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2.481 Aktuelle Fachpublikationen in PLoS Genetics

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Juvenile Hormone-Receptor Complex Acts on Mcm4 and Mcm7 to Promote Polyploidy and Vitellogenesis in the Migratory Locust

23.10.2014 | Wei Guo et al., PLoS Genetics, 2014

by Wei Guo, Zhongxia Wu, Jiasheng Song, Feng Jiang, Zhiming Wang, Shun Deng, Virginia K. Walker, Shutang Zhou Juvenile hormone (JH), a sesquiterpenoid produced by the corpora allata, coordinates insect growth, metamorphosis, and reproduction. While JH action for the repression of larval ...

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Topoisomerase II Is Required for the Proper Separation of Heterochromatic Regions during Drosophila melanogaster Female Meiosis

23.10.2014 | Stacie E. Hughes et al., PLoS Genetics, 2014

by Stacie E. Hughes, R. Scott Hawley Heterochromatic homology ensures the segregation of achiasmate chromosomes during meiosis I in Drosophila melanogaster females, perhaps as a consequence of the heterochromatic threads that connect achiasmate homologs during prometaphase I. Here, we ask how ...

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HIPPO Pathway Members Restrict SOX2 to the Inner Cell Mass Where It Promotes ICM Fates in the Mouse Blastocyst

23.10.2014 | Eryn Wicklow et al., PLoS Genetics, 2014

by Eryn Wicklow, Stephanie Blij, Tristan Frum, Yoshikazu Hirate, Richard A. Lang, Hiroshi Sasaki, Amy Ralston Pluripotent epiblast (EPI) cells, present in the inner cell mass (ICM) of the mouse blastocyst, are progenitors of both embryonic stem (ES) cells and the fetus. Discovering how ...

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A Mutation in the Mouse Ttc26 Gene Leads to Impaired Hedgehog Signaling

23.10.2014 | Ruth E. Swiderski et al., PLoS Genetics, 2014

by Ruth E. Swiderski, Yoko Nakano, Robert F. Mullins, Seongjin Seo, Botond Bánfi The phenotype of the spontaneous mutant mouse hop-sterile (hop) is characterized by a hopping gait, polydactyly, hydrocephalus, and male sterility. Previous analyses of the hop mouse revealed a deficiency of inner ...

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Dynamic Partnership between TFIIH, PGC-1α and SIRT1 Is Impaired in Trichothiodystrophy

23.10.2014 | Hussein Traboulsi et al., PLoS Genetics, 2014

by Hussein Traboulsi, Serena Davoli, Philippe Catez, Jean-Marc Egly, Emmanuel Compe The expression of protein-coding genes requires the selective role of many transcription factors, whose coordinated actions remain poorly understood. To further grasp the molecular mechanisms that govern ...

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Ancient Expansion of the Hox Cluster in Lepidoptera Generated Four Homeobox Genes Implicated in Extra-Embryonic Tissue Formation

23.10.2014 | Laura Ferguson et al., PLoS Genetics, 2014

by Laura Ferguson, Ferdinand Marlétaz, Jean-Michel Carter, William R. Taylor, Melanie Gibbs, Casper J. Breuker, Peter W. H. Holland Gene duplications within the conserved Hox cluster are rare in animal evolution, but in Lepidoptera an array of divergent Hox-related genes (Shx genes) has been ...

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The Not5 Subunit of the Ccr4-Not Complex Connects Transcription and Translation

23.10.2014 | Zoltan Villanyi et al., PLoS Genetics, 2014

by Zoltan Villanyi, Virginie Ribaud, Sari Kassem, Olesya O. Panasenko, Zoltan Pahi, Ishaan Gupta, Lars Steinmetz, Imre Boros, Martine A. Collart Recent studies have suggested that a sub-complex of RNA polymerase II composed of Rpb4 and Rpb7 couples the nuclear and cytoplasmic stages of gene ...

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Role of abd-A and Abd-B in Development of Abdominal Epithelia Breaks Posterior Prevalence Rule

23.10.2014 | Narendra Pratap Singh et al., PLoS Genetics, 2014

by Narendra Pratap Singh, Rakesh Kumar Mishra Hox genes that determine anteroposterior body axis formation in all bilaterians are often found to have partially overlapping expression pattern. Since posterior genes dominate over anterior Hox genes in the region of co-expression, the anterior Hox ...

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Nephronophthisis-Associated CEP164 Regulates Cell Cycle Progression, Apoptosis and Epithelial-to-Mesenchymal Transition

23.10.2014 | Gisela G. Slaats et al., PLoS Genetics, 2014

by Gisela G. Slaats, Amiya K. Ghosh, Lucas L. Falke, Stéphanie Le Corre, Indra A. Shaltiel, Glenn van de Hoek, Timothy D. Klasson, Marijn F. Stokman, Ive Logister, Marianne C. Verhaar, Roel Goldschmeding, Tri Q. Nguyen, Iain A. Drummond, Friedhelm Hildebrandt, Rachel H. Giles We recently ...

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Copy Number Variation in the Horse Genome

23.10.2014 | Sharmila Ghosh et al., PLoS Genetics, 2014

by Sharmila Ghosh, Zhipeng Qu, Pranab J. Das, Erica Fang, Rytis Juras, E. Gus Cothran, Sue McDonell, Daniel G. Kenney, Teri L. Lear, David L. Adelson, Bhanu P. Chowdhary, Terje Raudsepp We constructed a 400K WG tiling oligoarray for the horse and applied it for the discovery of copy number ...

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