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335 Aktuelle Fachpublikationen in PLoS Genetics

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Integration of the Unfolded Protein and Oxidative Stress Responses through SKN-1/Nrf

12.09.2013 | Kira M. Glover-Cutter et al., PLoS Genetics, 2013

by Kira M. Glover-Cutter, Stephanie Lin, T. Keith Blackwell The Unfolded Protein Response (UPR) maintains homeostasis in the endoplasmic reticulum (ER) and defends against ER stress, an underlying factor in various human diseases. During the UPR, numerous genes are activated that sustain and ...


Regulation of the Boundaries of Accessible Chromatin

12.09.2013 | Xiaoran Chai et al., PLoS Genetics, 2013

by Xiaoran Chai, Sanjanaa Nagarajan, Kwoneel Kim, Kibaick Lee, Jung Kyoon Choi Regulatory regions maintain nucleosome-depleted, open chromatin status but simultaneously require the presence of nucleosomes for specific histone modifications. It remains unclear how these can be achieved for ...


Extensive Divergence of Transcription Factor Binding in Drosophila Embryos with Highly Conserved Gene Expression

12.09.2013 | Mathilde Paris et al., PLoS Genetics, 2013

by Mathilde Paris, Tommy Kaplan, Xiao Yong Li, Jacqueline E. Villalta, Susan E. Lott, Michael B. Eisen To better characterize how variation in regulatory sequences drives divergence in gene expression, we undertook a systematic study of transcription factor binding and gene expression in ...


Chromatin-Specific Regulation of Mammalian rDNA Transcription by Clustered TTF-I Binding Sites

12.09.2013 | Sarah D. Diermeier et al., PLoS Genetics, 2013

by Sarah D. Diermeier, Attila Németh, Michael Rehli, Ingrid Grummt, Gernot Längst Enhancers and promoters often contain multiple binding sites for the same transcription factor, suggesting that homotypic clustering of binding sites may serve a role in transcription regulation. Here we show that ...


An Atypical Kinase under Balancing Selection Confers Broad-Spectrum Disease Resistance in Arabidopsis

12.09.2013 | Carine Huard-Chauveau et al., PLoS Genetics, 2013

by Carine Huard-Chauveau, Laure Perchepied, Marilyne Debieu, Susana Rivas, Thomas Kroj, Ilona Kars, Joy Bergelson, Fabrice Roux, Dominique Roby The failure of gene-for-gene resistance traits to provide durable and broad-spectrum resistance in an agricultural context has led to the search for ...


Functional Dissection of Regulatory Models Using Gene Expression Data of Deletion Mutants

05.09.2013 | Jin'e Li et al., PLoS Genetics, 2013

by Jin'e Li, Yi Liu, Min Liu, Jing-Dong J. Han Genome-wide gene expression profiles accumulate at an alarming rate, how to integrate these expression profiles generated by different laboratories to reverse engineer the cellular regulatory network has been a major challenge. To automatically ...


Convergent Transcription Induces Dynamic DNA Methylation at disiRNA Loci

05.09.2013 | Yunkun Dang et al., PLoS Genetics, 2013

by Yunkun Dang, Liande Li, Wei Guo, Zhihong Xue, Yi Liu Cytosine methylation of DNA is an important epigenetic gene silencing mechanism in plants, fungi, and animals. In the filamentous fungus Neurospora crassa, nearly all known DNA methylations occur in transposon relics and repetitive ...


VAPB/ALS8 MSP Ligands Regulate Striated Muscle Energy Metabolism Critical for Adult Survival in Caenorhabditis elegans

05.09.2013 | Sung Min Han et al., PLoS Genetics, 2013

by Sung Min Han, Hajer El Oussini, Jelena Scekic-Zahirovic, Jack Vibbert, Pauline Cottee, Jeevan K. Prasain, Hugo J. Bellen, Luc Dupuis, Michael A. Miller Mutations in VAPB/ALS8 are associated with amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), two motor neuron diseases ...


Divergent Transcriptional Regulatory Logic at the Intersection of Tissue Growth and Developmental Patterning

05.09.2013 | Matthew Slattery et al., PLoS Genetics, 2013

by Matthew Slattery, Roumen Voutev, Lijia Ma, Nicolas Nègre, Kevin P. White, Richard S. Mann The Yorkie/Yap transcriptional coactivator is a well-known regulator of cellular proliferation in both invertebrates and mammals. As a coactivator, Yorkie (Yki) lacks a DNA binding domain and must ...


Cell Interactions and Patterned Intercalations Shape and Link Epithelial Tubes in C. elegans

05.09.2013 | Jeffrey P. Rasmussen et al., PLoS Genetics, 2013

by Jeffrey P. Rasmussen, Jessica L. Feldman, Sowmya Somashekar Reddy, James R. Priess Many animal organs are composed largely or entirely of polarized epithelial tubes, and the formation of complex organ systems, such as the digestive or vascular systems, requires that separate tubes link with ...


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