01.06.2011 | Zidan, Ahmed S.; Mokhtar, Mahmoud, Journal of Pharmaceutical Sciences, 2011

Abstract Flurbiprofen was formulated as a proniosomal transdermal gel with high drug loading (55.4%, w/w), using a series of nonionic surfactant and cholesterol. A two‐factor, three‐level randomized full factorial strategy was developed to optimize simultaneously the effect of surfactant ...

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01.06.2011 | Álvarez, Covadonga; Núñez, Ignacio; Torrado, Juan J.; Gordon, John; Potthast, Henrike; Garc&iac ..., Journal of Pharmaceutical Sciences, 2011

Abstract The aim of the study was to investigate the ability of in vitro dissolution to ensure bioequivalence of ibuprofen products. Ibuprofen is a Biopharmaceutics Classification System (BCS) class II drug with low solubility at pH 1.2 and 4.5 and high solubility at pH 6.8. The ...

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01.06.2011 | Kurmi, Balak D.; Gajbhiye, Virendra; Kayat, Jitendra; Jain, Narendra K., Journal of Pharmaceutical Sciences, 2011

Abstract The present investigation was aimed at developing and exploring the potential of lactoferrin (Lf)‐conjugated dendritic nanocomposite for lung targeting of methotrexate (MTX). The 5.0G poly(propylene imine) (PPI) dendrimer and Lf‐conjugated 5.0G PPI dendrimer were synthesized and ...

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01.06.2011 | Rawat, Manoj K.; Jain, Achint; Singh, Sanjay, Journal of Pharmaceutical Sciences, 2011

Abstract The purpose of this work was to develop prolonged release binary lipid matrix‐based solid lipid nanoparticles (SLN) of repaglinide (RG) for oral intestinal delivery and to improve the bioavailability of RG. SLN were designed by using glycerol monostearate and tristearin as lipid ...

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01.06.2011 | Rawat, Manoj K.; Jain, Achint; Singh, Sanjay, Journal of Pharmaceutical Sciences, 2011

Abstract The purpose of present study is to examine effect of binary lipid matrix (combination of lipids) on the entrapment and storage stability of repaglinide (RG) loaded solid lipid nanoparticles (SLN). Solid lipid nanoparticles were prepared by modified solvent injection method for ...

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01.06.2011 | Brummitt, Rebecca K.; Nesta, Douglas P.; Chang, Liuquan; Chase, Susan F.; Laue, Thomas M.; Roberts, Christopher J., Journal of Pharmaceutical Sciences, 2011

Abstract Monomeric and aggregated states of an IgG1 antibody were characterized under acidic conditions as a function of solution pH (3.5–5.5). A combination of intrinsic/extrinsic fluorescence (FL), circular dichroism, calorimetry, chromatography, capillary electrophoresis, and laser ...

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01.06.2011 | Zamek‐Gliszczynski, Maciej J.; Ruterbories, Kenneth J.; Ajamie, Rose T.; Wickremsinhe, Enaksha R.; Pothuri, L ..., Journal of Pharmaceutical Sciences, 2011

Abstract Definitive plasma protein binding (PB) studies in drug development are routinely conducted with radiolabeled material, where the radiochemical purity limits quantitative PB measurement. Recent and emerging regulatory guidances increasingly expect quantitative determination of the ...

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01.06.2011 | Lima, Ádley A.N.; Soares‐Sobrinho, José L.; Silva, Jeckson L.; Corrêa‐Júnio ..., Journal of Pharmaceutical Sciences, 2011

Abstract The present study investigates the release mechanism of benznidazole (BNZ) in solid dispersions with polyethylene glycol 6000 (PEG 6000) and polyvinylpirrolydone K‐30 (PVP K‐30), with a view to observing the increase in solubility of BNZ in water in the presence of these two ...

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01.06.2011 | Nurulaini, Harjoh; Wong, Tin Wui, Journal of Pharmaceutical Sciences, 2011

Abstract Conventional alginate pellets underwent rapid drug dissolution and loss of multiparticulate characteristics such as aggregation in acidic medium, thereby promoting oral dose dumping. This study aimed to design sustained‐release dispersible alginate pellets through rapid in situ ...

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01.06.2011 | Tejwani, Ravindra W.; Davis, Malcolm E.; Anderson, Bradley D.; Stouch, Terry R., Journal of Pharmaceutical Sciences, 2011

Abstract Atomic‐level molecular dynamics simulations of 1,2‐dioleoyl‐sn‐glycero‐3‐phosphocholine (DOPC) bilayers containing small, amphiphilic, drug‐like molecules were carried out to examine the influence of polar functionality on membrane partitioning and transport. Three related ...

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