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401 Aktuelle Fachpublikationen in PLoS Genetics

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Eye Selector Logic for a Coordinated Cell Cycle Exit

19.02.2015 | Carla S. Lopes et al., PLoS Genetics, 2015

by Carla S. Lopes, Fernando Casares Organ-selector transcription factors control simultaneously cell differentiation and proliferation, ensuring the development of functional organs and their homeostasis. How this is achieved at the molecular level is still unclear. Here we have investigated ...

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An Integrative Multi-scale Analysis of the Dynamic DNA Methylation Landscape in Aging

18.02.2015 | Tian Yuan et al., PLoS Genetics, 2015

by Tian Yuan, Yinming Jiao, Simone de Jong, Roel A. Ophoff, Stephan Beck, Andrew E. Teschendorff Recent studies have demonstrated that the DNA methylome changes with age. This epigenetic drift may have deep implications for cellular differentiation and disease development. However, it remains ...

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Elevated In Vivo Levels of a Single Transcription Factor Directly Convert Satellite Glia into Oligodendrocyte-like Cells

13.02.2015 | Matthias Weider et al., PLoS Genetics, 2015

by Matthias Weider, Amélie Wegener, Christian Schmitt, Melanie Küspert, Simone Hillgärtner, Michael R. Bösl, Irm Hermans-Borgmeyer, Brahim Nait-Oumesmar, Michael Wegner Oligodendrocytes are the myelinating glia of the central nervous system and ensure rapid saltatory conduction. Shortage or ...

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HYPER RECOMBINATION1 of the THO/TREX Complex Plays a Role in Controlling Transcription of the REVERSION-TO-ETHYLENE SENSITIVITY1 Gene in Arabidopsis

13.02.2015 | Congyao Xu et al., PLoS Genetics, 2015

by Congyao Xu, Xin Zhou, Chi-Kuang Wen Arabidopsis REVERSION-TO-ETHYLENE SENSITIVITY1 (RTE1) represses ethylene hormone responses by promoting ethylene receptor ETHYLENE RESPONSE1 (ETR1) signaling, which negatively regulates ethylene responses. To investigate the regulation of RTE1, we ...

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The Exosome Component Rrp6 Is Required for RNA Polymerase II Termination at Specific Targets of the Nrd1-Nab3 Pathway

13.02.2015 | Melanie J. Fox et al., PLoS Genetics, 2015

by Melanie J. Fox, Hongyu Gao, Whitney R. Smith-Kinnaman, Yunlong Liu, Amber L. Mosley The exosome and its nuclear specific subunit Rrp6 form a 3’-5’ exonuclease complex that regulates diverse aspects of RNA biology including 3’ end processing and degradation of a variety of noncoding RNAs ...

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P-TEFb, the Super Elongation Complex and Mediator Regulate a Subset of Non-paused Genes during Early Drosophila Embryo Development

13.02.2015 | Olle Dahlberg et al., PLoS Genetics, 2015

by Olle Dahlberg, Olga Shilkova, Min Tang, Per-Henrik Holmqvist, Mattias Mannervik Positive Transcription Elongation Factor b (P-TEFb) is a kinase consisting of Cdk9 and Cyclin T that releases RNA Polymerase II (Pol II) into active elongation. It can assemble into a larger Super Elongation ...

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Discovery of Transcription Factors and Regulatory Regions Driving In Vivo Tumor Development by ATAC-seq and FAIRE-seq Open Chromatin Profiling

13.02.2015 | Kristofer Davie et al., PLoS Genetics, 2015

by Kristofer Davie, Jelle Jacobs, Mardelle Atkins, Delphine Potier, Valerie Christiaens, Georg Halder, Stein Aerts Genomic enhancers regulate spatio-temporal gene expression by recruiting specific combinations of transcription factors (TFs). When TFs are bound to active regulatory regions, they ...

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Partially Redundant Enhancers Cooperatively Maintain Mammalian Pomc Expression Above a Critical Functional Threshold

11.02.2015 | Daniel D. Lam et al., PLoS Genetics, 2015

by Daniel D. Lam, Flavio S. J. de Souza, Sofia Nasif, Miho Yamashita, Rodrigo López-Leal, Veronica Otero-Corchon, Kana Meece, Harini Sampath, Aaron J. Mercer, Sharon L. Wardlaw, Marcelo Rubinstein, Malcolm J. Low Cell-specific expression of many genes is conveyed by multiple enhancers, with ...

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Altered Chromatin Occupancy of Master Regulators Underlies Evolutionary Divergence in the Transcriptional Landscape of Erythroid Differentiation

18.12.2014 | Jacob C. Ulirsch et al., PLoS Genetics, 2014

by Jacob C. Ulirsch, Jessica N. Lacy, Xiuli An, Narla Mohandas, Tarjei S. Mikkelsen, Vijay G. Sankaran Erythropoiesis is one of the best understood examples of cellular differentiation. Morphologically, erythroid differentiation proceeds in a nearly identical fashion between humans and mice, ...

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SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells

18.12.2014 | Bastien Gerby et al., PLoS Genetics, 2014

by Bastien Gerby, Cedric S. Tremblay, Mathieu Tremblay, Shanti Rojas-Sutterlin, Sabine Herblot, Josée Hébert, Guy Sauvageau, Sébastien Lemieux, Eric Lécuyer, Diogo F. T. Veiga, Trang Hoang The molecular determinants that render specific populations of normal cells susceptible to oncogenic ...

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