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miR-200a inhibits migration of triple-negative breast cancer cells through direct repression of the EPHA2 oncogene

01.09.2015 | Efrosini Tsouko; Jun Wang; Daniel E. Frigo; Eylem Aydoğdu; Cecilia Williams, Carcinogenesis , 2015

Triple-negative breast cancer (TNBC) is characterized by aggressiveness and affects 10–20% of breast cancer patients. Since TNBC lacks expression of ERα, PR and HER2, existing targeted treatments are not effective and the survival is poor. In this study, we demonstrate that the tumor suppressor ...


Enhanced Metabolizing Activity of Human ES Cell-Derived Hepatocytes Using a 3D Culture System with Repeated Exposures to Xenobiotics

01.09.2015 | Jong Hyun Kim; Yu Jin Jang; Su Yeon An; Jeongsang Son; Jaehun Lee; Gyunggyu Lee; Ji Young Park; Han-Jin Park; Dong-Y ..., Toxicological Sciences, 2015

Highly homogeneous and functional stem cell-derived hepatocyte-like cells (HLCs) are considered a promising option in the cell-based therapy of liver disease and the development of effective invitro toxicity screening tools. However, the purity of cells and expression and/or activity of drug ...


Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer

01.09.2015 | Hamed Khalili; Jian Gong; Hermann Brenner; Thomas R. Austin; Carolyn M. Hutter; Yoshifumi Baba; John A. Baron; Sonja ..., Carcinogenesis , 2015

Although genome-wide association studies (GWAS) have separately identified many genetic susceptibility loci for ulcerative colitis (UC), Crohn’s disease (CD) and colorectal cancer (CRC), there has been no large-scale examination for pleiotropy, or shared genetic susceptibility, for these ...


The Neurotoxic Effect of 13,19-Didesmethyl and 13-Desmethyl Spirolide C Phycotoxins Is Mainly Mediated by Nicotinic Rather Than Muscarinic Acetylcholine Receptors

01.09.2015 | Romulo Aráoz; Gilles Ouanounou; Bogdan I. Iorga; Amélie Goudet; Doria Alili; Muriel Amar; Evelyne Benoit; Jordi Molg ..., Toxicological Sciences, 2015

Spirolides are a large family of lipophilic marine toxins produced by dinoflagellates that have been detected in contaminated shellfish. Among them, 13,19-didesmethyl and 13-desmethyl spirolide C phycotoxins are widely distributed and their mode of action needs to be clearly defined. In order to ...


Freshwater Planarians as an Alternative Animal Model for Neurotoxicology

01.09.2015 | Danielle Hagstrom; Olivier Cochet-Escartin; Siqi Zhang; Cindy Khuu; Eva-Maria S. Collins, Toxicological Sciences, 2015

Traditional toxicology testing has relied on low-throughput, expensive mammalian studies; however, timely testing of the large number of environmental toxicants requires new invitro and invivo platforms for inexpensive medium- to high-throughput screening. Herein, we describe the suitability of ...


A Dose-Response Modeling Approach Shows That Effects From Mixture Exposure to the Skin Sensitizers Isoeugenol and Cinnamal Are in Line With Dose Addition and Not With Synergism

01.09.2015 | Anne S. Kienhuis; Wout Slob; Eric R. Gremmer; Jolanda P. Vermeulen; Janine Ezendam, Toxicological Sciences, 2015

Currently, hazard characterization of skin sensitizers is based on data obtained from studies examining single chemicals. Many consumer products, however, contain mixtures of sensitizers that might interact in such a way that the response induced by a substance is higher than predicted in the ...


Developmental Neurotoxicity of Tobacco Smoke Directed Toward Cholinergic and Serotonergic Systems: More Than Just Nicotine

01.09.2015 | Theodore A. Slotkin; Samantha Skavicus; Jennifer Card; Ashley Stadler; Edward D. Levin; Frederic J. Seidler, Toxicological Sciences, 2015

Tobacco smoke contains thousands of compounds in addition to nicotine, a known neuroteratogen. We evaluated the developmental neurotoxicity of tobacco smoke extract (TSE) administered to pregnant rats starting preconception and continued through the second postnatal week. We simulated nicotine ...


Pharmacokinetics of tecomin in rats after intragastric and intravenous administration

28.08.2015 | Lina Guo, Yushuai Peng, Can Zhao, Xin Yang, Lijia Liu, Rufeng Wang, Biomedical Chromatography, 2015

ABSTRACT The pharmacokinetics of tecomin, which is a potential bioactive compound from the flowers of Trollius chinensis, was studied. The results showed that this compound was easily absorbed and rapidly metabolized into veratric acid in vivo, and then the latter was eliminated slowly. In ...


Genome‐wide Association Study of Autism Spectrum Disorder in the East Asian Populations

28.08.2015 | Xiaoxi Liu, Takafumi Shimada, Takeshi Otowa, Yu‐Yu Wu, Yoshiya Kawamura, Mamoru Tochigi, Yasuhide Iwata, Tadashi Ume ..., Autism Research, 2015

Autism spectrum disorder is a heterogeneous neurodevelopmental disorder with strong genetic basis. To identify common genetic variations conferring the risk of ASD, we performed a two‐stage genome‐wide association study using ASD family and healthy control samples obtained from East Asian ...


The Significance and Therapeutic Potential of GATA3 Expression and Mutation in Breast Cancer: A Systematic Review

27.08.2015 | Feng Du, Peng Yuan, Teng Wang, Jiuda Zhao, Zitong Zhao, Yang Luo, Binghe Xu, Medicinal Research Reviews, 2015

Abstract GATA3 is a critical transcription factor in the development of various human systems. The notion that GATA3 expression is required for the differentiation and maintenance of normal breast tissue has been well established. Recently, GATA3 is found to actively participate in the ...


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