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3.604 Aktuelle Fachpublikationen zum Thema Addition

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Carbon Monoxide and Nitric Oxide interactions in Magnocellular Neurosecretory Neurons during Water Deprivation

13.12.2014 | Wagner L. Reis, Vinicia C. Biancardi, Sookjin Son, Jose Antunes‐Rodrigues, Javier E. Stern, Journal of Neuroendocrinology, 2014

Abstract Nitric oxide (NO) and carbon monoxide (CO) are diffusible gas messengers in the brain. Previously, we have shown their independent involvement in central fluid/electrolyte homeostasis control. Here, we investigated a possible functional interaction between NO/CO in the regulation of ...


Nanocomposite Bone Scaffolds Based on Biodegradable Polymers and Hydroxyapatite

11.12.2014 | Johannes Becker, Lichun Lu, M. Brett Runge, Heng Zeng, Michael J. Yaszemski, Mahrokh Dadsetan, Journal of Biomedical Materials Research Part A, 2014

Abstract In tissue engineering, development of an osteoconductive construct that integrates with host tissue remains a challenge. In this work, the effect of bone‐like minerals on maturation of pre‐osteoblast cells was investigated using polymer‐mineral scaffolds composed of poly(propylene ...


Amphipathic α-Helices in Apolipoproteins Are Crucial to the Formation of Infectious Hepatitis C Virus Particles

11.12.2014 | Takasuke Fukuhara et al., PLoS Pathogens, 2014

by Takasuke Fukuhara, Masami Wada, Shota Nakamura, Chikako Ono, Mai Shiokawa, Satomi Yamamoto, Takashi Motomura, Toru Okamoto, Daisuke Okuzaki, Masahiro Yamamoto, Izumu Saito, Takaji Wakita, Kazuhiko Koike, Yoshiharu Matsuura Apolipoprotein B (ApoB) and ApoE have been shown to participate in ...


Prenatal Testosterone Excess Decreases Neurokinin 3 Receptor Immunoreactivity within the Arcuate Nucleus KNDy cell population

10.12.2014 | T. Ahn, C. Fergani, L.M. Coolen, V. Padmanabhan, M.N. Lehman, Journal of Neuroendocrinology, 2014

Abstract Prenatal exposure of the female ovine fetus to excess testosterone (T) leads to neuroendocrine disruptions in adulthood, evidenced by defects in responsiveness to the ability of gonadal steroids to regulate GnRH secretion. In the ewe, neurones of the arcuate nucleus (ARC), which ...


Antigen targeting reveals splenic CD169+ macrophages as promoters of germinal center B‐cell responses

09.12.2014 | Henrike Veninga, Ellen G.F. Borg, Kyle Vreeman, Philip R. Taylor, Hakan Kalay, Yvette Kooyk, Georg Kraal, Luisa Mart ..., European Journal of Immunology, 2014

Antigen (Ag) delivery to specific antigen‐presenting cells (APCs) is an attractive approach in developing strategies for vaccination. CD169+ macrophages in the marginal zone of the spleen represent a suitable target for delivery of Ag because of their strategic location, which is optimal for the ...


Simeprevir added to peginterferon and ribavirin lessens time with fatigue, depressive symptoms and functional limitations in patients with chronic hepatitis C compared with peginterferon and ribavirin: results from 1161 patients in the QUEST‐1, QUEST‐2 and PROMISE studies

09.12.2014 | J. Scott, L. Gilles, M. Fu, E. Brohan, C. Panter, R. Arbuckle, W. Jessner, M. Beumont, Journal of Viral Hepatitis, 2014

Summary The value of adding simeprevir (SMV) vs placebo (PBO) to peginterferon and ribavirin (PR) for treatment of chronic hepatitis C virus infection was examined using patient‐reported outcomes (PROs); further, concordance of PROs with virology endpoints and adverse events (AEs) was ...


Prevalence of human papillomavirus and its genotype among 1336 invasive cervical cancer patients in Hunan province, central south China

08.12.2014 | Linqian Wang, Baiping Wu, Junjun Li, Liyu Chen, Journal of Medical Virology, 2014

Existing data on the genotype distribution of human papillomavirus (HPV) are limited in Hunan province, central south China. To evaluate the prevalence of HPV infection and its genotype among women with invasive cervical cancer in Hunan, a total of 1,336 patients were included in this study ...


Meshology: a fast-growing field involving mesh and/or tape removal procedures and their outcomes

06.12.2014 | Dominic Lee; Chasta Bacsu; Philippe E Zimmern, Expert Review of Medical Devices, 2014

Stress urinary incontinence and pelvic organ prolapse are two of the commonest conditions affecting women today. It is associated with significant compromise to quality of life. Through the years, there has been an evolution of technique and graft material to augment repairs for durability. ...


Traumatic Brain Injury Induces Rapid Enhancement of Cortical Excitability in Juvenile Rats

05.12.2014 | Joshua Nichols, Roxy Perez, Chen Wu, P. David Adelson, Trent Anderson, CNS Neuroscience & Therapeutics, 2014

Summary Aims Following a traumatic brain injury (TBI), 5–50% of patients will develop posttraumatic epilepsy (PTE) with children being particularly susceptible. Currently, PTE cannot be prevented and there is limited understanding of the underlying epileptogenic mechanisms. We hypothesize ...


A Portion of Inhibitory Neurons in Human Temporal Lobe Epilepsy are Functionally Upregulated: An Endogenous Mechanism for Seizure Termination

05.12.2014 | Bo Wen, Hao Qian, Jing Feng, Rong‐Jing Ge, Xin Xu, Zhi‐Qiang Cui, Ru‐Yuan Zhu, Long‐Sheng Pan, Zhi‐Pei Lin, Jin‐Hui Wang, CNS Neuroscience & Therapeutics, 2014

Summary Main Problem Epilepsy is one of common neurological disorders. The medication is often ineffective to the patients suffering from intractable temporal lobe epilepsy (TLE). As their seizures are usually self‐terminated, the elucidation of the mechanism underlying endogenous seizure ...


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