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575 Aktuelle Fachpublikationen in Pharmacogenomics
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Systems pharmacology assessment of the 5-fluorouracil pathway
30.03.2011 | Filipe A Muhale; Barbara A Wetmore; Russell S Thomas; Howard L McLeod, Pharmacogenomics, 2011
Aim: To assess the impact of the 5-fluorouracil (5-FU) drug-pathway genes on cytotoxicity, and determine whether loss-of-function analyses coupled with functional assays can help prioritize pharmacogenomic candidate genes. Materials & methods: Dose-response experiments were used to quantify ...
Identification of predictive markers of cytarabine response in AML by integrative analysis of gene-expression profiles with multiple phenotypes
30.03.2011 | Jatinder K Lamba; Kristine R Crews; Stanley B Pounds; Xueyuan Cao; Varsha Gandhi; William Plunkett; Bass ..., Pharmacogenomics, 2011
Aim: To identify gene-expression signatures predicting cytarabine response by an integrative analysis of multiple clinical and pharmacological end points in acute myeloid leukemia (AML) patients. Materials & methods: We performed an integrated analysis to associate the gene expression of ...
Gene-wide tagging study of the association between ABCC2, ABCC5 and ABCG2 genetic polymorphisms and multidrug resistance in epilepsy
30.03.2011 | Patrick Kwan; Virginia Wong; Ping Wing Ng; Colin Hiu Tung Lui; Ngai Chuen Sin; Ka Sing Wong; Larry Baum, Pharmacogenomics, 2011
Aim: To determine the association between polymorphisms of the multidrug transporter genes ABCC2, ABCC5 and ABCG2, and drug resistance in epilepsy by genotyping comprehensive sets of tagging SNPs. Materials & methods: A total of 25 tagging SNPs from ABCC2, ABCC5 and ABCG2 genes were genotyped ...
Conference Scene: Report on the 8th Annual Cold Spring Harbor/Wellcome Trust meeting on Pharmacogenomics and Personalized Medicine
30.03.2011 | Daniel F Carr; Ana Alfirevic, Pharmacogenomics, 2011
The joint Cold Spring Harbor/Wellcome Trust Conference on pharmacogenomics, held in the USA and the UK in alternate years, focuses on the growing contribution of genomic technologies to the study of variable human responses to therapeutic agents. The meeting brings together researchers from ...
Research Highlights
30.03.2011 | Adrián LLerena; Pedro Dorado; Eva M Peñas-LLedó, Pharmacogenomics, 2011
Pharmacogenomics , March 2011, Vol. 12, No. 3, Pages 311-313.
Letter to the Editor: Reply to Kobunai et al.
30.03.2011 | Pietro Carotenuto; Cristin Roma; Anna Maria Rachiglio; Nicola Normanno, Pharmacogenomics, 2011
Pharmacogenomics , March 2011, Vol. 12, No. 3, Pages 309-310.
Letter to the Editor: Does a cost-effective approach for the determination of KRAS mutations maximize the patient’s benefit in a clinical setting?
30.03.2011 | Takashi Kobunai; Toshiaki Watanabe; Yoko Yamamoto; Toshio Fukusato, Pharmacogenomics, 2011
Pharmacogenomics , March 2011, Vol. 12, No. 3, Pages 307-308.
News & Views in ... Pharmacogenomics
30.03.2011 | Pharmacogenomics, 2011
Pharmacogenomics , March 2011, Vol. 12, No. 3, Pages 303-305.
Gene copy number variations: it is important to determine which allele is affected
30.03.2011 | Anuradha Ramamoorthy; Todd C Skaar, Pharmacogenomics, 2011
Pharmacogenomics , March 2011, Vol. 12, No. 3, Pages 299-301.
Polymorphisms present in G-protein-coupled receptor kinases and their effect on β-blocker treatment
30.03.2011 | Philip W Raake; Walter J Koch; Patrick Most, Pharmacogenomics, 2011
Pharmacogenomics , March 2011, Vol. 12, No. 3, Pages 295-297.
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