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1.136 Aktuelle Fachpublikationen in Molecular Microbiology
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Peptidoglycan at its peaks: how chromatographic analyses can reveal bacterial cell‐wall structure and assembly
17.05.2013 | Samantha M. Desmarais, Miguel A. Pedro, Felipe Cava, Kerwyn Casey Huang, Molecular Microbiology, 2013
Abstract The peptidoglycan (PG) cell wall is a unique macromolecule responsible for both shape determination and cellular integrity under osmotic stress in virtually all bacteria. A quantitative understanding of the relationships between PG architecture, morphogenesis, immune system ...
Both human ferredoxins equally efficiently rescue ferredoxin deficiency in Trypanosoma brucei
16.05.2013 | Piya Changmai, Eva Horáková, Shaojun Long, Eva Černotíková‐Stříbrná, Lindsay M. McDonald, Esteban J. Bontempi, Juliu ..., Molecular Microbiology, 2013
Summary Ferredoxins are highly conserved proteins that function universally as electron transporters. They not only require Fe‐S clusters for their own activity, but are also involved in Fe‐S formation itself. We identified two homologues of ferredoxin in the genome of the parasitic ...
Superoxide poisons mononuclear iron enzymes by causing mismetallation
16.05.2013 | Mianzhi Gu, James A. Imlay, Molecular Microbiology, 2013
Summary Superoxide (O2‐) is a primary agent of intracellular oxidative stress. Genetic studies in many organisms have confirmed that excess O2‐ disrupts metabolism, but to date only a small family of [4Fe‐4S] dehydratases have been identified as direct targets. This investigation reveals ...
A Novel RNA Polymerase‐Binding Protein Controlling Genes Involved in Spore Germination in Bacillus subtilis
16.05.2013 | Bjorn A. Traag, Arturo Ramirez‐Peralta, Anna F. Wang Erickson, Peter Setlow, Richard Losick, Molecular Microbiology, 2013
Summary A growing class of proteins regulates transcription through interaction with DNA‐dependent RNA polymerase. Here we report that a recently identified, highly conserved sporulation gene ylyA encodes a novel RNA polymerase‐binding protein that influences the expression of genes under ...
The RNAi machinery regulates growth and development in the filamentous fungus Trichoderma atroviride
15.05.2013 | Nohemi Carreras‐Villaseñor, Edgardo U. Esquivel‐Naranjo, J. Manuel Villalobos‐Escobedo, Cei Abreu‐Goodger, Alfredo H ..., Molecular Microbiology, 2013
Summary The RNAi machinery is generally involved in genome protection in filamentous fungi, however the physiological role of RNAi has been poorly studied in fungal models. Here, we report that in the filamentous fungus Trichoderma atroviride, the products of the dcr2 and rdr3 genes ...
The unstructured domain of colicin N kills Escherichia coli
15.05.2013 | Christopher L. Johnson, Helen Ridley, Robert J. Pengelly, Mohd Zulkifli Salleh, Jeremy H. Lakey, Molecular Microbiology, 2013
Summary Bacteria often produce toxins which kill competing bacteria. Colicins, produced by and toxic to Escherichia coli bacteria are three‐domain proteins so efficient that one molecule can kill a cell. The C‐terminal domain carries the lethal activity and the central domain is required ...
Metabolite‐dependent regulation of gene expression in Trypanosoma brucei
14.05.2013 | Dong‐Hyun Kim, Michael Peter Barrett, Molecular Microbiology, 2013
Summary Mechanisms regulating gene expression in trypanosomatid protozoa differ significantly from those in other eukaryotes. Transcription of the genome appears to be more or less constitutive with the polyadenylation and trans‐splicing of large polycistronic RNAs producing monocistronic ...
The availability of purine nucleotides regulates natural competence by controlling translation of the competence activator Sxy
13.05.2013 | Sunita Sinha, Joshua Mell, Rosemary Redfield, Molecular Microbiology, 2013
Summary Many bacteria are naturally competent, able to bind and take up DNA from their extracellular environment. This DNA can serve as a significant source of nutrients, in addition to providing genetic material for recombination. The regulation of competence in several model organisms ...
Functional dissection and evidence for intercellular transfer of the heterocyst‐differentiation PatS morphogen
13.05.2013 | Laura Corrales‐Guerrero, Vicente Mariscal, Enrique Flores, Antonia Herrero, Molecular Microbiology, 2013
Summary The formation of a diazotrophic cyanobacterial filament represents a simple example of biological development. In Anabaena, a non‐random pattern of one nitrogen‐fixing heterocyst separated by about 10 photosynthetic vegetative cells results from lateral inhibition elicited by the ...
RNA‐Seq facilitates a new perspective on signal transduction and gene regulation in important plant pathogens
10.05.2013 | Frank‐Jörg Vorhölter, Molecular Microbiology, 2013
Summary RNA‐Seq is opening new doors for the functional understanding of microorganisms. Advances in RNA‐Seq technology are allowing investigators to focus their studies on specific functional questions. An interesting example is presented by An et al. (2013) in this issue of Molecular ...
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