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3.029 Aktuelle Fachpublikationen in PLoS Genetics

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Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling

20.08.2015 | Suresh Marada et al., PLoS Genetics, 2015

by Suresh Marada, Gemma Navarro, Ashley Truong, Daniel P. Stewart, Angela M. Arensdorf, Sigrid Nachtergaele, Edgar Angelats, Joseph T. Opferman, Rajat Rohatgi, Peter J. McCormick, Stacey K. Ogden The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the ...


The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells

20.08.2015 | Naomi Levy-Strumpf et al., PLoS Genetics, 2015

by Naomi Levy-Strumpf, Meghan Krizus, Hong Zheng, Louise Brown, Joseph G. Culotti Wnt and Netrin signaling regulate diverse essential functions. Using a genetic approach combined with temporal gene expression analysis, we found a regulatory link between the Wnt receptor MOM-5/Frizzled and the ...


Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development

19.08.2015 | Yu Hasegawa et al., PLoS Genetics, 2015

by Yu Hasegawa, Deanne Taylor, Dmitry A. Ovchinnikov, Ernst J. Wolvetang, Laurence de Torrenté, Jessica C. Mar An analysis of gene expression variability can provide an insightful window into how regulatory control is distributed across the transcriptome. In a single cell analysis, the ...


In Vivo Evidence for Lysosome Depletion and Impaired Autophagic Clearance in Hereditary Spastic Paraplegia Type SPG11

18.08.2015 | Rita-Eva Varga et al., PLoS Genetics, 2015

by Rita-Eva Varga, Mukhran Khundadze, Markus Damme, Sandor Nietzsche, Birgit Hoffmann, Tobias Stauber, Nicole Koch, J. Christopher Hennings, Patricia Franzka, Antje K. Huebner, Michael M. Kessels, Christoph Biskup, Thomas J. Jentsch, Britta Qualmann, Thomas Braulke, Ingo Kurth, Christian Beetz, ...


Correction: Exome Sequencing of Phenotypic Extremes Identifies CAV2 and TMC6 as Interacting Modifiers of Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis

18.08.2015 | Mary J. Emond et al., PLoS Genetics, 2015

by Mary J. Emond, Tin Louie, Julia Emerson, Jessica X. Chong, Rasika A. Mathias, Michael R. Knowles, Mark J. Rieder, Holly K. Tabor, Debbie A. Nickerson, Kathleen C. Barnes, NHLBI GO Exome Sequencing Project , Lung GO, Ronald L. Gibson, Michael J. Bamshad


Strong Selective Sweeps on the X Chromosome in the Human-Chimpanzee Ancestor Explain Its Low Divergence

14.08.2015 | Julien Y. Dutheil et al., PLoS Genetics, 2015

by Julien Y. Dutheil, Kasper Munch, Kiwoong Nam, Thomas Mailund, Mikkel H. Schierup The human and chimpanzee X chromosomes are less divergent than expected based on autosomal divergence. We study incomplete lineage sorting patterns between humans, chimpanzees and gorillas to show that this low ...


Runx1 Transcription Factor Is Required for Myoblasts Proliferation during Muscle Regeneration

14.08.2015 | Kfir Baruch Umansky et al., PLoS Genetics, 2015

by Kfir Baruch Umansky, Yael Gruenbaum-Cohen, Michael Tsoory, Ester Feldmesser, Dalia Goldenberg, Ori Brenner, Yoram Groner Following myonecrosis, muscle satellite cells proliferate, differentiate and fuse, creating new myofibers. The Runx1 transcription factor is not expressed in naïve ...


Cyclin G Functions as a Positive Regulator of Growth and Metabolism in Drosophila

14.08.2015 | Patrick Fischer et al., PLoS Genetics, 2015

by Patrick Fischer, Martina K. La Rosa, Adriana Schulz, Anette Preiss, Anja C. Nagel In multicellular organisms, growth and proliferation is adjusted to nutritional conditions by a complex signaling network. The Insulin receptor/target of rapamycin (InR/TOR) signaling cascade plays a pivotal ...


Satellite DNA Modulates Gene Expression in the Beetle Tribolium castaneum after Heat Stress

14.08.2015 | Isidoro Feliciello et al., PLoS Genetics, 2015

by Isidoro Feliciello, Ivana Akrap, Đurđica Ugarković Non-coding repetitive DNAs have been proposed to perform a gene regulatory role, however for tandemly repeated satellite DNA no such role was defined until now. Here we provide the first evidence for a role of satellite DNA in the modulation ...


SHOEBOX Modulates Root Meristem Size in Rice through Dose-Dependent Effects of Gibberellins on Cell Elongation and Proliferation

14.08.2015 | Jintao Li et al., PLoS Genetics, 2015

by Jintao Li, Yu Zhao, Huangwei Chu, Likai Wang, Yanru Fu, Ping Liu, Narayana Upadhyaya, Chunli Chen, Tongmin Mou, Yuqi Feng, Prakash Kumar, Jian Xu Little is known about how the size of meristem cells is regulated and whether it participates in the control of meristem size in plants. Here, we ...


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