10.05.2013 | Sofía Fraile, Jose I. Jiménez, Carlos Gutiérrez, Víctor Lorenzo, PROTEOMICS, 2013

The presence of given antigens in environmental samples (e.g. biodegradative enzymes) report the quality and catalytic vigor of particular soils or aquatic ecosystems. In this context, we have developed the NanoPad system, consisting of a complete platform for isolation, amplification and ...

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10.05.2013 | Serena Tolin, Giorgio Arrigoni, Anna Rita Trentin, Sonja Veljovic‐Jovanovic, Micaela Pivato, B. Zechman, Antonio Masi, PROTEOMICS, 2013

The existence of a gamma‐glutamyl cycle consisting of intracellular GSH synthesis, extrusion to the apoplastic space and recovery by gamma‐glutamyl transferase (GGT)‐assisted degradation into its constituent amino acids, has been demonstrated in plants. To address the significance of this ...

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10.05.2013 | Dawei Liu, Kristina L. Ford, Ute Roessner, Siria Natera, Andrew M. Cassin, John H. Patterson, Antony Bacic, PROTEOMICS, 2013

Salinity is one of the major abiotic stresses affecting plant productivity but surprisingly, a thorough understanding of the salt‐responsive networks responsible for sustaining growth and maintaining crop yield remains a significant challenge. Rice suspension culture cells (SCCs), a single ...

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03.05.2013 | L. Renee Ruhaak, Uyen Thao Nguyen, Carol Stroble, Sandra L. Taylor, Ayumu Taguchi, Samir M. Hanash, Carlito B. Lebri ..., PROTEOMICS, 2013

Purpose There is a need to identify better glycan biomarkers for diagnosis, early detection and treatment monitoring in lung cancer using biofluids such as blood. Biofluids are complex mixtures of proteins dominated by a few high abundance proteins that may not have specificity for lung ...

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03.05.2013 | Atsushi Kuno, Takashi Sato, Hiroko Shimazaki, Sachiko Unno, Kozue Saitou, Katsue Kiyohara, Maki Sogabe, Chikayuki Ts ..., PROTEOMICS, 2013

Purpose: Wisteria floribunda agglutinin‐positive human Mac‐2 binding protein (WFA+‐hM2BP) was recently validated as a liver fibrosis glycobiomarker with a fully automated lectin‐antibody sandwich immunoassay. In this study, we supplied recombinant WFA+‐hM2BP as the standard glycoprotein and ...

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03.05.2013 | Ronald J. Copeland, Guanghui Han, Gerald W. Hart, PROTEOMICS, 2013

O‐linked‐β‐N‐acetylglucosamine (O‐GlcNAc) is a dynamic post‐translational modification of the 3′‐hydroxyl groups of serine or threonine residues of nuclear, cytoplasmic, and mitochondrial proteins. The cycling of this modification is regulated in response to nutrients, stress, and other ...

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03.05.2013 | Koji Ueda, PROTEOMICS, 2013

Carbohydrate antigens are the most frequently and traditionally used biomarkers for cancer, such as CA19–9, CA125, DUPAN‐II, AFP‐L3, and many others. The diagnostic potential of them was simply based on the cancer‐specific alterations of glycan structures on particular glycoproteins in ...

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02.05.2013 | Jean Armengaud, Erica Marie Hartmann, Céline Bland, PROTEOMICS, 2013

Proteogenomics sensu stricto refers to the use of proteomic data to refine the annotation of genomes from model organisms. Because of the limitations of automatic annotation pipelines, a relatively high number of errors occur during the structural annotation of genes coding for proteins. ...

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02.05.2013 | Lennart Martens, PROTEOMICS, 2013

Proteomics has fast become a standard tool in the life sciences, with increasingly sophisticated approaches and instruments delivering ever growing numbers of identified and quantified proteins. Yet despite the enormous technological progress, and the triumphant papers published on ...

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27.04.2013 | Hajo Zech, Michael Hensler, Sebastian Koßmehl, Katharina Drüppel, Lars Wöhlbrand, Kathleen Trautwein, Thomas Colby, ..., PROTEOMICS, 2013

Time‐resolved utilization of multiple amino acids by Phaeobacter inhibens DSM 17395 was studied during growth with casamino acids. The 15 detected amino acids could be grouped according to depletion rate into four different categories, i.e. from rapid (category I) to non‐depletion (category ...

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