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Leptin deficiency in vivo enhances the ability of splenic dendritic cells to activate T cells

01.11.2014 | Oscar Ramirez; Kristine M. Garza, International Immunology, 2014

Leptin is a pleiotropic adipokine that is critical for regulating food intake and energy expenditure and also participates in functions of the immune system, including those of antigen-presenting cells. Here, we assess the effect of leptin deficiency on the function splenic dendritic cells (sDC). ...

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NKG2D functions as an activating receptor on natural killer cells in the common marmoset (Callithrix jacchus)

01.11.2014 | Masamichi Watanabe; Yohei Kudo; Mitsuko Kawano; Masafumi Nakayama; Kyohei Nakamura; Mai Kameda; Masamune Ebara; Take ..., International Immunology, 2014

The natural killer group 2 membrane D (NKG2D) receptor is an NK-activating receptor that plays an important role in host defense against tumors and viral infections. Although the marmoset is an important and reliable animal model, especially for the study of human-specific viral infections, ...

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Osteocalcin/fibronectin‐functionalized collagen matrices for bone tissue engineering

24.10.2014 | Kim S.G., Lee D.S., Lee S., Jang J.H., Journal of Biomedical Materials Research Part A, 2014

Abstract Collagen is the most abundant protein found in the extracellular matrix (ECM) and is widely used to build scaffolds for biomedical applications which are the result of its biocompatibility and biodegradability. In the present study, we constructed a rhOCN/FNIII9‐10 fusion protein and ...

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Synergistic effect of sustained release of growth factors and dynamic culture on osteoblastic differentiation of mesenchymal stem cells

24.10.2014 | Giovanna Della Porta, Bao‐Ngoc B. Nguyen, R. Campardelli, Ernesto Reverchon, John P. Fisher, Journal of Biomedical Materials Research Part A, 2014

Abstract Microparticles have been utilized as delivery vehicles of soluble factors to modify cellular behavior and therefore enhance tissue engineering regeneration. When incorporated into 3D systems, microparticles can provide geometrical and temporal controlled release of bioactive agents, ...

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Relation between muscle mass, motor units and type of training in master athletes

24.10.2014 | Michael Drey, Cornel C. Sieber, Hans Degens, Jamie McPhee, Marko T. Korhonen, Klaus Müller, Bergita Ganse, Jörn Ritt ..., Clinical Physiology and Functional Imaging, 2014

Summary Objective The aim of this study was to measure the number of motor units and muscle mass in power‐trained and endurance‐trained master athletes compared with community‐dwelling older adults. Methods Seventy‐five master athletes (52 power‐ and 23 endurance‐trained athletes) ...

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Current strategies in multiphasic scaffold design for osteochondral tissue engineering: A review

24.10.2014 | Azizeh‐Mitra Yousefi, Md Enamul Hoque, Rangabhatala G.S.V. Prasad, Nicholas Uth, Journal of Biomedical Materials Research Part A, 2014

Abstract The repair of osteochondral defects requires a tissue engineering approach that aims at mimicking the physiological properties and structure of two different tissues (cartilage and bone) using specifically‐designed scaffold‐cell constructs. Biphasic and triphasic approaches utilize ...

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Motor symptoms after deep brain stimulation of the subthalamic nucleus

24.10.2014 | B. Lilleeng, M. Gjerstad, R. Baardsen, I. Dalen, J. P. Larsen, Acta Neurologica Scandinavica, 2014

Objectives Stimulation of the subthalamic nucleus (STN‐DBS) is an established treatment with long‐term beneficial effects on motor symptoms in patients with Parkinson's disease (PD). The efficacy of STN‐DBS on non‐dopaminergic motor symptoms remains less elucidated. In this study, we have ...

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Twenty‐one years to the right diagnosis – clinical overlap of Simpson–Golabi–Behmel and Beckwith–Wiedemann Syndrome

22.10.2014 | C. Knopp, S. Rudnik‐Schöneborn, K. Zerres, M. Gencik, S. Spengler, T. Eggermann, American Journal of Medical Genetics Part A, 2014

Clinical overlap makes the diagnosis of overgrowth syndromes challenging. Clinical overlap exists between Simpson–Golabi–Behmel syndrome (SGBS) and Beckwith–Wiedemann syndrome (BWS) which share pre‐ and postnatal overgrowth, macroglossia, umbilical hernia, organomegaly, ear lobe creases, and ...

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Estimation of Thurstonian Models for Various Forced‐Choice Sensory Discrimination Methods as a Form of the “M + N” Test

21.10.2014 | Jian Bi, Hye‐Seong Lee, Michael O'Mahony, Journal of Sensory Studies, 2014

Abstract Psychometric functions for discrimination tests, which connect probabilities of correct response, pc, with Thurstonian discriminal distances, d′, are of theoretical and practical significance. This paper uses a computer‐intensive approach to produce simulation‐derived psychometric ...

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Cerebral regulatory T cells restrain microglia/macrophage‐mediated inflammatory responses via IL‐10

20.10.2014 | Luokun Xie, Gourav Roy Choudhury, Ali Winters, Shao‐Hua Yang, Kunlin Jin, European Journal of Immunology, 2014

Forkhead box P3 (Foxp3)+ regulatory T (Treg) cells maintain the immune tolerance and prevent inflammatory responses in the periphery. However, the presence of Treg cells in the central nervous system under steady state has not been studied. Here, for the first time, we show a substantial ...

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