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2.590 Aktuelle Fachpublikationen in PLoS Genetics

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The rem Mutations in the ATP-Binding Groove of the Rad3/XPD Helicase Lead to Xeroderma pigmentosum-Cockayne Syndrome-Like Phenotypes

11.12.2014 | Emilia Herrera-Moyano et al., PLoS Genetics, 2014

by Emilia Herrera-Moyano, María Moriel-Carretero, Beth A. Montelone, Andrés Aguilera The eukaryotic TFIIH complex is involved in Nucleotide Excision Repair and transcription initiation. We analyzed three yeast mutations of the Rad3/XPD helicase of TFIIH known as rem (recombination and mutation ...

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A Massively Parallel Pipeline to Clone DNA Variants and Examine Molecular Phenotypes of Human Disease Mutations

11.12.2014 | Xiaomu Wei et al., PLoS Genetics, 2014

by Xiaomu Wei, Jishnu Das, Robert Fragoza, Jin Liang, Francisco M. Bastos de Oliveira, Hao Ran Lee, Xiujuan Wang, Matthew Mort, Peter D. Stenson, David N. Cooper, Steven M. Lipkin, Marcus B. Smolka, Haiyuan Yu Understanding the functional relevance of DNA variants is essential for all exome and ...

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The miR9863 Family Regulates Distinct Mla Alleles in Barley to Attenuate NLR Receptor-Triggered Disease Resistance and Cell-Death Signaling

11.12.2014 | Jie Liu et al., PLoS Genetics, 2014

by Jie Liu, Xiliu Cheng, Da Liu, Weihui Xu, Roger Wise, Qian-Hua Shen Barley (Hordeum vulgare L.) Mla alleles encode coiled-coil (CC), nucleotide binding, leucine-rich repeat (NB-LRR) receptors that trigger isolate-specific immune responses against the powdery mildew fungus, Blumeria graminis ...

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Echoes of the Past: Hereditarianism and A Troublesome Inheritance

11.12.2014 | Marcus Feldman, PLoS Genetics, 2014

by Marcus Feldman

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Mutations in Global Regulators Lead to Metabolic Selection during Adaptation to Complex Environments

11.12.2014 | Gerda Saxer et al., PLoS Genetics, 2014

by Gerda Saxer, Michael D. Krepps, Eric D. Merkley, Charles Ansong, Brooke L. Deatherage Kaiser, Marie-Thérèse Valovska, Nikola Ristic, Ping T. Yeh, Vittal P. Prakash, Owen P. Leiser, Luay Nakhleh, Henry S. Gibbons, Helen W. Kreuzer, Yousif Shamoo Adaptation to ecologically complex environments ...

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The nphp-2 and arl-13 Genetic Modules Interact to Regulate Ciliogenesis and Ciliary Microtubule Patterning in C. elegans

11.12.2014 | Simon R. F. Warburton-Pitt et al., PLoS Genetics, 2014

by Simon R. F. Warburton-Pitt, Malan Silva, Ken C. Q. Nguyen, David H. Hall, Maureen M. Barr Cilia are microtubule-based cellular organelles that mediate signal transduction. Cilia are organized into several structurally and functionally distinct compartments: the basal body, the transition ...

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Non-coding roX RNAs Prevent the Binding of the MSL-complex to Heterochromatic Regions

11.12.2014 | Margarida L. A. Figueiredo et al., PLoS Genetics, 2014

by Margarida L. A. Figueiredo, Maria Kim, Philge Philip, Anders Allgardsson, Per Stenberg, Jan Larsson Long non-coding RNAs contribute to dosage compensation in both mammals and Drosophila by inducing changes in the chromatin structure of the X-chromosome. In Drosophila melanogaster, roX1 and ...

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Genome-Wide Analysis of DNA Methylation Dynamics during Early Human Development

11.12.2014 | Hiroaki Okae et al., PLoS Genetics, 2014

by Hiroaki Okae, Hatsune Chiba, Hitoshi Hiura, Hirotaka Hamada, Akiko Sato, Takafumi Utsunomiya, Hiroyuki Kikuchi, Hiroaki Yoshida, Atsushi Tanaka, Mikita Suyama, Takahiro Arima DNA methylation is globally reprogrammed during mammalian preimplantation development, which is critical for normal ...

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Analysis of a Plant Complex Resistance Gene Locus Underlying Immune-Related Hybrid Incompatibility and Its Occurrence in Nature

11.12.2014 | Rubén Alcázar et al., PLoS Genetics, 2014

by Rubén Alcázar, Marcel von Reth, Jaqueline Bautor, Eunyoung Chae, Detlef Weigel, Maarten Koornneef, Jane E. Parker Mechanisms underlying speciation in plants include detrimental (incompatible) genetic interactions between parental alleles that incur a fitness cost in hybrids. We reported on ...

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Identification of Rare Causal Variants in Sequence-Based Studies: Methods and Applications to VPS13B, a Gene Involved in Cohen Syndrome and Autism

11.12.2014 | Iuliana Ionita-Laza et al., PLoS Genetics, 2014

by Iuliana Ionita-Laza, Marinela Capanu, Silvia De Rubeis, Kenneth McCallum, Joseph D. Buxbaum Pinpointing the small number of causal variants among the abundant naturally occurring genetic variation is a difficult challenge, but a crucial one for understanding precise molecular mechanisms of ...

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