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367 Aktuelle Fachpublikationen in PLoS Genetics

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Systematic Dissection of Coding Exons at Single Nucleotide Resolution Supports an Additional Role in Cell-Specific Transcriptional Regulation

23.10.2014 | Ramon Y. Birnbaum et al., PLoS Genetics, 2014

by Ramon Y. Birnbaum, Rupali P. Patwardhan, Mee J. Kim, Gregory M. Findlay, Beth Martin, Jingjing Zhao, Robert J. A. Bell, Robin P. Smith, Angel A. Ku, Jay Shendure, Nadav Ahituv In addition to their protein coding function, exons can also serve as transcriptional enhancers. Mutations in these ...

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The Nuclear Immune Receptor RPS4 Is Required for RRS1SLH1-Dependent Constitutive Defense Activation in Arabidopsis thaliana

23.10.2014 | Kee Hoon Sohn et al., PLoS Genetics, 2014

by Kee Hoon Sohn, Cécile Segonzac, Ghanasyam Rallapalli, Panagiotis F. Sarris, Joo Yong Woo, Simon J. Williams, Toby E. Newman, Kyung Hee Paek, Bostjan Kobe, Jonathan D. G. Jones Plant nucleotide-binding leucine-rich repeat (NB-LRR) disease resistance (R) proteins recognize specific “avirulent” ...

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A Conserved Role for p48 Homologs in Protecting Dopaminergic Neurons from Oxidative Stress

23.10.2014 | Peter Bou Dib et al., PLoS Genetics, 2014

by Peter Bou Dib, Bettina Gnägi, Fiona Daly, Virginie Sabado, Damla Tas, Dominique A. Glauser, Peter Meister, Emi Nagoshi Parkinson's disease (PD) is the most common neurodegenerative movement disorder characterized by the progressive loss of dopaminergic (DA) neurons. Both environmental and ...

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Recovery from an Acute Infection in C. elegans Requires the GATA Transcription Factor ELT-2

23.10.2014 | Brian Head et al., PLoS Genetics, 2014

by Brian Head, Alejandro Aballay The mechanisms involved in the recognition of microbial pathogens and activation of the immune system have been extensively studied. However, the mechanisms involved in the recovery phase of an infection are incompletely characterized at both the cellular and ...

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Juvenile Hormone-Receptor Complex Acts on Mcm4 and Mcm7 to Promote Polyploidy and Vitellogenesis in the Migratory Locust

23.10.2014 | Wei Guo et al., PLoS Genetics, 2014

by Wei Guo, Zhongxia Wu, Jiasheng Song, Feng Jiang, Zhiming Wang, Shun Deng, Virginia K. Walker, Shutang Zhou Juvenile hormone (JH), a sesquiterpenoid produced by the corpora allata, coordinates insect growth, metamorphosis, and reproduction. While JH action for the repression of larval ...

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HIPPO Pathway Members Restrict SOX2 to the Inner Cell Mass Where It Promotes ICM Fates in the Mouse Blastocyst

23.10.2014 | Eryn Wicklow et al., PLoS Genetics, 2014

by Eryn Wicklow, Stephanie Blij, Tristan Frum, Yoshikazu Hirate, Richard A. Lang, Hiroshi Sasaki, Amy Ralston Pluripotent epiblast (EPI) cells, present in the inner cell mass (ICM) of the mouse blastocyst, are progenitors of both embryonic stem (ES) cells and the fetus. Discovering how ...

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Dynamic Partnership between TFIIH, PGC-1α and SIRT1 Is Impaired in Trichothiodystrophy

23.10.2014 | Hussein Traboulsi et al., PLoS Genetics, 2014

by Hussein Traboulsi, Serena Davoli, Philippe Catez, Jean-Marc Egly, Emmanuel Compe The expression of protein-coding genes requires the selective role of many transcription factors, whose coordinated actions remain poorly understood. To further grasp the molecular mechanisms that govern ...

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The Not5 Subunit of the Ccr4-Not Complex Connects Transcription and Translation

23.10.2014 | Zoltan Villanyi et al., PLoS Genetics, 2014

by Zoltan Villanyi, Virginie Ribaud, Sari Kassem, Olesya O. Panasenko, Zoltan Pahi, Ishaan Gupta, Lars Steinmetz, Imre Boros, Martine A. Collart Recent studies have suggested that a sub-complex of RNA polymerase II composed of Rpb4 and Rpb7 couples the nuclear and cytoplasmic stages of gene ...

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daf-31 Encodes the Catalytic Subunit of N Alpha-Acetyltransferase that Regulates Caenorhabditis elegans Development, Metabolism and Adult Lifespan

16.10.2014 | Di Chen et al., PLoS Genetics, 2014

by Di Chen, Jiuli Zhang, Justin Minnerly, Tiffany Kaul, Donald L. Riddle, Kailiang Jia The Caenorhabditis elegans dauer larva is a facultative state of diapause. Mutations affecting dauer signal transduction and morphogenesis have been reported. Of these, most that result in constitutive ...

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Signature Gene Expression Reveals Novel Clues to the Molecular Mechanisms of Dimorphic Transition in Penicillium marneffei

16.10.2014 | Ence Yang et al., PLoS Genetics, 2014

by Ence Yang, Wang-Ngai Chow, Gang Wang, Patrick C. Y. Woo, Susanna K. P. Lau, Kwok-Yung Yuen, Xiaorong Lin, James J. Cai Systemic dimorphic fungi cause more than one million new infections each year, ranking them among the significant public health challenges currently encountered. Penicillium ...

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