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409 Aktuelle Fachpublikationen in PLoS Genetics

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Zinc Finger Independent Genome-Wide Binding of Sp2 Potentiates Recruitment of Histone-Fold Protein Nf-y Distinguishing It from Sp1 and Sp3

20.03.2015 | Sara Völkel et al., PLoS Genetics, 2015

by Sara Völkel, Bastian Stielow, Florian Finkernagel, Thorsten Stiewe, Andrea Nist, Guntram Suske Transcription factors are grouped into families based on sequence similarity within functional domains, particularly DNA-binding domains. The Specificity proteins Sp1, Sp2 and Sp3 are paradigmatic ...

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Tfap2a Promotes Specification and Maturation of Neurons in the Inner Ear through Modulation of Bmp, Fgf and Notch Signaling

17.03.2015 | Husniye Kantarci et al., PLoS Genetics, 2015

by Husniye Kantarci, Renee K. Edlund, Andrew K. Groves, Bruce B. Riley Neurons of the statoacoustic ganglion (SAG) transmit auditory and vestibular information from the inner ear to the hindbrain. SAG neuroblasts originate in the floor of the otic vesicle. New neuroblasts soon delaminate and ...

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Cis-Regulatory Mechanisms for Robust Olfactory Sensory Neuron Class-restricted Odorant Receptor Gene Expression in Drosophila

11.03.2015 | Shadi Jafari et al., PLoS Genetics, 2015

by Shadi Jafari, Mattias Alenius Odor perception requires that each olfactory sensory neuron (OSN) class continuously express a single odorant receptor (OR) regardless of changes in the environment. However, little is known about the control of the robust, class-specific OR expression involved. ...

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The Ribosome Biogenesis Factor Nol11 Is Required for Optimal rDNA Transcription and Craniofacial Development in Xenopus

10.03.2015 | John N. Griffin et al., PLoS Genetics, 2015

by John N. Griffin, Samuel B. Sondalle, Florencia del Viso, Susan J. Baserga, Mustafa K. Khokha The production of ribosomes is ubiquitous and fundamental to life. As such, it is surprising that defects in ribosome biogenesis underlie a growing number of symptomatically distinct inherited ...

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Pervasive Variation of Transcription Factor Orthologs Contributes to Regulatory Network Evolution

06.03.2015 | Shilpa Nadimpalli et al., PLoS Genetics, 2015

by Shilpa Nadimpalli, Anton V. Persikov, Mona Singh Differences in transcriptional regulatory networks underlie much of the phenotypic variation observed across organisms. Changes to cis-regulatory elements are widely believed to be the predominant means by which regulatory networks evolve, yet ...

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Sequence Features and Transcriptional Stalling within Centromere DNA Promote Establishment of CENP-A Chromatin

04.03.2015 | Sandra Catania et al., PLoS Genetics, 2015

by Sandra Catania, Alison L. Pidoux, Robin C. Allshire Centromere sequences are not conserved between species, and there is compelling evidence for epigenetic regulation of centromere identity, with location being dictated by the presence of chromatin containing the histone H3 variant CENP-A. ...

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The Bicoid Class Homeodomain Factors ceh-36/OTX and unc-30/PITX Cooperate in C. elegans Embryonic Progenitor Cells to Regulate Robust Development

04.03.2015 | Travis Walton et al., PLoS Genetics, 2015

by Travis Walton, Elicia Preston, Gautham Nair, Amanda L. Zacharias, Arjun Raj, John Isaac Murray While many transcriptional regulators of pluripotent and terminally differentiated states have been identified, regulation of intermediate progenitor states is less well understood. Previous high ...

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acal is a Long Non-coding RNA in JNK Signaling in Epithelial Shape Changes during Drosophila Dorsal Closure

24.02.2015 | Luis Daniel Ríos-Barrera et al., PLoS Genetics, 2015

by Luis Daniel Ríos-Barrera, Irene Gutiérrez-Pérez, María Domínguez, Juan Rafael Riesgo-Escovar Dorsal closure is an epithelial remodeling process taking place during Drosophila embryogenesis. JNK signaling coordinates dorsal closure. We identify and characterize acal as a novel negative dorsal ...

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Eye Selector Logic for a Coordinated Cell Cycle Exit

19.02.2015 | Carla S. Lopes et al., PLoS Genetics, 2015

by Carla S. Lopes, Fernando Casares Organ-selector transcription factors control simultaneously cell differentiation and proliferation, ensuring the development of functional organs and their homeostasis. How this is achieved at the molecular level is still unclear. Here we have investigated ...

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An Integrative Multi-scale Analysis of the Dynamic DNA Methylation Landscape in Aging

18.02.2015 | Tian Yuan et al., PLoS Genetics, 2015

by Tian Yuan, Yinming Jiao, Simone de Jong, Roel A. Ophoff, Stephan Beck, Andrew E. Teschendorff Recent studies have demonstrated that the DNA methylome changes with age. This epigenetic drift may have deep implications for cellular differentiation and disease development. However, it remains ...

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