02.05.2013 | Joel B. Berletch et al., PLoS Genetics, 2013

by Joel B. Berletch, Xinxian Deng, Di Kim Nguyen, Christine M. Disteche The Rhox cluster on the mouse X chromosome contains reproduction-related homeobox genes expressed in a sexually dimorphic manner. We report that two members of the Rhox cluster, Rhox6 and 9, are regulated by ...

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02.05.2013 | Harm van Bakel et al., PLoS Genetics, 2013

by Harm van Bakel, Kyle Tsui, Marinella Gebbia, Sanie Mnaimneh, Timothy R. Hughes, Corey Nislow Nucleosomes in all eukaryotes examined to date adopt a characteristic architecture within genes and play fundamental roles in regulating transcription, yet the identity and precise roles of many ...

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02.05.2013 | Isabelle Vallet-Gely et al., PLoS Genetics, 2013

by Isabelle Vallet-Gely, Frédéric Boccard The study of chromosomal organization and segregation in a handful of bacteria has revealed surprising variety in the mechanisms mediating such fundamental processes. In this study, we further emphasized this diversity by revealing an original ...

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02.05.2013 | Eva Bjur et al., PLoS Genetics, 2013

by Eva Bjur, Ola Larsson, Ekaterina Yurchenko, Lei Zheng, Valentina Gandin, Ivan Topisirovic, Shui Li, Carston R. Wagner, Nahum Sonenberg, Ciriaco A. Piccirillo Regulatory T cells expressing the transcription factor Foxp3 play indispensable roles for the induction and maintenance of ...

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02.05.2013 | Yaser Atlasi et al., PLoS Genetics, 2013

by Yaser Atlasi, Rubina Noori, Claudia Gaspar, Patrick Franken, Andrea Sacchetti, Haleh Rafati, Tokameh Mahmoudi, Charles Decraene, George A. Calin, Bradley J. Merrill, Riccardo Fodde Canonical Wnt signaling plays a rate-limiting role in regulating self-renewal and differentiation in mouse ...

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02.05.2013 | Tamara M. Stawicki et al., PLoS Genetics, 2013

by Tamara M. Stawicki, Seika Takayanagi-Kiya, Keming Zhou, Yishi Jin Neuropeptides play crucial roles in modulating neuronal networks, including changing intrinsic properties of neurons and synaptic efficacy. We previously reported a Caenorhabditis elegans mutant, acr-2(gf), that displays ...

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25.04.2013 | Aurélie Kapusta et al., PLoS Genetics, 2013

by Aurélie Kapusta, Zev Kronenberg, Vincent J. Lynch, Xiaoyu Zhuo, LeeAnn Ramsay, Guillaume Bourque, Mark Yandell, Cédric Feschotte Advances in vertebrate genomics have uncovered thousands of loci encoding long noncoding RNAs (lncRNAs). While progress has been made in elucidating the ...

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25.04.2013 | Barbara Piasecka et al., PLoS Genetics, 2013

by Barbara Piasecka, Paweł Lichocki, Sébastien Moretti, Sven Bergmann, Marc Robinson-Rechavi Developmental constraints have been postulated to limit the space of feasible phenotypes and thus shape animal evolution. These constraints have been suggested to be the strongest during ...

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25.04.2013 | Henner F. Farin et al., PLoS Genetics, 2013

by Henner F. Farin, Timo H-W. Lüdtke, Martina K. Schmidt, Susann Placzko, Karin Schuster-Gossler, Marianne Petry, Vincent M. Christoffels, Andreas Kispert Vertebrate limb outgrowth is driven by a positive feedback loop that involves Sonic hedgehog (Shh) and Gremlin1 (Grem1) in the ...

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25.04.2013 | Kaixiang Cao et al., PLoS Genetics, 2013

by Kaixiang Cao, Nathalie Lailler, Yunzhe Zhang, Ashwath Kumar, Karan Uppal, Zheng Liu, Eva K. Lee, Hongwei Wu, Magdalena Medrzycki, Chenyi Pan, Po-Yi Ho, Guy P. Cooper, Xiao Dong, Christoph Bock, Eric E. Bouhassira, Yuhong Fan H1 linker histones facilitate higher-order chromatin ...

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