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2.974 Aktuelle Fachpublikationen in PLoS Genetics

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Irrepressible: An Interview with Mark Ptashne

16.07.2015 | Jane Gitschier, PLoS Genetics, 2015

by Jane Gitschier

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Inactivation of Retinoblastoma Protein (Rb1) in the Oocyte: Evidence That Dysregulated Follicle Growth Drives Ovarian Teratoma Formation in Mice

15.07.2015 | Qi-En Yang et al., PLoS Genetics, 2015

by Qi-En Yang, So I. Nagaoka, Ivy Gwost, Patricia A. Hunt, Jon M. Oatley The origin of most ovarian tumors is undefined. Here, we report development of a novel mouse model in which conditional inactivation of the tumor suppressor gene Rb1 in oocytes leads to the formation of ovarian teratomas ...

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Genome-Wide Reprogramming of Transcript Architecture by Temperature Specifies the Developmental States of the Human Pathogen Histoplasma

15.07.2015 | Sarah A. Gilmore et al., PLoS Genetics, 2015

by Sarah A. Gilmore, Mark Voorhies, Dana Gebhart, Anita Sil Eukaryotic cells integrate layers of gene regulation to coordinate complex cellular processes; however, mechanisms of post-transcriptional gene regulation remain poorly studied. The human fungal pathogen Histoplasma capsulatum (Hc) ...

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Emergence, Retention and Selection: A Trilogy of Origination for Functional De Novo Proteins from Ancestral LncRNAs in Primates

15.07.2015 | Jia-Yu Chen et al., PLoS Genetics, 2015

by Jia-Yu Chen, Qing Sunny Shen, Wei-Zhen Zhou, Jiguang Peng, Bin Z. He, Yumei Li, Chu-Jun Liu, Xuke Luan, Wanqiu Ding, Shuxian Li, Chunyan Chen, Bertrand Chin-Ming Tan, Yong E. Zhang, Aibin He, Chuan-Yun Li While some human-specific protein-coding genes have been proposed to originate from ...

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Molecular Clock of Neutral Mutations in a Fitness-Increasing Evolutionary Process

15.07.2015 | Toshihiko Kishimoto et al., PLoS Genetics, 2015

by Toshihiko Kishimoto, Bei-Wen Ying, Saburo Tsuru, Leo Iijima, Shingo Suzuki, Tomomi Hashimoto, Ayana Oyake, Hisaka Kobayashi, Yuki Someya, Dai Narisawa, Tetsuya Yomo The molecular clock of neutral mutations, which represents linear mutation fixation over generations, is theoretically ...

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The SMC Loader Scc2 Promotes ncRNA Biogenesis and Translational Fidelity

15.07.2015 | Musinu Zakari et al., PLoS Genetics, 2015

by Musinu Zakari, Rhonda Trimble Ross, Allison Peak, Marco Blanchette, Chris Seidel, Jennifer L. Gerton The Scc2-Scc4 complex is essential for loading the cohesin complex onto DNA. Cohesin has important roles in chromosome segregation, DSB repair, and chromosome condensation. Here we report ...

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TFIIS-Dependent Non-coding Transcription Regulates Developmental Genome Rearrangements

15.07.2015 | Kamila Maliszewska-Olejniczak et al., PLoS Genetics, 2015

by Kamila Maliszewska-Olejniczak, Julita Gruchota, Robert Gromadka, Cyril Denby Wilkes, Olivier Arnaiz, Nathalie Mathy, Sandra Duharcourt, Mireille Bétermier, Jacek K. Nowak Because of their nuclear dimorphism, ciliates provide a unique opportunity to study the role of non-coding RNAs (ncRNAs) ...

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Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ~2,000 Sardinians Using Tailored Sequencing Analysis Tools

14.07.2015 | Jun Ding et al., PLoS Genetics, 2015

by Jun Ding, Carlo Sidore, Thomas J. Butler, Mary Kate Wing, Yong Qian, Osorio Meirelles, Fabio Busonero, Lam C. Tsoi, Andrea Maschio, Andrea Angius, Hyun Min Kang, Ramaiah Nagaraja, Francesco Cucca, Gonçalo R. Abecasis, David Schlessinger DNA sequencing identifies common and rare genetic ...

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Identification of a Novel Regulatory Mechanism of Nutrient Transport Controlled by TORC1-Npr1-Amu1/Par32

14.07.2015 | Mélanie Boeckstaens et al., PLoS Genetics, 2015

by Mélanie Boeckstaens, Ahmad Merhi, Elisa Llinares, Pascale Van Vooren, Jean-Yves Springael, René Wintjens, Anna Maria Marini Fine-tuning the plasma-membrane permeability to essential nutrients is fundamental to cell growth optimization. Nutritional signals including nitrogen availability are ...

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A Genome Scan for Genes Underlying Microgeographic-Scale Local Adaptation in a Wild Arabidopsis Species

14.07.2015 | Shosei Kubota et al., PLoS Genetics, 2015

by Shosei Kubota, Takaya Iwasaki, Kousuke Hanada, Atsushi J. Nagano, Asao Fujiyama, Atsushi Toyoda, Sumio Sugano, Yutaka Suzuki, Kouki Hikosaka, Motomi Ito, Shin-Ichi Morinaga Adaptive divergence at the microgeographic scale has been generally disregarded because high gene flow is expected to ...

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