14.06.2013 | Ian Johnson et al., PLoS ONE, 2013

by Ian Johnson, Huinan Liu Controlling degradation of magnesium or its alloys in physiological saline solutions is essential for their potential applications in clinically viable implants. Rapid degradation of magnesium-based materials reduces the mechanical properties of implants ...

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11.06.2013 | Arion I. Stettner; Daniel Segrè, Proceedings of the National Academy of Sciences current issue, 2013

In a universe being dragged into disorder by the second law of thermodynamics, living cells must expend energy to maintain their complex organization. In addition to providing a carbon source for biosynthesis, the classical Embden–Meyerhof–Parnas (EMP) and Entner-Doudoroff (ED) pathways help ...

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10.06.2013 | Patrik Vuilleumier, Annals of the New York Academy of Sciences, 2013

Spatial neglect is generally defined by various deficits in processing information from one (e.g., left) side of space contralateral to focal (e.g., right) hemisphere damage. Although classically associated with parietal lobe functions, there is now compelling evidence that neglect can ...

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07.06.2013 | Qingqing Cai et al., PLoS ONE, 2013

by Qingqing Cai, Huiqiang Huang, Dong Qian, Kailin Chen, Junhua Luo, Ying Tian, Tianxin Lin, Tongyu Lin 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid purified from soy fermentation products, induces apoptosis in human cancer cells. We investigated the ...

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07.06.2013 | Hélène Bugaut et al., PLoS ONE, 2013

by Hélène Bugaut, Mélanie Bruchard, Hélène Berger, Valentin Derangère, Ludivine Odoul, Romain Euvrard, Sylvain Ladoire, Fanny Chalmin, Frédérique Végran, Cédric Rébé, Lionel Apetoh, François Ghiringhelli, Grégoire Mignot Bleomycin (BLM) is an anticancer drug currently used for the ...

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07.06.2013 | Paraskevi Georgakopoulos et al., PLoS ONE, 2013

by Paraskevi Georgakopoulos, Robin A. Lockington, Joan M. Kelly A mutation screen in Aspergillus nidulans uncovered mutations in the acdX gene that led to altered repression by acetate, but not by glucose. AcdX of A. nidulans is highly conserved with Spt8p of Saccharomyces cerevisiae, and ...

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07.06.2013 | Miriam Taegtmeyer et al., PLoS ONE, 2013

by Miriam Taegtmeyer, Alun Davies, Mary Mwangome, Elisabeth M. van der Elst, Susan M. Graham, Matt A. Price, Eduard J. Sanders The role of men who have sex with men (MSM) in the African HIV epidemic is gaining recognition yet capacity to address the HIV prevention needs of this group is ...

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07.06.2013 | Christin Klenke et al., PLoS ONE, 2013

by Christin Klenke, Darius Widera, Thomas Engelen, Janine Müller, Thomas Noll, Karsten Niehaus, M. Lienhard Schmitz, Barbara Kaltschmidt, Christian Kaltschmidt Signaling via NF-κB in neurons depends on complex formation with interactors such as dynein/dynactin motor complex and can be ...

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07.06.2013 | Pooja Pal et al., PLoS ONE, 2013

by Pooja Pal, Savita Lochab, Jitendra Kumar Kanaujiya, Isha Kapoor, Sabyasachi Sanyal, Gerhard Behre, Arun Kumar Trivedi CCAAT/Enhancer Binding Protein Alpha (C/EBPα) is a key transcription factor involved in the adipocyte differentiation. Here for the first time we demonstrate that E6AP, ...

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04.06.2013 | Yoon Park; Hyung-seung Jin; Yun-Cai Liu, Proceedings of the National Academy of Sciences current issue, 2013

The ubiquitin conjugation system plays an important role in immune regulation; however, the ubiquitin-specific proteases (USPs) that carry out deubiquitination of cellular substrates are poorly understood. Here we show that in vivo knockdown of the deubiquitinating enzyme USP9X attenuates ...

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