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4.218 Aktuelle Fachpublikationen zum Thema Addition

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Atypical phenotypes associated with pathogenic CHD7 variants and a proposal for broadening CHARGE syndrome clinical diagnostic criteria

22.11.2015 | Caitlin L. Hale, Adrienne N. Niederriter, Glenn E. Green, Donna M. Martin, American Journal of Medical Genetics Part A, 2015

CHARGE syndrome (Coloboma of the eye, Heart defects, Atresia of the choanae, Retardation of growth and/or development, Genital and/or urinary anomalies, and Ear malformations, including deafness and vestibular disorders) is a genetic condition characterized by a specific and recognizable ...


The immunoproteasome controls the availability of the cardio‐protective pattern recognition molecule Pentraxin3

18.11.2015 | Anna Paeschke, Anna Possehl, Karin Klingel, Martin Voss, Karolin Voss, Meike Kesphol, Martina Sauter, Hermen S. Over ..., European Journal of Immunology, 2015

Cardiomyocyte death as a result of viral infection is an excellent model for dissecting the inflammatory stress response that occurs in heart tissue. We reported earlier that a specific proteasome isoform, the immunoproteasome, prevents exacerbation of coxsackievirusB3 (CVB3) induced myocardial ...


Molecular cloning and expression of a GABA receptor subunit from the crayfish Procambarus clarkii

18.11.2015 | Eric N. Jiménez‐Vázquez, Clara E. Díaz‐Velásquez, R.M. Uribe, Juan M. Arias, Ubaldo García, Journal of Neuroscience Research, 2015

Molecular cloning has introduced an unexpected, large diversity of neurotransmitter hetero‐ oligomeric receptors. Extensive research on the molecular structure of the γ‐aminobutyric acid receptor (GABAR) has been of great significance for understanding how the nervous system works in both ...


Nitrogen monoxide and carbon monoxide transfer interpretation: state of the art

18.11.2015 | Jean Benoit Martinot, Hervé Guénard, Anh‐Tuan Dinh‐Xuan, Henri Gin, Claire Dromer, Clinical Physiology and Functional Imaging, 2015

Summary Just a few clinicians routinely measure the subcomponents of the lung diffusing capacity for Carbone monoxide (DLCO). This is because the measurement of membrane and blood conductances for CO (DmCO and DbCO=θCO×Vc, respectively) by the classic Roughton and Forster method is ...


Community‐Driven Research Agenda to Reduce Health Disparities

17.11.2015 | Pearl A. McElfish, Peter Kohler, Chris Smith, Scott Warmack, Bill Buron, Jonell Hudson, Melissa Bridges, Rachel Purv ..., Clinical and Translational Science, 2015

Abstract This paper describes how a new regional campus of an academic health center engaged in a community‐based participatory research (CBPR) process to set a community‐driven research agenda to address health disparities. The campus is situated among growing Marshallese and Hispanic ...


TSLP production by dendritic cells is modulated by IL‐1β and components of the endoplasmic reticulum stress response

17.11.2015 | Matthew J. Elder, Steven J. Webster, David L. Williams, J. S. Hill Gaston, Jane C. Goodall, European Journal of Immunology, 2015

Thymic stromal lymphopoietin (TSLP) produced by epithelial cells acts on dendritic cells (DCs) to drive differentiation of TH2‐cells, and is therefore important in allergic disease pathogenesis. However, DCs themselves make significant amounts of TSLP in response to microbial products, but ...


Methamphetamine induces the release of endothelin

16.11.2015 | Jeong‐Woo Seo, Susan M. Jones, Trisha A. Hostetter, Jeffrey J. Iliff, G. Alexander West, Journal of Neuroscience Research, 2015

Methamphetamine is a potent psychostimulant drug of abuse that increases release and blocks reuptake of dopamine, producing intense euphoria, factors that may contribute to its widespread abuse. It also produces severe neurotoxicity resulting from oxidative stress, DNA damage, blood–brain ...


Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients

15.11.2015 | Katherine L. Wright; Jessica R. Adams; Jeff C. Liu; Amanda J. Loch; Ruth G. Wong; Christine E.B. Jo; Lauren A. Beck; ..., Cancer Research, 2015

Breast cancer is associated with alterations in a number of growth factor and hormone-regulated signaling pathways. Mouse models of metastatic breast cancer typically feature mutated oncoproteins that activate PI3K, Stat3, and Ras signaling, but the individual and combined roles of these pathways ...


Understanding the Unique Attributes of MUC16 (CA125): Potential Implications in Targeted Therapy

15.11.2015 | Srustidhar Das; Surinder K. Batra, Cancer Research, 2015

CA125, the most widely used ovarian cancer biomarker, was first identified approximately 35 years ago in an antibody screen against ovarian cancer antigen. Two decades later, it was cloned and characterized to be a transmembrane mucin, MUC16. Since then, several studies have investigated its ...


The carbocyanine dye DiD labels in vitro and in vivo neural stem cells of the subventricular zone as well as myelinated structures following in vivo injection in the lateral ventricle

14.11.2015 | Dario Carradori, Kristell Barreau, Joël Eyer, Journal of Neuroscience Research, 2015

Carbocyanines are fluorescent lipophilic cationic dyes used since the early 1980s as neuronal tracers. Several applications of these compounds have been developed thanks to their low cell toxicity, lateral diffusion within the cellular membranes, and good photostability. ...


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