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6.537 Aktuelle Fachpublikationen zum Thema Addition

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Expression of stage-specific embryonic antigen-4 (SSEA-4) defines spontaneous loss of epithelial phenotype in human solid tumor cells

01.08.2015 | Kavitha Sivasubramaniyan; Abhishek Harichandan; Karin Schilbach; Andreas F Mack; Jens Bedke; Arnulf Stenzl; Lothar K ..., Glycobiology , 2015

Stage-specific embryonic antigen-4 (SSEA-4) is a glycosphingolipid, which is overexpressed in some cancers and has been linked to disease progression. However, little is known about the functions of SSEA-4 and the characteristics of SSEA-4 expressing tumor cells. Our studies identified SSEA-4 ...


4-Methylumbelliferone inhibits hepatocellular carcinoma growth by decreasing IL-6 production and angiogenesis

01.08.2015 | Flavia Piccioni; Esteban Fiore; Juan Bayo; Catalina Atorrasagasti; Estanislao Peixoto; Manglio Rizzo; Mariana Malvic ..., Glycobiology , 2015

Cirrhosis is characterized by an excessive accumulation of extracellular matrix components including hyaluronic acid (HA) and is widely considered a preneoplastic condition for hepatocellular carcinoma (HCC). 4-Methylumbelliferone (4MU) is an inhibitor of HA synthesis and has anticancer activity ...


Measurements of Neuronal Soma Size and Estimated Peptide Concentrations in Addition to Cell Abundance Offer a Higher Resolution of Seasonal and Reproductive Influences of GnRH-I and GnIH in European Starlings

01.08.2015 | Nelson Amorin; Rebecca M. Calisi, Integrative and Comparative Biology, 2015

Hypothalamic neuropeptides involved in vertebrate reproduction, gonadotropin releasing hormone (GnRH-I) and gonadotropin-inhibitory hormone (GnIH), can vary in the abundance of immunoreactive cells as a function of the reproductive status and nest box occupation of European starlings (Sturnus ...


A Comprehensive Transcriptomic and Proteomic Analysis of Hydra Head Regeneration

01.08.2015 | Hendrik O. Petersen; Stefanie K. Höger; Mario Looso; Tobias Lengfeld; Anne Kuhn; Uwe Warnken; Chiemi Nishimiya-Fujis ..., Molecular Biology and Evolution, 2015

The cnidarian freshwater polyp Hydra sp. exhibits an unparalleled regeneration capacity in the animal kingdom. Using an integrative transcriptomic and stable isotope labeling by amino acids in cell culture proteomic/phosphoproteomic approach, we studied stem cell-based regeneration in Hydra ...


Dissecting Molecular Evolution in the Highly Diverse Plant Clade Caryophyllales Using Transcriptome Sequencing

01.08.2015 | Ya Yang; Michael J. Moore; Samuel F. Brockington; Douglas E. Soltis; Gane Ka-Shu Wong; Eric J. Carpenter; Yong Zhang ..., Molecular Biology and Evolution, 2015

Many phylogenomic studies based on transcriptomes have been limited to "single-copy" genes due to methodological challenges in homology and orthology inferences. Only a relatively small number of studies have explored analyses beyond reconstructing species relationships. We sampled 69 ...


DEOD: uncovering dominant effects of cancer-driver genes based on a partial covariance selection method

01.08.2015 | Bayarbaatar Amgalan; Hyunju Lee, Bioinformatics, 2015

Motivation: The generation of a large volume of cancer genomes has allowed us to identify disease-related alterations more accurately, which is expected to enhance our understanding regarding the mechanism of cancer development. With genomic alterations detected, one challenge is to pinpoint ...


PRROC: computing and visualizing precision-recall and receiver operating characteristic curves in R

01.08.2015 | Jan Grau; Ivo Grosse; Jens Keilwagen, Bioinformatics, 2015

Summary: Precision-recall (PR) and receiver operating characteristic (ROC) curves are valuable measures of classifier performance. Here, we present the R-package PRROC, which allows for computing and visualizing both PR and ROC curves. In contrast to available R-packages, PRROC allows for ...


Learning chromatin states with factorized information criteria

01.08.2015 | Michiaki Hamada; Yukiteru Ono; Ryohei Fujimaki; Kiyoshi Asai, Bioinformatics, 2015

Motivation: Recent studies have suggested that both the genome and the genome with epigenetic modifications, the so-called epigenome, play important roles in various biological functions, such as transcription and DNA replication, repair, and recombination. It is well known that specific ...


YeastFab: the design and construction of standard biological parts for metabolic engineering in Saccharomyces cerevisiae

27.07.2015 | Yakun Guo; Junkai Dong; Tong Zhou; Jamie Auxillos; Tianyi Li; Weimin Zhang; Lihui Wang; Yue Shen; Yisha Luo; Yijing ..., Nucleic Acids Research, 2015

It is a routine task in metabolic engineering to introduce multicomponent pathways into a heterologous host for production of metabolites. However, this process sometimes may take weeks to months due to the lack of standardized genetic tools. Here, we present a method for the design and ...


The RAD52-like protein ODB1 is required for the efficient excision of two mitochondrial introns spliced via first-step hydrolysis

27.07.2015 | José M. Gualberto; Monique Le Ret; Barbara Beator; Kristina Kühn, Nucleic Acids Research, 2015

Transcript splicing in plant mitochondria involves numerous nucleus-encoded factors, most of which are of eukaryotic origin. Some of these belong to protein families initially characterised to perform unrelated functions. The RAD52-like ODB1 protein has been reported to have roles in homologous ...


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