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178 Aktuelle Fachpublikationen zum Thema Addition

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Synthesis of Multifunctional Cellulose Nanocrystals for Lectin Recognition and Bacterial Imaging

12.03.2015 | Juan Zhou; Núria Butchosa; H. Surangi N. Jayawardena; JaeHyeung Park; Qi Zhou; Mingdi Yan; Olof Ramström, Biomacromolecules, 2015

Multifunctional cellulose nanocrystals have been synthesized and applied as a new type of glyconanomaterial in lectin binding and bacterial imaging. The cellulose nanocrystals were prepared by TEMPO-mediated oxidation and acidic hydrolysis, followed by functionalization with a quinolone ...


Enzyme Degradable Polymersomes from Hyaluronic Acid-block-poly(ε-caprolactone) Copolymers for the Detection of Enzymes of Pathogenic Bacteria

19.02.2015 | Simon Haas; Nicole Hain; Mohammad Raoufi; Stephan Handschuh-Wang; Tao Wang; Xin Jiang; Holger Schönherr, Biomacromolecules, 2015

We introduce a new hyaluronidase-responsive amphiphilic block copolymer system, based on hyaluronic acid (HYA) and polycaprolactone (PCL), that can be assembled into polymersomes by an inversed solvent shift method. By exploiting the triggered release of encapsulated dye molecules, these ...


Tea Stains-Inspired Initiator Primer for Surface Grafting of Antifouling and Antimicrobial Polymer Brush Coatings

16.02.2015 | Dicky Pranantyo; Li Qun Xu; Koon-Gee Neoh; En-Tang Kang; Ying Xian Ng; Serena Lay-Ming Teo, Biomacromolecules, 2015

Inspired by tea stains, plant polyphenolic tannic acid (TA) was beneficially employed as the primer anchor for functional polymer brushes. The brominated TA (TABr) initiator primer was synthesized by partial modification of TA with alkyl bromide functionalities. TABr with trihydroxyphenyl ...


Protective Effects and Mechanisms of G5 PAMAM Dendrimers against Acute Pancreatitis Induced by Caerulein in Mice

16.12.2014 | Yin Tang; Yingchun Han; Lu Liu; Wenwen Shen; Huayu Zhang; Yunan Wang; Xin Cui; Yuhui Wang; George Liu; Rong Qi, Biomacromolecules, 2014

In this study, generation 5 (G5) polyamidoamine (PAMAM) dendrimers with two different surface groups, G4.5-COOH and G5-OH, were investigated for their protective effects on pancreas injury in a caerulein-induced acute pancreatitis (AP) mouse model. Both dendrimers significantly decreased ...


Effects of Synthetic Biomacromolecule Addition on the Flow Behavior of Concentrated Mesenchymal Cell Suspensions

12.12.2014 | Benoît G. C. Maisonneuve; Denis C. D. Roux; Peter Thorn; Justin J. Cooper-White, Biomacromolecules, 2014

In the fields of tissue engineering and regenerative medicine, many researchers and companies alike are investigating the utility of concentrated mesenchymal stem cell suspensions as therapeutic injectables, with the hope of regenerating the damaged tissue site. These cells are seldom used alone, ...


Advances in Combination Therapies Based on Nanoparticles for Efficacious Cancer Treatment: An Analytical Report

11.12.2014 | Serge Mignani; Maria Bryszewska; Barbara Klajnert-Maculewicz; Maria Zablocka; Jean-Pierre Majoral, Biomacromolecules, 2014

The main objective of nanomedicine research is the development of nanoparticles as drug delivery systems or drugs per se to tackle diseases as cancer, which are a leading cause of death with developed nations. Targeted treatments against solid tumors generally lead to dramatic regressions, but, ...


Tuning the Properties of Mucin via Layer-by-Layer Assembly

04.12.2014 | Jiyoung Ahn; Thomas Crouzier; Katharina Ribbeck; Michael F. Rubner; Robert E. Cohen, Biomacromolecules, 2014

Multilayer films consisting of bovine submaxillary mucin (BSM) and poly(allylamine hydrochloride) (PAH) were prepared on various substrates using layer-by-layer assembly. The effects of both the assembly pH and ionic strength on multilayer characteristics were investigated by assessing film ...


Adhesion Properties of Catechol-Based Biodegradable Amino Acid-Based Poly(ester urea) Copolymers Inspired from Mussel Proteins

26.11.2014 | Jinjun Zhou; Adrian P. Defante; Fei Lin; Ying Xu; Jiayi Yu; Yaohua Gao; Erin Childers; Ali Dhinojwala; Matthew L. Becker, Biomacromolecules, 2014

Amino acid-based poly(ester urea) (PEU) copolymers functionalized with pendant catechol groups that address the need for strongly adhesive yet degradable biomaterials have been developed. Lap-shear tests with aluminum adherends demonstrated that these polymers have lap-shear adhesion strengths ...


Influence of Amino Acids, Buffers, and pH on the γ-Irradiation-Induced Degradation of Alginates

20.11.2014 | Ann-Sissel T. Ulset; Hideki Mori; Marianne Ø. Dalheim; Masayuki Hara; Bjørn E. Christensen, Biomacromolecules, 2014

Alginate-based biomaterials and medical devices are commonly subjected to γ-irradiation as a means of sterilization, either in the dry state or the gel (hydrated) state. In this process the alginate chains degrade randomly in a dose-dependent manner, altering alginates’ material properties. The ...


“Green” Synthesis of Unnatural Poly(Amino Acid)s with Zwitterionic Character and pH-Responsive Solution Behavior, Mediated by Linear–Dendritic Laccase Complexes

28.10.2014 | Ivan Gitsov; Lili Wang; Nikolay Vladimirov; Arsen Simonyan; David J. Kiemle; Andri Schutz, Biomacromolecules, 2014

This article describes the enzyme-catalyzed “green” synthesis of an unnatural poly(amino acid). dl-Tyrosine was polymerized under environmentally friendly conditions using linear–dendritic laccase complexes as initiators and water as solvent. The influence of the dendron generation in the ...


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