10.05.2013 | Megan S. Kane, Mark E. Lindsay, Daniel P. Judge, Jemima Barrowman, Colette Ap Rhys, Lisa Simonson, Harry C. Dietz, S ..., American Journal of Medical Genetics Part A, 2013

Abstract Hutchinson–Gilford Progeria Syndrome (HGPS) is a premature aging disorder caused by mutations in LMNA, which encodes the nuclear scaffold proteins lamin A and C. In HGPS and related progerias, processing of prelamin A is blocked at a critical step mediated by the zinc ...

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09.05.2013 | Alexander G. Ophir, Grace Sorochman, Brittany L. Evans, George S. Prounis, Journal of Neuroendocrinology, 2013

Abstract During pregnancy, females undergo several physiologically driven changes that facilitate adaptive behaviours and prepare the mother to care for her developing offspring. The nonapeptide hormone oxytocin is best recognised for its involvement in mammalian pregnancy and has been ...

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09.05.2013 | Sven C. Mueller, Journal of Neuroendocrinology, 2013

Abstract Mounting magnetic resonance imaging (MRI) research is characterising the neurobiological trajectories of healthy human brain development. In parallel, studies increasingly acknowledge the relevance of perturbations of these trajectories for adolescent and adult psychopathology. ...

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09.05.2013 | Mike Ludwig, Vicky A. Tobin, Michael F. Callahan, Eirini Papadaki, Axel Becker, Mario Engelmann, Gareth Leng, Journal of Neuroendocrinology, 2013

Abstract Intranasal administration has been widely used to investigate effects of the neuropeptides vasopressin and oxytocin on human behaviors and neurological disorders, but exactly what happens when these neuropeptides are administered intranasally is far from clear. In particular, it ...

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09.05.2013 | David C. Goldstone et al., PLoS Pathogens, 2013

by David C. Goldstone, Thomas G. Flower, Neil J. Ball, Marta Sanz-Ramos, Melvyn W. Yap, Roksana W. Ogrodowicz, Nicole Stanke, Juliane Reh, Dirk Lindemann, Jonathan P. Stoye, Ian A. Taylor The Spumaretrovirinae, or foamyviruses (FVs) are complex retroviruses that infect many species of ...

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09.05.2013 | Selinda J. Orr et al., PLoS Pathogens, 2013

by Selinda J. Orr, Ashley R. Burg, Tim Chan, Laura Quigley, Gareth W. Jones, Jill W. Ford, Deborah Hodge, Catherine Razzook, Joseph Sarhan, Yava L. Jones, Gillian C. Whittaker, Kimberly C. Boelte, Lyudmila Lyakh, Marco Cardone, Geraldine M. O'Connor, Cuiyan Tan, Hongchuan Li, Stephen K. ...

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07.05.2013 | Danhua Pu, Yiping Shen, Jie Wu, Autism Research, 2013

Methylenetetrahydrofolate reductase (MTHFR) is essential for DNA biosynthesis and the epigenetic process of DNA methylation, and its gene polymorphisms have been implicated as risk factors for birth defects, neurological disorders, and cancers. However, reports on the association of MTHFR ...

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07.05.2013 | Allisyn C. Moran et al., PLoS Medicine, 2013

by Allisyn C. Moran, Kate Kerber, Deborah Sitrin, Tanya Guenther, Claudia S. Morrissey, Holly Newby, Joy Fishel, P. Stan Yoder, Zelee Hill, Joy E. Lawn Neonatal mortality accounts for 43% of under-five mortality. Consequently, improving newborn survival is a global priority. However, ...

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03.05.2013 | Muhammed K. Mazumder, Rajib Paul, Anupom Borah, CNS Neuroscience & Therapeutics, 2013

Summary Aim Till date, the mode of action of β‐PEA on neurons is not well illustrated. We tested the hypothesis that β–PEA has the ability to cause oxidative stress by inhibiting the antioxidant enzyme DT‐diaphorase and mitochondrial complexes (Complex‐I and ...

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03.05.2013 | Yun Song, Xu Chen, Li‐Yan Wang, Wei Gao, Mei‐Jia Zhu, CNS Neuroscience & Therapeutics, 2013

Summary Background and purpose Alzheimer's disease (AD) is a progressive neurodegenerative disorder, and Aβ‐induced neuronal damage is the major pathology of AD. There is increasing evidence that neuroinflammation induced by Aβ is also involved in the pathogenesis of AD. Fasudil is a ...

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