05.11.2012 | Andreia Neves Carvalho, Carla Marques, Elsa Rodrigues, Colin J. Henderson, C. Roland Wolf, Paulo Pereira, Maria João ..., Molecular Neurobiology, 2012

The ubiquitin–proteasome system (UPS) is the primary proteolytic complex responsible for the elimination of damaged and misfolded intracellular proteins, often formed upon oxidative stress. Parkinson’s disease (PD) is neuropathologically characterized by selective death of dopaminergic ...

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20.10.2012 | Andreia Barateiro, Veronique E. Miron, Sofia D. Santos, João B. Relvas, Adelaide Fernandes, Charles ffrench-Constant ..., Molecular Neurobiology, 2012

High levels of serum unconjugated bilirubin (UCB) in newborns are associated with axonal damage and glial reactivity that may contribute to subsequent neurologic injury and encephalopathy (kernicterus). Impairments in myelination and white matter damage were observed at autopsy in kernicteric ...

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20.10.2012 | Haitao Wang, Xiaolu Duan, Yannan Ren, Yizhi Liu, Min Huang, Peiqing Liu, Rikang Wang, Guoquan Gao, Lihua Zhou, Zhong ..., Molecular Neurobiology, 2012

Forkhead box O3 (FoxO3a) is a forkhead family transcription factor playing important roles in non-neuronal differentiation, metabolism, proliferation, and survival, but its role in neuronal differentiation remains unclear. In the present study, we investigated the role of FoxO3a in neuronal ...

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19.10.2012 | Ryszard Pluta, Wanda Furmaga-Jabłońska, Ryszard Maciejewski, Marzena Ułamek-Kozioł, Mirosław Jabłoński, Molecular Neurobiology, 2012

Amyloid precursor protein cleavage through β- and γ-secretases produces β-amyloid peptide, which is believed to be responsible for death of neurons and dementia in Alzheimer’s disease. Levels of β- and γ-secretase are increased in sensitive areas of the Alzheimer’s disease brain, but the ...

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13.10.2012 | Hea-Jin Jung, John M. Lee, Shao H. Yang, Stephen G. Young, Loren G. Fong, Molecular Neurobiology, 2012

The nuclear lamina is an intermediate filament meshwork composed largely of four nuclear lamins — lamins A and C (A-type lamins) and lamins B1 and B2 (B-type lamins). Located immediately adjacent to the inner nuclear membrane, the nuclear lamina provides a structural scaffolding for the cell ...

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13.10.2012 | Aron Kos, Nikkie F. Olde Loohuis, Jeffrey C. Glennon, Tansu Celikel, Gerard J. M. Martens, Paul H. Tiesinga, Armaz A ..., Molecular Neurobiology, 2012

The emergence of optogenetics technology facilitated widespread applications for interrogation of complex neural networks, such as activation of specific axonal pathways, previously found impossible with electrical stimulation. Consequently, within the short period of its application in ...

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12.10.2012 | Sylvain Ferrandon, Paul Saultier, Julien Carras, Priscillia Battiston-Montagne, Gersende Alphonse, Michael Beuve, Cé ..., Molecular Neurobiology, 2012

Despite a standard of care combining surgery, radiotherapy (RT), and temozolomide chemotherapy, the average overall survival (OS) of glioblastoma patients is only 15 months, and even far lower when the patient cannot benefit from this combination. Therefore, there is a strong need for new ...

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10.10.2012 | Clarissa M. Comim, Tatiana Barichello, Denis Grandgirard, Felipe Dal-Pizzol, João Quevedo, Stephen L. Leib, Molecular Neurobiology, 2012

The brain is one of the first organs affected during sepsis development resulting in apoptosis for a short-term and cognitive impairment for a long-term. Despite its importance, the mechanisms of brain dysfunction during sepsis are not fully elucidated. Thus, we here, in an animal model of ...

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10.10.2012 | Hong-hai Hu, Shu-ji Li, Pu Wang, Hua-cheng Yan, Xiong Cao, Feng-qin Hou, Ying-ying Fang, Xin-hong Zhu, Tian-ming Gao, Molecular Neurobiology, 2012

Our previous data indicate that the inhibition of L-type calcium channels (LTCCs) might be the cause of post-ischemic neuronal injury and that the activation of LTCCs can give rise to neuroprotection. In the present study, we aimed to profile the intervention window of Bay K8644, an LTCC ...

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10.10.2012 | Emma L. Clayton, Shane Minogue, Mark G. Waugh, Molecular Neurobiology, 2012

The four mammalian phosphatidylinositol 4-kinases, together with the PI(4,5)P2 depleting 5-phosphatases of the oculocerebrorenal syndrome of Lowe and synaptojanin families, modulate neuronal pools of PI4P lipid and regulate intracellular membrane trafficking in the endocytic and secretory ...

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