26.11.2012 | Kai Schönig, Sabine Freundlieb, Manfred Gossen, Transgenic Research, 2012

Here we introduce the “Tet-Transgenic Rodents” database, documenting most of the published Tet-transgenic mouse lines generated in the past 2 decades. Aside from the >500 mouse lines listed, it also includes the first of the recently reported Tet-transgenic rat models. Since the Tet ...

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26.11.2012 | Kenneth Cornetta, Kimberly Tessanne, Charles Long, Jing Yao, Carey Satterfield, Mark Westhusin, Transgenic Research, 2012

The safety of HIV-1 based vectors was evaluated during the production of transgenic sheep. Vectors were introduced into the perivitelline space of in vivo derived one-cell sheep embryos by microinjection then transferred into the oviducts of recipient females. At 60–70 days of gestation, a ...

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06.11.2012 | A. Wiśniewska, J. Dąbrowska-Bronk, K. Szafrański, S. Fudali, M. Święcicka, M. Czarny, A. Wilkowska, K. Morgiewicz, J ..., Transgenic Research, 2012

The potato cyst nematode (Globodera rostochiensis) induces feeding sites (syncytia) in tomato and potato roots. In a previous study, 135 tomato genes up-regulated during G. rostochiensis migration and syncytium development were identified. Five genes (CYP97A29, DFR, FLS, NIK and PMEI) were ...

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05.11.2012 | Cerrone Cabanos, Atsushi Ekyo, Yoshiki Amari, Naoki Kato, Masaharu Kuroda, Satoshi Nagaoka, Fumio Takaiwa, Shigeru U ..., Transgenic Research, 2012

Hypercholesterolemia, a form of cardiovascular disease, is one of the leading causes of deaths worldwide. Lactostatin (Ile-Ile-Ala-Glu-Lys), derived from β-lactoglobulin in cow’s milk, is a bioactive peptide with hypocholesterolemic activity higher than sitosterol, a known ...

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02.11.2012 | Wataru Kimura, Mohammad Tofael Kabir Sharkar, Nishat Sultana, Mohammod Johirul Islam, Tadayoshi Uezato, Naoyuki Miura, Transgenic Research, 2012

Thymus development is a complicated process that includes highly dynamic morphological changes and reciprocal tissue interactions between endoderm-derived epithelial cells of the anterior foregut and neural crest-derived mesenchymal cells. We generated and characterized a Tbx1-AmCyan1 ...

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02.11.2012 | Götz Laible, Scott C. Fahrenkrug, Transgenic Research, 2012

UC Davis transgenic animal research conference VIII Content Type Journal Article Category Meeting Report Pages 1-2 DOI 10.1007/s11248-012-9670-7 Authors Götz Laible, AgResearch, Ruakura Research Centre, Hamilton, 3240 New Zealand Scott C. Fahrenkrug, Center for Genome ...

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31.10.2012 | Jannik Ejnar Jakobsen, Marianne G. Johansen, Mette Schmidt, Frederik Dagnæs-Hansen, Karen Dam, Anders Gunnarsson, Yi ..., Transgenic Research, 2012

Targeted transgenesis using site-specific recombinases is an attractive method to create genetically modified animals as it allows for integration of the transgene in a pre-selected transcriptionally active genomic site. Here we describe the application of recombinase-mediated cassette ...

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30.10.2012 | Sumitaka Hasegawa, Kazutoshi Harada, Yukie Morokoshi, Satoshi Tsukamoto, Takako Furukawa, Tsuneo Saga, Transgenic Research, 2012

H-ferritin (HF) is a core subunit of the iron storage protein ferritin, and plays a central role in the regulation of cellular iron homeostasis. Recent studies revealed that ferritin and HF are involved in a wide variety of iron-independent functions, including regulating biological processes ...

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29.10.2012 | Simone Grasso, Chiara Lico, Francesca Imperatori, Luca Santi, Transgenic Research, 2012

Structure, size, physicochemical properties and production strategies make many plant viruses ideal protein based nanoscaffolds, nanocontainers and nano-building blocks expected to deliver a multitude of applications in different fields such as biomedicine, pharmaceutical chemistry, ...

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19.10.2012 | Shivakumar Pattada Devaiah, Deborah Vicuna Requesens, Yeun-Kyung Chang, Kendall R. Hood, Ashley Flory, John A. Howar ..., Transgenic Research, 2012

The technology of converting lignocellulose to biofuels has advanced swiftly over the past few years, and enzymes are a significant constituent of this technology. In this regard, cost effective production of cellulases has been the focus of research for many years. One approach to reach cost ...

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