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[Special Issue Review] Antibodies in HIV-1 Vaccine Development and Therapy

13.09.2013 | Florian Klein; Hugo Mouquet; Pia Dosenovic; Johannes F. Scheid; Louise Scharf; Michel C. Nussenzweig, Science , 2013

Despite 30 years of study, there is no HIV-1 vaccine and, until recently, there was little hope for a protective immunization. Renewed optimism in this area of research comes in part from the results of a recent vaccine trial and the use of single-cell antibody-cloning techniques that uncovered ...


In Silico Approach for Predicting Toxicity of Peptides and Proteins

13.09.2013 | Sudheer Gupta et al., PLoS ONE, 2013

by Sudheer Gupta, Pallavi Kapoor, Kumardeep Chaudhary, Ankur Gautam, Rahul Kumar, Open Source Drug Discovery Consortium , Gajendra P. S. Raghava Background Over the past few decades, scientific research has been focused on developing peptide/protein-based therapies to treat various diseases. ...


Wnt11b Is Involved in Cilia-Mediated Symmetry Breakage during Xenopus Left-Right Development

13.09.2013 | Peter Walentek et al., PLoS ONE, 2013

by Peter Walentek, Isabelle Schneider, Axel Schweickert, Martin Blum Breakage of bilateral symmetry in amphibian embryos depends on the development of a ciliated epithelium at the gastrocoel roof during early neurulation. Motile cilia at the gastrocoel roof plate (GRP) give rise to leftward ...


Broad MICA/B Expression in the Small Bowel Mucosa: A Link between Cellular Stress and Celiac Disease

13.09.2013 | Yessica L. Allegretti et al., PLoS ONE, 2013

by Yessica L. Allegretti, Constanza Bondar, Luciana Guzman, Eduardo Cueto Rua, Nestor Chopita, Mercedes Fuertes, Norberto W. Zwirner, Fernando G. Chirdo The MICA/B genes (MHC class I chain related genes A and B) encode for non conventional class I HLA molecules which have no role in antigen ...


Genetic Effects on DNA Methylation and Its Potential Relevance for Obesity in Mexican Americans

13.09.2013 | Melanie A. Carless et al., PLoS ONE, 2013

by Melanie A. Carless, Hemant Kulkarni, Mark Z. Kos, Jac Charlesworth, Juan M. Peralta, Harald H. H. Göring, Joanne E. Curran, Laura Almasy, Thomas D. Dyer, Anthony G. Comuzzie, Michael C. Mahaney, John Blangero Several studies have identified effects of genetic variation on DNA methylation ...


Energies, Vol. 6, Pages 4786-4798: General and Simple Decision Method for DG Penetration Level in View of Voltage Regulation at Distribution Substation Transformers

10.09.2013 | Song, Il-Keun ; Jung, Won-Wook ; Chu, Chul-Min ; Cho, Seong-Soo ; Kang, Hyun-Koo ; Choi, Joon-Ho, Energies, 2013

A distribution system was designed and operated by considering unidirectional power flow from a utility source to end-use loads. The large penetrations of distributed generation (DG) into the existing distribution system causes a variety of technical problems, such as frequent tap changing ...


Money and trust among strangers [Economic Sciences]

10.09.2013 | Gabriele Camera; Marco Casari; Maria Bigoni, Proceedings of the National Academy of Sciences current issue, 2013

What makes money essential for the functioning of modern society? Through an experiment, we present evidence for the existence of a relevant behavioral dimension in addition to the standard theoretical arguments. Subjects faced repeated opportunities to help an anonymous counterpart who changed ...


Glycan Elongation Beyond the Mucin Associated Tn Antigen Protects Tumor Cells from Immune-Mediated Killing

06.09.2013 | Caroline B. Madsen et al., PLoS ONE, 2013

by Caroline B. Madsen, Kirstine Lavrsen, Catharina Steentoft, Malene B. Vester-Christensen, Henrik Clausen, Hans H. Wandall, Anders Elm Pedersen Membrane bound mucins are up-regulated and aberrantly glycosylated during malignant transformation in many cancer cells. This results in a negatively ...


Abrogated Thioredoxin System Causes Increased Sensitivity to TNF-α-Induced Apoptosis via Enrichment of p-ERK 1/2 in the Nucleus

06.09.2013 | Min-Hyuk Yoo et al., PLoS ONE, 2013

by Min-Hyuk Yoo, Bradley A. Carlson, Vadim N. Gladyshev, Dolph L. Hatfield Thioredoxin (Trx) and thioredoxin reductase 1 (TR1) are among the major redox regulators in mammalian cells and have a wide variety of roles, including removal of intracellular reactive oxygen species (ROS) and ...


Evaluation of Truncated NhhA Protein as a Candidate Meningococcal Vaccine Antigen

06.09.2013 | Ian R. Peak et al., PLoS ONE, 2013

by Ian R. Peak, Yogitha N. Srikhanta, Vincent E. Weynants, Christiane Feron, Jan T. Poolman, Michael P. Jennings NhhA (Neisseria hia homologue) is an outer membrane protein from Neisseria meningitidis, the causative agent of meningococcal disease. The protein is surface exposed and its ...


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