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6.109 Aktuelle Fachpublikationen zum Thema Addition

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Antitumor properties of a new non-anticoagulant heparin analog from the mollusk Nodipecten nodosus: Effect on P-selectin, heparanase, metastasis and cellular recruitment

01.04.2015 | Angélica Maciel Gomes; Eliene Oliveira Kozlowski; Lubor Borsig; Felipe C O B Teixeira; Israel Vlodavsky; Mauro S G Pavão, Glycobiology , 2015

Inflammation and cancer are related pathologies acting synergistically to promote tumor progression. In both, hematogenous metastasis and inflammation, P-selectin participates in interactions involving tumor cells, platelets, leukocytes and endothelium. Heparin has been shown to inhibit ...


Conserved ion and amino acid transporters identified as phosphorylcholine-modified N-glycoproteins by metabolic labeling with propargylcholine in Caenorhabditis elegans cells

01.04.2015 | Casey J Snodgrass; Amanda R Burnham-Marusich; John C Meteer; Patricia M Berninsone, Glycobiology , 2015

Phosphorylcholine (PC) modification of proteins by pathogens has been implicated in mediating host–pathogen interactions. Parasitic nematodes synthesize PC-modified biomolecules that can modulate the host's antibody and cytokine production to favor nematode survival, contributing to long-term ...


Enzymatic properties and subtle differences in the substrate specificity of phylogenetically distinct invertebrate N-glycan processing hexosaminidases

01.04.2015 | Martin Dragosits; Shi Yan; Ebrahim Razzazi-Fazeli; Iain B H Wilson; Dubravko Rendic, Glycobiology , 2015

Fused lobes (FDL) hexosaminidases are the most recently genetically defined glycosidases involved in the biosynthesis of N-glycans in invertebrates, and their narrow specificity is essential for the generation of paucimannosidic N-glycans in insects. In this study, we explored the potential of ...


Novel selection methods for DNA-encoded chemical libraries

01.03.2015 | Author(s): Alix I Chan , Lynn M McGregor , David R Liu, Current Opinion in Chemical Biology, 2015

Publication date: June 2015 Source:Current Opinion in Chemical Biology, Volume 26 Author(s): Alix I Chan , Lynn M McGregor , David R Liu Driven by the need for new compounds to serve as biological probes and leads for therapeutic development and the growing accessibility of DNA ...


Genomic Signatures Reveal New Evidences for Selection of Important Traits in Domestic Cattle

01.03.2015 | Lingyang Xu; Derek M. Bickhart; John B. Cole; Steven G. Schroeder; Jiuzhou Song; Curtis P. Van Tassell; Tad S. Sonst ..., Molecular Biology and Evolution, 2015

We investigated diverse genomic selections using high-density single nucleotide polymorphism data of five distinct cattle breeds. Based on allele frequency differences, we detected hundreds of candidate regions under positive selection across Holstein, Angus, Charolais, Brahman, and N'Dama. In ...


Functional Conservation of Both CDS- and 3′-UTR-Located MicroRNA Binding Sites between Species

01.03.2015 | Guojing Liu; Rui Zhang; Jin Xu; Chung-I Wu; Xuemei Lu, Molecular Biology and Evolution, 2015

MicroRNAs (miRNAs) mediate gene regulation posttranscriptionally through pairing of their seed (2–7 nt) to 3'-untranslated regions (3'-UTRs) or coding regions (coding sequences [CDSs]) of their target genes. CDS target sites generally show weaker repression effects than 3'-UTR sites. However, ...


Venom-Related Transcripts from Bothrops jararaca Tissues Provide Novel Molecular Insights into the Production and Evolution of Snake Venom

01.03.2015 | Inácio L.M. Junqueira-de-Azevedo; Carolina Mancini Val Bastos; Paulo Lee Ho; Milene Schmidt Luna; Norma Yamanouye; N ..., Molecular Biology and Evolution, 2015

Attempts to reconstruct the evolutionary history of snake toxins in the context of their co-option to the venom gland rarely account for nonvenom snake genes that are paralogous to toxins, and which therefore represent important connectors to ancestral genes. In order to reevaluate this process, ...


Control of homeostatic and pathogenic balance in adipose tissue by ganglioside GM3

01.03.2015 | Masakazu Nagafuku; Takashige Sato; Saya Sato; Kyoko Shimizu; Toshio Taira; Jin-Ichi Inokuchi, Glycobiology , 2015

Ganglioside GM3 (Siaα2-3Galβ1-4Glcβ1-1Cer) has been known to participate in insulin signaling by regulating the association of the insulin receptor in caveolae microdomains (lipid rafts), which is essential for the execution of the complete insulin metabolic signaling in adipocytes. ...


Oridonin inhibits BxPC-3 cell growth through cell apoptosis

01.03.2015 | Bin Xu; Wen Shen; Xing Liu; Ting Zhang; Jun Ren; Yongjun Fan; Jian Xu, Acta Biochimica et Biophysica Sinica, 2015

Oridonin, an ent-kaurene diterpenoid extracted from the traditional Chinese herb Rabdosia rubescens, has multiple biological and pharmaceutical functions and has been used clinically for many years. While the antitumor function of oridonin has been corroborated by numerous lines of evidence, its ...


STK33 plays an important positive role in the development of human large cell lung cancers with variable metastatic potential

01.03.2015 | Ping Wang; Hongzhong Cheng; Jianqiang Wu; Anrun Yan; Libin Zhang, Acta Biochimica et Biophysica Sinica, 2015

Serine/threonine kinase 33 (STK33) is a novel protein that has attracted considerable interest in recent years. Previous research has revealed that STK33 expression plays a special role in cancer cell proliferation. However, the mechanisms of STK33 induction of cancer cells remain largely ...


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