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480 Aktuelle Fachpublikationen in PLoS Genetics

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SmD1 Modulates the miRNA Pathway Independently of Its Pre-mRNA Splicing Function

26.08.2015 | Xiao-Peng Xiong et al., PLoS Genetics, 2015

by Xiao-Peng Xiong, Georg Vogler, Krishna Kurthkoti, Anastasia Samsonova, Rui Zhou microRNAs (miRNAs) are a class of endogenous regulatory RNAs that play a key role in myriad biological processes. Upon transcription, primary miRNA transcripts are sequentially processed by Drosha and Dicer ...

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Evidence for Retromutagenesis as a Mechanism for Adaptive Mutation in Escherichia coli

25.08.2015 | Jordan Morreall et al., PLoS Genetics, 2015

by Jordan Morreall, Alice Kim, Yuan Liu, Natalya Degtyareva, Bernard Weiss, Paul W. Doetsch Adaptive mutation refers to the continuous outgrowth of new mutants from a non-dividing cell population during selection, in apparent violation of the neo-Darwinian principle that mutation precedes ...

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The Evolutionarily Conserved LIM Homeodomain Protein LIM-4/LHX6 Specifies the Terminal Identity of a Cholinergic and Peptidergic C . elegans Sensory/Inter/Motor Neuron-Type

25.08.2015 | Jinmahn Kim et al., PLoS Genetics, 2015

by Jinmahn Kim, Jihye Yeon, Seong-Kyoon Choi, Yang Hoon Huh, Zi Fang, Seo Jin Park, Myoung Ok Kim, Zae Young Ryoo, Kyeongjin Kang, Hee-Seok Kweon, Won Bae Jeon, Chris Li, Kyuhyung Kim The expression of specific transcription factors determines the differentiated features of postmitotic neurons. ...

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YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

21.08.2015 | Claudia Stein et al., PLoS Genetics, 2015

by Claudia Stein, Anaïs Flore Bardet, Guglielmo Roma, Sebastian Bergling, Ieuan Clay, Alexandra Ruchti, Claudia Agarinis, Tobias Schmelzle, Tewis Bouwmeester, Dirk Schübeler, Andreas Bauer YAP1 is a major effector of the Hippo pathway and a well-established oncogene. Elevated YAP1 activity due ...

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Retinoic Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish

21.08.2015 | Diana M. Mitchell et al., PLoS Genetics, 2015

by Diana M. Mitchell, Craig B. Stevens, Ruth A. Frey, Samuel S. Hunter, Ryuichi Ashino, Shoji Kawamura, Deborah L. Stenkamp The signaling molecule retinoic acid (RA) regulates rod and cone photoreceptor fate, differentiation, and survival. Here we elucidate the role of RA in differential ...

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Runx1 Transcription Factor Is Required for Myoblasts Proliferation during Muscle Regeneration

14.08.2015 | Kfir Baruch Umansky et al., PLoS Genetics, 2015

by Kfir Baruch Umansky, Yael Gruenbaum-Cohen, Michael Tsoory, Ester Feldmesser, Dalia Goldenberg, Ori Brenner, Yoram Groner Following myonecrosis, muscle satellite cells proliferate, differentiate and fuse, creating new myofibers. The Runx1 transcription factor is not expressed in naïve ...

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SHOEBOX Modulates Root Meristem Size in Rice through Dose-Dependent Effects of Gibberellins on Cell Elongation and Proliferation

14.08.2015 | Jintao Li et al., PLoS Genetics, 2015

by Jintao Li, Yu Zhao, Huangwei Chu, Likai Wang, Yanru Fu, Ping Liu, Narayana Upadhyaya, Chunli Chen, Tongmin Mou, Yuqi Feng, Prakash Kumar, Jian Xu Little is known about how the size of meristem cells is regulated and whether it participates in the control of meristem size in plants. Here, we ...

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Hypoxia and Temperature Regulated Morphogenesis in Candida albicans

14.08.2015 | Prashant R. Desai et al., PLoS Genetics, 2015

by Prashant R. Desai, Lasse van Wijlick, Dagmar Kurtz, Mateusz Juchimiuk, Joachim F. Ernst Candida albicans is a common commensal in the human gut but in predisposed patients it can become an important human fungal pathogen. As a commensal, C. albicans adapts to low-oxygen conditions and ...

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The Spalt Transcription Factors Generate the Transcriptional Landscape of the Drosophila melanogaster Wing Pouch Central Region

04.08.2015 | María F. Organista et al., PLoS Genetics, 2015

by María F. Organista, Mercedes Martín, Jesus M. de Celis, Rosa Barrio, Ana López-Varea, Nuria Esteban, Mar Casado, Jose F. de Celis The Drosophila genes spalt major (salm) and spalt-related (salr) encode Zn-finger transcription factors regulated by the Decapentaplegic (Dpp) signalling pathway ...

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The Nucleosome Acidic Patch Regulates the H2B K123 Monoubiquitylation Cascade and Transcription Elongation in Saccharomyces cerevisiae

04.08.2015 | Christine E. Cucinotta et al., PLoS Genetics, 2015

by Christine E. Cucinotta, Alexandria N. Young, Kristin M. Klucevsek, Karen M. Arndt Eukaryotes regulate gene expression and other nuclear processes through the posttranslational modification of histones. In S. cerevisiae, the mono-ubiquitylation of histone H2B on lysine 123 (H2B K123ub) ...

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