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A Novel Role for SIRT-1 in L-Arginine Protection against STZ Induced Myocardial Fibrosis in Rats

12.12.2014 | Sherine M. Rizk et al., PLoS ONE, 2014

by Sherine M. Rizk, Shohda A. El-Maraghy, Noha N. Nassar Background L-arginine (L-ARG) effectively protects against diabetic impediments. In addition, silent information regulator (SIRT-1) activators are emerging as a new clinical concept in treating diabetic complications. Accordingly, this ...


Paramagnetic Beads and Magnetically Mediated Strain Enhance Cardiomyogenesis in Mouse Embryoid Bodies

12.12.2014 | Laura R. Geuss et al., PLoS ONE, 2014

by Laura R. Geuss, Douglas C. Wu, Divya Ramamoorthy, Corinne D. Alford, Laura J. Suggs Mechanical forces play an important role in proper embryologic development, and similarly such forces can directly impact pluripotency and differentiation of mouse embryonic stem cells (mESC) in vitro. In ...


Cloning of the Cryptochrome-Encoding PeCRY1 Gene from Populus euphratica and Functional Analysis in Arabidopsis

12.12.2014 | Ke Mao et al., PLoS ONE, 2014

by Ke Mao, Libo Jiang, Wenhao Bo, Fang Xu, Rongling Wu Cryptochromes are photolyase-like blue/UV-A light receptors that evolved from photolyases. In plants, cryptochromes regulate various aspects of plant growth and development. Despite of their involvement in the control of important plant ...


Human Rhinovirus Induced Cytokine/Chemokine Responses in Human Airway Epithelial and Immune Cells

12.12.2014 | Devi Rajan et al., PLoS ONE, 2014

by Devi Rajan, Courtney E. McCracken, Hannah B. Kopleman, Shuya Y. Kyu, F. Eun-Hyung Lee, Xiaoyan Lu, Larry J. Anderson Infections with human rhinovirus (HRV) are commonly associated with acute upper and lower respiratory tract disease and asthma exacerbations. The role that HRVs play in these ...


Significance of Urinary Full-Length Megalin in Patients with IgA Nephropathy

12.12.2014 | Takuto Seki et al., PLoS ONE, 2014

by Takuto Seki, Katsuhiko Asanuma, Rin Asao, Kanae Nonaka, Yu Sasaki, Juan Alejandro Oliva Trejo, Hiroyuki Kurosawa, Yoshiaki Hirayama, Satoshi Horikoshi, Yasuhiko Tomino, Akihiko Saito Background and Objectives Megalin is highly expressed at the apical membranes of proximal tubular epithelial ...


S-Nitrosoglutathione Accelerates Recovery from 5-Fluorouracil-Induced Oral Mucositis

05.12.2014 | Maria Adriana Skeff et al., PLoS ONE, 2014

by Maria Adriana Skeff, Gerly A. C. Brito, Marcelo G. de Oliveira, Cintia M. Braga, Matheus M. Cavalcante, Victor Baldim, Rosenilde C. Holanda-Afonso, Carina M. Silva-Boghossian, Ana Paula Colombo, Ronaldo A. Ribeiro, Vivaldo Moura-Neto, Renata F. C. Leitão Introduction Mucositis induced by ...


Temporal and Spatial Stability of Ammonia-Oxidizing Archaea and Bacteria in Aquarium Biofilters

05.12.2014 | Samik Bagchi et al., PLoS ONE, 2014

by Samik Bagchi, Siegfried E. Vlaeminck, Laura A. Sauder, Mariela Mosquera, Josh D. Neufeld, Nico Boon Nitrifying biofilters are used in aquaria and aquaculture systems to prevent accumulation of ammonia by promoting rapid conversion to nitrate via nitrite. Ammonia-oxidizing archaea (AOA), as ...


New Type of Sendai Virus Vector Provides Transgene-Free iPS Cells Derived from Chimpanzee Blood

05.12.2014 | Yasumitsu Fujie et al., PLoS ONE, 2014

by Yasumitsu Fujie, Noemi Fusaki, Tomohiko Katayama, Makoto Hamasaki, Yumi Soejima, Minami Soga, Hiroshi Ban, Mamoru Hasegawa, Satoshi Yamashita, Shigemi Kimura, Saori Suzuki, Tetsuro Matsuzawa, Hirofumi Akari, Takumi Era Induced pluripotent stem cells (iPSCs) are potentially valuable cell ...


Functional Study of the Hap4-Like Genes Suggests That the Key Regulators of Carbon Metabolism HAP4 and Oxidative Stress Response YAP1 in Yeast Diverged from a Common Ancestor

05.12.2014 | Nataliya Petryk et al., PLoS ONE, 2014

by Nataliya Petryk, You-Fang Zhou, Kateryna Sybirna, Marie-Hélène Mucchielli, Bernard Guiard, Wei-Guo Bao, Oleh V. Stasyk, Olena G. Stasyk, Olena S. Krasovska, Karine Budin, Nancie Reymond, Sandrine Imbeaud, Sophie Coudouel, Hervé Delacroix, Andriy Sibirny, Monique Bolotin-Fukuhara The ...


Role of Medio-Dorsal Frontal and Posterior Parietal Neurons during Auditory Detection Performance in Rats

05.12.2014 | Kaitlin S. Bohon et al., PLoS ONE, 2014

by Kaitlin S. Bohon, Michael C. Wiest To further characterize the role of frontal and parietal cortices in rat cognition, we recorded action potentials simultaneously from multiple sites in the medio-dorsal frontal cortex and posterior parietal cortex of rats while they performed a two-choice ...


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