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393 Aktuelle Fachpublikationen in PLoS Genetics

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Altered Chromatin Occupancy of Master Regulators Underlies Evolutionary Divergence in the Transcriptional Landscape of Erythroid Differentiation

18.12.2014 | Jacob C. Ulirsch et al., PLoS Genetics, 2014

by Jacob C. Ulirsch, Jessica N. Lacy, Xiuli An, Narla Mohandas, Tarjei S. Mikkelsen, Vijay G. Sankaran Erythropoiesis is one of the best understood examples of cellular differentiation. Morphologically, erythroid differentiation proceeds in a nearly identical fashion between humans and mice, ...


SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells

18.12.2014 | Bastien Gerby et al., PLoS Genetics, 2014

by Bastien Gerby, Cedric S. Tremblay, Mathieu Tremblay, Shanti Rojas-Sutterlin, Sabine Herblot, Josée Hébert, Guy Sauvageau, Sébastien Lemieux, Eric Lécuyer, Diogo F. T. Veiga, Trang Hoang The molecular determinants that render specific populations of normal cells susceptible to oncogenic ...


Global Analysis of Photosynthesis Transcriptional Regulatory Networks

11.12.2014 | Saheed Imam et al., PLoS Genetics, 2014

by Saheed Imam, Daniel R. Noguera, Timothy J. Donohue Photosynthesis is a crucial biological process that depends on the interplay of many components. This work analyzed the gene targets for 4 transcription factors: FnrL, PrrA, CrpK and MppG (RSP_2888), which are known or predicted to control ...


Rgs6 is Required for Adult Maintenance of Dopaminergic Neurons in the Ventral Substantia Nigra

11.12.2014 | Panojot Bifsha et al., PLoS Genetics, 2014

by Panojot Bifsha, Jianqi Yang, Rory A. Fisher, Jacques Drouin Parkinson disease (PD) is characterized by the preferential, but poorly understood, vulnerability to degeneration of midbrain dopaminergic (mDA) neurons in the ventral substantia nigra compacta (vSNc). These sensitive mDA neurons ...


Maf1 Is a Novel Target of PTEN and PI3K Signaling That Negatively Regulates Oncogenesis and Lipid Metabolism

11.12.2014 | Beth M. Palian et al., PLoS Genetics, 2014

by Beth M. Palian, Aarti D. Rohira, Sandra A. S. Johnson, Lina He, Ni Zheng, Louis Dubeau, Bangyan L. Stiles, Deborah L. Johnson Maf1 was initially identified as a transcriptional repressor of RNA pol III-transcribed genes, yet little is known about its other potential target genes or its ...


Genome-Wide Analysis of leafbladeless1-Regulated and Phased Small RNAs Underscores the Importance of the TAS3 ta-siRNA Pathway to Maize Development

11.12.2014 | Marcela C. Dotto et al., PLoS Genetics, 2014

by Marcela C. Dotto, Katherine A. Petsch, Milo J. Aukerman, Mary Beatty, Molly Hammell, Marja C. P. Timmermans Maize leafbladeless1 (lbl1) encodes a key component in the trans-acting short-interfering RNA (ta-siRNA) biogenesis pathway. Correlated with a great diversity in ta-siRNAs and the ...


The rem Mutations in the ATP-Binding Groove of the Rad3/XPD Helicase Lead to Xeroderma pigmentosum-Cockayne Syndrome-Like Phenotypes

11.12.2014 | Emilia Herrera-Moyano et al., PLoS Genetics, 2014

by Emilia Herrera-Moyano, María Moriel-Carretero, Beth A. Montelone, Andrés Aguilera The eukaryotic TFIIH complex is involved in Nucleotide Excision Repair and transcription initiation. We analyzed three yeast mutations of the Rad3/XPD helicase of TFIIH known as rem (recombination and mutation ...


Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway

04.12.2014 | Stephen A. Ramsey et al., PLoS Genetics, 2014

by Stephen A. Ramsey, Yuliya Vengrenyuk, Prashanthi Menon, Irina Podolsky, Jonathan E. Feig, Alan Aderem, Edward A. Fisher, Elizabeth S. Gold We report the first systems biology investigation of regulators controlling arterial plaque macrophage transcriptional changes in response to lipid ...


Microevolution of Candida albicans in Macrophages Restores Filamentation in a Nonfilamentous Mutant

04.12.2014 | Anja Wartenberg et al., PLoS Genetics, 2014

by Anja Wartenberg, Jörg Linde, Ronny Martin, Maria Schreiner, Fabian Horn, Ilse D. Jacobsen, Sabrina Jenull, Thomas Wolf, Karl Kuchler, Reinhard Guthke, Oliver Kurzai, Anja Forche, Christophe d'Enfert, Sascha Brunke, Bernhard Hube Following antifungal treatment, Candida albicans, and other ...


Topoisomerase I Plays a Critical Role in Suppressing Genome Instability at a Highly Transcribed G-Quadruplex-Forming Sequence

04.12.2014 | Puja Yadav et al., PLoS Genetics, 2014

by Puja Yadav, Victoria Harcy, Juan Lucas Argueso, Margaret Dominska, Sue Jinks-Robertson, Nayun Kim G-quadruplex or G4 DNA is a non-B secondary DNA structure that comprises a stacked array of guanine-quartets. Cellular processes such as transcription and replication can be hindered by ...


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