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2.756 Aktuelle Fachpublikationen in PLoS Genetics

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Host Genetic Variation Influences Gene Expression Response to Rhinovirus Infection

13.04.2015 | Minal Çalışkan et al., PLoS Genetics, 2015

by Minal Çalışkan, Samuel W. Baker, Yoav Gilad, Carole Ober Rhinovirus (RV) is the most prevalent human respiratory virus and is responsible for at least half of all common colds. RV infections may result in a broad spectrum of effects that range from asymptomatic infections to severe lower ...

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Simultaneous Discovery, Estimation and Prediction Analysis of Complex Traits Using a Bayesian Mixture Model

07.04.2015 | Gerhard Moser et al., PLoS Genetics, 2015

by Gerhard Moser, Sang Hong Lee, Ben J. Hayes, Michael E. Goddard, Naomi R. Wray, Peter M. Visscher Gene discovery, estimation of heritability captured by SNP arrays, inference on genetic architecture and prediction analyses of complex traits are usually performed using different statistical ...

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Multi-locus Analysis of Genomic Time Series Data from Experimental Evolution

07.04.2015 | Jonathan Terhorst et al., PLoS Genetics, 2015

by Jonathan Terhorst, Christian Schlötterer, Yun S. Song Genomic time series data generated by evolve-and-resequence (E&R) experiments offer a powerful window into the mechanisms that drive evolution. However, standard population genetic inference procedures do not account for sampling serially ...

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A Multi-layered Protein Network Stabilizes the Escherichia coli FtsZ-ring and Modulates Constriction Dynamics

07.04.2015 | Jackson Buss et al., PLoS Genetics, 2015

by Jackson Buss, Carla Coltharp, Gleb Shtengel, Xinxing Yang, Harald Hess, Jie Xiao The prokaryotic tubulin homolog, FtsZ, forms a ring-like structure (FtsZ-ring) at midcell. The FtsZ-ring establishes the division plane and enables the assembly of the macromolecular division machinery ...

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Proteolysis of Virulence Regulator ToxR Is Associated with Entry of Vibrio cholerae into a Dormant State

07.04.2015 | Salvador Almagro-Moreno et al., PLoS Genetics, 2015

by Salvador Almagro-Moreno, Tae K. Kim, Karen Skorupski, Ronald K. Taylor Vibrio cholerae O1 is a natural inhabitant of aquatic environments and causes the diarrheal disease, cholera. Two of its primary virulence regulators, TcpP and ToxR, are localized in the inner membrane. TcpP is encoded on ...

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Comprehensive Profiling of Amino Acid Response Uncovers Unique Methionine-Deprived Response Dependent on Intact Creatine Biosynthesis

07.04.2015 | Xiaohu Tang et al., PLoS Genetics, 2015

by Xiaohu Tang, Melissa M. Keenan, Jianli Wu, Chih-An Lin, Laura Dubois, J. Will Thompson, Stephen J. Freedland, Susan K. Murphy, Jen-Tsan Chi Besides being building blocks for protein synthesis, amino acids serve a wide variety of cellular functions, including acting as metabolic intermediates ...

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Lipid-Induced Epigenomic Changes in Human Macrophages Identify a Coronary Artery Disease-Associated Variant that Regulates PPAP2B Expression through Altered C/EBP-Beta Binding

02.04.2015 | Michael E. Reschen et al., PLoS Genetics, 2015

by Michael E. Reschen, Kyle J. Gaulton, Da Lin, Elizabeth J. Soilleux, Andrew J. Morris, Susan S. Smyth, Christopher A. O'Callaghan Genome-wide association studies (GWAS) have identified over 40 loci that affect risk of coronary artery disease (CAD) and the causal mechanisms at the majority of ...

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Chromosome Replacement and Deletion Lead to Clonal Polymorphism of Berry Color in Grapevine

02.04.2015 | Frédérique Pelsy et al., PLoS Genetics, 2015

by Frédérique Pelsy, Vincent Dumas, Lucie Bévilacqua, Stéphanie Hocquigny, Didier Merdinoglu Clonal polymorphism mainly results from somatic mutations that occur naturally during plant growth. In grapevine, arrays of clones have been selected within varieties as a valuable source of diversity, ...

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Nxf1 Natural Variant E610G Is a Semi-dominant Suppressor of IAP-Induced RNA Processing Defects

02.04.2015 | Dorothy Concepcion et al., PLoS Genetics, 2015

by Dorothy Concepcion, Kevin D. Ross, Kasey R. Hutt, Gene W. Yeo, Bruce A. Hamilton Endogenous retroviruses and retrotransposons contribute functional genetic variation in animal genomes. In mice, Intracisternal A Particles (IAPs) are a frequent source of both new mutations and polymorphism ...

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The Evolutionary Origination and Diversification of a Dimorphic Gene Regulatory Network through Parallel Innovations in cis and trans

02.04.2015 | Eric M. Camino et al., PLoS Genetics, 2015

by Eric M. Camino, John C. Butts, Alison Ordway, Jordan E. Vellky, Mark Rebeiz, Thomas M. Williams The origination and diversification of morphological characteristics represents a key problem in understanding the evolution of development. Morphological traits result from gene regulatory ...

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