20.10.2012 | Yuan Miao, Ai-Lin Li, Liang Wang, Chui-Feng Fan, Xiu-Peng Zhang, Hong-Tao Xu, Lian-He Yang, Yang Liu, En-Hua Wang, Pathology & Oncology Research, 2012

Neural precursor cell expressed, developmentally down-regulated 9 (NEDD9) is overexpressed in multiple tumor types, where it is thought to regulate tumor cell metastasis and act as a trigger of the epithelial-mesenchymal transition (EMT). Loss of E-cadherin/β-catenin and upregulation of ...

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16.10.2012 | Jose Aneiros-Fernandez, Salvador Arias-Santiago, Borja Arias-Santiago, Maria Herrero-Fernández, V. Carriel, Jose Ane ..., Pathology & Oncology Research, 2012

We contribute the first immunohistochemical study of MT1 melatonin receptor in Warthin’s tumor and normal parotid gland. All 14 Warthin’s tumors studied showed intense cytoplasmic positivity for MT1 receptor in all cylindrical epithelial cells lining spaces and a less intense positivity in ...

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16.10.2012 | Kuang Youlin, Zhang Jianwei, Gou Xin, Zhang Li, Weng Xiaodong, Liu Xiuheng, Zhu Hengchen, Chen Zhiyuan, Pathology & Oncology Research, 2012

It has been shown that human prostate cancer (PCa) cells induced apoptotic death of the most potent antigen-presenting cells, dendritic cells (DCs), which are responsible for the induction of specific antitumor immune responses. Here, we investigated the function of 4-1BB on protecting DCs ...

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15.10.2012 | Gábor Cserni, Istvánné Bezsenyi, László Markó, Pathology & Oncology Research, 2012

The optimal locoregional treatment of patients diagnosed with sentinel node (SN) micrometastasis is controversial. A previously reported and validated nomogram was used to calculate the risk of non-SN metastasis in patients with SN micrometastasis over a period of 2 years. Patients were given ...

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14.10.2012 | Tibor Takács, Attila Paszt, Zsolt Simonka, Szabolcs Ábrahám, Bernadett Borda, Aurél Ottlakán, Katalin Ormándi, Máté ..., Pathology & Oncology Research, 2012

The purpose of this study was to compare the two methods—guidewire localisation and the radioguided occult lesion localisation—used in the localisation and surgical removal of non-palpable breast tumours. This retrospective study enrolled patients diagnosed with nonpalpable malignant breast ...

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13.10.2012 | Jean-Jacques Candelier, Lucien Frappart, Tarik Yadaden, Henriette Poaty, Jean-Yves Picard, Sophie Prévot, Philippe C ..., Pathology & Oncology Research, 2012

Abnormal trophoblast differentiation is the main cause of gestational trophoblast diseases in the case of hydatidiform moles and choriocarcinomas. Here we investigated the expression patterns of two gene products, p16 and Bcl-2, implicated in cell cycle regulation and apoptosis, respectively, ...

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12.10.2012 | Yizhen Shen, Yi Liu, Shaoge Liu, Aimin Zhang, Pathology & Oncology Research, 2012

Bladder cancer is one of the most common malignancies in the world. Toll-like receptor 4 (TLR4) plays important roles in regulating innate immunity and may affect the development of cancers. Polymorphisms in TLR4 gene have been shown to be associated with impaired immune responses. Here, we ...

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10.10.2012 | Hayam A. Aiad, Manar A. Bashandy, Asmaa G. Abdou, Ahmad A. Zahran, Pathology & Oncology Research, 2012

We aimed to assess the utility of quantitative analysis of AgNORs and Ki67 labeling index (LI) in the differential diagnosis of different thyroid lesions. This study included: 25 papillary carcinomas, 7 follicular carcinomas, 21 follicular adenomas and 27 nodular goiters. Using a ...

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10.10.2012 | Yong-Il Ji, Bo-Young Lee, Yun-Jeong Kang, Jin-Ok Jo, Sang Ho Lee, Heung Yeol Kim, Young-Ok Kim, Chulmin Lee, Suk Bon ..., Pathology & Oncology Research, 2012

Thymosin β4 (Tβ4), a small acidic actin binding peptide, is overexpressed in a side population of cancer stem cells and CD133-positive colorectal cancer stem cells. In order to understand the relationship between Tβ4 and CD133, we studied the expression patterns of Tβ4 and CD133 in ovarian ...

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10.10.2012 | Basil R. Obeidat, Ismail I. Matalka, Alia A. Mohtaseb, Nabih S Al-Kaisi, Pathology & Oncology Research, 2012

To assess the immuno-histochemical expression of various markers in, endometrial biopsies of patients with endometrial cancer, and to correlate their expression with the final pathologic findings. Sixty-two patients with primary endometrial cancer who underwent surgical treatment were ...

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