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213 Aktuelle Fachpublikationen zum Thema Addition

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Rapid Gelling Chitosan/Polylysine Hydrogel with Enhanced Bulk Cohesive and Interfacial Adhesive Force: Mimicking Features of Epineurial Matrix for Peripheral Nerve Anastomosis

27.01.2016 | Yalin Zhou; Jin Zhao; Xiaolei Sun; Sidi Li; Xin Hou; Xubo Yuan; Xiaoyan Yuan, Biomacromolecules, 2016

Prompt and strong reconnection of severed peripheral nerves is crucial to nerve regeneration. The development of biocompatible nerve adhesives that are stronger than commonly used fibrin glue would be extremely beneficial to this field. We designed an in situ forming nerve adhesive hydrogel ...

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Liposome-Cross-Linked Hybrid Hydrogels for Glutathione-Triggered Delivery of Multiple Cargo Molecules

25.01.2016 | Yingkai Liang; Kristi L. Kiick, Biomacromolecules, 2016

Novel, liposome-cross-linked hybrid hydrogels cross-linked by the Michael-type addition of thiols with maleimides were prepared via the use of maleimide-functionalized liposome cross-linkers and thiolated polyethylene glycol (PEG) polymers. Gelation of the materials was confirmed by oscillatory ...

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Improved Doxorubicin Encapsulation and Pharmacokinetics of Ferritin–Fusion Protein Nanocarriers Bearing Proline, Serine, and Alanine Elements

30.12.2015 | Elisabetta Falvo; Elisa Tremante; Alessandro Arcovito; Massimiliano Papi; Nadav Elad; Alberto Boffi; Veronica Morea; ..., Biomacromolecules, 2015

A novel human ferritin-based nanocarrier, composed of 24 modified monomers able to auto-assemble into a modified protein cage, was produced and used as selective carrier of anti-tumor payloads. Each modified monomer derives from the genetic fusion of two distinct modules, namely the heavy chain ...

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Molecular Design of Squalene/Squalane Countertypes via the Controlled Oligomerization of Isoprene and Evaluation of Vaccine Adjuvant Applications

29.12.2015 | Kevin Adlington; Jaouad El harfi; Jianing Li; Kim Carmichael; Jeffrey A. Guderian; Christopher B. Fox; Derek J. Irvine, Biomacromolecules, 2015

The potential to replace shark-derived squalene in vaccine adjuvant applications with synthetic squalene/poly(isoprene) oligomers, synthesized by the controlled oligomerization of isoprene is demonstrated. Following on from our previous work regarding the synthesis of poly(isoprene) oligomers, we ...

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Resilin-PEG Hybrid Hydrogels Yield Degradable Elastomeric Scaffolds with Heterogeneous Microstructure

22.12.2015 | Christopher L. McGann; Robert E. Akins; Kristi L. Kiick, Biomacromolecules, 2015

Hydrogels derived from resilin-like polypeptides (RLPs) have shown outstanding mechanical resilience and cytocompatibility; expanding the versatility of RLP-based materials via conjugation with other polypeptides and polymers would offer great promise in the design of a range of materials. Here, ...

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Sunflower Polymers for Folate-Mediated Drug Delivery

10.12.2015 | Christine E. Wang; Hua Wei; Nicholas Tan; Andrew J. Boydston; Suzie H. Pun, Biomacromolecules, 2015

Polymeric delivery vehicles can improve the safety and efficacy of chemotherapy drugs by facilitating preferential tumor delivery. Polymer–drug conjugates are especially attractive carriers because additional formulation steps are not required during manufacturing, and drug release profiles can ...

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Investigation into the Relaxation Dynamics of Polymer–Protein Conjugates Reveals Surprising Role of Polymer Solvation on Inherent Protein Flexibility

04.12.2015 | Daniela Russo; Marie Plazanet; José Teixeira; Martine Moulin; Michael Härtlein; Frederik R. Wurm; Tobias Steinbach, Biomacromolecules, 2015

Fully biodegradable protein–polymer conjugates, namely, MBP-PMeEP (maltose binding protein–poly methyl-ethylene phosphonate), have been investigated in order to understand the role of polymer solvation on protein flexibility. Using elastic and quasi-elastic incoherent neutron scattering, in ...

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Studies of Highly-Ordered Heterodiantennary Mannose/Glucose-Functionalized Polymers and Concanavalin A Protein Interactions Using Isothermal Titration Calorimetry

01.12.2015 | Ravi S. Loka; Matthew S. McConnell; Hien M. Nguyen, Biomacromolecules, 2015

Preparations of the highly ordered monoantennary, homofunctional diantennary, and heterofunctional diantennary neoglycopolymers of α-d-mannose and β-d-glucose residues were achieved via ring-opening metathesis polymerization. Isothermal titration calorimetry measurements of these synthetic ...

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Interactions between Cellulolytic Enzymes with Native, Autohydrolysis, and Technical Lignins and the Effect of a Polysorbate Amphiphile in Reducing Nonproductive Binding

25.11.2015 | Consuelo Fritz; Ana Ferrer; Carlos Salas; Hasan Jameel; Orlando J. Rojas, Biomacromolecules, 2015

Understanding enzyme–substrate interactions is critical in designing strategies for bioconversion of lignocellulosic biomass. In this study we monitored molecular events, in situ and in real time, including the adsorption and desorption of cellulolytic enzymes on lignins and cellulose, by using ...

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Contribution of Electrostatics in the Fibril Stability of a Model Ionic-Complementary Peptide

23.11.2015 | Marta Owczarz; Tommaso Casalini; Anna C. Motta; Massimo Morbidelli; Paolo Arosio, Biomacromolecules, 2015

In this work we quantified the role of electrostatic interactions in the self-assembly of a model amphiphilic peptide (RADA 16-I) into fibrillar structures by a combination of size exclusion chromatography and molecular simulations. For the peptide under investigation, it is found that a net ...

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