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1.879 Aktuelle Fachpublikationen zum Thema Addition

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Detection Theory in Identification of RNA-DNA Sequence Differences Using RNA-Sequencing

14.11.2014 | Jonathan M. Toung et al., PLoS ONE, 2014

by Jonathan M. Toung, Nicholas Lahens, John B. Hogenesch, Gregory Grant Advances in sequencing technology have allowed for detailed analyses of the transcriptome at single-nucleotide resolution, facilitating the study of RNA editing or sequence differences between RNA and DNA genome-wide. In ...


ARFGAP1 Is Dynamically Associated with Lipid Droplets in Hepatocytes

14.11.2014 | Joan Gannon et al., PLoS ONE, 2014

by Joan Gannon, Julia Fernandez-Rodriguez, Hussam Alamri, Shi Bo Feng, Fariba Kalantari, Sarita Negi, Amy H. Y. Wong, Alexander Mazur, Lennart Asp, Ali Fazel, Ayat Salman, Anthoula Lazaris, Peter Metrakos, John J. M. Bergeron, Tommy Nilsson The ARF GTPase Activating Protein 1 (ARFGAP1) ...


Maximizing Negative Correlations in Resting-State Functional Connectivity MRI by Time-Lag

14.11.2014 | Gadi Goelman et al., PLoS ONE, 2014

by Gadi Goelman, Noam Gordon, Omer Bonne This paper aims to better understand the physiological meaning of negative correlations in resting state functional connectivity MRI (r-fcMRI). The correlations between anatomy-based brain regions of 18 healthy humans were calculated and analyzed with ...


Delirium, Sedation and Analgesia in the Intensive Care Unit: A Multinational, Two-Part Survey among Intensivists

14.11.2014 | Alawi Luetz et al., PLoS ONE, 2014

by Alawi Luetz, Felix Balzer, Finn M. Radtke, Christina Jones, Giuseppe Citerio, Bernhard Walder, Bjoern Weiss, Klaus-Dieter Wernecke, Claudia Spies Analgesia, sedation and delirium management are important parts of intensive care treatment as they are relevant for patients' clinical and ...


Energies, Vol. 7, Pages 7305-7329: An Integrated Energy-Efficient Operation Methodology for Metro Systems Based on a Real Case of Shanghai Metro Line One

13.11.2014 | Gong, Cheng ; Zhang, Shiwen ; Zhang, Feng ; Jiang, Jianguo ; Wang, Xinheng, Energies, 2014

Metro systems are one of the most important transportation systems in people’s lives. Due to the huge amount of energy it consumes every day, highly-efficient operation of a metro system will lead to significant energy savings. In this paper, a new integrated Energy-efficient Operation ...


Differential Effect of HDAC3 on Cytoplasmic and Nuclear Huntingtin Aggregates

07.11.2014 | Tatsuo Mano et al., PLoS ONE, 2014

by Tatsuo Mano, Takayoshi Suzuki, Shoji Tsuji, Atsushi Iwata Histone deacetylases (HDACs) are potential therapeutic targets of polyglutamine (pQ) diseases including Huntington’s disease (HD) that may function to correct aberrant transcriptional deactivation caused by mutant pQ proteins. HDAC3 ...


Regulation of Coagulation Factor XI Expression by MicroRNAs in the Human Liver

07.11.2014 | Salam Salloum-Asfar et al., PLoS ONE, 2014

by Salam Salloum-Asfar, Raúl Teruel-Montoya, Ana B. Arroyo, Nuria García-Barberá, Amarjit Chaudhry, Erin Schuetz, Ginés Luengo-Gil, Vicente Vicente, Rocío González-Conejero, Constantino Martínez High levels of factor XI (FXI) increase the risk of thromboembolic disease. However, the genetic and ...


MicroRNA-378 Regulates Adiponectin Expression in Adipose Tissue: A New Plausible Mechanism

07.11.2014 | Masayoshi Ishida et al., PLoS ONE, 2014

by Masayoshi Ishida, Michio Shimabukuro, Shusuke Yagi, Sachiko Nishimoto, Chisayo Kozuka, Daiju Fukuda, Takeshi Soeki, Hiroaki Masuzaki, Masato Tsutsui, Masataka Sata Aims Mechanisms regulating adiponectin expression have not been fully clarified. MicroRNAs (miRNAs), small non-coding RNAs that ...


Interplay of the Bacterial Ribosomal A-Site, S12 Protein Mutations and Paromomycin Binding: A Molecular Dynamics Study

07.11.2014 | Joanna Panecka et al., PLoS ONE, 2014

by Joanna Panecka, Cameron Mura, Joanna Trylska The conformational properties of the aminoacyl-tRNA binding site (A-site), and its surroundings in the Escherichia coli 30S ribosomal subunit, are of great relevance in designing antibacterial agents. The 30S subunit A-site is near ribosomal ...



06.11.2014 | ;, Nature, 2014

Correction Nature 515, 7525 (2014). In the News story ‘Geneticists tap human knockouts’ (Nature514, 548; 2014), the team investigating knockouts found some 200,000 variations that knocked out ...


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