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Inhibition of the Cancer Stem Cells-Like Properties by Arsenic Trioxide, Involved in the Attenuation of Endogenous Transforming Growth Factor Beta Signal

01.01.2015 | Yuan Li; Fei Jiang; Qinqiang Liu; Jian Shen; Xingxing Wang; Zhong Li; Jianping Zhang; Xiang Lu, Toxicological Sciences, 2015

The elevation of cancer stem cells (CSCs)-like properties is involved in the initiation and progression of various human cancers. Current standard practices for treatment of cancers are less than satisfactory because of CSCs-mediated recurrence. For this reason, targeting the CSCs or the cancer ...


Formation of a Protein Corona on Silver Nanoparticles Mediates Cellular Toxicity via Scavenger Receptors

01.01.2015 | Jonathan H. Shannahan; Ramakrishna Podila; Abdullah A. Aldossari; Hilary Emerson; Brian A. Powell; Pu Chun Ke; Appar ..., Toxicological Sciences, 2015

Addition of a protein corona (PC) or protein adsorption layer on the surface of nanomaterials following their introduction into physiological environments may modify their activity, bio-distribution, cellular uptake, clearance, and toxicity. We hypothesize that silver nanoparticles (AgNPs) will ...


Tungsten Targets the Tumor Microenvironment to Enhance Breast Cancer Metastasis

01.01.2015 | Alicia M. Bolt; Valérie Sabourin; Manuel Flores Molina; Alice M. Police; Luis Fernando Negro Silva; Dany Plourde; Ma ..., Toxicological Sciences, 2015

The number of individuals exposed to high levels of tungsten is increasing, yet there is limited knowledge of the potential human health risks. Recently, a cohort of breast cancer patients was left with tungsten in their breasts following testing of a tungsten-based shield during intraoperative ...


Schisandrol B Protects Against Acetaminophen-Induced Hepatotoxicity by Inhibition of CYP-Mediated Bioactivation and Regulation of Liver Regeneration

01.01.2015 | Yiming Jiang; Xiaomei Fan; Ying Wang; Pan Chen; Hang Zeng; Huasen Tan; Frank J. Gonzalez; Min Huang; Huichang Bi, Toxicological Sciences, 2015

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver failure. Schisandra sphenanthera is a traditional hepato-protective Chinese medicine and Schisandrol B (SolB) is one of its major active constituents. In this study, the protective effect of SolB against ...


PINK1 phosphorylates transglutaminase 2 and blocks its proteasomal degradation

30.12.2014 | Boram Min, Young‐Chang Kwon, Kwang‐Min Choe, Kwang Chul Chung, Journal of Neuroscience Research, 2014

Parkinson's disease (PD) is characterized by progressive dopaminergic neuronal loss and the formation of abnormal protein aggregates, referred to as Lewy bodies (LBs). PINK1 is a serine/threonine protein kinase that protects cells from stress‐induced mitochondrial dysfunction. PINK1 gene ...


Relationship Between Contact Force Sensing Technology and Medium Term Outcome of Atrial Fibrillation Ablation: A Multicenter Study of 600 Patients

27.12.2014 | JULIAN W. E. JARMAN, SANDEEP PANIKKER, MOLOY DAS, GARETH J. WYNN, WAQAS ULLAH, ANDRIANOS KONTOGEORGIS, SHOUVIK K. HA ..., Journal of Cardiovascular Electrophysiology, 2014

Abstract Introduction Contact force sensing (CFS) technology improves acute pulmonary vein isolation durability; however, its impact on the clinical outcome of ablating atrial fibrillation (AF) is unknown. Methods and Results First time AF ablation procedures employing CFS from four ...


Alpha‐Adrenoceptor Modulation in Central Nervous System Trauma: Pain, Spasms, and Paralysis – An Unlucky Triad

27.12.2014 | Stefanie Lemmens, Bert Brône, Dearbhaile Dooley, Sven Hendrix, Nathalie Geurts, Medicinal Research Reviews, 2014

Abstract Many researchers have attempted to pharmacologically modulate the adrenergic system to control locomotion, pain, and spasms after central nervous system (CNS) trauma, although such efforts have led to conflicting results. Despite this, multiple studies highlight that α‐adrenoceptors ...


Recruitment of activating NK‐cell receptors 2B4 and NKG2D to membrane microdomains in mammalian cells is dependent on their transmembrane regions

26.12.2014 | Stephan A. Gütgemann, Mina M. Sandusky, Sabine Wingert, Maren Claus, Carsten Watzl, European Journal of Immunology, 2014

Membrane microdomains play an important role in the regulation of natural killer (NK) cell activities. These cholesterol‐rich membrane domains are enriched at the activating immunological synapse and several activating NK‐cell receptors are known to localize to membrane microdomains upon ...


The multiple functional roles of mesenchymal stem cells in participating in treating liver diseases

23.12.2014 | Wei‐hui Liu, Fu‐qiang Song, Li‐na Ren, Wen‐qiong Guo, Tao Wang, Ya‐xing Feng, Li‐jun Tang, Kun Li, Journal of Cellular and Molecular Medicine, 2014

Abstract Mesenchymal stem cells (MSCs) are a group of stem cells derived from the mesodermal mesenchyme. MSCs can be obtained from a variety of tissues, including bone marrow, umbilical cord tissue, umbilical cord blood, peripheral blood and adipose tissue. Under certain conditions, MSCs can ...


Effect of the preparation methods on architecture, crystallinity, hydrolytic degradation, bioactivity, and biocompatibility of PCL/bioglass composite scaffolds

23.12.2014 | Michal Dziadek, Justyna Pawlik, Elzbieta Menaszek, Ewa Stodolak‐Zych, Katarzyna Cholewa‐Kowalska, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2014

Abstract In this study, two different composition gel derived silica‐rich (S2) or calcium‐rich (A2) bioactive glasses (SBG) from a basic CaOP2O5SiO2 system were incorporated into poly(ε‐caprolactone) (PCL) matrix to obtain novel bioactive composite scaffolds for bone tissue engineering ...


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