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Genome‐wide association analyses reveal complex genetic architecture underlying natural variation for flowering time in canola

02.10.2015 | Harsh Raman, Rosy Raman, Neil Coombes, Jie Song, Roslyn Prangnell, Champa Bandaranayake, Riffat Tahira, Vignesh Sund ..., Plant, Cell & Environment, 2015

ABSTRACT Optimum flowering time is the key to maximise canola production in order to meet global demand of vegetable oil, biodiesel and canola‐meal. We reveal extensive variation in flowering time across diverse genotypes of canola under field, glasshouse and controlled environmental ...


Synthesis, Biological Evaluation and Molecular Docking of (R)‐2‐((8‐(3‐aminopiperidin‐1‐yl)‐3‐methyl‐7‐(3‐methylbut‐2‐en‐1‐yl)‐2,6‐dioxo‐2,3,6,7‐tetrahydro‐1H‐purin‐1‐yl)methyl)benzonitrile as Dipeptidyl Peptidase IV Inhibitors

02.10.2015 | Yan Ran, Heying Pei, Mingfeng Shao, Lijuan Chen, Chemical Biology & Drug Design, 2015

Abstract Type 2 diabetes (T2D) is classified as a major metabolic disorder, which has affected approximately 194 million people worldwide. DPP‐IV inhibitors as a new therapy have shown several advantages over traditional anti‐diabetic drugs. Based on the similar binding modes of Alogliptin and ...


The multiple roles of epidermal growth factor repeat O-glycans in animal development

01.10.2015 | Amanda R Haltom; Hamed Jafar-Nejad, Glycobiology , 2015

The epidermal growth factor (EGF)-like repeat is a common, evolutionarily conserved motif found in secreted proteins and the extracellular domain of transmembrane proteins. EGF repeats harbor six cysteine residues which form three disulfide bonds and help generate the three-dimensional structure ...


Protective effects of polysialic acid on proteolytic cleavage of FGF2 and proBDNF/BDNF

01.10.2015 | Masaya Hane; Shuhei Matsuoka; Sayaka Ono; Shinji Miyata; Ken Kitajima; Chihiro Sato, Glycobiology , 2015

Polysialic acid (polySia) is a linear polymer of sialic acid that modifies neural cell adhesion molecule (NCAM) in the vertebrate brain. PolySia is a large and exclusive molecule that functions as a negative regulator of cell–cell interactions. Recently, we demonstrated that polySia can ...


Geophysiology of Wood Frogs: Landscape Patterns of Prevalence of Disease and Circulating Hormone Concentrations across the Eastern Range

01.10.2015 | Erica J. Crespi; Leslie J. Rissler; Nichole M. Mattheus; Kristin Engbrecht; Sarah I. Duncan; Travis Seaborn; Emily M ..., Integrative and Comparative Biology, 2015

One of the major challenges for conservation physiologists is to determine how current or future environmental conditions relate to the health of animals at the population level. In this study, we measured prevalence of disease, mean condition of the body, and mean resting levels of ...


Not So Fast: Swimming Behavior of Sailfish during Predator–Prey Interactions using High-Speed Video and Accelerometry

01.10.2015 | Stefano Marras; Takuji Noda; John F. Steffensen; Morten B. S. Svendsen; Jens Krause; Alexander D. M. Wilson; Ralf H. ..., Integrative and Comparative Biology, 2015

Billfishes are considered among the fastest swimmers in the oceans. Despite early estimates of extremely high speeds, more recent work showed that these predators (e.g., blue marlin) spend most of their time swimming slowly, rarely exceeding 2 m s–1. Predator–prey interactions provide a context ...


Parallel Domestication of the Heading Date 1 Gene in Cereals

01.10.2015 | Huanhuan Liu; Hangqin Liu; Leina Zhou; Zhihai Zhang; Xuan Zhang; Mingli Wang; Haixia Li; Zhongwei Lin, Molecular Biology and Evolution, 2015

Flowering time is one of the key determinants of crop adaptation to local environments during domestication. However, the genetic basis underlying flowering time is yet to be elucidated in most cereals. Although staple cereals, such as rice, maize, wheat, barley, and sorghum, have spread and ...


Down-regulation of lipocalin 2 suppresses the growth of human lung adenocarcinoma through oxidative stress involving Nrf2/HO-1 signaling

01.10.2015 | Baoquan Song; Hairui Zhang; Lei Jiang; Ying Chi; Jianjian Tian; Wenjing Du; Bentong Yu; Zhongchao Han, Acta Biochimica et Biophysica Sinica, 2015

Lipocalin 2 (LCN2), a multifunctional secretory protein known as neutrophil gelatinase-associated lipocalin (NGAL), is expressed in a variety of cancers. However, little is known about the biological functions of NGAL in the development of lung adenocarcinoma. In the present study, we primarily ...


Down-regulation of CEACAM1 in breast cancer

01.10.2015 | Changcheng Yang; Pingqing He; Yiwen Liu; Yiqing He; Cuixia Yang; Yan Du; Muqing Zhou; Wenjuan Wang; Guoliang Zhang; ..., Acta Biochimica et Biophysica Sinica, 2015

Carcinoembryonic antigen-related adhesion molecule 1 (CEACAM1) is a type 1 transmembrane glycoprotein belonging to the CEA family, which has been found to exist as either soluble forms in body fluids or membrane-bound forms on the cell surface. Aberrant CEACAM1 expression is associated with tumor ...


antaRNA: ant colony-based RNA sequence design

01.10.2015 | Robert Kleinkauf; Martin Mann; Rolf Backofen, Bioinformatics, 2015

Motivation: RNA sequence design is studied at least as long as the classical folding problem. Although for the latter the functional fold of an RNA molecule is to be found, inverse folding tries to identify RNA sequences that fold into a function-specific target structure. In combination with ...


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