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205 Aktuelle Fachpublikationen zum Thema Addition

mit folgenden Suchkriterien:

Interactions between Cellulolytic Enzymes with Native, Autohydrolysis, and Technical Lignins and the Effect of a Polysorbate Amphiphile in Reducing Nonproductive Binding

25.11.2015 | Consuelo Fritz; Ana Ferrer; Carlos Salas; Hasan Jameel; Orlando J. Rojas, Biomacromolecules, 2015

Understanding enzyme–substrate interactions is critical in designing strategies for bioconversion of lignocellulosic biomass. In this study we monitored molecular events, in situ and in real time, including the adsorption and desorption of cellulolytic enzymes on lignins and cellulose, by using ...


Contribution of Electrostatics in the Fibril Stability of a Model Ionic-Complementary Peptide

23.11.2015 | Marta Owczarz; Tommaso Casalini; Anna C. Motta; Massimo Morbidelli; Paolo Arosio, Biomacromolecules, 2015

In this work we quantified the role of electrostatic interactions in the self-assembly of a model amphiphilic peptide (RADA 16-I) into fibrillar structures by a combination of size exclusion chromatography and molecular simulations. For the peptide under investigation, it is found that a net ...


Supported Lipid Bilayer Platform To Test Inhibitors of the Membrane Attack Complex: Insights into Biomacromolecular Assembly and Regulation

15.10.2015 | Saziye Yorulmaz; Joshua A. Jackman; Walter Hunziker; Nam-Joon Cho, Biomacromolecules, 2015

Complement activation plays an important role in innate immune defense by triggering formation of the membrane attack complex (MAC), which is a biomacromolecular assembly that exhibits membrane-lytic activity against foreign invaders including various pathogens and biomaterials. Understanding the ...


Sequence Adaptive Peptide–Polysaccharide Nanostructures by Biocatalytic Self-Assembly

12.10.2015 | Yousef M. Abul-Haija; Rein V. Ulijn, Biomacromolecules, 2015

Coassembly of peptides and polysaccharides can give rise to the formation of nanostructures with tunable morphologies. We show that in situ enzymatic exchange of a dipeptide sequence in aromatic peptide amphiphiles/polysaccharide coassemblies enables dynamic formation and degradation of different ...


Aligned Electroactive TMV Nanofibers as Enabling Scaffold for Neural Tissue Engineering

07.10.2015 | Yehong Wu; Sheng Feng; Xingjie Zan; Yuan Lin; Qian Wang, Biomacromolecules, 2015

Electroactive nanofibers were fabricated by in situ polymerization of aniline on the surface of tobacco mosaic virus (TMV) using sodium poly(styrenesulfonate) (PSS) as dopant. These electroactive TMV/PANi/PSS nanofibers were employed to support growth of neuronal cells, resulting in augmentation ...


EKylation: Addition of an Alternating-Charge Peptide Stabilizes Proteins

01.10.2015 | Erik J. Liu; Andrew Sinclair; Andrew J. Keefe; Brent L. Nannenga; Brandon L. Coyle; François Baneyx; Shaoyi Jiang, Biomacromolecules, 2015

For nearly 40 years, therapeutic proteins have been stabilized by chemical conjugation of polyethylene glycol (PEG), but recently zwitterionic materials have proved to be a more effective substitute. In this work, we demonstrate that genetic fusion of alternating-charge extensions consisting of ...


Living Composites of Electrospun Yeast Cells for Bioremediation and Ethanol Production

15.09.2015 | Ilya Letnik; Ron Avrahami; J. Stefan Rokem; Andreas Greiner; Eyal Zussman; Charles Greenblatt, Biomacromolecules, 2015

The preparation of composites of living functional cells and polymers is a major challenge. We have fabricated such “living composites” by preparation of polymeric microtubes that entrap yeast cells. Our approach was the process of coaxial electrospinning in which a core containing the yeast was ...


Development of Guanidinium-Rich Protein Mimics for Efficient siRNA Delivery into Human T Cells

14.09.2015 | Brittany M. deRonde; Joe A. Torres; Lisa M. Minter; Gregory N. Tew, Biomacromolecules, 2015

RNA interference is gaining attention as a means to explore new molecular pathways and for its potential as a therapeutic; however, its application in immortal and primary T cells is limited due to challenges with efficient delivery in these cell types. Herein, we report the development of ...


Surface Chemistry Influences Interfacial Fibrinogen Self-Association

10.09.2015 | Blake B. Langdon; Mark Kastantin; Daniel K. Schwartz, Biomacromolecules, 2015

Surface chemistry modifications have been exploited in many applications in order to tune protein adsorption, layer formation, and aggregation. However, the kinetic processes by which surface chemistry influences protein adsorption and aggregation remain elusive. By combining intermolecular ...


Composition and Function of Spider Glues Maintained During the Evolution of Cobwebs

10.09.2015 | Dharamdeep Jain; Ci Zhang; Lydia Rose Cool; Todd A. Blackledge; Chrys Wesdemiotis; Toshikazu Miyoshi; Ali Dhinojwala, Biomacromolecules, 2015

Capture silks are an interesting class of biological glues that help spiders subdue their prey. Viscid capture silk produced by the orb web spiders is a combination of hygroscopic salts that aid in water uptake and interact with adhesive glycoproteins to make them soft and sticky. The orb was a ...


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