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2.921 Aktuelle Fachpublikationen in PLoS Genetics

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Separable Crossover-Promoting and Crossover-Constraining Aspects of Zip1 Activity during Budding Yeast Meiosis

26.06.2015 | Karen Voelkel-Meiman et al., PLoS Genetics, 2015

by Karen Voelkel-Meiman, Cassandra Johnston, Yashna Thappeta, Vijayalakshmi V. Subramanian, Andreas Hochwagen, Amy J. MacQueen Accurate chromosome segregation during meiosis relies on the presence of crossover events distributed among all chromosomes. MutSγ and MutLγ homologs (Msh4/5 and ...


The Analysis of Pendolino ( peo ) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres

25.06.2015 | Giovanni Cenci et al., PLoS Genetics, 2015

by Giovanni Cenci, Laura Ciapponi, Marta Marzullo, Grazia D. Raffa, Patrizia Morciano, Domenico Raimondo, Romina Burla, Isabella Saggio, Maurizio Gatti Drosophila telomeres are sequence-independent structures that are maintained by transposition to chromosome ends of three specialized ...


Epigenetic Aging Signatures Are Coherently Modified in Cancer

25.06.2015 | Qiong Lin et al., PLoS Genetics, 2015

by Qiong Lin, Wolfgang Wagner Aging is associated with highly reproducible DNA methylation (DNAm) changes, which may contribute to higher prevalence of malignant diseases in the elderly. In this study, we analyzed epigenetic aging signatures in 5,621 DNAm profiles of 25 cancer types from The ...


Minor Cause—Major Effect: A Novel Mode of Control of Bistable Gene Expression

25.06.2015 | Jan Kampf et al., PLoS Genetics, 2015

by Jan Kampf, Jörg Stülke


AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance

25.06.2015 | Romina Burla et al., PLoS Genetics, 2015

by Romina Burla, Mariateresa Carcuro, Grazia D. Raffa, Alessandra Galati, Domenico Raimondo, Angela Rizzo, Mattia La Torre, Emanuela Micheli, Laura Ciapponi, Giovanni Cenci, Enrico Cundari, Antonio Musio, Annamaria Biroccio, Stefano Cacchione, Maurizio Gatti, Isabella Saggio Telomeres are ...


A Novel Feedback Loop That Controls Bimodal Expression of Genetic Competence

25.06.2015 | Pamela Gamba et al., PLoS Genetics, 2015

by Pamela Gamba, Martijs J. Jonker, Leendert W. Hamoen Gene expression can be highly heterogeneous in isogenic cell populations. An extreme type of heterogeneity is the so-called bistable or bimodal expression, whereby a cell can differentiate into two alternative expression states. Stochastic ...


The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding

24.06.2015 | Xin Xie et al., PLoS Genetics, 2015

by Xin Xie, Michael J. T. Stubbington, Jesper K. Nissen, Kristian G. Andersen, Daniel Hebenstreit, Sarah A. Teichmann, Alexander G. Betz The lineage factor Foxp3 is essential for the development and maintenance of regulatory T cells, but little is known about the mechanisms involved. Here, we ...


Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping

24.06.2015 | Chris Wallace et al., PLoS Genetics, 2015

by Chris Wallace, Antony J Cutler, Nikolas Pontikos, Marcin L Pekalski, Oliver S Burren, Jason D Cooper, Arcadio Rubio García, Ricardo C Ferreira, Hui Guo, Neil M Walker, Deborah J Smyth, Stephen S Rich, Suna Onengut-Gumuscu, Stephen J Sawcer, Maria Ban, Sylvia Richardson, John A Todd, Linda S ...


The Eukaryotic-Like Ser/Thr Kinase PrkC Regulates the Essential WalRK Two-Component System in Bacillus subtilis

23.06.2015 | Elizabeth A. Libby et al., PLoS Genetics, 2015

by Elizabeth A. Libby, Lindsie A. Goss, Jonathan Dworkin Most bacteria contain both eukaryotic-like Ser/Thr kinases (eSTKs) and eukaryotic-like Ser/Thr phosphatases (eSTPs). Their role in bacterial physiology is not currently well understood in large part because the conditions where the eSTKs ...


The Yeast GSK-3 Homologue Mck1 Is a Key Controller of Quiescence Entry and Chronological Lifespan

23.06.2015 | Zhenzhen Quan et al., PLoS Genetics, 2015

by Zhenzhen Quan, Lu Cao, Yingzhi Tang, Yanchun Yan, Stephen G. Oliver, Nianshu Zhang Upon starvation for glucose or any other core nutrient, yeast cells exit from the mitotic cell cycle and acquire a set of G0-specific characteristics to ensure long-term survival. It is not well understood ...


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