16.05.2013 | Peter Siegert et al., PLoS Pathogens, 2013

by Peter Siegert, Gudula Schmidt, Panagiotis Papatheodorou, Thomas Wieland, Klaus Aktories, Joachim H. C. Orth The 146-kDa Pasteurella multocida toxin (PMT) is the main virulence factor to induce P. multocida-associated progressive atrophic rhinitis in various animals. PMT leads to a ...

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16.05.2013 | Barbara A. Scholz et al., PLoS Pathogens, 2013

by Barbara A. Scholz, Marie L. Harth-Hertle, Georg Malterer, Juergen Haas, Joachim Ellwart, Thomas F. Schulz, Bettina Kempkes Since Kaposi's sarcoma associated herpesvirus (KSHV) establishes a persistent infection in human B cells, B cells are a critical compartment for viral pathogenesis. ...

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16.05.2013 | Steve M. Taylor et al., PLoS Pathogens, 2013

by Steve M. Taylor, Carla Cerami, Rick M. Fairhurst Plasmodium falciparum malaria kills over 500,000 children every year and has been a scourge of humans for millennia. Owing to the co-evolution of humans and P. falciparum parasites, the human genome is imprinted with polymorphisms that ...

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16.05.2013 | Iwana Schmitz et al., PLoS Pathogens, 2013

by Iwana Schmitz, Christoph Schneider, Anja Fröhlich, Helge Frebel, Daniel Christ, Warren J. Leonard, Tim Sparwasser, Annette Oxenius, Stefan Freigang, Manfred Kopf Foxp3+ regulatory T (Treg) cells are essential for the maintenance of immune homeostasis and tolerance. During viral ...

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16.05.2013 | Yang Chen et al., PLoS Pathogens, 2013

by Yang Chen, Igor Tascón, M. Ramona Neunuebel, Chiara Pallara, Jacqueline Brady, Lisa N. Kinch, Juan Fernández-Recio, Adriana L. Rojas, Matthias P. Machner, Aitor Hierro The covalent attachment of adenosine monophosphate (AMP) to proteins, a process called AMPylation (adenylylation), has ...

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16.05.2013 | Kouichi Kitamura et al., PLoS Pathogens, 2013

by Kouichi Kitamura, Zhe Wang, Sajeda Chowdhury, Miyuki Simadu, Miki Koura, Masamichi Muramatsu The covalently closed circular DNA (cccDNA) of the hepatitis B virus (HBV) plays an essential role in chronic hepatitis. The cellular repair system is proposed to convert cytoplasmic ...

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16.05.2013 | Alexander S. Hahn et al., PLoS Pathogens, 2013

by Alexander S. Hahn, Ronald C. Desrosiers Cellular Ephrin receptor tyrosine kinases (Ephrin receptors, Ephs) were found to interact efficiently with the gH/gL glycoprotein complex of the rhesus monkey rhadinovirus (RRV). Since EphA2 was recently identified as a receptor for the Kaposi's ...

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16.05.2013 | Timothy J. LaRocca et al., PLoS Pathogens, 2013

by Timothy J. LaRocca, Priyadarshini Pathak, Salvatore Chiantia, Alvaro Toledo, John R. Silvius, Jorge L. Benach, Erwin London Lipid rafts in eukaryotic cells are sphingolipid and cholesterol-rich, ordered membrane regions that have been postulated to play roles in many membrane functions, ...

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16.05.2013 | Freda E. C. Jen et al., PLoS Pathogens, 2013

by Freda E. C. Jen, Matthew J. Warren, Benjamin L. Schulz, Peter M. Power, W. Edward Swords, Jeffery N. Weiser, Michael A. Apicella, Jennifer L. Edwards, Michael P. Jennings Pili of pathogenic Neisseria are major virulence factors associated with adhesion, twitching motility, ...

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16.05.2013 | Jonathan D. Cook et al., PLoS Pathogens, 2013

by Jonathan D. Cook, Jeffrey E. Lee

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