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2.452 Aktuelle Fachpublikationen in PLoS Genetics

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Controlling Meiotic Recombinational Repair – Specifying the Roles of ZMMs, Sgs1 and Mus81/Mms4 in Crossover Formation

16.10.2014 | Ashwini Oke et al., PLoS Genetics, 2014

by Ashwini Oke, Carol M. Anderson, Phoebe Yam, Jennifer C. Fung Crossovers (COs) play a critical role in ensuring proper alignment and segregation of homologous chromosomes during meiosis. How the cell balances recombination between CO vs. noncrossover (NCO) outcomes is not completely ...


At Short Telomeres Tel1 Directs Early Replication and Phosphorylates Rif1

16.10.2014 | Akila Sridhar et al., PLoS Genetics, 2014

by Akila Sridhar, Sylwia Kedziora, Anne D. Donaldson The replication time of Saccharomyces cerevisiae telomeres responds to TG1–3 repeat length, with telomeres of normal length replicating late during S phase and short telomeres replicating early. Here we show that Tel1 kinase, which is ...


Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 (IFNL4)

16.10.2014 | Felix M. Key et al., PLoS Genetics, 2014

by Felix M. Key, Benjamin Peter, Megan Y. Dennis, Emilia Huerta-Sánchez, Wei Tang, Ludmila Prokunina-Olsson, Rasmus Nielsen, Aida M. Andrés Interferon lambda 4 gene (IFNL4) encodes IFN-λ4, a new member of the IFN-λ family with antiviral activity. In humans IFNL4 open reading frame is truncated ...


Basement Membrane and Cell Integrity of Self-Tissues in Maintaining Drosophila Immunological Tolerance

16.10.2014 | Moon Jong Kim et al., PLoS Genetics, 2014

by Moon Jong Kim, Kwang-Min Choe The mechanism underlying immune system recognition of different types of pathogens has been extensively studied over the past few decades; however, the mechanism by which healthy self-tissue evades an attack by its own immune system is less well-understood. ...


Uncovering Enhancer Functions Using the α-Globin Locus

16.10.2014 | Douglas Vernimmen, PLoS Genetics, 2014

by Douglas Vernimmen Over the last three decades, studies of the α- and β-globin genes clusters have led to elucidation of the general principles of mammalian gene regulation, such as RNA stability, termination of transcription, and, more importantly, the identification of remote regulatory ...


White Cells Facilitate Opposite- and Same-Sex Mating of Opaque Cells in Candida albicans

16.10.2014 | Li Tao et al., PLoS Genetics, 2014

by Li Tao, Chengjun Cao, Weihong Liang, Guobo Guan, Qiuyu Zhang, Clarissa J. Nobile, Guanghua Huang Modes of sexual reproduction in eukaryotic organisms are extremely diverse. The human fungal pathogen Candida albicans undergoes a phenotypic switch from the white to the opaque phase in order to ...


Functional Interaction between Ribosomal Protein L6 and RbgA during Ribosome Assembly

16.10.2014 | Megha Gulati et al., PLoS Genetics, 2014

by Megha Gulati, Nikhil Jain, Joseph H. Davis, James R. Williamson, Robert A. Britton RbgA is an essential GTPase that participates in the assembly of the large ribosomal subunit in Bacillus subtilis and its homologs are implicated in mitochondrial and eukaryotic large subunit assembly. How ...


The Kinesin AtPSS1 Promotes Synapsis and is Required for Proper Crossover Distribution in Meiosis

16.10.2014 | Yann Duroc et al., PLoS Genetics, 2014

by Yann Duroc, Afef Lemhemdi, Cécile Larchevêque, Aurélie Hurel, Maria Cuacos, Laurence Cromer, Christine Horlow, Susan J. Armstrong, Liudmila Chelysheva, Raphael Mercier Meiotic crossovers (COs) shape genetic diversity by mixing homologous chromosomes at each generation. CO distribution is a ...


The DAF-16 FOXO Transcription Factor Regulates natc-1 to Modulate Stress Resistance in Caenorhabditis elegans, Linking Insulin/IGF-1 Signaling to Protein N-Terminal Acetylation

16.10.2014 | Kurt Warnhoff et al., PLoS Genetics, 2014

by Kurt Warnhoff, John T. Murphy, Sandeep Kumar, Daniel L. Schneider, Michelle Peterson, Simon Hsu, James Guthrie, J. David Robertson, Kerry Kornfeld The insulin/IGF-1 signaling pathway plays a critical role in stress resistance and longevity, but the mechanisms are not fully characterized. To ...


The Vesicle Protein SAM-4 Regulates the Processivity of Synaptic Vesicle Transport

16.10.2014 | Qun Zheng et al., PLoS Genetics, 2014

by Qun Zheng, Shikha Ahlawat, Anneliese Schaefer, Tim Mahoney, Sandhya P. Koushika, Michael L. Nonet Axonal transport of synaptic vesicles (SVs) is a KIF1A/UNC-104 mediated process critical for synapse development and maintenance yet little is known of how SV transport is regulated. Using C. ...


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