26.11.2012 | Min-Kyung Jung, Ki Yoon Kim, Na-Young Lee, Young-Sook Kang, Yu Jin Hwang, Yunha Kim, Jung-Joon Sung, Ann McKee, Neil ..., Molecular Neurobiology, 2012

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by progressive paralysis caused by the degeneration of motor neurons throughout the central nervous system. Mutations of the free radical scavenging enzyme Cu/Zn superoxide dismutase 1 (SOD1) are a cause of ...

mehr

26.11.2012 | Shu-Qin Li, Wen-Bin Li, Min Zhang, Yu-Zhou Wu, Yu-Yan Hu, Molecular Neurobiology, 2012

Recent evidence suggests that limb ischemic preconditioning (LIP) protects neurons against cerebral ischemia-reperfusion injury. However, the mechanisms of LIP are not well understood. Neuroglobin (Ngb) is a recently discovered globin that affords protection against hypoxic/ischemic brain ...

mehr

26.11.2012 | Mehmet Ozansoy, A. Nazli Başak, Molecular Neurobiology, 2012

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, defined by the presence of resting tremor, muscular rigidity, bradykinesia, and postural instability. PD is characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta of ...

mehr

26.11.2012 | Rena Li, Ping He, Jie Cui, Matthias Staufenbiel, Nobuhiro Harada, Yong Shen, Molecular Neurobiology, 2012

Estrogens have been found to improve memory and reduce risk of dementia, although conflicting results such as failure of estrogen replacement therapy for treatment of Alzheimer's disease (AD) also has been reported. Only recently, our published human brain studies showed a depletion of brain ...

mehr

15.11.2012 | Wibke Singer, Annalisa Zuccotti, Mirko Jaumann, Sze Chim Lee, Rama Panford-Walsh, Hao Xiong, Ulrike Zimmermann, Chri ..., Molecular Neurobiology, 2012

Increasing evidence shows that hearing loss is a risk factor for tinnitus and hyperacusis. Although both often coincide, a causal relationship between tinnitus and hyperacusis has not been shown. Currently, tinnitus and hyperacusis are assumed to be caused by elevated responsiveness in ...

mehr

13.11.2012 | Yanxing Chen, Zhihou Liang, Julie Blanchard, Chun-Ling Dai, Shenggang Sun, Moon H. Lee, Inge Grundke-Iqbal, Khalid I ..., Molecular Neurobiology, 2012

Alzheimer’s disease (AD) can be divided into sporadic AD (SAD) and familial AD (FAD). Most AD cases are sporadic and result from multiple etiologic factors, including environmental, genetic, and metabolic factors, whereas FAD is caused by mutations in the presenilins or amyloid-β (Aβ) ...

mehr

13.11.2012 | Stefanie Malan-Müller, Sîan Megan Joanna Hemmings, Soraya Seedat, Molecular Neurobiology, 2012

Epigenetic and regulatory elements provide an additional layer of complexity to the heterogeneity of anxiety disorders. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that have recently drawn interest as epigenetic modulators of gene expression in psychiatric disorders. miRNAs elicit ...

mehr

09.11.2012 | Zui Tao, Jiaman Dai, Jianrong He, Chunshi Li, Yaochen Li, Zheng Qin Yin, Molecular Neurobiology, 2012

Sodium iodate (NaIO3)-induced retina injury is one of models that is commonly used to study various retinal diseases caused by retinal pigment epithelium (RPE) injury such as AMD. Previous researches have revealed that RPE and photoreceptors are main impaired objects in this model. By ...

mehr

08.11.2012 | Mustafa S. Kassem, Jim Lagopoulos, Tim Stait-Gardner, William S. Price, Tariq W. Chohan, Jonathon C. Arnold, Sean N. ..., Molecular Neurobiology, 2012

Stress, unaccompanied by signs of post-traumatic stress disorder, is known to decrease grey matter volume (GMV) in the anterior cingulate cortex (ACC) and hippocampus but not the amygdala in humans. We sought to determine if this was the case in stressed mice using high-resolution magnetic ...

mehr

07.11.2012 | Zhongyu Liu, Mengyu Xie, Zhiqiang Yao, Yulong Niu, Youquan Bu, Chunfang Gao, Molecular Neurobiology, 2012

Glioma is one of the most common tumors of the central nervous system, and one of its main types is astrocytoma. Microarray technology has been widely used to explore the molecular mechanism of cancer. It is universally accepted that meta-analysis considerably improves the statistical ...

mehr