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438 Aktuelle Fachpublikationen in PLoS Genetics

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Biological Significance of Photoreceptor Photocycle Length: VIVID Photocycle Governs the Dynamic VIVID-White Collar Complex Pool Mediating Photo-adaptation and Response to Changes in Light Intensity

15.05.2015 | Arko Dasgupta et al., PLoS Genetics, 2015

by Arko Dasgupta, Chen-Hui Chen, ChangHwan Lee, Amy S. Gladfelter, Jay C. Dunlap, Jennifer J. Loros Most organisms on earth sense light through the use of chromophore-bearing photoreceptive proteins with distinct and characteristic photocycle lengths, yet the biological significance of this ...

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The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation

14.05.2015 | Lydia M. Castelli et al., PLoS Genetics, 2015

by Lydia M. Castelli, David Talavera, Christopher J. Kershaw, Sarah S. Mohammad-Qureshi, Joseph L. Costello, William Rowe, Paul F. G. Sims, Christopher M. Grant, Simon J. Hubbard, Mark P. Ashe, Graham D. Pavitt Translation initiation factor eIF4E mediates mRNA selection for protein synthesis ...

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Accounting for Experimental Noise Reveals That mRNA Levels, Amplified by Post-Transcriptional Processes, Largely Determine Steady-State Protein Levels in Yeast

07.05.2015 | Gábor Csárdi et al., PLoS Genetics, 2015

by Gábor Csárdi, Alexander Franks, David S. Choi, Edoardo M. Airoldi, D. Allan Drummond Cells respond to their environment by modulating protein levels through mRNA transcription and post-transcriptional control. Modest observed correlations between global steady-state mRNA and protein ...

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Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes

05.05.2015 | Artem G. Lada et al., PLoS Genetics, 2015

by Artem G. Lada, Sergei F. Kliver, Alok Dhar, Dmitrii E. Polev, Alexey E. Masharsky, Igor B. Rogozin, Youri I. Pavlov Mutations in genomes of species are frequently distributed non-randomly, resulting in mutation clusters, including recently discovered kataegis in tumors. DNA editing ...

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Windpipe Controls Drosophila Intestinal Homeostasis by Regulating JAK/STAT Pathway via Promoting Receptor Endocytosis and Lysosomal Degradation

29.04.2015 | Wenyan Ren et al., PLoS Genetics, 2015

by Wenyan Ren, Yan Zhang, Min Li, Longfei Wu, Guolun Wang, Gyeong-Hun Baeg, Jia You, Zhouhua Li, Xinhua Lin The adult intestinal homeostasis is tightly controlled by proper proliferation and differentiation of intestinal stem cells. The JAK/STAT (Janus Kinase/Signal Transducer and Activator of ...

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Systematic Profiling of Poly(A)+ Transcripts Modulated by Core 3’ End Processing and Splicing Factors Reveals Regulatory Rules of Alternative Cleavage and Polyadenylation

23.04.2015 | Wencheng Li et al., PLoS Genetics, 2015

by Wencheng Li, Bei You, Mainul Hoque, Dinghai Zheng, Wenting Luo, Zhe Ji, Ji Yeon Park, Samuel I. Gunderson, Auinash Kalsotra, James L. Manley, Bin Tian Alternative cleavage and polyadenylation (APA) results in mRNA isoforms containing different 3’ untranslated regions (3’UTRs) and/or coding ...

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Cross-Population Joint Analysis of eQTLs: Fine Mapping and Functional Annotation

23.04.2015 | Xiaoquan Wen et al., PLoS Genetics, 2015

by Xiaoquan Wen, Francesca Luca, Roger Pique-Regi Mapping expression quantitative trait loci (eQTLs) has been shown as a powerful tool to uncover the genetic underpinnings of many complex traits at molecular level. In this paper, we present an integrative analysis approach that leverages eQTL ...

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Genome-Wide Negative Feedback Drives Transgenerational DNA Methylation Dynamics in Arabidopsis

22.04.2015 | Tasuku Ito et al., PLoS Genetics, 2015

by Tasuku Ito, Yoshiaki Tarutani, Taiko Kim To, Mohamed Kassam, Evelyne Duvernois-Berthet, Sandra Cortijo, Kazuya Takashima, Hidetoshi Saze, Atsushi Toyoda, Asao Fujiyama, Vincent Colot, Tetsuji Kakutani Epigenetic variations of phenotypes, especially those associated with DNA methylation, are ...

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Competition between VanU G Repressor and VanR G Activator Leads to Rheostatic Control of vanG Vancomycin Resistance Operon Expression

21.04.2015 | Florence Depardieu et al., PLoS Genetics, 2015

by Florence Depardieu, Vincent Mejean, Patrice Courvalin Enterococcus faecalis BM4518 is resistant to vancomycin by synthesis of peptidoglycan precursors ending in D-alanyl-D-serine. In the chromosomal vanG locus, transcription of the resistance genes from the PYG resistance promoter is ...

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The Chromatin Remodeler CHD8 Is Required for Activation of Progesterone Receptor-Dependent Enhancers

20.04.2015 | María Ceballos-Chávez et al., PLoS Genetics, 2015

by María Ceballos-Chávez, Alicia Subtil-Rodríguez, Eugenia G. Giannopoulou, Daniel Soronellas, Elena Vázquez-Chávez, Guillermo P. Vicent, Olivier Elemento, Miguel Beato, José C. Reyes While the importance of gene enhancers in transcriptional regulation is well established, the mechanisms and ...

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