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1.952 Aktuelle Fachpublikationen zum Thema Addition

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The reverse transcriptase–RNase H: from viruses to antiviral defense

19.02.2015 | Karin Moelling, Felix Broecker, Annals of the New York Academy of Sciences, 2015

Ubiquitous, reverse transcriptase may have contributed to the transition from the RNA to the DNA world, a transition that also involved RNase H–like activities. Both enzymes shaped various genomes and antiviral defense systems as endogenous retroviruses (ERVs) and transposable elements (TEs). A ...


[Report] An arboreal docodont from the Jurassic and mammaliaform ecological diversification

13.02.2015 | Qing-Jin Meng; Qiang Ji; Yu-Guang Zhang; Di Liu; David M. Grossnickle; Zhe-Xi Luo, Science , 2015

A new docodontan mammaliaform from the Middle Jurassic of China has skeletal features for climbing and dental characters indicative of an omnivorous diet that included plant sap. This fossil expands the range of known locomotor adaptations in docodontans to include climbing, in addition to ...


Inhibition of Autophagy Suppresses Sertraline-Mediated Primary Ciliogenesis in Retinal Pigment Epithelium Cells

11.02.2015 | Eun Sung Kim et al., PLoS ONE, 2015

by Eun Sung Kim, Ji Hyun Shin, So Jung Park, Yoon Kyung Jo, Jae-Sung Kim, Il-Hwan Kang, Jung-Bum Nam, Doo-Young Chung, Yoonchul Cho, EunJoo H. Lee, Jong Wook Chang, Dong-Hyung Cho Primary cilia are conserved cellular organelles that regulate diverse signaling pathways. Autophagy is a complex ...


Early Olfactory Environment Influences Social Behaviour in Adult Octodon degus

11.02.2015 | Natalia Márquez et al., PLoS ONE, 2015

by Natalia Márquez, Jaime Martínez-Harms, Rodrigo A. Vásquez, Jorge Mpodozis We evaluated the extent to which manipulation of early olfactory environment can influence social behaviours in the South American Hystricognath rodent Octodon degus. The early olfactory environment of newborn degus ...


Immune-mediated antitumor effect by type 2 diabetes drug, metformin [Immunology and Inflammation]

10.02.2015 | Shingo Eikawa; Mikako Nishida; Shusaku Mizukami; Chihiro Yamazaki; Eiichi Nakayama; Heiichiro Udono, Proceedings of the National Academy of Sciences current issue, 2015

Metformin, a prescribed drug for type 2 diabetes, has been reported to have anti-cancer effects; however, the underlying mechanism is poorly understood. Here we show that this mechanism may be immune-mediated. Metformin enabled normal but not T-cell–deficient SCID mice to reject solid tumors. In ...


Protein folding and binding can emerge as evolutionary spandrels through structural coupling [Evolution]

10.02.2015 | Michael Manhart; Alexandre V. Morozov, Proceedings of the National Academy of Sciences current issue, 2015

Binding interactions between proteins and other molecules mediate numerous cellular processes, including metabolism, signaling, and gene regulation. These interactions often evolve in response to changes in the protein’s chemical or physical environment (such as the addition of an antibiotic). ...


ABCE1 Is a Highly Conserved RNA Silencing Suppressor

06.02.2015 | Kairi Kärblane et al., PLoS ONE, 2015

by Kairi Kärblane, Jelena Gerassimenko, Lenne Nigul, Alla Piirsoo, Agata Smialowska, Kadri Vinkel, Per Kylsten, Karl Ekwall, Peter Swoboda, Erkki Truve, Cecilia Sarmiento ATP-binding cassette sub-family E member 1 (ABCE1) is a highly conserved protein among eukaryotes and archaea. Recent ...


Cost-Effectiveness Analysis of Brief and Expanded Evidence-Based Risk Reduction Interventions for HIV-Infected People Who Inject Drugs in the United States

06.02.2015 | Dahye L. Song et al., PLoS ONE, 2015

by Dahye L. Song, Frederick L. Altice, Michael M. Copenhaver, Elisa F. Long Aims Two behavioral HIV prevention interventions for people who inject drugs (PWID) infected with HIV include the Holistic Health Recovery Program for HIV+ (HHRP+), a comprehensive evidence-based CDC-supported program, ...


Generation and Characterization of Antibodies against Asian Elephant (Elephas maximus) IgG, IgM, and IgA

06.02.2015 | Alan F. Humphreys et al., PLoS ONE, 2015

by Alan F. Humphreys, Jie Tan, RongSheng Peng, Susan M. Benton, Xiang Qin, Kim C. Worley, Rose L. Mikulski, Dar-Chone Chow, Timothy G. Palzkill, Paul D. Ling Asian elephant (Elephas maximus) immunity is poorly characterized and understood. This gap in knowledge is particularly concerning as ...


[Report] Direct observation and kinetics of a hydroperoxyalkyl radical (QOOH)

06.02.2015 | John D. Savee; Ewa Papajak; Brandon Rotavera; Haifeng Huang; Arkke J. Eskola; Oliver Welz; Leonid Sheps; Craig A. Ta ..., Science , 2015

Oxidation of organic compounds in combustion and in Earth’s troposphere is mediated by reactive species formed by the addition of molecular oxygen (O2) to organic radicals. Among the most crucial and elusive of these intermediates are hydroperoxyalkyl radicals, often denoted “QOOH.” These species ...


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