01.02.2011 | Han, Mee‐Jung; Lee, Jeong Wook; Lee, Sang Yup, PROTEOMICS, 2011

Abstract The abilities of microorganisms to produce a wide variety of products ranging from human therapeutics to chemicals and to tolerate or detoxify exogenous stresses such as toxic compounds and pollutants are of great importance in fundamental and applied research. Proteomics has ...

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01.02.2011 | Hughes, Chris S.; Nuhn, Amelia A.; Postovit, Lynne M.; Lajoie, Gilles A., PROTEOMICS, 2011

Abstract Human embryonic stem cells (hESCs) offer exciting potential in regenerative medicine for the treatment of a host of diseases including cancer, Alzheimer's and Parkinson's disease. They also provide insight into human development and disease and can be used as models for drug ...

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01.02.2011 | Klein, Julie; Kavvadas, Panagiotis; Prakoura, Niki; Karagianni, Fani; Schanstra, Joost P.; Bascands, Jean‐Lou ..., PROTEOMICS, 2011

Abstract Chronic kidney disease (CKD) is the end‐point of a number of renal and systemic diseases. The high incidence and financial burden of CKD makes it imperative to diagnose CKD at early stages when therapeutic interventions are far more effective. A key component of CKD is the ...

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01.02.2011 | Skalnikova, Helena; Motlik, Jan; Gadher, Suresh Jivan; Kovarova, Hana, PROTEOMICS, 2011

Abstract Within a mammalian organism, the interaction among cells both at short and long distances is mediated by soluble factors released by cells into the extracellular environment. The secreted proteins may involve extracellular matrix proteins, proteinases, growth factors, protein ...

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01.02.2011 | Mischerikow, Nikolai; Heck, Albert J. R., PROTEOMICS, 2011

Abstract Protein modifications are biologically important events that may be studied by mass spectrometry based high‐throughput proteome analyses. In recent years, several new technologies have emerged that have widened and deepened the targeted analysis of one important, albeit ...

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01.02.2011 | Prokudin, Ivan; Stasyk, Taras; Rainer, Johannes; Bonn, Guenther K.; Kofler, Reinhard; Huber, Lukas A., PROTEOMICS, 2011

Abstract Scaffold proteins regulate intracellular MAP kinase signaling by providing critical spatial and temporal specificity. We have shown previously that the scaffold protein MEK1 partner (MP1) is localized to late endosomes by the adaptor protein p14. Using conditional gene disruption ...

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01.02.2011 | Schmitz‐Spanke, Simone; Rettenmeier, Albert W., PROTEOMICS, 2011

Abstract The simultaneous analysis of a wide array of proteins may provide valuable information on the activation and suppression of cellular systems at different stages of the exposure‐disease continuum. In this review, results of proteomic studies in the field of toxicology are covered, ...

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01.02.2011 | Casado‐Vela, Juan; Cebrián, Arancha; Gómez del Pulgar, Maria Teresa; Sánchez‐L&oa ..., PROTEOMICS, 2011

Abstract Recent reviews pinpointed the enormous diversity of proteins found in living organisms, especially in higher eukaryotes. Protein diversity is driven through three main processes: first, at deoxyribonucleic acid (DNA) level (i.e. gene polymorphisms), second, at precursor messenger ...

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01.02.2011 | Hahn, Bettina; Böhm, Martin; Raia, Valentina; Zinn, Nico; Möller, Peter; Klingmüller, Ursula; Lehmann ..., PROTEOMICS, 2011

Abstract Reversible protein phosphorylation is a key mediator for intracellular signal transduction. Here we report an innovative method for accurate, site‐specific protein phosphorylation degree determination by nanoLC‐ESI‐MS/MS. A stable isotope‐labeled pair of peptide/phosphopeptide ...

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01.02.2011 | Dowling, Paul; Clynes, Martin, PROTEOMICS, 2011

Abstract In the strictest sense, the cell secretome (conditioned media) refers to the collection of proteins that contain a signal peptide and are processed via the endoplasmic reticulum and Golgi apparatus through the classical secretion pathway. More generally, the secretome also ...

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