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4.515 Aktuelle Fachpublikationen zum Thema Addition

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Guanosine and its modified derivatives are endogenous ligands for TLR7

01.05.2016 | Takuma Shibata; Umeharu Ohto; Shosaku Nomura; Kayoko Kibata; Yuji Motoi; Yan Zhang; Yusuke Murakami; Ryutaro Fukui; ..., International Immunology, 2016

Toll-like receptor (TLR) 7and 8 were considered to recognize single-strand RNA (ssRNA) from viruses. Although these receptors also respond to synthetic small chemical ligands, such as CL075 and R848, it remains to be determined whether these receptors sense natural small molecules or not. In the ...

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Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice

01.05.2016 | Zhongshuang Hu; Taisuke Murakami; Kaori Suzuki; Hiroshi Tamura; Johannes Reich; Kyoko Kuwahara-Arai; Toshiaki Iba; I ..., International Immunology, 2016

LL-37 is the only known member of the cathelicidin family of antimicrobial peptides in humans. In addition to its broad spectrum of antimicrobial activities, LL-37 can modulate various inflammatory reactions. We previously revealed that LL-37 suppresses the LPS/ATP-induced pyroptosis of ...

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Circulating miRNAs with prognostic value in metastatic breast cancer and for early detection of metastasis

01.05.2016 | Dharanija Madhavan; Cike Peng; Markus Wallwiener; Manuela Zucknick; Juliane Nees; Sarah Schott; Anja Rudolph; Sabine ..., Carcinogenesis , 2016

Metastasis is the principal cause of high morbidity and mortality among breast cancer (BC) patients. Identification of markers that can be routinely monitored to predict onset of metastasis in BC patients and prognosis of metastatic breast cancer (MBC) patients would increase their median ...

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Regression analysis of case K interval‐censored failure time data in the presence of informative censoring

28.04.2016 | Peijie Wang, Hui Zhao, Jianguo Sun, Biometrics, 2016

Summary Interval‐censored failure time data occur in many fields such as demography, economics, medical research, and reliability and many inference procedures on them have been developed (Sun, 2006; Chen, Sun, and Peace, 2012). However, most of the existing approaches assume that the ...

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Pregnancy as a critical window for blood pressure regulation in mother and child: programming and reprogramming

28.04.2016 | Nina D. Paauw, Bas B. van Rijn, A. Titia Lely, Jaap A. Joles, Acta Physiologica, 2016

Abstract Pregnancy is a critical time for long‐term blood pressure regulation in both mother and child. Pregnancies complicated by placental insufficiency, resulting in preeclampsia and intrauterine growth restriction, are associated with a threefold increased risk of the mother to develop ...

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The effects of acute aerobic exercise on a task‐switching paradigm and BDNF levels in young adults with different levels of cardiorespiratory fitness

28.04.2016 | Chia‐Liang Tsai, Chien‐Yu Pan, Fu‐Chen Chen, Chun‐Hao Wang, Feng‐Ying Chou, Experimental Physiology, 2016

Abstract This study investigated the effects of acute aerobic exercise on neuropsychological and neurophysiological performances in young adults with different cardiorespiratory fitness levels when performing a task‐switching paradigm, and explored the potential associations between acute ...

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In vivo engineering of mobilized stem cell grafts with the immunomodulatory drug FTY720 for allogeneic transplantation

27.04.2016 | Tadepally Lakshmikanth, Frank Heuts, SSV Jagadeeswara Rao Muvva, Robert P. A. Wallin, Anna‐Karin Persson, Cyril Faur ..., European Journal of Immunology, 2016

The immunological attributes of stem cell grafts play an important role in the outcome of allogeneic stem cell transplants. Currently, ex vivo manipulation techniques such as bulk T cell depletion or positive selection of CD34+ cells are utilized to improve the immunological attributes of grafts ...

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Impact of elective termination on the occurrence of severe birth defects identified in a hospital‐based active malformations surveillance program (1999 to 2002)

26.04.2016 | Emma G. Thomas, M. Hassan Toufaily, Marie‐Noel Westgate, Anne‐Therese Hunt, Angela E. Lin, Lewis B. Holmes, Birth Defects Research Part A: Clinical and Molecular Teratology, 2016

Background The number of affected infants and the types of malformations identified by a malformation surveillance programs can be impacted if elective terminations for malformations are not included. Methods The occurrence of malformations in all newborn infants was determined in a ...

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The role of objective facial analysis using FDNA in making diagnoses following whole exome analysis. Report of two patients with mutations in the BAF complex genes

26.04.2016 | Karen W. Gripp, Laura Baker, Aida Telegrafi, Kristin G. Monaghan, American Journal of Medical Genetics Part A, 2016

The genetic basis of numerous intellectual disability (ID) syndromes has recently been identified by applying exome analysis on a research or clinical basis. There is significant clinical overlap of biologically related syndromes, as exemplified by Nicolaides–Baraitser (NCBRS) and Coffin–Siris ...

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Role of regulatory b cells in neuroimmunologic disorders

26.04.2016 | Jinming Han, Li Sun, Xueli Fan, Zhongkun Wang, Yun Cheng, Jie Zhu, Tao Jin, Journal of Neuroscience Research, 2016

B lymphocytes augment the immune response by producing antibodies and activating T cells by antigen presentation. Recent studies have highlighted a specific and functionally significant B‐cell subset that could downregulate excessive immune and inflammatory responses through a vast array of ...

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