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3.663 Aktuelle Fachpublikationen zum Thema Addition

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The differential characterization of GPR55 receptor in human peripheral blood reveals a distinctive expression in monocytes and NK cells and a proinflammatory role in these innate cells

01.03.2015 | Valerio Chiurchiù; Mirko Lanuti; Marco De Bardi; Luca Battistini; Mauro Maccarrone, International Immunology, 2015

G protein-coupled receptor 55 (GPR55) is activated by endogenous, plant-derived and synthetic cannabinoids. Recent studies reported a broad tissue distribution for GPR55 and found prominent roles for this receptor in inflammatory pain, gut and bone physiology, as well as cancer. However, little ...


Disease origin and progression in amyotrophic lateral sclerosis: an immunology perspective

01.03.2015 | Andrea Malaspina; Fabiola Puentes; Sandra Amor, International Immunology, 2015

The immune system is inextricably linked with many neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), a devastating neuromuscular disorder affecting motor cell function with an average survival of 3 years from symptoms onset. In ALS, there is a dynamic interplay between the ...


The sexual dimorphic association of cardiorespiratory fitness to working memory in children

21.02.2015 | Eric S. Drollette, Mark R. Scudder, Lauren B. Raine, R. Davis Moore, Matthew B. Pontifex, Kirk I. Erickson, Charles ..., Developmental Science, 2015

Abstract The present investigation examined the sexual dimorphic patterns of cardiorespiratory fitness to working memory in preadolescent children (age range: 7.7–10.9). Data were collected in three separate studies (Study 1: n=97, 42 females; Study 2: n=95, 45 females; Study 3: n=84, 37 ...


Changing patterns of rotavirus strains circulating in Ireland: Re‐emergence of G2P[4] and identification of novel genotypes in Ireland

20.02.2015 | P.J. Collins, Emily Mulherin, Helen O'Shea, Olivia Cashman, Grainne Lennon, Eugene Pidgeon, Suzie Coughlan, William ..., Journal of Medical Virology, 2015

Worldwide, Group A Rotavirus (RVA) is recognized as the most common aetiological agent of acute diarrheal disease in children. One hundred and ninety seven positive faecal samples were obtained from patients between 2006 and 2008. Reverse transcriptase polymerase chain reaction (RT‐PCR) was ...


Dicer regulated let‐7 expression levels in p53‐induced cancer repression requires cyclin D1

20.02.2015 | Xin Sun, Shou‐Ching Tang, Chongwen Xu, Lianjin Jin, Ersilia Mirabelli, Jie Zhou, Qi Qin, Hong Ren, Journal of Cellular and Molecular Medicine, 2015

Abstract Let‐7 miRNAs act as tumour suppressors by directly binding to the 3′UTRs of downstream gene products. The regulatory role of let‐7 in downstream gene expression has gained much interest in the cancer research community, as it controls multiple biological functions and determines cell ...


Metabolic and hypoxic adaptation to anti‐angiogenic therapy: a target for induced essentiality

19.02.2015 | Alan McIntyre, Adrian L Harris, EMBO Molecular Medicine, 2015

Abstract Anti‐angiogenic therapy has increased the progression‐free survival of many cancer patients but has had little effect on overall survival, even in colon cancer (average 6–8weeks) due to resistance. The current licensed targeted therapies all inhibit VEGF signalling (Table). Many ...


Novel STAMBP mutation and additional findings in an arabic family

18.02.2015 | Eissa A. Faqeih, Laila Bastaki, Rasim Ozgur Rosti, Emily G. Spencer, AbdulAli P. Zada, Mohammad A. M. Saleh, Kyongmi ..., American Journal of Medical Genetics Part A, 2015

Microcephaly‐capillary malformation syndrome (MIC‐CAP syndrome) is a newly recognized autosomal recessive congenital neurocutaneous central nervous system disorder characterized by severe microcephaly, early‐onset seizures, profound psychomotor disability, and multiple cutaneous capillary ...


Spontaneous calcification process in primary renal cells from a medullary sponge kidney patient harbouring a GDNF mutation

18.02.2015 | Federica Mezzabotta, Rosalba Cristofaro, Monica Ceol, Dorella Del Prete, Giovanna Priante, Alessandra Familiari, Ant ..., Journal of Cellular and Molecular Medicine, 2015

Abstract Medullary nephrocalcinosis is a hallmark of medullary sponge kidney (MSK). We had the opportunity to study a spontaneous calcification process in vitro by utilizing the renal cells of a patient with MSK who was heterozygous for the c.‐27 + 18G>A variant in the GDNF gene encoding glial ...


Clinical predictors of fever in stroke patients: relevance of nasogastric tube

18.02.2015 | A. Muscari, G. M. Puddu, C. Conte, R. Falcone, B. Kolce, M. V. Lega, M. Zoli, Acta Neurologica Scandinavica, 2015

Objectives Fever frequently occurs in stroke patients and worsens their prognosis. However, only few studies have assessed the determinants of fever in acute stroke, and no study has specifically addressed the possible prediction of the development of fever. Materials and methods This ...


Including a subject‐paced trial may make the PASAT more acceptable for MS patients

18.02.2015 | O. Bosnes, O.‐P. Dahl, O. Almkvist, Acta Neurologica Scandinavica, 2015

The Paced Auditory Serial Addition Test (PASAT) is regularly used in the evaluation of cognition in multiple sclerosis (MS). However, the test may impose frustration, distress, and anxiety in patients, which may result in refusal to participate by many patients. Objectives In this study, ...


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