01.05.2013 | Pascal Andujar; Jean-Claude Pairon; Annie Renier; Alexis Descatha; Ilir Hysi; Issam Abd-Alsamad; Marie-Annick Billon ..., Mutagenesis, 2013

Given the interest in defining biomarkers of asbestos exposure and to provide insights into asbestos-related and cell-specific mechanisms of neoplasia, the identification of gene alterations in asbestos-related cancers can help to a better understanding of exposure risk. To understand the ...

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01.05.2013 | Sebastiano Di Bucchianico; Maria Rita Fabbrizi; Superb K. Misra; Eugenia Valsami-Jones; Deborah Berhanu; Paul Reip; ..., Mutagenesis, 2013

In nanotoxicology, the capacity of nanoparticles of the same composition but different shape to induce cytotoxicity and genotoxicity is largely unknown. A series of cytotoxic and genotoxic responses following in vitro exposure to differently shaped CuO nanoparticles (CuO NPs, mass ...

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01.05.2013 | Tove Sandberg Liljendahl; Anna Blomqvist; Eva M. Andersson; Lars Barregard; Dan Segerbäck, Mutagenesis, 2013

The incidence of skin cancer is rising rapidly in many countries, presumably due to increased leisure time exposure to solar ultraviolet radiation (UVR). UVR causes DNA lesions, such as the thymine dimer (T=T), which have been causatively linked to the development of skin cancer. T=T is ...

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01.05.2013 | Amaya Azqueta; Leire Arbillaga; Adela López de Cerain; Andrew Collins, Mutagenesis, 2013

The alkaline comet assay, when employed as a genotoxicity test, has relatively low sensitivity because it fails to detect—at non-cytotoxic concentrations—known genotoxins that do not induce breaks or alkali-labile sites. We demonstrate that this limitation is overcome by incorporating in the ...

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01.05.2013 | Judith H. Ford, Mutagenesis, 2013

Ageing is associated with a reduction in the fidelity of cell division as shown by increases in trisomic and polyploid cells; however, to date, the underlying age-specific changes in cell division have not been identified. Understanding these specific changes in cell division could give ...

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01.05.2013 | Philipp Hofer; Julia Zerelles; Andreas Baierl; Stephan Madersbacher; Georg Schatzl; Agnes Maj-Hes; Hedwig Sutterlüty ..., Mutagenesis, 2013

Telomere dysfunction is an early event in the development of prostate cancer and telomerase (TERT) activity is detectable in the majority of prostate cancers. Genetic variation in TERT and its regulatory elements may influence prostate carcinogenesis. MNS16A, a functional polymorphic tandem ...

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01.05.2013 | Gui-Mei Chen; Chen-Chen Feng; Qian-Ling Ye; Tao Jin-hui; Rui Li; Hui Peng; Mo Zhou; Rui-Xue Leng; Jing Li; Han Cen; ..., Mutagenesis, 2013

The P2X7 receptor is a ligand-gated cationic channel receptor that is actived by ATP and normally expressed by a variety of immune system cells, including macrophages and lymphocytes. Because it leads to release of IL-1β and cell death by apoptosis or necrosis, it is a potential therapeutic ...

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01.05.2013 | Emiliano Basso; Mario Fiore; Stefano Leone; Francesca Degrassi; Renata Cozzi, Mutagenesis, 2013

In recent years, a great interest has emerged in resveratrol (RSV) activity in the prevention of various pathologies including cancer. We recently showed that RSV is able to interfere with topoisomerase II-α (TOPO2) activity in cancer cells, thus inducing a delay in S-phase progression with ...

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01.05.2013 | Kentaro Taira; Satomi Kaneto; Kota Nakano; Shinji Watanabe; Eizo Takahashi; Sakae Arimoto; Keinosuke Okamoto; Roel M ..., Mutagenesis, 2013

DNA alkylation damage can be repaired by nucleotide excision repair (NER), base excision repair (BER) or by direct removal of alkyl groups from modified bases by O 6-alkylguanine DNA alkyltransferase (AGT; E.C. 2.1.1.63). DNA mismatch repair (MMR) is also likely involved in this repair. We ...

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01.05.2013 | Arun Gupta; Clayton R. Hunt; Raj K. Pandita; Juhee Pae; K. Komal; Mayank Singh; Jerry W. Shay; Rakesh Kumar; Kiyoshi ..., Mutagenesis, 2013

Ataxia telangiectasia patients develop lymphoid malignancies of both B- and T-cell origin. Similarly, ataxia telangiectasia mutated (Atm)-deficient mice exhibit severe defects in T-cell maturation and eventually develop thymomas. The function of ATM is known to be influenced by the mammalian ...

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