04.02.2011 | Lisa A. D’Agostino; Karen P. Lam; Richard Lee; Philip Britz-McKibbin; Lisa A. D’Agostino; Karen P. Lam; ..., Journal of Proteome Research, 2011

Thiol homeostasis plays an important role in human health and aging by regulation of cellular responses to oxidative stress. Due to major constraints that hamper reliable plasma thiol/disulfide redox status assessment in clinical research, we introduce an improved strategy for comprehensive ...

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04.02.2011 | Cheng-Cheng Zhang; Jason C. Rogalski; Daniel M. Evans; Cordula Klockenbusch; Ronald C. Beavis; Juergen Kast, Journal of Proteome Research, 2011

Experiments to probe for protein−protein interactions are the focus of functional proteomic studies, thus proteomic data repositories are increasingly likely to contain a large cross-section of such information. Here, we use the Global Proteome Machine database (GPMDB), which is the largest ...

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04.02.2011 | J. Patrick Murphy; Devanand M. Pinto, Journal of Proteome Research, 2011

Altered expression of glycolysis proteins is an important yet poorly understood characteristic of cancer. To better understand the glycolytic changes during tumorigenesis, we designed a liquid chromatography multiple reaction monitoring (LC−MRM) assay targeting the “glycolysis proteome” in ...

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04.02.2011 | Hyun-Jin Kim; Jin Hee Kim; Siwon Noh; Haeng Jeon Hur; Mi Jeong Sung; Jin-Taek Hwang; Jae Ho Park; Hye Jeong Yang; My ..., Journal of Proteome Research, 2011

Liver and serum metabolites of obese and lean mice fed on high fat or normal diets were analyzed using ultraperformance liquid chromatography−quadrupole-time-of-flight mass spectrometry, gas chromatography−mass spectrometry, and partial least-squares-discriminant analysis (PLS-DA). Obese and ...

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04.02.2011 | Sung-Ho Yun; Chi-Won Choi; Sang-Oh Kwon; Gun Wook Park; Kun Cho; Kyung-Hoon Kwon; Jin Young Kim; Jong Shin Yoo; Je C ..., Journal of Proteome Research, 2011

Acinetobacter baumannii is a Gram-negative, nonmotile aerobic bacterium that has emerged as an important nosocomial pathogen. Multidrug-resistant (MDR) A. baumannii is difficult to treat with antibiotics, and treatment failure in infected patients is of great concern in clinical settings. To ...

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04.02.2011 | Feng Ge; Liang Zhang; Sheng-Ce Tao; Kaio Kitazato; Zhi-Ping Zhang; Xian-En Zhang; Li-Jun Bi, Journal of Proteome Research, 2011

Tumor reversion is defined as the process by which cancer cells lose their malignant phenotype. However, relatively little is known about the cellular proteome changes that occur during the reversion process. A biological model of multiple myeloma (MM) reversion was established by using the ...

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04.02.2011 | Tulip Nuwal; Seok Heo; Gert Lubec; Erich Buchner, Journal of Proteome Research, 2011

Synapsins are synaptic vesicle-associated phosphoproteins that play a major role in the fine regulation of neurotransmitter release. In Drosophila, synapsins are required for complex behavior including learning and memory. Synapsin isoforms were immunoprecipitated from homogenates of ...

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04.02.2011 | Panagiotis L. Kastritis; Alexandre M. J. J. Bonvin, Journal of Proteome Research, 2011

Journal of Proteome Research DOI: 10.1021/pr101118t

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04.02.2011 | Consuelo Marín-Vicente; Marta Guerrero-Valero; Michael L. Nielsen; Mikhail M. Savitski; Juan C. Gómez-Fe ..., Journal of Proteome Research, 2011

PKCα is a key mediator of the neuronal differentiation controlled by NGF and ATP. However, its downstream signaling pathways remain to be elucidated. To identify the signaling partners of PKCα, we analyzed proteins coimmunoprecipitated with this enzyme in PC12 cells differentiated with NGF ...

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04.02.2011 | Feng Tan; Kangling Zhang; Hana Mujahid; Desh Pal S. Verma; Zhaohua Peng, Journal of Proteome Research, 2011

The cell wall is a critical extracellular structure that provides protection and structural support in plant cells. To study the biological function of the cell wall and the regulation of cell wall resynthesis, we examined cellular responses to enzymatic removal of the cell wall in rice ...

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