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Metabolic syndrome in female migraine patients is associated with medication overuse headache: a clinic‐based study in China

15.05.2015 | Z. He, L. Dong, Y. Zhang, Q. Kong, G. Tan, J. Zhou, European Journal of Neurology, 2015

Background and purpose Migraine and metabolic syndrome have been reported to coexist to a marked degree, especially in women migraine patients, but the relationship between these two conditions is still unclear. This study was performed to evaluate the association of headache characteristics ...


Intracellular calcium levels as screening tool for nanoparticle toxicity

15.05.2015 | Claudia Meindl, Tatjana Kueznik, Martina Bösch, Eva Roblegg, Eleonore Fröhlich, Journal of Applied Toxicology, 2015

Abstract The use of engineered nano‐sized materials led to revolutionary developments in many industrial applications and in the medical field. These materials, however, also may cause cytotoxicity. In addition to size, surface properties and shape were identified as relevant parameters for ...


Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR–Ligand Off-Rates Measurements on Living Cells

15.05.2015 | Michael Hebeisen; Julien Schmidt; Philippe Guillaume; Petra Baumgaertner; Daniel E. Speiser; Immanuel Luescher; Nath ..., Cancer Research, 2015

The avidity of the T-cell receptor (TCR) for antigenic peptides presented by the peptide–MHC (pMHC) on cells is a key parameter for cell-mediated immunity. Yet a fundamental feature of most tumor antigen-specific CD8+ T cells is that this avidity is low. In this study, we addressed the need to ...


Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms

15.05.2015 | Stefan Klingler; Baofeng Guo; Jun Yao; Haiyan Yan; Ling Zhang; Angelina V. Vaseva; Sida Chen; Peter Canoll; James W. ..., Cancer Research, 2015

Epidermal growth factor receptor (EGFR) is highly amplified, mutated, and overexpressed in human malignant gliomas. Despite its prevalence and growth-promoting functions, therapeutic strategies to inhibit EGFR kinase activity have not been translated into profound beneficial effects in glioma ...


The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome

14.05.2015 | Faycal Guedj, Jeroen L. A. Pennings, Millie A. Ferres, Leah C. Graham, Heather C. Wick, Klaus A. Miczek, Donna K. Sl ..., American Journal of Medical Genetics Part A, 2015

Human fetuses with Down syndrome demonstrate abnormal brain growth and reduced neurogenesis. Despite the prenatal onset of the phenotype, most therapeutic trials have been conducted in adults. Here, we present evidence for fetal brain molecular and neonatal behavioral alterations in the Ts1Cje ...


Sleep apnea in patients reporting insomnia or restless legs symptoms

14.05.2015 | M. T. Bianchi, B. Goparaju, M. Moro, Acta Neurologica Scandinavica, 2015

Objective Insomnia and restless legs syndrome (RLS) are defined by self‐reported symptoms, and polysomnography (PSG) is not routinely indicated. Occult obstructive sleep apnea (OSA), common even in asymptomatic adults, may complicate management of patients presenting with insomnia or restless ...


Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms

14.05.2015 | Marieke C. Verweij et al., PLoS Pathogens, 2015

by Marieke C. Verweij, Mary Wellish, Travis Whitmer, Daniel Malouli, Martin Lapel, Stipan Jonjić, Juergen G. Haas, Victor R. DeFilippis, Ravi Mahalingam, Klaus Früh Varicella zoster virus (VZV) causes chickenpox in humans and, subsequently, establishes latency in the sensory ganglia from where ...


Steady‐state tilt has no effect on cerebrovascular CO2reactivityin anterior and posterior cerebral circulations

13.05.2015 | Michael M. Tymko, Rachel J. Skow, Christina M. MacKay, Trevor A. Day, Experimental Physiology, 2015

Cerebral autoregulation is a protective feature of the cerebrovasculature that maintains relatively constant cerebral perfusion in the face of static and dynamic fluctuations in mean arterial pressure (MAP). However, the extent to which the cerebrovasculature can autoregulate in the face of ...


Vitamin K1 distribution following intravenous vitamin K1‐Fat emulsion administration in rats

12.05.2015 | Xue Xiao, Yan‐Ni Mi, Bing‐Hua Zhang, Fa. Wang, Lei Cao, Yong‐Xiao Cao, Biomedical Chromatography, 2015

ABSTRACT This study investigated vitamin K1 (VK1) distribution following intravenous vitamin K1‐fat emulsion (VK1‐FE) administration and compared it with that after VK1 injection. Rats were intravenously injected with VK1‐FE or VK1. The organ and tissue VK1 concentrations were determined using ...


Human infection with an avian influenza A (H9N2) virus in the middle region of China

12.05.2015 | Yiwei Huang, Xiaodan Li, Hong Zhang, Bozhong Chen, Yonglin Jiang, Lei Yang, Wenfei Zhu, Shixiong Hu, Siyu Zhou, Yunl ..., Journal of Medical Virology, 2015

During the epidemic period of the novel H7N9 viruses, an influenza A (H9N2) virus was isolated from a 7‐year‐old boy with influenza‐like illness in Yongzhou city of Hunan province in November 2013. To identify the possible source of infection, environmental specimens collected from local live ...


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