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359 Aktuelle Fachpublikationen in PLoS Genetics

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daf-31 Encodes the Catalytic Subunit of N Alpha-Acetyltransferase that Regulates Caenorhabditis elegans Development, Metabolism and Adult Lifespan

16.10.2014 | Di Chen et al., PLoS Genetics, 2014

by Di Chen, Jiuli Zhang, Justin Minnerly, Tiffany Kaul, Donald L. Riddle, Kailiang Jia The Caenorhabditis elegans dauer larva is a facultative state of diapause. Mutations affecting dauer signal transduction and morphogenesis have been reported. Of these, most that result in constitutive ...

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Signature Gene Expression Reveals Novel Clues to the Molecular Mechanisms of Dimorphic Transition in Penicillium marneffei

16.10.2014 | Ence Yang et al., PLoS Genetics, 2014

by Ence Yang, Wang-Ngai Chow, Gang Wang, Patrick C. Y. Woo, Susanna K. P. Lau, Kwok-Yung Yuen, Xiaorong Lin, James J. Cai Systemic dimorphic fungi cause more than one million new infections each year, ranking them among the significant public health challenges currently encountered. Penicillium ...

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KDM5 Interacts with Foxo to Modulate Cellular Levels of Oxidative Stress

16.10.2014 | Xingyin Liu et al., PLoS Genetics, 2014

by Xingyin Liu, Christina Greer, Julie Secombe Increased cellular levels of oxidative stress are implicated in a large number of human diseases. Here we describe the transcription co-factor KDM5 (also known as Lid) as a new critical regulator of cellular redox state. Moreover, this occurs ...

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RNA-Processing Protein TDP-43 Regulates FOXO-Dependent Protein Quality Control in Stress Response

16.10.2014 | Tao Zhang et al., PLoS Genetics, 2014

by Tao Zhang, Gerard Baldie, Goran Periz, Jiou Wang Protein homeostasis is critical for cell survival and functions during stress and is regulated at both RNA and protein levels. However, how the cell integrates RNA-processing programs with post-translational protein quality control systems is ...

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Uncovering Enhancer Functions Using the α-Globin Locus

16.10.2014 | Douglas Vernimmen, PLoS Genetics, 2014

by Douglas Vernimmen Over the last three decades, studies of the α- and β-globin genes clusters have led to elucidation of the general principles of mammalian gene regulation, such as RNA stability, termination of transcription, and, more importantly, the identification of remote regulatory ...

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The DAF-16 FOXO Transcription Factor Regulates natc-1 to Modulate Stress Resistance in Caenorhabditis elegans, Linking Insulin/IGF-1 Signaling to Protein N-Terminal Acetylation

16.10.2014 | Kurt Warnhoff et al., PLoS Genetics, 2014

by Kurt Warnhoff, John T. Murphy, Sandeep Kumar, Daniel L. Schneider, Michelle Peterson, Simon Hsu, James Guthrie, J. David Robertson, Kerry Kornfeld The insulin/IGF-1 signaling pathway plays a critical role in stress resistance and longevity, but the mechanisms are not fully characterized. To ...

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The bHLH-PAS Transcription Factor Dysfusion Regulates Tarsal Joint Formation in Response to Notch Activity during Drosophila Leg Development

16.10.2014 | Sergio Córdoba et al., PLoS Genetics, 2014

by Sergio Córdoba, Carlos Estella A characteristic of all arthropods is the presence of flexible structures called joints that connect all leg segments. Drosophila legs include two types of joints: the proximal or “true” joints that are motile due to the presence of muscle attachment and the ...

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Salt-Induced Stabilization of EIN3/EIL1 Confers Salinity Tolerance by Deterring ROS Accumulation in Arabidopsis

16.10.2014 | Jinying Peng et al., PLoS Genetics, 2014

by Jinying Peng, Zhonghai Li, Xing Wen, Wenyang Li, Hui Shi, Longshu Yang, Huaiqiu Zhu, Hongwei Guo Ethylene has been regarded as a stress hormone to regulate myriad stress responses. Salinity stress is one of the most serious abiotic stresses limiting plant growth and development. But how ...

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Genome-Wide Mapping of Yeast RNA Polymerase II Termination

09.10.2014 | Paul Schaughency et al., PLoS Genetics, 2014

by Paul Schaughency, Jonathan Merran, Jeffry L. Corden Yeast RNA polymerase II (Pol II) terminates transcription of coding transcripts through the polyadenylation (pA) pathway and non-coding transcripts through the non-polyadenylation (non-pA) pathway. We have used PAR-CLIP to map the position ...

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Comprehensive Mapping of the Escherichia coli Flagellar Regulatory Network

02.10.2014 | Devon M. Fitzgerald et al., PLoS Genetics, 2014

by Devon M. Fitzgerald, Richard P. Bonocora, Joseph T. Wade Flagellar synthesis is a highly regulated process in all motile bacteria. In Escherichia coli and related species, the transcription factor FlhDC is the master regulator of a multi-tiered transcription network. FlhDC activates ...

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