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542 Aktuelle Fachpublikationen in PLoS Genetics

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Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation

28.01.2016 | Long Guo et al., PLoS Genetics, 2016

by Long Guo, Hiroshi Yamashita, Ikuyo Kou, Aki Takimoto, Makiko Meguro-Horike, Shin-ichi Horike, Tetsushi Sakuma, Shigenori Miura, Taiji Adachi, Takashi Yamamoto, Shiro Ikegawa, Yuji Hiraki, Chisa Shukunami Previously, we identified an adolescent idiopathic scoliosis susceptibility locus near ...

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A Novel, Noncanonical BMP Pathway Modulates Synapse Maturation at the Drosophila Neuromuscular Junction

27.01.2016 | Mikolaj J. Sulkowski et al., PLoS Genetics, 2016

by Mikolaj J. Sulkowski, Tae Hee Han, Carolyn Ott, Qi Wang, Esther M. Verheyen, Jennifer Lippincott-Schwartz, Mihaela Serpe At the Drosophila NMJ, BMP signaling is critical for synapse growth and homeostasis. Signaling by the BMP7 homolog, Gbb, in motor neurons triggers a canonical ...

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Dynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic Stress

22.01.2016 | Michelle L. Oeser et al., PLoS Genetics, 2016

by Michelle L. Oeser, Triana Amen, Cory M. Nadel, Amanda I. Bradley, Benjamin J. Reed, Ramon D. Jones, Janani Gopalan, Daniel Kaganovich, Richard G. Gardner Cells are often exposed to physical or chemical stresses that can damage the structures of essential biomolecules. Stress-induced cellular ...

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Base J and H3.V Regulate Transcriptional Termination in Trypanosoma brucei

21.01.2016 | Danae Schulz et al., PLoS Genetics, 2016

by Danae Schulz, Maryam Zaringhalam, F. Nina Papavasiliou, Hee-Sook Kim Trypanosoma brucei is a protozoan parasite that lacks many transcription factors found in other eukaryotes, such as those whose binding demarcates enhancers. T. brucei retains histone variants and modifications, however, ...

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Histone H3 Variant Regulates RNA Polymerase II Transcription Termination and Dual Strand Transcription of siRNA Loci in Trypanosoma brucei

21.01.2016 | David Reynolds et al., PLoS Genetics, 2016

by David Reynolds, Brigitte T. Hofmeister, Laura Cliffe, Magdy Alabady, T. Nicolai Siegel, Robert J. Schmitz, Robert Sabatini Base J, β-D-glucosyl-hydroxymethyluracil, is a chromatin modification of thymine in the nuclear DNA of flagellated protozoa of the order Kinetoplastida. In Trypanosoma ...

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A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity

14.01.2016 | Qingyun Li et al., PLoS Genetics, 2016

by Qingyun Li, Scott Barish, Sumie Okuwa, Abigail Maciejewski, Alicia T. Brandt, Dominik Reinhold, Corbin D. Jones, Pelin Cayirlioglu Volkan Sensory neuron diversity is required for organisms to decipher complex environmental cues. In Drosophila, the olfactory environment is detected by 50 ...

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PAF Complex Plays Novel Subunit-Specific Roles in Alternative Cleavage and Polyadenylation

14.01.2016 | Yan Yang et al., PLoS Genetics, 2016

by Yan Yang, Wencheng Li, Mainul Hoque, Liming Hou, Steven Shen, Bin Tian, Brian D. Dynlacht The PAF complex (Paf1C) has been shown to regulate chromatin modifications, gene transcription, and RNA polymerase II (PolII) elongation. Here, we provide the first genome-wide profiles for the ...

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Arabidopsis Flower and Embryo Developmental Genes are Repressed in Seedlings by Different Combinations of Polycomb Group Proteins in Association with Distinct Sets of Cis-regulatory Elements

13.01.2016 | Hua Wang et al., PLoS Genetics, 2016

by Hua Wang, Chunmei Liu, Jingfei Cheng, Jian Liu, Lei Zhang, Chongsheng He, Wen-Hui Shen, Hong Jin, Lin Xu, Yijing Zhang Polycomb repressive complexes (PRCs) play crucial roles in transcriptional repression and developmental regulation in both plants and animals. In plants, depletion of ...

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The Drosophila Helicase MLE Targets Hairpin Structures in Genomic Transcripts

11.01.2016 | Simona Cugusi et al., PLoS Genetics, 2016

by Simona Cugusi, Yujing Li, Peng Jin, John C. Lucchesi RNA hairpins are a common type of secondary structures that play a role in every aspect of RNA biochemistry including RNA editing, mRNA stability, localization and translation of transcripts, and in the activation of the RNA interference ...

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Arabidopsis ERF1 Mediates Cross-Talk between Ethylene and Auxin Biosynthesis during Primary Root Elongation by Regulating ASA1 Expression

08.01.2016 | Jie-Li Mao et al., PLoS Genetics, 2016

by Jie-Li Mao, Zi-Qing Miao, Zhen Wang, Lin-Hui Yu, Xiao-Teng Cai, Cheng-Bin Xiang The gaseous phytohormone ethylene participates in the regulation of root growth and development in Arabidopsis. It is known that root growth inhibition by ethylene involves auxin, which is partially mediated by ...

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