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2.199 Aktuelle Fachpublikationen in PLoS Genetics

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A Synthetic Community Approach Reveals Plant Genotypes Affecting the Phyllosphere Microbiota

17.04.2014 | Natacha Bodenhausen et al., PLoS Genetics, 2014

by Natacha Bodenhausen, Miriam Bortfeld-Miller, Martin Ackermann, Julia A. Vorholt The identity of plant host genetic factors controlling the composition of the plant microbiota and the extent to which plant genes affect associated microbial populations is currently unknown. Here, we use a ...

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Transcription-Associated R-Loop Formation across the Human FMR1 CGG-Repeat Region

17.04.2014 | Erick W. Loomis et al., PLoS Genetics, 2014

by Erick W. Loomis, Lionel A. Sanz, Frédéric Chédin, Paul J. Hagerman Expansion of a trinucleotide (CGG) repeat element within the 5′ untranslated region (5′UTR) of the human FMR1 gene is responsible for a number of heritable disorders operating through distinct pathogenic mechanisms: gene ...

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Epigenetic Regulation by Heritable RNA

17.04.2014 | Reinhard Liebers et al., PLoS Genetics, 2014

by Reinhard Liebers, Minoo Rassoulzadegan, Frank Lyko Genomic concepts are based on the assumption that phenotypes arise from the expression of genetic variants. However, the presence of non-Mendelian inheritance patterns provides a direct challenge to this view and suggests an important role ...

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Fine Mapping of Dominant X-Linked Incompatibility Alleles in Drosophila Hybrids

17.04.2014 | Daniel R. Matute et al., PLoS Genetics, 2014

by Daniel R. Matute, Jackie Gavin-Smyth Sex chromosomes have a large effect on reproductive isolation and play an important role in hybrid inviability. In Drosophila hybrids, X-linked genes have pronounced deleterious effects on fitness in male hybrids, which have only one X chromosome. Several ...

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Methylome Diversification through Changes in DNA Methyltransferase Sequence Specificity

10.04.2014 | Yoshikazu Furuta et al., PLoS Genetics, 2014

by Yoshikazu Furuta, Hiroe Namba-Fukuyo, Tomoko F. Shibata, Tomoaki Nishiyama, Shuji Shigenobu, Yutaka Suzuki, Sumio Sugano, Mitsuyasu Hasebe, Ichizo Kobayashi Epigenetic modifications such as DNA methylation have large effects on gene expression and genome maintenance. Helicobacter pylori, a ...

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Widespread Use of Non-productive Alternative Splice Sites in Saccharomyces cerevisiae

10.04.2014 | Tadashi Kawashima et al., PLoS Genetics, 2014

by Tadashi Kawashima, Stephen Douglass, Jason Gabunilas, Matteo Pellegrini, Guillaume F. Chanfreau Saccharomyces cerevisiae has been used as a model system to investigate the mechanisms of pre-mRNA splicing but only a few examples of alternative splice site usage have been described in this ...

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Chromatin Landscapes of Retroviral and Transposon Integration Profiles

10.04.2014 | Johann de Jong et al., PLoS Genetics, 2014

by Johann de Jong, Waseem Akhtar, Jitendra Badhai, Alistair G. Rust, Roland Rad, John Hilkens, Anton Berns, Maarten van Lohuizen, Lodewyk F. A. Wessels, Jeroen de Ridder The ability of retroviruses and transposons to insert their genetic material into host DNA makes them widely used tools in ...

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Uncoupling Transcription from Covalent Histone Modification

10.04.2014 | Hesheng Zhang et al., PLoS Genetics, 2014

by Hesheng Zhang, Lu Gao, Jayamani Anandhakumar, David S. Gross It is widely accepted that transcriptional regulation of eukaryotic genes is intimately coupled to covalent modifications of the underlying chromatin template, and in certain cases the functional consequences of these modifications ...

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