25.04.2013 | Haythem Latif et al., PLoS Genetics, 2013

by Haythem Latif, Joshua A. Lerman, Vasiliy A. Portnoy, Yekaterina Tarasova, Harish Nagarajan, Alexandra C. Schrimpe-Rutledge, Richard D. Smith, Joshua N. Adkins, Dae-Hee Lee, Yu Qiu, Karsten Zengler The generation of genome-scale data is becoming more routine, yet the subsequent analysis ...

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25.04.2013 | Craig P. Giacomini et al., PLoS Genetics, 2013

by Craig P. Giacomini, Steven Sun, Sushama Varma, A. Hunter Shain, Marilyn M. Giacomini, Jay Balagtas, Robert T. Sweeney, Everett Lai, Catherine A. Del Vecchio, Andrew D. Forster, Nicole Clarke, Kelli D. Montgomery, Shirley Zhu, Albert J. Wong, Matt van de Rijn, Robert B. West, Jonathan R. ...

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25.04.2013 | Samantha Wilkinson et al., PLoS Genetics, 2013

by Samantha Wilkinson, Zen H. Lu, Hendrik-Jan Megens, Alan L. Archibald, Chris Haley, Ian J. Jackson, Martien A. M. Groenen, Richard P. M. A. Crooijmans, Rob Ogden, Pamela Wiener Following domestication, livestock breeds have experienced intense selection pressures for the development of ...

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25.04.2013 | Jueng Soo You et al., PLoS Genetics, 2013

by Jueng Soo You, Daniel D. De Carvalho, Chao Dai, Minmin Liu, Kurinji Pandiyan, Xianghong J. Zhou, Gangning Liang, Peter A. Jones Nucleosome occupancy controls the accessibility of the transcription machinery to DNA regulatory regions and serves an instructive role for gene ...

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25.04.2013 | Salvador C. Herrera et al., PLoS Genetics, 2013

by Salvador C. Herrera, Raquel Martín, Ginés Morata All organisms have developed mechanisms to respond to organ or tissue damage that may appear during development or during the adult life. This process of regeneration is a major long-standing problem in Developmental Biology. We are using ...

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18.04.2013 | Nancy Maizels et al., PLoS Genetics, 2013

by Nancy Maizels, Lucas T. Gray Recent experiments provide fascinating examples of how G4 DNA and G4 RNA structures—aka quadruplexes—may contribute to normal biology and to genomic pathologies. Quadruplexes are transient and therefore difficult to identify directly in living cells, which ...

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18.04.2013 | Maria de Haro et al., PLoS Genetics, 2013

by Maria de Haro, Ismael Al-Ramahi, Karlie R. Jones, Jerrah K. Holth, Lubov T. Timchenko, Juan Botas We report the identification and characterization of a previously unknown suppressor of myopathy caused by expansion of CUG repeats, the mutation that triggers Myotonic Dystrophy Type 1 ...

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18.04.2013 | Mathieu Dalvai et al., PLoS Genetics, 2013

by Mathieu Dalvai, Laurence Fleury, Luca Bellucci, Silvia Kocanova, Kerstin Bystricky Histone variants, including histone H2A.Z, are incorporated into specific genomic sites and participate in transcription regulation. The role of H2A.Z at these sites remains poorly characterized. Our ...

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18.04.2013 | Tim Connallon et al., PLoS Genetics, 2013

by Tim Connallon, Andrew G. Clark X inactivation—the transcriptional silencing of one X chromosome copy per female somatic cell—is universal among therian mammals, yet the choice of which X to silence exhibits considerable variation among species. X inactivation strategies can range from ...

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18.04.2013 | Zhemin Zhou et al., PLoS Genetics, 2013

by Zhemin Zhou, Angela McCann, Eva Litrup, Ronan Murphy, Martin Cormican, Seamus Fanning, Derek Brown, David S. Guttman, Sylvain Brisse, Mark Achtman Salmonella enterica serovar Agona has caused multiple food-borne outbreaks of gastroenteritis since it was first isolated in 1952. We ...

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