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3.388 Aktuelle Fachpublikationen in PLoS Genetics

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Extensive Recombination of a Yeast Diploid Hybrid through Meiotic Reversion

01.02.2016 | Raphaëlle Laureau et al., PLoS Genetics, 2016

by Raphaëlle Laureau, Sophie Loeillet, Francisco Salinas, Anders Bergström, Patricia Legoix-Né, Gianni Liti, Alain Nicolas In somatic cells, recombination between the homologous chromosomes followed by equational segregation leads to loss of heterozygosity events (LOH), allowing the expression ...


Continuous Influx of Genetic Material from Host to Virus Populations

01.02.2016 | Clément Gilbert et al., PLoS Genetics, 2016

by Clément Gilbert, Jean Peccoud, Aurélien Chateigner, Bouziane Moumen, Richard Cordaux, Elisabeth A. Herniou Many genes of large double-stranded DNA viruses have a cellular origin, suggesting that host-to-virus horizontal transfer (HT) of DNA is recurrent. Yet, the frequency of these transfers ...


A Mutation in PMP2 Causes Dominant Demyelinating Charcot-Marie-Tooth Neuropathy

01.02.2016 | Young Bin Hong et al., PLoS Genetics, 2016

by Young Bin Hong, Jaesoon Joo, Young Se Hyun, Geon Kwak, Yu-Ri Choi, Ha Kyung Yeo, Dong Hwan Jwa, Eun Ja Kim, Won Min Mo, Soo Hyun Nam, Sung Min Kim, Jeong Hyun Yoo, Heasoo Koo, Hwan Tae Park, Ki Wha Chung, Byung-Ok Choi Charcot-Marie-Tooth disease (CMT) is a heterogeneous group of peripheral ...


The Zinc-Finger Protein SOP1 Is Required for a Subset of the Nuclear Exosome Functions in Arabidopsis

01.02.2016 | Kian Hématy et al., PLoS Genetics, 2016

by Kian Hématy, Yannick Bellec, Ram Podicheti, Nathalie Bouteiller, Pauline Anne, Céline Morineau, Richard P. Haslam, Frederic Beaudoin, Johnathan A. Napier, Keithanne Mockaitis, Dominique Gagliardi, Hervé Vaucheret, Heike Lange, Jean-Denis Faure Correct gene expression requires tight RNA ...


Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross

01.02.2016 | Anna L. Tyler et al., PLoS Genetics, 2016

by Anna L. Tyler, Leah Rae Donahue, Gary A. Churchill, Gregory W. Carter The extent and strength of epistasis is commonly unresolved in genetic studies, and observed epistasis is often difficult to interpret in terms of biological consequences or overall genetic architecture. We investigated ...


Graded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome Pathway

01.02.2016 | Scott A. Keith et al., PLoS Genetics, 2016

by Scott A. Keith, Sarah K. Maddux, Yayu Zhong, Meghna N. Chinchankar, Annabel A. Ferguson, Arjumand Ghazi, Alfred L. Fisher The maintenance of cellular proteins in a biologically active and structurally stable state is a vital endeavor involving multiple cellular pathways. One such pathway is ...


Iterative Usage of Fixed and Random Effect Models for Powerful and Efficient Genome-Wide Association Studies

01.02.2016 | Xiaolei Liu et al., PLoS Genetics, 2016

by Xiaolei Liu, Meng Huang, Bin Fan, Edward S. Buckler, Zhiwu Zhang False positives in a Genome-Wide Association Study (GWAS) can be effectively controlled by a fixed effect and random effect Mixed Linear Model (MLM) that incorporates population structure and kinship among individuals to adjust ...


GBStools: A Statistical Method for Estimating Allelic Dropout in Reduced Representation Sequencing Data

01.02.2016 | Thomas F. Cooke et al., PLoS Genetics, 2016

by Thomas F. Cooke, Muh-Ching Yee, Marina Muzzio, Alexandra Sockell, Ryan Bell, Omar E. Cornejo, Joanna L. Kelley, Graciela Bailliet, Claudio M. Bravi, Carlos D. Bustamante, Eimear E. Kenny Reduced representation sequencing methods such as genotyping-by-sequencing (GBS) enable low-cost ...


Staufen1 Regulates Multiple Alternative Splicing Events either Positively or Negatively in DM1 Indicating Its Role as a Disease Modifier

29.01.2016 | Emma Bondy-Chorney et al., PLoS Genetics, 2016

by Emma Bondy-Chorney, Tara E. Crawford Parks, Aymeric Ravel-Chapuis, Roscoe Klinck, Lynda Rocheleau, Martin Pelchat, Benoit Chabot, Bernard J. Jasmin, Jocelyn Côté Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by an expansion of CUG repeats in the 3' UTR of the DMPK gene. ...


Long-Term Persistence of Bi-functionality Contributes to the Robustness of Microbial Life through Exaptation

29.01.2016 | Maximilian G. Plach et al., PLoS Genetics, 2016

by Maximilian G. Plach, Bernd Reisinger, Reinhard Sterner, Rainer Merkl Modern enzymes are highly optimized biocatalysts that process their substrates with extreme efficiency. Many enzymes catalyze more than one reaction; however, the persistence of such ambiguities, their consequences and ...


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