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2.690 Aktuelle Fachpublikationen in PLoS Genetics

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Linking Aβ42-Induced Hyperexcitability to Neurodegeneration, Learning and Motor Deficits, and a Shorter Lifespan in an Alzheimer’s Model

16.03.2015 | Yong Ping et al., PLoS Genetics, 2015

by Yong Ping, Eu-Teum Hahm, Girma Waro, Qian Song, Dai-An Vo-Ba, Ashley Licursi, Han Bao, Logan Ganoe, Kelly Finch, Susan Tsunoda Alzheimer’s disease (AD) is the most prevalent form of dementia in the elderly. β-amyloid (Aβ) accumulation in the brain is thought to be a primary event leading to ...

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The ATM Signaling Cascade Promotes Recombination-Dependent Pachytene Arrest in Mouse Spermatocytes

13.03.2015 | Sarai Pacheco et al., PLoS Genetics, 2015

by Sarai Pacheco, Marina Marcet-Ortega, Julian Lange, Maria Jasin, Scott Keeney, Ignasi Roig Most mutations that compromise meiotic recombination or synapsis in mouse spermatocytes result in arrest and apoptosis at the pachytene stage of the first meiotic prophase. Two main mechanisms are ...

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Clonality and Evolutionary History of Rhabdomyosarcoma

13.03.2015 | Li Chen et al., PLoS Genetics, 2015

by Li Chen, Jack F. Shern, Jun S. Wei, Marielle E. Yohe, Young K. Song, Laura Hurd, Hongling Liao, Daniel Catchpoole, Stephen X. Skapek, Frederic G. Barr, Douglas S. Hawkins, Javed Khan To infer the subclonality of rhabdomyosarcoma (RMS) and predict the temporal order of genetic events for the ...

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Reproductive Isolation of Hybrid Populations Driven by Genetic Incompatibilities

13.03.2015 | Molly Schumer et al., PLoS Genetics, 2015

by Molly Schumer, Rongfeng Cui, Gil G. Rosenthal, Peter Andolfatto Despite its role in homogenizing populations, hybridization has also been proposed as a means to generate new species. The conceptual basis for this idea is that hybridization can result in novel phenotypes through recombination ...

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RECG Maintains Plastid and Mitochondrial Genome Stability by Suppressing Extensive Recombination between Short Dispersed Repeats

13.03.2015 | Masaki Odahara et al., PLoS Genetics, 2015

by Masaki Odahara, Yuichi Masuda, Mayuko Sato, Mayumi Wakazaki, Chizuru Harada, Kiminori Toyooka, Yasuhiko Sekine Maintenance of plastid and mitochondrial genome stability is crucial for photosynthesis and respiration, respectively. Recently, we have reported that RECA1 maintains mitochondrial ...

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NatB Domain-Containing CRA-1 Antagonizes Hydrolase ACER-1 Linking Acetyl-CoA Metabolism to the Initiation of Recombination during C. elegans Meiosis

13.03.2015 | Jinmin Gao et al., PLoS Genetics, 2015

by Jinmin Gao, Hyun-Min Kim, Andrew E. Elia, Stephen J. Elledge, Monica P. Colaiácovo The formation of DNA double-strand breaks (DSBs) must take place during meiosis to ensure the formation of crossovers, which are required for accurate chromosome segregation, therefore avoiding aneuploidy. ...

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The Role of China in the Global Spread of the Current Cholera Pandemic

13.03.2015 | Xavier Didelot et al., PLoS Genetics, 2015

by Xavier Didelot, Bo Pang, Zhemin Zhou, Angela McCann, Peixiang Ni, Dongfang Li, Mark Achtman, Biao Kan Epidemics and pandemics of cholera, a severe diarrheal disease, have occurred since the early 19th century and waves of epidemic disease continue today. Cholera epidemics are caused by ...

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Genome-wide Association Study and Meta-Analysis Identify ISL1 as Genome-wide Significant Susceptibility Gene for Bladder Exstrophy

12.03.2015 | Markus Draaken et al., PLoS Genetics, 2015

by Markus Draaken, Michael Knapp, Tracie Pennimpede, Johanna M. Schmidt, Anne-Karolin Ebert, Wolfgang Rösch, Raimund Stein, Boris Utsch, Karin Hirsch, Thomas M. Boemers, Elisabeth Mangold, Stefanie Heilmann, Kerstin U. Ludwig, Ekkehart Jenetzky, Nadine Zwink, Susanne Moebus, Bernhard G. Herrmann, ...

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Resistance to Gray Leaf Spot of Maize: Genetic Architecture and Mechanisms Elucidated through Nested Association Mapping and Near-Isogenic Line Analysis

12.03.2015 | Jacqueline M. Benson et al., PLoS Genetics, 2015

by Jacqueline M. Benson, Jesse A. Poland, Brent M. Benson, Erik L. Stromberg, Rebecca J. Nelson Gray leaf spot (GLS), caused by Cercospora zeae-maydis and Cercospora zeina, is one of the most important diseases of maize worldwide. The pathogen has a necrotrophic lifestyle and no major genes are ...

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Cis-Regulatory Mechanisms for Robust Olfactory Sensory Neuron Class-restricted Odorant Receptor Gene Expression in Drosophila

11.03.2015 | Shadi Jafari et al., PLoS Genetics, 2015

by Shadi Jafari, Mattias Alenius Odor perception requires that each olfactory sensory neuron (OSN) class continuously express a single odorant receptor (OR) regardless of changes in the environment. However, little is known about the control of the robust, class-specific OR expression involved. ...

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