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Dendritic cells and macrophages in the kidney: a spectrum of good and evil

15.10.2014 | Natasha M. Rogers; David A. Ferenbach; Jeffrey S. Isenberg; Angus W. Thomson; Jeremy Hughes, Nature Clinical Practice Nephrology, 2014

Renal dendritic cells and macrophages are key factors in the initiation and propagation of renal disease and tissue regeneration. In this Review, the authors discuss the common and distinct characteristics of dendritic cells and macrophages as well as current understanding of the renal-specific ...


Guillain-Barre and Miller Fisher syndromes[mdash]new diagnostic classification

15.10.2014 | Benjamin R. Wakerley; Antonino Uncini; Nobuhiro Yuki; the GBS Classification Group, Nature Clinical Practice Neurology, 2014

Nature Reviews Neurology. doi:10.1038/nrneurol.2014.190 Authors: Benjamin R. Wakerley, Antonino Uncini & Nobuhiro Yuki


The past 10 years of gastroenterology and hepatology[mdash]reflections and predictions

15.10.2014 | Scott L. Friedman; Eamonn M. M. Quigley; Keith A. Sharkey; Joseph J. Y. Sung; David C. Whitcomb, Nature Clinical Practice Gastroenterology & Hepatology, 2014

Nature Reviews Gastroenterology & Hepatology. doi:10.1038/nrgastro.2014.167 Authors: Scott L. Friedman, Eamonn M. M. Quigley, Keith A. Sharkey, Joseph J. Y. Sung & David C. Whitcomb


Diagnosing coeliac disease and the potential for serological markers

15.10.2014 | Steffen Husby; Joseph A. Murray, Nature Clinical Practice Gastroenterology & Hepatology, 2014

Coeliac disease is a common gastrointestinal disease that can present at any age. Previous diagnosis relied on duodenal biopsy however contemporary techniques of antibody detection and determination of genetic susceptibility using HLA genotyping have improved diagnostic accuracy and reduced the ...


Ischaemic stroke in young adults: risk factors and long-term consequences

15.10.2014 | Noortje A. M. M. Maaijwee; Loes C. A. Rutten-Jacobs; Pauline Schaapsmeerders; Ewoud J. van Dijk; Frank-Erik de Leeuw, Nature Clinical Practice Neurology, 2014

Nature Reviews Neurology. doi:10.1038/nrneurol.2014.183 Author: Noortje A. M. M. Maaijwee, Loes C. A. Rutten-Jacobs, Pauline Schaapsmeerders, Ewoud J. van Dijk & Frank-Erik de Leeuw


Selective serotonin reuptake inhibitor exposure alters osteoblast gene expression and craniofacial development in mice

12.10.2014 | James J. Cray, Seth M. Weinberg, Trish E. Parsons, R. Nicole Howie, Mohammed Elsalanty, Jack C. Yu, Birth Defects Research Part A: Clinical and Molecular Teratology, 2014

Background Selective serotonin reuptake inhibitor (SSRI) use in pregnancy has been linked to craniofacial birth defects. Little is known about the effects of serotonin or SSRIs on craniofacial development. Here, we provide evidence that citalopram (SSRI) alters the osteogenic profile of murine ...


Greater sensitivity to novelty in rats is associated with increased motor impulsivity following repeated exposure to a stimulating environment: implications for the etiology of impulse control deficits

12.10.2014 | Jacqueline‐Marie N. Ferland, Fiona D. Zeeb, Katrina Yu, Sukhbir Kaur, Matthew D. Taves, Catharine A. Winstanley, European Journal of Neuroscience, 2014

Abstract Heightened motor impulsivity and increased novelty‐seeking commonly co‐occur in psychiatric disorders, including drug addiction. However, the relationship between these two phenomena remains unclear. One‐time tests of novelty sensitivity commonly used in preclinical experiments, such ...


Superoxide anions in the paraventricular nucleus mediate cardiac sympathetic afferent reflex in insulin resistance rats

12.10.2014 | Hai‐Jian Sun, Hong Zhou, Xue‐Mei Feng, Qing Gao, Lei Ding, Chao‐Shu Tang, Guo‐Qing Zhu, Ye‐Bo Zhou, Acta Physiologica, 2014

Abstract Aim Cardiac sympathetic afferent reflex (CSAR) participates in sympathetic over‐excitation. Superoxide anions and angiotensin II (Ang II) mechanisms are associated with sympathetic outflow and CSAR in the paraventricular nucleus (PVN). This study was designed to investigate whether ...


IL‐27 stimulates human NK‐cell effector functions and primes for IL‐18 responsiveness

12.10.2014 | Andrea Ziblat, Carolina I. Domaica, Raúl G. Spallanzani, Ximena L. Raffo Iraolagoitia, Lucas E. Rossi, Damián E. Avi ..., European Journal of Immunology, 2014

IL‐27, a member of the IL‐12 family of cytokines, is produced by APCs, and displays pro‐ and anti‐inflammatory effects. How IL‐27 affects human NK cells still remain unknown. In this study, we observed that mature dendritic cells (mDCs) secreted IL‐27 and that blockade of IL‐27R (CD130) reduced ...


MicroRNA‐146a controls Th1‐differentiation of human CD4+ lymphocytes via targeting PRKCε

12.10.2014 | Patrick Möhnle, Stefanie V. Schütz, Verena van der Heide, Max Hübner, Benjamin Luchting, Julia Sedlbauer, Elisabeth ..., European Journal of Immunology, 2014

T cell functions must be tightly controlled to keep the balance between vital pro‐inflammatory activity and detrimental over‐activation. Micro‐RNA‐146a (miR‐146a) has been identified as a key negative regulator of T cell responses in mice. Its role in human T cells and its relevance to human ...


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