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2.639 Aktuelle Fachpublikationen in PLoS Genetics

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The Arabidopsis DNA Polymerase δ Has a Role in the Deposition of Transcriptionally Active Epigenetic Marks, Development and Flowering

18.02.2015 | Francisco M. Iglesias et al., PLoS Genetics, 2015

by Francisco M. Iglesias, Natalia A. Bruera, Sebastián Dergan-Dylon, Cristina Marino-Buslje, Hernán Lorenzi, Julieta L. Mateos, Franziska Turck, George Coupland, Pablo D. Cerdán DNA replication is a key process in living organisms. DNA polymerase α (Polα) initiates strand synthesis, which is ...

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Genomic Selection and Association Mapping in Rice (Oryza sativa): Effect of Trait Genetic Architecture, Training Population Composition, Marker Number and Statistical Model on Accuracy of Rice Genomic Selection in Elite, Tropical Rice Breeding Lines

17.02.2015 | Jennifer Spindel et al., PLoS Genetics, 2015

by Jennifer Spindel, Hasina Begum, Deniz Akdemir, Parminder Virk, Bertrand Collard, Edilberto Redoña, Gary Atlin, Jean-Luc Jannink, Susan R. McCouch Genomic Selection (GS) is a new breeding method in which genome-wide markers are used to predict the breeding value of individuals in a breeding ...

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Elevated In Vivo Levels of a Single Transcription Factor Directly Convert Satellite Glia into Oligodendrocyte-like Cells

13.02.2015 | Matthias Weider et al., PLoS Genetics, 2015

by Matthias Weider, Amélie Wegener, Christian Schmitt, Melanie Küspert, Simone Hillgärtner, Michael R. Bösl, Irm Hermans-Borgmeyer, Brahim Nait-Oumesmar, Michael Wegner Oligodendrocytes are the myelinating glia of the central nervous system and ensure rapid saltatory conduction. Shortage or ...

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HYPER RECOMBINATION1 of the THO/TREX Complex Plays a Role in Controlling Transcription of the REVERSION-TO-ETHYLENE SENSITIVITY1 Gene in Arabidopsis

13.02.2015 | Congyao Xu et al., PLoS Genetics, 2015

by Congyao Xu, Xin Zhou, Chi-Kuang Wen Arabidopsis REVERSION-TO-ETHYLENE SENSITIVITY1 (RTE1) represses ethylene hormone responses by promoting ethylene receptor ETHYLENE RESPONSE1 (ETR1) signaling, which negatively regulates ethylene responses. To investigate the regulation of RTE1, we ...

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Sex-specific Trans-regulatory Variation on the Drosophila melanogaster X Chromosome

13.02.2015 | Michael Stocks et al., PLoS Genetics, 2015

by Michael Stocks, Rebecca Dean, Björn Rogell, Urban Friberg The X chromosome constitutes a unique genomic environment because it is present in one copy in males, but two copies in females. This simple fact has motivated several theoretical predictions with respect to how standing genetic ...

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Transcriptome Wide Annotation of Eukaryotic RNase III Reactivity and Degradation Signals

13.02.2015 | Jules Gagnon et al., PLoS Genetics, 2015

by Jules Gagnon, Mathieu Lavoie, Mathieu Catala, Francis Malenfant, Sherif Abou Elela Detection and validation of the RNA degradation signals controlling transcriptome stability are essential steps for understanding how cells regulate gene expression. Here we present complete genomic and ...

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The Exosome Component Rrp6 Is Required for RNA Polymerase II Termination at Specific Targets of the Nrd1-Nab3 Pathway

13.02.2015 | Melanie J. Fox et al., PLoS Genetics, 2015

by Melanie J. Fox, Hongyu Gao, Whitney R. Smith-Kinnaman, Yunlong Liu, Amber L. Mosley The exosome and its nuclear specific subunit Rrp6 form a 3’-5’ exonuclease complex that regulates diverse aspects of RNA biology including 3’ end processing and degradation of a variety of noncoding RNAs ...

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P-TEFb, the Super Elongation Complex and Mediator Regulate a Subset of Non-paused Genes during Early Drosophila Embryo Development

13.02.2015 | Olle Dahlberg et al., PLoS Genetics, 2015

by Olle Dahlberg, Olga Shilkova, Min Tang, Per-Henrik Holmqvist, Mattias Mannervik Positive Transcription Elongation Factor b (P-TEFb) is a kinase consisting of Cdk9 and Cyclin T that releases RNA Polymerase II (Pol II) into active elongation. It can assemble into a larger Super Elongation ...

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Evolutionary Signatures amongst Disease Genes Permit Novel Methods for Gene Prioritization and Construction of Informative Gene-Based Networks

13.02.2015 | Nolan Priedigkeit et al., PLoS Genetics, 2015

by Nolan Priedigkeit, Nicholas Wolfe, Nathan L. Clark Genes involved in the same function tend to have similar evolutionary histories, in that their rates of evolution covary over time. This coevolutionary signature, termed Evolutionary Rate Covariation (ERC), is calculated using only gene ...

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Genomics of Divergence along a Continuum of Parapatric Population Differentiation

13.02.2015 | Philine G. D. Feulner et al., PLoS Genetics, 2015

by Philine G. D. Feulner, Frédéric J. J. Chain, Mahesh Panchal, Yun Huang, Christophe Eizaguirre, Martin Kalbe, Tobias L. Lenz, Irene E. Samonte, Monika Stoll, Erich Bornberg-Bauer, Thorsten B. H. Reusch, Manfred Milinski The patterns of genomic divergence during ecological speciation are ...

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