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1.541 Aktuelle Fachpublikationen in PLoS Pathogens

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Glycosaminoglycans and Sialylated Glycans Sequentially Facilitate Merkel Cell Polyomavirus Infectious Entry

29.07.2011 | Rachel M. Schowalter et al., PLoS Pathogens, 2011

by Rachel M. Schowalter, Diana V. Pastrana, Christopher B. Buck Merkel cell polyomavirus (MCV or MCPyV) appears to be a causal factor in the development of Merkel cell carcinoma, a rare but highly lethal form of skin cancer. Although recent reports indicate that MCV virions are ...

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C-Terminal Region of EBNA-2 Determines the Superior Transforming Ability of Type 1 Epstein-Barr Virus by Enhanced Gene Regulation of LMP-1 and CXCR7

29.07.2011 | Laila Cancian et al., PLoS Pathogens, 2011

by Laila Cancian, Rachel Bosshard, Walter Lucchesi, Claudio Elgueta Karstegl, Paul J. Farrell Type 1 Epstein-Barr virus (EBV) strains immortalize B lymphocytes in vitro much more efficiently than type 2 EBV, a difference previously mapped to the EBNA-2 locus. Here we demonstrate ...

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Structural Basis of Chemokine Sequestration by CrmD, a Poxvirus-Encoded Tumor Necrosis Factor Receptor

29.07.2011 | Xiaoguang Xue et al., PLoS Pathogens, 2011

by Xiaoguang Xue, Qingyu Lu, Hui Wei, Dongli Wang, Dongwei Chen, Guangjun He, Li Huang, Hanzhong Wang, Xinquan Wang Pathogens have evolved sophisticated mechanisms to evade detection and destruction by the host immune system. Large DNA viruses encode homologues of chemokines and ...

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Transformation of Natural Genetic Variation into Haemophilus Influenzae Genomes

29.07.2011 | Joshua Chang Mell et al., PLoS Pathogens, 2011

by Joshua Chang Mell, Svetlana Shumilina, Ira M. Hall, Rosemary J. Redfield Many bacteria are able to efficiently bind and take up double-stranded DNA fragments, and the resulting natural transformation shapes bacterial genomes, transmits antibiotic resistance, and allows escape ...

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Elevated 17β-Estradiol Protects Females from Influenza A Virus Pathogenesis by Suppressing Inflammatory Responses

29.07.2011 | Dionne P. Robinson et al., PLoS Pathogens, 2011

by Dionne P. Robinson, Maria E. Lorenzo, William Jian, Sabra L. Klein Studies of the 1918 H1N1 influenza pandemic, the H5N1 avian influenza outbreak, and the 2009 H1N1 pandemic illustrate that sex and pregnancy contribute to severe outcome from infection, suggesting a role for sex ...

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A Permeable Cuticle Is Associated with the Release of Reactive Oxygen Species and Induction of Innate Immunity

29.07.2011 | Floriane L'Haridon et al., PLoS Pathogens, 2011

by Floriane L'Haridon, Angélique Besson-Bard, Matteo Binda, Mario Serrano, Eliane Abou-Mansour, Francine Balet, Henk-Jan Schoonbeek, Stephane Hess, Ricardo Mir, José Léon, Olivier Lamotte, Jean-Pierre Métraux Wounded leaves of Arabidopsis thaliana show transient immunity to ...

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Multiple Translocation of the AVR-Pita Effector Gene among Chromosomes of the Rice Blast Fungus Magnaporthe oryzae and Related Species

29.07.2011 | Izumi Chuma et al., PLoS Pathogens, 2011

by Izumi Chuma, Chihiro Isobe, Yuma Hotta, Kana Ibaragi, Natsuru Futamata, Motoaki Kusaba, Kentaro Yoshida, Ryohei Terauchi, Yoshikatsu Fujita, Hitoshi Nakayashiki, Barbara Valent, Yukio Tosa Magnaporthe oryzae is the causal agent of rice blast disease, a devastating problem ...

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Novel Chikungunya Vaccine Candidate with an IRES-Based Attenuation and Host Range Alteration Mechanism

29.07.2011 | Kenneth Plante et al., PLoS Pathogens, 2011

by Kenneth Plante, Eryu Wang, Charalambos D. Partidos, James Weger, Rodion Gorchakov, Konstantin Tsetsarkin, Erin M. Borland, Ann M. Powers, Robert Seymour, Dan T. Stinchcomb, Jorge E. Osorio, Ilya Frolov, Scott C. Weaver Chikungunya virus (CHIKV) is a reemerging mosquito-borne ...

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A Salmonella Typhimurium-Typhi Genomic Chimera: A Model to Study Vi Polysaccharide Capsule Function In Vivo

29.07.2011 | Angela M. Jansen et al., PLoS Pathogens, 2011

by Angela M. Jansen, Lindsay J. Hall, Simon Clare, David Goulding, Kathryn E. Holt, Andrew J. Grant, Piero Mastroeni, Gordon Dougan, Robert A. Kingsley The Vi capsular polysaccharide is a virulence-associated factor expressed by Salmonella enterica serotype Typhi but absent from ...

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“Persisters”: Survival at the Cellular Level

29.07.2011 | Clinton C. Dawson et al., PLoS Pathogens, 2011

by Clinton C. Dawson, Chaidan Intapa, Mary Ann Jabra-Rizk

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