09.05.2013 | Jakob Gramstrup Petersen et al., PLoS Genetics, 2013

by Jakob Gramstrup Petersen, Teresa Rojo Romanos, Vaida Juozaityte, Alba Redo Riveiro, Ingrid Hums, Lisa Traunmüller, Manuel Zimmer, Roger Pocock Animals harbor specialized neuronal systems that are used for sensing and coordinating responses to changes in oxygen (O2) and carbon dioxide ...

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09.05.2013 | Petra Bulankova et al., PLoS Genetics, 2013

by Petra Bulankova, Svetlana Akimcheva, Nicole Fellner, Karel Riha Meiosis is a modified cell division in which a single S-phase is followed by two rounds of chromosome segregation resulting in the production of haploid gametes. The meiotic mode of chromosome segregation requires extensive ...

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09.05.2013 | Nazareth Bastajian et al., PLoS Genetics, 2013

by Nazareth Bastajian, Helena Friesen, Brenda J. Andrews The Bck2 protein is a potent genetic regulator of cell-cycle-dependent gene expression in budding yeast. To date, most experiments have focused on assessing a potential role for Bck2 in activation of the G1/S-specific transcription ...

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09.05.2013 | Pierre-Étienne Jacques et al., PLoS Genetics, 2013

by Pierre-Étienne Jacques, Justin Jeyakani, Guillaume Bourque Although emerging evidence suggests that transposable elements (TEs) have contributed novel regulatory elements to the human genome, their global impact on transcriptional networks remains largely uncharacterized. Here ...

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09.05.2013 | Clément Monot et al., PLoS Genetics, 2013

by Clément Monot, Monika Kuciak, Sébastien Viollet, Ashfaq Ali Mir, Caroline Gabus, Jean-Luc Darlix, Gaël Cristofari L1 retrotransposons have a prominent role in reshaping mammalian genomes. To replicate, the L1 ribonucleoprotein particle (RNP) first uses its endonuclease (EN) to nick the ...

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09.05.2013 | Shane Woods et al., PLoS Genetics, 2013

by Shane Woods, Avril Coghlan, David Rivers, Tobias Warnecke, Sean J. Jeffries, Taejoon Kwon, Anthony Rogers, Laurence D. Hurst, Julie Ahringer When a duplicate gene has no apparent loss-of-function phenotype, it is commonly considered that the phenotype has been masked as a result of ...

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09.05.2013 | Timothée Flutre et al., PLoS Genetics, 2013

by Timothée Flutre, Xiaoquan Wen, Jonathan Pritchard, Matthew Stephens Mapping expression Quantitative Trait Loci (eQTLs) represents a powerful and widely adopted approach to identifying putative regulatory variants and linking them to specific genes. Up to now eQTL studies have been ...

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09.05.2013 | Andrew D. Beggs et al., PLoS Genetics, 2013

by Andrew D. Beggs, Angela Jones, Neil Shepherd, Abed Arnaout, Caroline Finlayson, A. Muti Abulafi, Dion G. Morton, Glenn M. Matthews, Shirley V. Hodgson, Ian P. M. Tomlinson Serrated adenomas form a distinct subtype of colorectal pre-malignant lesions that may progress to ...

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09.05.2013 | Leticia Labrador et al., PLoS Genetics, 2013

by Leticia Labrador, Consuelo Barroso, James Lightfoot, Thomas Müller-Reichert, Stephane Flibotte, Jon Taylor, Donald G. Moerman, Anne M. Villeneuve, Enrique Martinez-Perez Pairing of homologous chromosomes during early meiosis is essential to prevent the formation of aneuploid gametes. ...

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09.05.2013 | Benjamin Georgi et al., PLoS Genetics, 2013

by Benjamin Georgi, Benjamin F. Voight, Maja Bućan Understanding the core set of genes that are necessary for basic developmental functions is one of the central goals in biology. Studies in model organisms identified a significant fraction of essential genes through the analysis of ...

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