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183 Aktuelle Fachpublikationen zum Thema Addition

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Antibiotic Activity of Iron-Sequestering Polymers

22.04.2015 | Nashwa El-Gendy; Jian Qian; Kate Eshelman; Mario Rivera; Cory Berkland, Biomacromolecules, 2015

Increasing antibiotic resistance has compelled the development of novel antibiotics and adjuvant therapies that enhance the efficacy of existing antibiotics. Iron plays a critical role in bacterial infections, yet the use of iron chelators as adjuvant therapy with antibiotics has yielded highly ...

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Exploring the Nature of Cellulose Microfibrils

30.03.2015 | Ying Su; Christian Burger; Hongyang Ma; Benjamin Chu; Benjamin S. Hsiao, Biomacromolecules, 2015

Ultrathin cellulose microfibril fractions were extracted from spruce wood powder using combined delignification, TEMPO-catalyzed oxidation, and sonication processes. Small-angle X-ray scattering of these microfibril fractions in a “dilute” aqueous suspension (concentration 0.077 wt %) revealed ...

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Multicolor Fluorescent Labeling of Cellulose Nanofibrils by Click Chemistry

27.03.2015 | Julien R. G. Navarro; Guillaume Conzatti; Yang Yu; Andreas B. Fall; Renny Mathew; Mattias Edén; Lennart Bergström, Biomacromolecules, 2015

We have chemically modified cellulose nanofibrils (CNF) with furan and maleimide groups, and selectively labeled the modified CNF with fluorescent probes; 7-mercapto-4-methylcoumarin and fluorescein diacetate 5-maleimide, through two specific click chemistry reactions: Diels–Alder cycloaddition ...

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Biocompatible Hydrogel Nanocomposite with Covalently Embedded Silver Nanoparticles

26.03.2015 | Clara García-Astrain; Cheng Chen; María Burón; Teodoro Palomares; Arantxa Eceiza; Ljiljana Fruk; M. Ángeles Corcuera ..., Biomacromolecules, 2015

Bionanocomposite materials, combining the properties of biopolymers and nanostructured materials, are attracting interest of the wider scientific community due to their potential application in design of implants, drug delivery systems, and tissue design platforms. Herein, we report on the use of ...

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Exploring the Kinetics of Gelation and Final Architecture of Enzymatically Cross-Linked Chitosan/Gelatin Gels

26.03.2015 | Marcelo A. da Silva; Franziska Bode; Isabelle Grillo; Cécile A. Dreiss, Biomacromolecules, 2015

Small-angle neutron scattering (SANS) was used to characterize the nanoscale structure of enzymatically cross-linked chitosan/gelatin hydrogels obtained from two protocols: a pure chemical cross-linking process (C), which uses the natural enzyme microbial transglutaminase, and a ...

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Synthesis of Multifunctional Cellulose Nanocrystals for Lectin Recognition and Bacterial Imaging

12.03.2015 | Juan Zhou; Núria Butchosa; H. Surangi N. Jayawardena; JaeHyeung Park; Qi Zhou; Mingdi Yan; Olof Ramström, Biomacromolecules, 2015

Multifunctional cellulose nanocrystals have been synthesized and applied as a new type of glyconanomaterial in lectin binding and bacterial imaging. The cellulose nanocrystals were prepared by TEMPO-mediated oxidation and acidic hydrolysis, followed by functionalization with a quinolone ...

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Enzyme Degradable Polymersomes from Hyaluronic Acid-block-poly(ε-caprolactone) Copolymers for the Detection of Enzymes of Pathogenic Bacteria

19.02.2015 | Simon Haas; Nicole Hain; Mohammad Raoufi; Stephan Handschuh-Wang; Tao Wang; Xin Jiang; Holger Schönherr, Biomacromolecules, 2015

We introduce a new hyaluronidase-responsive amphiphilic block copolymer system, based on hyaluronic acid (HYA) and polycaprolactone (PCL), that can be assembled into polymersomes by an inversed solvent shift method. By exploiting the triggered release of encapsulated dye molecules, these ...

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Tea Stains-Inspired Initiator Primer for Surface Grafting of Antifouling and Antimicrobial Polymer Brush Coatings

16.02.2015 | Dicky Pranantyo; Li Qun Xu; Koon-Gee Neoh; En-Tang Kang; Ying Xian Ng; Serena Lay-Ming Teo, Biomacromolecules, 2015

Inspired by tea stains, plant polyphenolic tannic acid (TA) was beneficially employed as the primer anchor for functional polymer brushes. The brominated TA (TABr) initiator primer was synthesized by partial modification of TA with alkyl bromide functionalities. TABr with trihydroxyphenyl ...

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Protective Effects and Mechanisms of G5 PAMAM Dendrimers against Acute Pancreatitis Induced by Caerulein in Mice

16.12.2014 | Yin Tang; Yingchun Han; Lu Liu; Wenwen Shen; Huayu Zhang; Yunan Wang; Xin Cui; Yuhui Wang; George Liu; Rong Qi, Biomacromolecules, 2014

In this study, generation 5 (G5) polyamidoamine (PAMAM) dendrimers with two different surface groups, G4.5-COOH and G5-OH, were investigated for their protective effects on pancreas injury in a caerulein-induced acute pancreatitis (AP) mouse model. Both dendrimers significantly decreased ...

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Effects of Synthetic Biomacromolecule Addition on the Flow Behavior of Concentrated Mesenchymal Cell Suspensions

12.12.2014 | Benoît G. C. Maisonneuve; Denis C. D. Roux; Peter Thorn; Justin J. Cooper-White, Biomacromolecules, 2014

In the fields of tissue engineering and regenerative medicine, many researchers and companies alike are investigating the utility of concentrated mesenchymal stem cell suspensions as therapeutic injectables, with the hope of regenerating the damaged tissue site. These cells are seldom used alone, ...

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