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2.184 Aktuelle Fachpublikationen in PLoS Genetics

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Unexpected Role of the Steroid-Deficiency Protein Ecdysoneless in Pre-mRNA Splicing

10.04.2014 | Ann-Katrin Claudius et al., PLoS Genetics, 2014

by Ann-Katrin Claudius, Patrizia Romani, Tobias Lamkemeyer, Marek Jindra, Mirka Uhlirova The steroid hormone ecdysone coordinates insect growth and development, directing the major postembryonic transition of forms, metamorphosis. The steroid-deficient ecdysoneless1 (ecd1) strain of Drosophila ...

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RNA Editome in Rhesus Macaque Shaped by Purifying Selection

10.04.2014 | Jia-Yu Chen et al., PLoS Genetics, 2014

by Jia-Yu Chen, Zhiyu Peng, Rongli Zhang, Xin-Zhuang Yang, Bertrand Chin-Ming Tan, Huaying Fang, Chu-Jun Liu, Mingming Shi, Zhi-Qiang Ye, Yong E. Zhang, Minghua Deng, Xiuqin Zhang, Chuan-Yun Li Understanding of the RNA editing process has been broadened considerably by the next generation ...

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DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

03.04.2014 | Ana Osorio et al., PLoS Genetics, 2014

by Ana Osorio, Roger L. Milne, Karoline Kuchenbaecker, Tereza Vaclová, Guillermo Pita, Rosario Alonso, Paolo Peterlongo, Ignacio Blanco, Miguel de la Hoya, Mercedes Duran, Orland Díez, Teresa Ramón y Cajal, Irene Konstantopoulou, Cristina Martínez-Bouzas, Raquel Andrés Conejero, Penny Soucy, ...

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The Mechanism of Gene Targeting in Human Somatic Cells

03.04.2014 | Yinan Kan et al., PLoS Genetics, 2014

by Yinan Kan, Brian Ruis, Sherry Lin, Eric A. Hendrickson Gene targeting in human somatic cells is of importance because it can be used to either delineate the loss-of-function phenotype of a gene or correct a mutated gene back to wild-type. Both of these outcomes require a form of DNA ...

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Sox5 Functions as a Fate Switch in Medaka Pigment Cell Development

03.04.2014 | Yusuke Nagao et al., PLoS Genetics, 2014

by Yusuke Nagao, Takao Suzuki, Atsushi Shimizu, Tetsuaki Kimura, Ryoko Seki, Tomoko Adachi, Chikako Inoue, Yoshihiro Omae, Yasuhiro Kamei, Ikuyo Hara, Yoshihito Taniguchi, Kiyoshi Naruse, Yuko Wakamatsu, Robert N. Kelsh, Masahiko Hibi, Hisashi Hashimoto Mechanisms generating diverse cell types ...

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Cell Type-Specific Functions of Period Genes Revealed by Novel Adipocyte and Hepatocyte Circadian Clock Models

03.04.2014 | Chidambaram Ramanathan et al., PLoS Genetics, 2014

by Chidambaram Ramanathan, Haiyan Xu, Sanjoy K. Khan, Yang Shen, Paula J. Gitis, David K. Welsh, John B. Hogenesch, Andrew C. Liu In animals, circadian rhythms in physiology and behavior result from coherent rhythmic interactions between clocks in the brain and those throughout the body. ...

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A LINE-1 Insertion in DLX6 Is Responsible for Cleft Palate and Mandibular Abnormalities in a Canine Model of Pierre Robin Sequence

03.04.2014 | Zena T. Wolf et al., PLoS Genetics, 2014

by Zena T. Wolf, Elizabeth J. Leslie, Boaz Arzi, Kartika Jayashankar, Nili Karmi, Zhonglin Jia, Douglas J. Rowland, Amy Young, Noa Safra, Saundra Sliskovic, Jeffrey C. Murray, Claire M. Wade, Danika L. Bannasch Cleft palate (CP) is one of the most commonly occurring craniofacial birth defects ...

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A Central Role for GRB10 in Regulation of Islet Function in Man

03.04.2014 | Inga Prokopenko et al., PLoS Genetics, 2014

by Inga Prokopenko, Wenny Poon, Reedik Mägi, Rashmi Prasad B, S. Albert Salehi, Peter Almgren, Peter Osmark, Nabila Bouatia-Naji, Nils Wierup, Tove Fall, Alena Stančáková, Adam Barker, Vasiliki Lagou, Clive Osmond, Weijia Xie, Jari Lahti, Anne U. Jackson, Yu-Ching Cheng, Jie Liu, Jeffrey R. ...

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