01.06.2013 | Koji Yahara; Yoshikazu Furuta; Kenshiro Oshima; Masaru Yoshida; Takeshi Azuma; Masahira Hattori; Ikuo Uchiyama; Ichi ..., Molecular Biology and Evolution, 2013

Identifying population structure forms an important basis for genetic and evolutionary studies. Most current methods to identify population structure have limitations in analyzing haplotypes and recombination across the genome. Recently, a method of chromosome painting in silico has been ...

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01.06.2013 | Yann Lesecque; Dominique Mouchiroud; Laurent Duret, Molecular Biology and Evolution, 2013

GC-biased gene conversion (gBGC) is a process associated with recombination that favors the transmission of GC alleles over AT alleles during meiosis. gBGC plays a major role in genome evolution in many eukaryotes. However, the molecular mechanisms of gBGC are still unknown. Different steps ...

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01.06.2013 | Timothy G. Vaughan; Alexei J. Drummond, Molecular Biology and Evolution, 2013

In this article, we present a versatile new software tool for the simulation and analysis of stochastic models of population phylodynamics and chemical kinetics. Models are specified via an expressive and human-readable XML format and can be used as the basis for generating either single ...

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01.06.2013 | Patrick C. Brunner; Stefano F.F. Torriani; Daniel Croll; Eva H. Stukenbrock; Bruce A. McDonald, Molecular Biology and Evolution, 2013

Zymoseptoria tritici is an important fungal pathogen on wheat that originated in the Fertile Crescent. Its closely related sister species Z. pseudotritici and Z. ardabiliae infect wild grasses in the same region. This recently emerged host–pathogen system provides a rare opportunity to ...

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01.06.2013 | Danielle L Aldredge; Maria R Geronimo; Serenus Hua; Charles C Nwosu; Carlito B Lebrilla; Daniela Barile, Glycobiology , 2013

Bovine milk oligosaccharides (BMOs) are recognized by the dairy and food industries, as well as by infant formula manufacturers, as novel, high-potential bioactive food ingredients. Recent studies revealed that bovine milk contains complex oligosaccharides structurally related to those ...

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01.06.2013 | Alison C MacKinnon; Xiaojun Liu; Patrick WF Hadoke; Mark R Miller; David E Newby; Tariq Sethi, Glycobiology , 2013

Atherosclerosis is a major risk factor for cardiovascular disease (CVD) and stroke. Galectin-3 is a carbohydrate-binding lectin implicated in the pathophysiology of CVD and is highly expressed within atherosclerotic lesions in mice and humans. The object of this present study was to use ...

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01.06.2013 | Shui-Hua Wang; Chih-Ming Tsai; Kuo-I Lin; Kay-Hooi Khoo, Glycobiology , 2013

The occurrence of a terminal disialyl motif on mammalian O-glycans is increasingly being identified through recent mass spectrometry (MS)-based glycomic profiling. In most cases, it is carried on simple core 1 structures in which both the galactose and N-acetyl galactosamine can be ...

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01.06.2013 | David W Scott; Rakesh P Patel, Glycobiology , 2013

Inflammation is a major contributing element to a host of diseases with the interaction between leukocytes and the endothelium being key in this process. Much is understood about the nature of the adhesion molecule proteins expressed on any given leukocyte and endothelial cell that modulates ...

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01.06.2013 | Xinping Yue; Jingning Lu; Linda Auduong; Mark D Sides; Joseph A Lasky, Glycobiology , 2013

Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-β1 (TGF-β1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-β1 and that TGF-β1 induces the expression of Sulf1 as well as ...

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01.06.2013 | Masahiko Yabu; Hiroaki Korekane; Koji Hatano; Yasufumi Kaneda; Norio Nonomura; Chihiro Sato; Ken Kitajima; Yasuhide ..., Glycobiology , 2013

We previously reported on the accumulation of a substantial amount of free N-acetylneuraminic acid (Neu5Ac)-containing complex-type N-glycans in human pancreatic cancer cells (Yabu M, Korekane H, Takahashi H, Ohigashi H, Ishikawa O, Miyamoto Y. 2013. Accumulation of free Neu5Ac-containing ...

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