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6.477 Aktuelle Fachpublikationen zum Thema Addition

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Expression of stage-specific embryonic antigen-4 (SSEA-4) defines spontaneous loss of epithelial phenotype in human solid tumor cells

01.08.2015 | Kavitha Sivasubramaniyan; Abhishek Harichandan; Karin Schilbach; Andreas F Mack; Jens Bedke; Arnulf Stenzl; Lothar K ..., Glycobiology , 2015

Stage-specific embryonic antigen-4 (SSEA-4) is a glycosphingolipid, which is overexpressed in some cancers and has been linked to disease progression. However, little is known about the functions of SSEA-4 and the characteristics of SSEA-4 expressing tumor cells. Our studies identified SSEA-4 ...


4-Methylumbelliferone inhibits hepatocellular carcinoma growth by decreasing IL-6 production and angiogenesis

01.08.2015 | Flavia Piccioni; Esteban Fiore; Juan Bayo; Catalina Atorrasagasti; Estanislao Peixoto; Manglio Rizzo; Mariana Malvic ..., Glycobiology , 2015

Cirrhosis is characterized by an excessive accumulation of extracellular matrix components including hyaluronic acid (HA) and is widely considered a preneoplastic condition for hepatocellular carcinoma (HCC). 4-Methylumbelliferone (4MU) is an inhibitor of HA synthesis and has anticancer activity ...


Metallome of Pseudomonas aeruginosa: a role for siderophores

03.07.2015 | Olivier Cunrath, Valérie A. Geoffroy, Isabelle J. Schalk, Environmental Microbiology, 2015

ABSTRACT In this paper, we describe the total metal composition (metallome) of P. aeruginosa. ICP‐AES (inductively coupled plasma atomic emission spectroscopy) analyses showed that P. aeruginosa cells concentrate each metal of the metallome from the extracellular media with different ...


Genome wide association mapping of time‐dependent growth responses to moderate drought stress in Arabidopsis

03.07.2015 | Johanna A. Bac‐Molenaar, Christine Granier, Joost J. B. Keurentjes, Dick Vreugdenhil, Plant, Cell & Environment, 2015

ABSTRACT Large areas of arable land are often confronted with irregular rainfall resulting in limited water availability for part(s) of the growing seasons, which demands research for drought tolerance of plants. Natural variation was observed for biomass accumulation upon controlled moderate ...


Near infrared in vivo flow cytometry for tracking fluorescent circulating cells

02.07.2015 | Yuanzhen Suo, Tao Liu, Chengying Xie, Dan Wei, Xu Tan, Liao Wu, Xiaoling Wang, Hao He, Guohua Shi, Xunbin Wei, Chunm ..., Cytometry Part A, 2015

Abstract The in vivo flow cytometry (IVFC) is now a powerful technique in biomedical research, especially for tracking specific cells in circulatory system. The current fluorescence‐based IVFC is limited to visible spectrum, while near infrared (NIR) dyes have their advantages, such as deeper ...


Sialidases as regulators of bioengineered cellular surfaces

01.07.2015 | Cristina Y Zamora; Matthew J Ryan; Marc d'Alarcao; Krishna Kumar, Glycobiology , 2015

Human sialidases (NEUs) catalyze the removal of N-acetyl neuraminic acids from the glycome of the cell and regulate a diverse repertoire of nominal cellular functions, such as cell signaling and adhesion. A greater understanding of their substrate permissivity is of interest in order to discern ...


Heparosan-glucuronate 5-epimerase: Molecular cloning and characterization of a novel enzyme

01.07.2015 | Hideo Mochizuki; Kiwamu Yamagishi; Kiyoshi Suzuki; Yeong Shik Kim; Koji Kimata, Glycobiology , 2015

Iduronic acid (IdoA) is a critical component of heparan sulfate in its interaction with functional proteins. Heparosan-N-sulfate-glucuronate 5-epimerase (HNSG-5epi) converts d-glucuronic acid (GlcA) residues in N-sulfated heparosan (NS-heparosan), as an intermediate in heparan sulfate ...


Matriglycan: a novel polysaccharide that links dystroglycan to the basement membrane

01.07.2015 | Takako Yoshida-Moriguchi; Kevin P Campbell, Glycobiology , 2015

Associations between cells and the basement membrane are critical for a variety of biological events including cell proliferation, cell migration, cell differentiation and the maintenance of tissue integrity. Dystroglycan is a highly glycosylated basement membrane receptor, and is involved in ...


Multispecies Analysis of Expression Pattern Diversification in the Recently Expanded Insect Ly6 Gene Family

01.07.2015 | Kohtaro Tanaka; Yoan Diekmann; Alexis Hazbun; Assia Hijazi; Barbara Vreede; Fernando Roch; Élio Sucena, Molecular Biology and Evolution, 2015

Gene families often consist of members with diverse expression domains reflecting their functions in a wide variety of tissues. However, how the expression of individual members, and thus their tissue-specific functions, diversified during the course of gene family expansion is not well ...


miR-125a-3p targets MTA1 to suppress NSCLC cell proliferation, migration, and invasion

01.07.2015 | Hong Zhang; Xiaoxia Zhu; Na Li; Dianhe Li; Zhou Sha; Xiaokang Zheng; Haofei Wang, Acta Biochimica et Biophysica Sinica, 2015

Metastasis-associated gene 1 (MTA1) is associated with cell growth, metastasis, and survival in non-small-cell lung cancer (NSCLC). Several previous reports have demonstrated that microRNAs affect gene expression through interaction between their seed region and the 3'-untranslated region of the ...


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