcihan Gulseren; I. Ceren Yasa; Oya Ustahuseyin; E. Deniz Tekin; Ayse B. Tekinay; Mustafa O. Guler, Biomacromolecules, 2015

Recognition of molecules and regulation of extracellular matrix synthesis are some of the functions of enzymes in addition to their catalytic activity. While a diverse array of enzyme-like materials have been developed, these efforts have largely been confined to the imitation of the chemical ...

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Functional Degradable Polymers by Radical Ring-Opening Copolymerization of MDO and Vinyl Bromobutanoate: Synthesis, Degradability and Post-Polymerization Modification

09.06.2015 | Guillaume G. Hedir; Craig A. Bell; Rachel K. O’Reilly; Andrew P. Dove, Biomacromolecules, 2015

The synthesis of vinyl bromobutanoate (VBr), a new vinyl acetate monomer derivative obtained by the palladium-catalyzed vinyl exchange reaction between vinyl acetate (VAc) and 4-bromobutyric acid is reported. The homopolymerization of this new monomer using the RAFT/MADIX polymerization technique ...

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Versatile Synthesis of Stable, Functional Polypeptides via Reaction with Epoxides

26.05.2015 | Eric G. Gharakhanian; Timothy J. Deming, Biomacromolecules, 2015

Methodology was developed for efficient alkylation of methionine residues using epoxides as a general strategy to introduce a wide range of functional groups onto polypeptides. Use of a spacer between epoxide and functional groups further allowed addition of sterically demanding functionalities. ...

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Antibiotic Activity of Iron-Sequestering Polymers

22.04.2015 | Nashwa El-Gendy; Jian Qian; Kate Eshelman; Mario Rivera; Cory Berkland, Biomacromolecules, 2015

Increasing antibiotic resistance has compelled the development of novel antibiotics and adjuvant therapies that enhance the efficacy of existing antibiotics. Iron plays a critical role in bacterial infections, yet the use of iron chelators as adjuvant therapy with antibiotics has yielded highly ...

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