10.05.2013 | Soohyun Um; Young-Joo Kim; Hyuknam Kwon; He Wen; Seong-Hwan Kim; Hak Cheol Kwon; Sunghyouk Park; Jongheon Shin; Dong ..., Journal of Natural Products, 2013

Sungsanpin (1), a new 15-amino-acid peptide, was discovered from a Streptomyces species isolated from deep-sea sediment collected off Jeju Island, Korea. The planar structure of 1 was determined by 1D and 2D NMR spectroscopy, mass spectrometry, and UV spectroscopy. The absolute configurations ...

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09.05.2013 | Zyed Rouis; Nabil Abid; Mahjoub Aouni; Laura Faiella; Fabrizio Dal Piaz; Nunziatina De Tommasi; Alessandra Braca, Journal of Natural Products, 2013

Six new benzophenone glycosides, 2,3′,4,5′,6-pentahydroxybenzophenone 4-O-(6″-benzoyl)-β-d-glucopyranoside (1), 2,3′,4,5′,6-pentahydroxybenzophenone 4-O-β-d-glucopyranoside (2), 2,3′,4,5′,6-pentahydroxybenzophenone 2-O-(2″-benzoyl)-α-l-arabinopyranoside (3), ...

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09.05.2013 | Yumin Dai; Liva Harinantenaina; Peggy J. Brodie; Michael Goetz; Yongchun Shen; Karen TenDyke; David G. I. Kingston, Journal of Natural Products, 2013

Investigation of the South African plant Urginea depressa Baker (Asparagaceae Juss.) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the six new homoisoflavonoids urgineanins A–F (1–6), the two known bufatrienolides 7 and 9, and the new ...

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09.05.2013 | Wei-Lun Yu; Brian D. Jones; MinJin Kang; Justin C. Hammons; James J. La Clair; Michael D. Burkart, Journal of Natural Products, 2013

Journal of Natural Products DOI: 10.1021/np3004497

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09.05.2013 | Volker Schmidts; Maic Fredersdorf; Tilo Lübken; Andrea Porzel; Norbert Arnold; Ludger Wessjohann; Christina M. Thiele, Journal of Natural Products, 2013

The hygrophorones, a class of cyclopentenones isolated from fruiting bodies of the genus Hygrophorus (basidiomycetes), show promising antifungal activity. While the constitution of 4,6-diacetylhygrophorone A12 (3) and the relative configuration of the stereogenic centers in the cyclopentenone ...

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09.05.2013 | Jiangtao Gao; Mohamed M. Radwan; Francisco León; Olivia Reed Dale; Afeef S. Husni; Yunshan Wu; Shari Lupien; Xiaonin ..., Journal of Natural Products, 2013

Bioassay-guided fractionation of a fungus Neocosmospora sp. (UM-031509) resulted in the isolation of three new resorcylic acid lactones, neocosmosin A (2), neocosmosin B (3), and neocosmosin C (4). Three known resorcylic acid lactones, monocillin IV (1), monocillin II (5), and radicicol (6), ...

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08.05.2013 | Shufen Li; Siyang Ni; Linzhuan Wu; Li Li; Bingya Jiang; Hongyuan Wang; Guizhi Sun; Maoluo Gan; Jingyan Li; Weiqing H ..., Journal of Natural Products, 2013

A novel natural geldanamycin analogue was discovered in Streptomyces hygroscopicus 17997. Its 4,5-dihydro form was also identified in the gdmP gene disruption mutant of Streptomyces hygroscopicus 17997. The structures of the two compounds were determined to be ...

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08.05.2013 | Clarisse Lejeune; Hua Tian; Jérôme Appenzeller; Ludmila Ermolenko; Marie-Thérèse Martin; Ali Al-Mourabit, Journal of Natural Products, 2013

The first biomimetic homodimerization of oroidin and clathrodin was effected in the presence HMPA and diphosphonate salts, strong guanidinium and amide chelating agents. The intermolecular associations probably interfere with the entropically and kinetically favored intramolecular ...

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06.05.2013 | Hao He; Ling-He Zang; Yong-Sheng Feng; Jian Wang; Wei-Wei Liu; Li-Xia Chen; Ning Kang; Shin-ichi Tashiro; Satoshi On ..., Journal of Natural Products, 2013

Physalin A (1) is a withanolide isolated from Physalis alkekengi var. franchetii. In this study, the selective growth inhibitory effects on tumor cells induced by 1 were screened, and the mechanism was investigated on 1-induced growth inhibition, including apoptosis and autophagy, in human ...

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06.05.2013 | Chew-Yan Gan; Yun-Yee Low; Noel F. Thomas; Toh-Seok Kam, Journal of Natural Products, 2013

Eight new indole alkaloids (1–8) belonging to the rhazinilam–leuconolam–leuconoxine group, in addition to 52 other alkaloids, were isolated from the stem-bark extract of Leuconotis griffithii, viz., nor-rhazinicine (1), 5,21-dihydrorhazinilam-N-oxide (2), 3,14-dehydroleuconolam (3), and ...

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