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3.780 Aktuelle Fachpublikationen zum Thema Addition

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Lentinan exerts synergistic apoptotic effects with paclitaxel in A549 cells via activating ROS‐TXNIP‐NLRP3 inflammasome

09.04.2015 | Wei Liu, Jun Gu, Jun Qi, Xiao‐Ning Zeng, Juan Ji, Zheng‐Zhen Chen, Xiu‐Lan Sun, Journal of Cellular and Molecular Medicine, 2015

Abstract Paclitaxel is generally used to treat cancers in clinic as an inhibitor of cell division. However, the acquired resistance in tumours limits its clinical efficacy. Therefore, the aim of this study was to detect whether co‐treatment with lentinan enhanced the anti‐cancer effects of ...

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Degradable hydrogels derived from PEG‐diacrylamide for hepatic tissue engineering

08.04.2015 | Kelly R. Stevens, Jordan S. Miller, Brandon L. Blakely, Christopher S. Chen, Sangeeta N. Bhatia, Journal of Biomedical Materials Research Part A, 2015

Abstract Engineered tissue constructs have the potential to augment or replace whole organ transplantation for the treatment of liver failure. Poly(ethylene glycol) (PEG)‐based systems are particularly promising for the construction of engineered liver tissue due to their biocompatibility and ...

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Overlap of juvenile polyposis syndrome and cowden syndrome due to de novo chromosome 10 deletion involving BMPR1A and PTEN: Implications for treatment and surveillance

05.04.2015 | Adebisi Alimi, Lauren A. Weeth‐Feinstein, Amy Stettner, Freddy Caldera, Jennifer M. Weiss, American Journal of Medical Genetics Part A, 2015

We describe a patient with a severe juvenile polyposis phenotype, due to a de novo deletion of chromosome 10q22.3‐q24.1. He was initially diagnosed with Juvenile polyposis syndrome (JPS) at age four after presenting with hematochezia due to multiple colonic juvenile polyps. He then re‐presented ...

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Strontium‐Impregnated Bioabsorbable Composite for Osteoporotic Fracture Fixation

04.04.2015 | Chang‐Chin Wu, Chih‐Lin Kuo, Fang‐Yu Fan, Kai‐Chiang Yang, Journal of Biomedical Materials Research Part A, 2015

Abstract Osteoporosis impairs the bone healing process as well as bone fracture fixation. The intervention of osteoporosis is considered to be one part of bone fracture treatment. Thus, orthopaedic fixators impregnated with anti‐osteoporosis regimens will improve fracture fixation in ...

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Obstructive heart defects associated with candidate genes, maternal obesity, and folic acid supplementation

02.04.2015 | Xinyu Tang, Mario A. Cleves, Todd G. Nick, Ming Li, Stewart L. MacLeod, Stephen W. Erickson, Jingyun Li, Gary M. Sha ..., American Journal of Medical Genetics Part A, 2015

Right‐sided and left‐sided obstructive heart defects (OHDs) are subtypes of congenital heart defects, in which the heart valves, arteries, or veins are abnormally narrow or blocked. Previous studies have suggested that the development of OHDs involved a complex interplay between genetic ...

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Different cortical projections from three subdivisions of the rat lateral posterior thalamic nucleus: a single‐neuron tracing study with viral vectors

02.04.2015 | Hisashi Nakamura, Hiroyuki Hioki, Takahiro Furuta, Takeshi Kaneko, European Journal of Neuroscience, 2015

Abstract The lateral posterior thalamic nucleus (LP) is one of the components of the extrageniculate pathway in the rat visual system, and is cytoarchitecturally divided into three subdivisions – lateral (LPl), rostromedial (LPrm), and caudomedial (LPcm) portions. To clarify the differences in ...

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Global Genome and Transcriptome Analyses of Magnaporthe oryzae Epidemic Isolate 98-06 Uncover Novel Effectors and Pathogenicity-Related Genes, Revealing Gene Gain and Lose Dynamics in Genome Evolution

02.04.2015 | Yanhan Dong et al., PLoS Pathogens, 2015

by Yanhan Dong, Ying Li, Miaomiao Zhao, Maofeng Jing, Xinyu Liu, Muxing Liu, Xianxian Guo, Xing Zhang, Yue Chen, Yongfeng Liu, Yanhong Liu, Wenwu Ye, Haifeng Zhang, Yuanchao Wang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang Genome dynamics of pathogenic organisms are driven by pathogen and host ...

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Repair of spinal cord injury by chitosan scaffold with glioma ECM and SB216763 implantation in adult rats

02.04.2015 | Rao Jian, Yang Yixu, lin sheyu, Shen Jianhong, Yan Yaohua, Su xing, Huang Qingfeng, Lu Xiaojian, Zhang Lei, Zhen yan ..., Journal of Biomedical Materials Research Part A, 2015

Abstract The loss of spinal cord tissue and the cavity formation are major obstacles to the repair of spinal cord injury (SCI). In the study, the scaffold of chitosan+ECM+SB216763 was fabricated and used for the repair of injured spinal cord injury. First, the biocompatibility of the scaffold ...

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Cell Type-Dependent Changes in CdSe/ZnS Quantum Dot Uptake and Toxic Endpoints

01.04.2015 | Bella B. Manshian; Stefaan J. Soenen; Abdullah Al-Ali; Andy Brown; Nicole Hondow; John Wills; Gareth J. S. Jenkins; ..., Toxicological Sciences, 2015

Toxicity of nanoparticles (NPs) is often correlated with the physicochemical characteristics of the materials. However, some discrepancies are noted in in-vitro studies on quantum dots (QDs) with similar physicochemical properties. This is partly related to variations in cell type. In this study, ...

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Co-culture system of human salivary gland epithelial cells and immune cells from primary Sjögren’s syndrome patients: an in vitro approach to study the effects of Rituximab on the activation of the Raf-1/ERK1/2 pathway

01.04.2015 | Sabrina Lisi; Margherita Sisto; Massimo D’Amore; Dario Domenico Lofrumento, International Immunology, 2015

Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disorder of the exocrine glands with associated lymphocytic infiltrates in the affected glands. Dryness of the mouth and eyes results from involvement of the salivary and lacrimal glands. The efficacy of Rituximab (RTX) in pSS is still open ...

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