27.11.2012 | Mumu Shi, Bo Yu, Hongguo Gao, Jingwen Mu, Changwei Ji, Molecular Biology Reports, 2012

Many studies investigated the relationship between matrix metalloproteinase 2 (MMP-2) overexpression and survival in patients with colorectal cancer (CRC), but yielded inconsistent results. To derive a more precise estimate of the prognostic significance of MMP-2 overexpression, we reviewed ...

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27.11.2012 | Marcelo Aguiar Costa-Lima, Márcia Rodrigues Amorim, Iêda Maria Orioli, Molecular Biology Reports, 2012

The association between Down syndrome (DS) and maternal polymorphisms in genes encoding folic acid metabolizing enzymes remains a controversial issue. A meta-analysis was performed to evaluate the association of maternal MTHFR 677C > T polymorphism and the risk of having a child with DS. ...

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27.11.2012 | Celina Galles, Claudia P. Spampinato, Molecular Biology Reports, 2012

The DNA mismatch repair (MMR) system is a major DNA repair pathway whose function is critical for the correction of DNA biosynthetic errors. MMR is initiated by the binding of MutS proteins to mismatches and unpaired nucleotides followed by the recruitment of MutL proteins. The major MutL ...

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27.11.2012 | R. Olbromski, E. Siadkowska, B. Żelazowska, L. Zwierzchowski, Molecular Biology Reports, 2012

Allelic expression imbalance (AEI) is an important genetic factor being the cause of differences in phenotypic traits that can be heritable. Studying AEI can be useful in searching for factors that modulate gene expression and help to understand molecular mechanisms underlying phenotypic ...

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27.11.2012 | Hui-Fang Li, Jing-Ting Shu, Yu-Feng Du, Yan-Ju Shan, Kuan-Wei Chen, Xue-Yu Zhang, Wei Han, Wen-Juan Xu, Molecular Biology Reports, 2012

Chicken prolactin (PRL) is a physiological candidate gene for egg production. Variations of T8052C and G8113C in exon 5 of PRL gene may associate with chicken egg production. The objective of the study was to investigate the association of these two single nucleotide polymorphisms in PRL gene ...

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27.11.2012 | Cinzia Daga, Marta Paludo, Sebastiano Luridiana, Maria Consuelo Mura, Sara Bodano, Michele Pazzola, Maria Luisa Dett ..., Molecular Biology Reports, 2012

The aim of the study was to detect polymorphism in the POU1F1 gene in Sarda breed goat, as well as to establish if SNPs could be associated with milk productive traits. The research was conducted on 129 Sarda breed goats from 4 to 5 years old, multiparous, lactating and in their third to ...

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27.11.2012 | Xianlin Zhao, Hongzhou Jiang, Molecular Biology Reports, 2012

Many studies have investigated the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and hemorrhagic stroke, but the impact of MTHFR C677T on hemorrhagic stroke is unclear owing to the obvious inconsistence among those studies. This study aimed to quantify the ...

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26.11.2012 | Maria Consuelo Mura, Cinzia Daga, Sara Bodano, Marta Paludo, Sebastiano Luridiana, Michele Pazzola, Maria Luisa Dett ..., Molecular Biology Reports, 2012

The aim of the study was to develop a reliable method for the RNA extraction from milk of Sarda sheep breed and to highlight if the extracted RNA can be used for expression study on mammary genes involved in milk fat synthesis using RT-qPCR. The main result is that a sample of 150 ml of milk ...

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26.11.2012 | Marianne Solhøj Nørskov, Molecular Biology Reports, 2012

GSTT1 null genotype and risk of coronary heart disease Content Type Journal Article Pages 1-3 DOI 10.1007/s11033-012-2260-1 Authors Marianne Solhøj Nørskov, Department of Clinical Biochemistry KB 3011, Section for Molecular Genetics, Rigshospitalet, Copenhagen University Hospital, ...

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26.11.2012 | Alireza Valdiani, Arash Javanmard, Daryush Talei, Soon Guan Tan, Sonia Nikzad, Mihdzar Abdul Kadir, Siti Nor Akmar A ..., Molecular Biology Reports, 2012

Erratum to: Microsatellite-based evidences of genetic bottlenecks in the cryptic species “Andrographis paniculata Nees”: a potential anticancer agent Content Type Journal Article Category Erratum Pages 1-1 DOI 10.1007/s11033-012-2259-7 Authors Alireza Valdiani, Department of ...

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