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4.354 Aktuelle Fachpublikationen zum Thema Addition

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Minocycline added to subcutaneous interferon β‐1a in multiple sclerosis: randomized RECYCLINE study

05.02.2016 | P. S. Sørensen, F. Sellebjerg, J. Lycke, M. Färkkilä, A. Créange, C. G. Lund, M. Schluep, J. L. Frederiksen, E. Sten ..., European Journal of Neurology, 2016

Background and purpose Combining different therapies may improve disease control in patients with relapsing−remitting multiple sclerosis (RRMS). This study assessed the efficacy and safety of minocycline added to subcutaneous (sc) interferon (IFN) β‐1a therapy. Methods This was a ...


A long journey coming to fruition: In sight of the pre‐selection T‐cell repertoire

05.02.2016 | Thomas Ciucci, Rémy Bosselut, European Journal of Immunology, 2016

In addition to MHC restriction and its structural correlate, the recognition of an MHC‐peptide complex by the T‐cell antigen receptor (TCR), T‐cell reactivity is constrained by positive and negative selection in the thymus. While mouse genetic studies have provided compelling evidence for both ...


ADAT3‐related intellectual disability: Further delineation of the phenotype

04.02.2016 | Ayman W. El‐Hattab, Mohammed A. Saleh, Amal Hashem, Mohammed Al‐Owain, Ali Al Asmari, Hala Rabei, Hanem Abdelraouf, ..., American Journal of Medical Genetics Part A, 2016

ADAT3‐related intellectual disability has been recently described in 24 individuals from eight Saudi families who had cognitive impairment and strabismus. Other common features included growth failure, microcephaly, tone abnormalities, epilepsy, and nonspecific brain abnormalities. A single ...


Commensal A4 bacteria inhibit intestinal Th2‐cell responses through induction of dendritic cell TGF‐β production

03.02.2016 | Wei Wu, Hou‐Pu Liu, Feidi Chen, Han Liu, Anthony T. Cao, Suxia Yao, Mingming Sun, Heather L Evans‐Marin, Ye Zhao, Qi ..., European Journal of Immunology, 2016

It has been shown that while commensal bacteria promote Th1, Th17, and Treg cells in lamina propria (LP) in steady‐state conditions, they suppress mucosal Th2 cells. However, it is still unclear whether there are specific commensal organisms down‐regulating Th2 responses, and the mechanism ...


Expression of Streptococcus pneumoniae Bacteriocins Is Induced by Antibiotics via Regulatory Interplay with the Competence System

03.02.2016 | Morten Kjos et al., PLoS Pathogens, 2016

by Morten Kjos, Eric Miller, Jelle Slager, Frank B. Lake, Oliver Gericke, Ian S. Roberts, Daniel E. Rozen, Jan-Willem Veening Pneumococcal bacteriocins (pneumocins) are antibacterial toxins that mediate intra-species competition within the human host. However, the triggers of pneumocin ...


Influence of collagen concentration and glutaraldehyde on collagen‐based scaffold properties

02.02.2016 | V. Pérez‐Puyana, A. Romero, A. Guerrero, Journal of Biomedical Materials Research Part A, 2016

Abstract Several studies have shown the influence of the physical properties of scaffolds on their mechanical properties. An initial characterization of a type of collagen protein was carried out by studying its composition andits solubility at different pH values and infrared spectroscopy. ...


Mobilization of lymphatic endothelial precursor cells and lymphatic neovascularization in primary Sjögren's syndrome

01.02.2016 | Alessia Alunno, Lidia Ibba‐Manneschi, Onelia Bistoni, Irene Rosa, Sara Caterbi, Roberto Gerli, Mirko Manetti, Journal of Cellular and Molecular Medicine, 2016

Abstract Although lymphatic neovascularization may be a key feature of chronic inflammation, it is almost unexplored in primary Sjögren's syndrome (pSS). A recent study revealed a pro‐lymphangiogenic function of interleukin (IL)‐17, a leading player in pSS pathogenesis. The aims of the study ...


Lipid peroxidation and apoptotic response in rat brain areas induced by long‐term administration of nandrolone: the mutual crosstalk between ROS and NF‐kB

01.02.2016 | Emanuela Turillazzi, Margherita Neri, Daniela Cerretani, Santina Cantatore, Paola Frati, Laura Moltoni, Francesco Pa ..., Journal of Cellular and Molecular Medicine, 2016

Abstract The aim of this study was to evaluate the played by oxidative stress in the apoptotic response in different brain areas of rats chronically treated with supra‐physiological doses of nandrolone decanoate (ND). Immunohistochemical study and Western blot analysis were performedto ...


Deficient visuospatial working memory functions and neural correlates of the default‐mode network in adolescents with autism spectrum disorder

01.02.2016 | Hsiang‐Yun Chien, Susan Shur‐Fen Gau, Wen‐Yih Isaac Tseng, Autism Research, 2016

In addition to the essential features of autism spectrum disorder (ASD), namely social communication deficits and repetitive behaviors, individuals with ASD may suffer from working memory deficits and an altered default‐mode network (DMN). We hypothesized that an altered DMN is related to ...


Multivariate pattern classification of pediatric Tourette syndrome using functional connectivity MRI

01.02.2016 | Deanna J. Greene, Jessica A. Church, Nico U.F. Dosenbach, Ashley N. Nielsen, Babatunde Adeyemo, Binyam Nardos, Steve ..., Developmental Science, 2016

Abstract Tourette syndrome (TS) is a developmental neuropsychiatric disorder characterized by motor and vocal tics. Individuals with TS would benefit greatly from advances in prediction of symptom timecourse and treatment effectiveness. As a first step, we applied a multivariate method – ...


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