16.05.2013 | Bruna Barneda-Zahonero et al., PLoS Genetics, 2013

by Bruna Barneda-Zahonero, Lidia Román-González, Olga Collazo, Haleh Rafati, Abul B. M. M. K. Islam, Lars H. Bussmann, Alessandro di Tullio, Luisa De Andres, Thomas Graf, Núria López-Bigas, Tokameh Mahmoudi, Maribel Parra B lymphopoiesis is the result of several cell-commitment, ...

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16.05.2013 | Nathan T. Martin et al., PLoS Genetics, 2013

by Nathan T. Martin, Kotoka Nakamura, Robert Davies, Shareef A. Nahas, Christina Brown, Rashmi Tunuguntla, Richard A. Gatti, Hailiang Hu ATM plays a critical role in cellular responses to DNA double-strand breaks (DSBs). We describe a new ATM–mediated DSB–induced DNA damage ...

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09.05.2013 | Jakob Gramstrup Petersen et al., PLoS Genetics, 2013

by Jakob Gramstrup Petersen, Teresa Rojo Romanos, Vaida Juozaityte, Alba Redo Riveiro, Ingrid Hums, Lisa Traunmüller, Manuel Zimmer, Roger Pocock Animals harbor specialized neuronal systems that are used for sensing and coordinating responses to changes in oxygen (O2) and carbon dioxide ...

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09.05.2013 | Nazareth Bastajian et al., PLoS Genetics, 2013

by Nazareth Bastajian, Helena Friesen, Brenda J. Andrews The Bck2 protein is a potent genetic regulator of cell-cycle-dependent gene expression in budding yeast. To date, most experiments have focused on assessing a potential role for Bck2 in activation of the G1/S-specific transcription ...

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09.05.2013 | Clément Monot et al., PLoS Genetics, 2013

by Clément Monot, Monika Kuciak, Sébastien Viollet, Ashfaq Ali Mir, Caroline Gabus, Jean-Luc Darlix, Gaël Cristofari L1 retrotransposons have a prominent role in reshaping mammalian genomes. To replicate, the L1 ribonucleoprotein particle (RNP) first uses its endonuclease (EN) to nick the ...

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02.05.2013 | Harm van Bakel et al., PLoS Genetics, 2013

by Harm van Bakel, Kyle Tsui, Marinella Gebbia, Sanie Mnaimneh, Timothy R. Hughes, Corey Nislow Nucleosomes in all eukaryotes examined to date adopt a characteristic architecture within genes and play fundamental roles in regulating transcription, yet the identity and precise roles of many ...

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02.05.2013 | Eva Bjur et al., PLoS Genetics, 2013

by Eva Bjur, Ola Larsson, Ekaterina Yurchenko, Lei Zheng, Valentina Gandin, Ivan Topisirovic, Shui Li, Carston R. Wagner, Nahum Sonenberg, Ciriaco A. Piccirillo Regulatory T cells expressing the transcription factor Foxp3 play indispensable roles for the induction and maintenance of ...

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25.04.2013 | Aurélie Kapusta et al., PLoS Genetics, 2013

by Aurélie Kapusta, Zev Kronenberg, Vincent J. Lynch, Xiaoyu Zhuo, LeeAnn Ramsay, Guillaume Bourque, Mark Yandell, Cédric Feschotte Advances in vertebrate genomics have uncovered thousands of loci encoding long noncoding RNAs (lncRNAs). While progress has been made in elucidating the ...

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25.04.2013 | Jun Yao et al., PLoS Genetics, 2013

by Jun Yao, David M. Truong, Alan M. Lambowitz Mobile group II introns retrohome by an RNP-based mechanism in which the intron RNA reverse splices into a DNA site and is reverse transcribed by the associated intron-encoded protein. The resulting intron cDNA is then integrated into the ...

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25.04.2013 | Haythem Latif et al., PLoS Genetics, 2013

by Haythem Latif, Joshua A. Lerman, Vasiliy A. Portnoy, Yekaterina Tarasova, Harish Nagarajan, Alexandra C. Schrimpe-Rutledge, Richard D. Smith, Joshua N. Adkins, Dae-Hee Lee, Yu Qiu, Karsten Zengler The generation of genome-scale data is becoming more routine, yet the subsequent analysis ...

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