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467 Aktuelle Fachpublikationen in PLoS Genetics

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TFIIS-Dependent Non-coding Transcription Regulates Developmental Genome Rearrangements

15.07.2015 | Kamila Maliszewska-Olejniczak et al., PLoS Genetics, 2015

by Kamila Maliszewska-Olejniczak, Julita Gruchota, Robert Gromadka, Cyril Denby Wilkes, Olivier Arnaiz, Nathalie Mathy, Sandra Duharcourt, Mireille Bétermier, Jacek K. Nowak Because of their nuclear dimorphism, ciliates provide a unique opportunity to study the role of non-coding RNAs (ncRNAs) ...

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RFX2 Is a Major Transcriptional Regulator of Spermiogenesis

10.07.2015 | W. Stephen Kistler et al., PLoS Genetics, 2015

by W. Stephen Kistler, Dominique Baas, Sylvain Lemeille, Marie Paschaki, Queralt Seguin-Estevez, Emmanuèle Barras, Wenli Ma, Jean-Luc Duteyrat, Laurette Morlé, Bénédicte Durand, Walter Reith Spermatogenesis consists broadly of three phases: proliferation of diploid germ cells, meiosis, and ...

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Genome Wide Binding Site Analysis Reveals Transcriptional Coactivation of Cytokinin-Responsive Genes by DELLA Proteins

02.07.2015 | Nora Marín-de la Rosa et al., PLoS Genetics, 2015

by Nora Marín-de la Rosa, Anne Pfeiffer, Kristine Hill, Antonella Locascio, Rishikesh P. Bhalerao, Pal Miskolczi, Anne L. Grønlund, Aakriti Wanchoo-Kohli, Stephen G. Thomas, Malcolm J. Bennett, Jan U. Lohmann, Miguel A. Blázquez, David Alabadí The ability of plants to provide a plastic response ...

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A Conserved Pattern of Primer-Dependent Transcription Initiation in Escherichia coli and Vibrio cholerae Revealed by 5′ RNA-seq

01.07.2015 | Sergey Y. Druzhinin et al., PLoS Genetics, 2015

by Sergey Y. Druzhinin, Ngat T. Tran, Kyle S. Skalenko, Seth R. Goldman, Jared G. Knoblauch, Simon L. Dove, Bryce E. Nickels Transcription initiation that involves the use of a 2- to ~4-nt oligoribonucleotide primer, “primer-dependent initiation,” (PDI) has been shown to be widely prevalent at ...

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Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

01.07.2015 | Momoko Horikoshi et al., PLoS Genetics, 2015

by Momoko Horikoshi, Reedik Mӓgi, Martijn van de Bunt, Ida Surakka, Antti-Pekka Sarin, Anubha Mahajan, Letizia Marullo, Gudmar Thorleifsson, Sara Hӓgg, Jouke-Jan Hottenga, Claes Ladenvall, Janina S. Ried, Thomas W. Winkler, Sara M. Willems, Natalia Pervjakova, Tõnu Esko, Marian Beekman, ...

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The Catalytic and Non-catalytic Functions of the Brahma Chromatin-Remodeling Protein Collaborate to Fine-Tune Circadian Transcription in Drosophila

01.07.2015 | Rosanna S. Kwok et al., PLoS Genetics, 2015

by Rosanna S. Kwok, Ying H. Li, Anna J. Lei, Isaac Edery, Joanna C. Chiu Daily rhythms in gene expression play a critical role in the progression of circadian clocks, and are under regulation by transcription factor binding, histone modifications, RNA polymerase II (RNAPII) recruitment and ...

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Reversible Oxidation of a Conserved Methionine in the Nuclear Export Sequence Determines Subcellular Distribution and Activity of the Fungal Nitrate Regulator NirA

01.07.2015 | Andreas Gallmetzer et al., PLoS Genetics, 2015

by Andreas Gallmetzer, Lucia Silvestrini, Thorsten Schinko, Bernd Gesslbauer, Peter Hortschansky, Christoph Dattenböck, María Isabel Muro-Pastor, Andreas Kungl, Axel A. Brakhage, Claudio Scazzocchio, Joseph Strauss The assimilation of nitrate, a most important soil nitrogen source, is tightly ...

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Ribosomal Protein Mutations Result in Constitutive p53 Protein Degradation through Impairment of the AKT Pathway

01.07.2015 | Ana T. Antunes et al., PLoS Genetics, 2015

by Ana T. Antunes, Yvonne J. Goos, Tamara C. Pereboom, Dorien Hermkens, Marcin W. Wlodarski, Lydie Da Costa, Alyson W. MacInnes Mutations in ribosomal protein (RP) genes can result in the loss of erythrocyte progenitor cells and cause severe anemia. This is seen in patients with ...

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Orthodenticle Is Required for the Expression of Principal Recognition Molecules That Control Axon Targeting in the Drosophila Retina

26.06.2015 | Chiara Mencarelli et al., PLoS Genetics, 2015

by Chiara Mencarelli, Franck Pichaud Parallel processing of neuronal inputs relies on assembling neural circuits into distinct synaptic-columns and layers. This is orchestrated by matching recognition molecules between afferent growth cones and target areas. Controlling the expression of these ...

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Silencing of DNase Colicin E8 Gene Expression by a Complex Nucleoprotein Assembly Ensures Timely Colicin Induction

26.06.2015 | Simona Kamenšek et al., PLoS Genetics, 2015

by Simona Kamenšek, Douglas F. Browning, Zdravko Podlesek, Stephen J. W. Busby, Darja Žgur-Bertok, Matej Butala Colicins are plasmid-encoded narrow spectrum antibiotics that are synthesized by strains of Escherichia coli and govern intraspecies competition. In a previous report, we demonstrated ...

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