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Human sialic acid acetyl esterase: Towards a better understanding of a puzzling enzyme

01.09.2015 | Flavia Orizio; Eufemia Damiati; Edoardo Giacopuzzi; Giuliana Benaglia; Stefano Pianta; Roland Schauer; Reinhard Schw ..., Glycobiology , 2015

Sialic acid acetyl esterase (SIAE) removes acetyl moieties from the hydroxyl groups in position 9 and 4 of sialic acid. Recently, a dispute has been opened on its association to autoimmunity. In order to get new insights on human SIAE biology and to clarify its seemingly contradictory molecular ...


Glycosaminoglycans affect heparanase location in CHO cell lines

01.09.2015 | Maria BR Piva; Eloah R Suarez; Carina M Melo; Renan P Cavalheiro; Helena B Nader; Maria AS Pinhal, Glycobiology , 2015

Glycosaminoglycans (GAG) play a ubiquitous role in tissues and cells. In eukaryotic cells, heparan sulfate (HS) is initially degraded by an endo-β-glucuronidase called heparanase-1 (HPSE). HS oligosaccharides generated by the action of HPSE intensify the activity of signaling molecules, ...


Crystal structure of a symbiosis-related lectin from octocoral

01.09.2015 | Akiko Kita; Mitsuru Jimbo; Ryuichi Sakai; Yukio Morimoto; Kunio Miki, Glycobiology , 2015

D-Galactose-binding lectin from the octocoral, Sinularia lochmodes (SLL-2), distributes densely on the cell surface of microalgae, Symbiodinium sp., an endosymbiotic dinoflagellate of the coral, and is also shown to be a chemical cue that transforms dinoflagellate into a non-motile (coccoid) ...


Cytotoxicity and genotoxicity of urban particulate matter in mammalian cells

01.09.2015 | Audrey F. Dumax-Vorzet; M. Tate; Richard Walmsley; Rhod H. Elder; Andrew C. Povey, Mutagenesis, 2015

Ambient air particulate matter (PM)-associated reactive oxygen species (ROS) have been linked to a variety of altered cellular outcomes. In this study, three different PM samples from diesel exhaust particles (DEPs), urban dust standard reference material SRM1649a and air collected in Manchester ...


Elucidation of changes in molecular signalling leading to increased cellular transformation in oncogenically progressed human bronchial epithelial cells exposed to radiations of increasing LET

01.09.2015 | Liang-Hao Ding; Seongmi Park; Yang Xie; Luc Girard; John D. Minna; Michael D. Story, Mutagenesis, 2015

The early transcriptional response and subsequent induction of anchorage-independent growth after exposure to particles of high Z and energy (HZE) as well as -rays were examined in human bronchial epithelial cells (HBEC3KT) immortalised without viral oncogenes and an isogenic variant cell line ...


Micronucleus formation by single and mixed heavy metals/loids and PAH compounds in HepG2 cells

01.09.2015 | Cheng Peng; Sasikumar Muthusamy; Qing Xia; Vincent Lal; Michael S. Denison; Jack C. Ng, Mutagenesis, 2015

Humans and other organisms are exposed to multi-chemical mixtures including commonly found carcinogens such as polycyclic aromatic hydrocarbons (PAHs) and heavy metal/loids. The joint effects of these chemicals as beyond the binary mixtures have not been well characterised. In this study, we ...


Inherited Magnetic Maps in Salmon and the Role of Geomagnetic Change

01.09.2015 | Nathan F. Putman, Integrative and Comparative Biology, 2015

Migration in animals has evolved as an adaptation to environmental variability across space and through time. The availability of reliable sensory cues and guidance mechanisms used in navigating among disparate locations is an essential component of this behavior. An "inherited magnetic map" is ...


Key Role of Amino Acid Repeat Expansions in the Functional Diversification of Duplicated Transcription Factors

01.09.2015 | Núria Radó-Trilla; Krisztina Arató; Cinta Pegueroles; Alicia Raya; Susana de la Luna; M. Mar Albà, Molecular Biology and Evolution, 2015

The high regulatory complexity of vertebrates has been related to two rounds of whole genome duplication (2R-WGD) that occurred before the divergence of the major vertebrate groups. Following these events, many developmental transcription factors (TFs) were retained in multiple copies and ...


Ablation of the 14‐3‐3gamma Protein Results in Neuronal Migration Delay and Morphological Defects in the Developing Cerebral Cortex

23.08.2015 | Tomoka Wachi, Brett Cornell, Courtney Marshall, Vladimir Zhukarev, Peter W. Baas, Kazuhito Toyo‐oka, Developmental Neurobiology, 2015

ABSTRACT 14‐3‐3 proteins are ubiquitously‐expressed and multifunctional proteins. There are seven isoforms in mammals with a high level of homology, suggesting potential functional redundancy. We previously found that two of seven isoforms, 14‐3‐3epsilon and 14‐3‐3zeta, are important for brain ...


The association between economic development, lifestyle differentiation, and C‐reactive protein concentration within rural communities in Hainan Island, China

22.08.2015 | Yosuke Inoue, Andrew Stickley, Aki Yazawa, Dandan Li, Jianwei Du, Yuming Jin, Yan Chen, Chiho Watanabe, American Journal of Human Biology, 2015

Objective Earlier fieldwork in rural areas of Hainan Island, China, demonstrated that during the course of economic development increasing differences had emerged in lifestyles within communities. It is possible that these variations might have stratified residents into subpopulations with ...


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