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420 Aktuelle Fachpublikationen in PLoS Genetics

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Lipid-Induced Epigenomic Changes in Human Macrophages Identify a Coronary Artery Disease-Associated Variant that Regulates PPAP2B Expression through Altered C/EBP-Beta Binding

02.04.2015 | Michael E. Reschen et al., PLoS Genetics, 2015

by Michael E. Reschen, Kyle J. Gaulton, Da Lin, Elizabeth J. Soilleux, Andrew J. Morris, Susan S. Smyth, Christopher A. O'Callaghan Genome-wide association studies (GWAS) have identified over 40 loci that affect risk of coronary artery disease (CAD) and the causal mechanisms at the majority of ...


The Evolutionary Origination and Diversification of a Dimorphic Gene Regulatory Network through Parallel Innovations in cis and trans

02.04.2015 | Eric M. Camino et al., PLoS Genetics, 2015

by Eric M. Camino, John C. Butts, Alison Ordway, Jordan E. Vellky, Mark Rebeiz, Thomas M. Williams The origination and diversification of morphological characteristics represents a key problem in understanding the evolution of development. Morphological traits result from gene regulatory ...


Spatial Fluctuations in Expression of the Heterocyst Differentiation Regulatory Gene hetR in Anabaena Filaments

01.04.2015 | Laura Corrales-Guerrero et al., PLoS Genetics, 2015

by Laura Corrales-Guerrero, Asaf Tal, Rinat Arbel-Goren, Vicente Mariscal, Enrique Flores, Antonia Herrero, Joel Stavans Under nitrogen deprivation, filaments of the cyanobacterium Anabaena undergo a process of development, resulting in a one-dimensional pattern of nitrogen-fixing heterocysts ...


Genome-Destabilizing Effects Associated with Top1 Loss or Accumulation of Top1 Cleavage Complexes in Yeast

01.04.2015 | Sabrina L. Andersen et al., PLoS Genetics, 2015

by Sabrina L. Andersen, Roketa S. Sloan, Thomas D. Petes, Sue Jinks-Robertson Topoisomerase 1 (Top1), a Type IB topoisomerase, functions to relieve transcription- and replication-associated torsional stress in DNA. We investigated the effects of Top1 on genome stability in Saccharomyces ...


A Role for the Budding Yeast Separase, Esp1, in Ty1 Element Retrotransposition

30.03.2015 | Krystina L. Ho et al., PLoS Genetics, 2015

by Krystina L. Ho, Lina Ma, Stephanie Cheung, Savrina Manhas, Nancy Fang, Kaiqian Wang, Barry Young, Christopher Loewen, Thibault Mayor, Vivien Measday Separase/Esp1 is a protease required at the onset of anaphase to cleave cohesin and thereby enable sister chromatid separation. Esp1 also ...


Ccr4-Not Regulates RNA Polymerase I Transcription and Couples Nutrient Signaling to the Control of Ribosomal RNA Biogenesis

27.03.2015 | R. Nicholas Laribee et al., PLoS Genetics, 2015

by R. Nicholas Laribee, Amira Hosni-Ahmed, Jason J. Workman, Hongfeng Chen Ribosomal RNA synthesis is controlled by nutrient signaling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. mTORC1 regulates ribosomal RNA expression by affecting RNA Polymerase I (Pol ...


The GATA Factor elt-1 Regulates C. elegans Developmental Timing by Promoting Expression of the let-7 Family MicroRNAs

27.03.2015 | Max L. Cohen et al., PLoS Genetics, 2015

by Max L. Cohen, Sunhong Kim, Kiyokazu Morita, Seong Heon Kim, Min Han Postembryonic development in Caenorhabditis elegans is a powerful model for the study of the temporal regulation of development and for the roles of microRNAs in controlling gene expression. Stable switch-like changes in ...


GAGA Factor Maintains Nucleosome-Free Regions and Has a Role in RNA Polymerase II Recruitment to Promoters

27.03.2015 | Nicholas J. Fuda et al., PLoS Genetics, 2015

by Nicholas J. Fuda, Michael J. Guertin, Sumeet Sharma, Charles G. Danko, André L. Martins, Adam Siepel, John T. Lis Previous studies have shown that GAGA Factor (GAF) is enriched on promoters with paused RNA Polymerase II (Pol II), but its genome-wide function and mechanism of action remain ...


Transcriptomic Profiling of Yersinia pseudotuberculosis Reveals Reprogramming of the Crp Regulon by Temperature and Uncovers Crp as a Master Regulator of Small RNAs

27.03.2015 | Aaron M. Nuss et al., PLoS Genetics, 2015

by Aaron M. Nuss, Ann Kathrin Heroven, Barbara Waldmann, Jan Reinkensmeier, Michael Jarek, Michael Beckstette, Petra Dersch One hallmark of pathogenic yersiniae is their ability to rapidly adjust their life-style and pathogenesis upon host entry. In order to capture the range, magnitude and ...


NLRC5 Exclusively Transactivates MHC Class I and Related Genes through a Distinctive SXY Module

26.03.2015 | Kristina Ludigs et al., PLoS Genetics, 2015

by Kristina Ludigs, Queralt Seguín-Estévez, Sylvain Lemeille, Isabel Ferrero, Giorgia Rota, Sonia Chelbi, Chantal Mattmann, H. Robson MacDonald, Walter Reith, Greta Guarda MHC class II (MHCII) genes are transactivated by the NOD-like receptor (NLR) family member CIITA, which is recruited to SXY ...


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