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7.054 Aktuelle Fachpublikationen zum Thema Addition

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An updated evolutionary study of Flaviviridae NS3 helicase and NS5 RNA-dependent RNA polymerase, reveals novel invariable motifs as potential pharmacological targets.

03.02.2016 | Louis Papageorgiou; Styliani Loukatou; Sofia Kossida; Dimitris Maroulis; Dimitrios Vlachakis, Molecular BioSystems, 2016

The rate of Flaviviridae family viruses infections worldwide has increased dramatically in the last few years. In addition, infections caused by arthropod vectors viruses including Hepatitis C, West Nile, Dengue fever, Yellow fever and Japanese encephalitis are emerging throughout the world. ...

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Changes in gene expression and histological injuries as a result of exposure of Crassostrea gigas to the toxic dinoflagellate Gymnodinium catenatum

01.02.2016 | Norma García-Lagunas; Reyna de Jesús Romero-Geraldo; Norma Yolanda Hernández-Saavedra, Journal of Molluscan Studies, 2016

The harmful alga Gymnodinium catenatum is one of the species that produces the neurotoxic, hydrophilic, tetrahydropurine derivatives known as paralytic shellfish toxins (PST). Studies have shown that several classes of marine toxins have genotoxic effects on bivalves. However, there are few ...

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Disentangling Sources of Selection on Exonic Transcriptional Enhancers

01.02.2016 | Rachel M. Agoglia; Hunter B. Fraser, Molecular Biology and Evolution, 2016

In addition to coding for proteins, exons can also impact transcription by encoding regulatory elements such as enhancers. It has been debated whether such features confer heightened selective constraint, or evolve neutrally. We have addressed this question by developing a new approach to ...

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SHV-129: A Gateway to Global Suppressors in the SHV {beta}-Lactamase Family?

01.02.2016 | Marisa L. Winkler; Robert A. Bonomo, Molecular Biology and Evolution, 2016

Enzymes are continually evolving in response to environmental pressures. In order to increase enzyme fitness, amino acid substitutions can occur leading to a changing function or an increased stability. These evolutionary drivers determine the activity of an enzyme and its success in future ...

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Genetic Determinism and Evolutionary Reconstruction of a Host Jump in a Plant Virus

01.02.2016 | Nikon Vassilakos; Vincent Simon; Aliki Tzima; Elisabeth Johansen; Benoît Moury, Molecular Biology and Evolution, 2016

In spite of their widespread occurrence, only few host jumps by plant viruses have been evidenced and the molecular bases of even fewer have been determined. A combination of three independent approaches, 1) experimental evolution followed by reverse genetics analysis, 2) positive selection ...

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Stepwise Functional Evolution in a Fungal Sugar Transporter Family

01.02.2016 | Carla Gonçalves; Marco A. Coelho; Madalena Salema-Oom; Paula Gonçalves, Molecular Biology and Evolution, 2016

Sugar transport is of the utmost importance for most cells and is central to a wide range of applied fields. However, despite the straightforward in silico assignment of many novel transporters, including sugar porters, to existing families, their exact biological role and evolutionary trajectory ...

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Determinants of the Usage of Splice-Associated cis-Motifs Predict the Distribution of Human Pathogenic SNPs

01.02.2016 | XianMing Wu; Laurence D. Hurst, Molecular Biology and Evolution, 2016

Where in genes do pathogenic mutations tend to occur and does this provide clues as to the possible underlying mechanisms by which single nucleotide polymorphisms (SNPs) cause disease? As splice-disrupting mutations tend to occur predominantly at exon ends, known also to be hot spots of ...

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Lysine enhances the effect of amphotericin B against Candida albicans in vitro

01.02.2016 | Liuya Zhao; Jingchen Jiang; Zhenyu Zhu; Zebin Liao; Xiangwen Yao; Yu Yang; Yingying Cao; Yuanying Jiang, Acta Biochimica et Biophysica Sinica, 2016

Amphotericin B (AmB) is a polyene antibiotic produced by Streptomyces nodosus and has been used for >50 years in the treatment of acute systemic fungal infections. In the present study, we demonstrated that lysine, an essential amino acid, could enhance the effect of AmB against Candida albicans ...

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Functional up-regulation of Nav1.8 sodium channel on dorsal root ganglia neurons contributes to the induction of scorpion sting pain

01.02.2016 | Pin Ye; Liming Hua; Yunlu Jiao; Zhenwei Li; Shichao Qin; Jin Fu; Feng Jiang; Tong Liu; Yonghua Ji, Acta Biochimica et Biophysica Sinica, 2016

BmK I, purified from the venom of scorpion Buthus martensi Karsch (BmK), is a receptor site-3-specific modulator of voltage-gated sodium channels (VGSCs) and can induce pain-related behaviors in rats. The tetrodotoxin-resistant (TTX-R) sodium channel Nav1.8 contributes to most of the sodium ...

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Probing the binding pocket of the broadly tuned human bitter taste receptor TAS2R14 by chemical modification of cognate agonists

30.01.2016 | Rafik Karaman, Stefanie Nowak, Antonella Di Pizio, Hothaifa Kitaneh, Alaa Abu‐Jaish, Wolfgang Meyerhof, Masha Y. Niv ..., Chemical Biology & Drug Design, 2016

Abstract Sensing potentially harmful bitter substances in the oral cavity is achieved by a group of ∼25 receptors, named TAS2Rs, which are expressed in specialized sensory cells and recognize individual but overlapping sets of bitter compounds. The receptors differ in their tuning breadths ...

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