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Risk of hepatocellular carcinoma and cancers at other sites among patients diagnosed with chronic hepatitis B virus infection in Sweden

13.09.2013 | Kristina Sundquist, Jan Sundquist, Jianguang Ji, Journal of Medical Virology, 2013

Abstract Hepatitis B virus (HBV) infection is one of most common viral infections worldwide. While chronic HBV infection has been shown consistently to be associated with hepatocellular carcinoma, data on associations with cancers at other sites are limited. In this study a total of 10,197 ...

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Piezoelectric properties of aligned collagen membranes

13.09.2013 | D. Denning, M. V. Paukshto, S. Habelitz, B. J. Rodriguez, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2013

Abstract Electromechanical coupling, a phenomenon present in collagenous materials, may influence cell–extracellular matrix interactions. Here, electromechanical coupling has been investigated via piezoresponse force microscopy in transparent and opaque membranes consisting of helical‐like ...

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The influence of gap junction network complexity on pulmonary artery smooth muscle reactivity in normoxic and chronic hypoxic conditions

12.09.2013 | Marko Gosak, Christelle Guibert, Marie Billaud, Etienne Roux, Marko Marhl, Experimental Physiology, 2013

Abstract  Experiments in intrapulmonary arteries (IPA) isolated from rats maintained in normoxia and chronic hypobaric hypoxia showed that in normoxia, the IPA contractile sensitivity to KCl was not modified by gap‐junction inhibition. By contrast, chronic hypoxia induced an ...

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Interplay between human microglia and neural stem/progenitor cells in an allogeneic co‐culture model

12.09.2013 | Jia Liu, Erik Hjorth, Mingqin Zhu, Cinzia Calzarossa, Eva‐Britt Samuelsson, Marianne Schultzberg, Elisabet Åkesson, Journal of Cellular and Molecular Medicine, 2013

Abstract Experimental neural cell therapies, including donor neural stem/progenitor cells (NPCs) have been reported to offer beneficial effects on the recovery after an injury and to counteract inflammatory and degenerative processes in the central nervous system (CNS). The interplay between ...

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MicroRNA‐155 controls Toll‐like receptor 3‐ and hepatitis C virus‐induced immune responses in the liver

12.09.2013 | M. Jiang, R. Broering, M. Trippler, J. Wu, E. Zhang, X. Zhang, G. Gerken, M. Lu, J. F. Schlaak, Journal of Viral Hepatitis, 2013

Summary The hepatitis C virus (HCV) establishes persistent infections despite strong activation of the innate immune system through TLR3 and other sensors. Therefore, we analysed regulatory mechanisms of TLR3‐induced immune responses in nonparenchymal liver cells (NPCs). Effects of ...

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Small RNA sX13: A Multifaceted Regulator of Virulence in the Plant Pathogen Xanthomonas

12.09.2013 | Cornelius Schmidtke et al., PLoS Pathogens, 2013

by Cornelius Schmidtke, Ulrike Abendroth, Juliane Brock, Javier Serrania, Anke Becker, Ulla Bonas Small noncoding RNAs (sRNAs) are ubiquitous posttranscriptional regulators of gene expression. Using the model plant-pathogenic bacterium Xanthomonas campestris pv. vesicatoria (Xcv), we ...

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Human Cytomegalovirus Gene UL76 Induces IL-8 Expression through Activation of the DNA Damage Response

12.09.2013 | Helena Costa et al., PLoS Pathogens, 2013

by Helena Costa, Rute Nascimento, John Sinclair, Robert Michael Evans Parkhouse Human cytomegalovirus (HCMV), a β-herpesvirus, has evolved many strategies to subvert both innate and adaptive host immunity in order to ensure its survival and propagation within the host. Induction of IL-8 is ...

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Human papillomavirus infection in women in four regions of Senegal

11.09.2013 | El Hadji Seydou Mbaye, Tarik Gheit, Ahmadou Dem, Sandrine McKay‐Chopin, Ndeye Coumba Toure‐Kane, Souleymane Mboup, M ..., Journal of Medical Virology, 2013

Abstract Cervical cancer is the most frequent cancer among women in Senegal. However, there are few data concerning the human papillomavirus (HPV) types inducing neoplasia and cervical cancers and their prevalence in the general population of Senegal. The aim of this study is to determine the ...

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Isolation of cross‐reactive human monoclonal antibodies that prevent binding of human noroviruses to histo‐blood group antigens

11.09.2013 | Kyoko Higo‐Moriguchi, Haruko Shirato, Yuichi Someya, Yoshikazu Kurosawa, Naokazu Takeda, Koki Taniguchi, Journal of Medical Virology, 2013

Abstract In order to identify the repertoire of antibodies generated on natural infection of norovirus (NoV) in humans, and to characterize the human monoclonal antibodies against NoV, three phage‐displayed antibody libraries originating from healthy person(s) were screened using purified ...

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Type dependent patterns of human adenovirus persistence in human T‐lymphocyte cell lines

11.09.2013 | Dominik Markel, Elena Lam, Gabriele Harste, Sebastian Darr, Mirja Ramke, Albert Heim, Journal of Medical Virology, 2013

Abstract Disseminated adenovirus infections cause significant mortality in stem cell transplanted patients and are suspected to originate from asymptomatic adenovirus persistence (“latency”) in lymphocytes. The infection of three human T‐lymphocyte lines (Jurkat, PM1, and CEM) with human ...

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