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1.696 Aktuelle Fachpublikationen in Journal of Natural Products

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Cytotoxic Plakortides from the Brazilian Marine Sponge Plakortis angulospiculatus

16.04.2015 | Evelyne A. Santos; Amanda L. Quintela; Elthon G. Ferreira; Thiciana S. Sousa; Francisco das Chagas L. Pinto; Eduardo ..., Journal of Natural Products, 2015

Three new plakortides, 7,8-dihydroplakortide E (1), 2, and 10, along with known natural products 3, 4, spongosoritin A (5), 6–8, and plakortide P (9), were isolated from Brazilian specimens of Plakortis angulospiculatus. Compounds 2, 3, 5, and 7–9 displayed cytotoxic activities with IC50 values ...


Phytotoxins from Tithonia diversifolia

16.04.2015 | Maria A. F. M. Miranda; Rosa M. Varela; Ascension Torres; José M. G. Molinillo; Sonia C. J. Gualtieri; Francisco A. ..., Journal of Natural Products, 2015

Tithonia diversifolia (Mexican sunflower) is a dominant plant of the Asteraceae family, which suggests it produces allelochemicals that interfere with the development of surrounding plants. The study described herein was conducted to identify the compounds that have phytotoxic activity in T. ...


Bioactive Maleic Anhydrides and Related Diacids from the Aquatic Hyphomycete Tricladium castaneicola

15.04.2015 | Chunguang Han; Hiroyuki Furukawa; Tomohiko Tomura; Ryosuke Fudou; Kenichi Kaida; Bong-Keun Choi; Genji Imokawa; Mako ..., Journal of Natural Products, 2015

Four maleic anhydride derivatives, tricladolides A–D (1–4), and three alkylidene succinic acid derivatives, tricladic acids A–C (5–7), were isolated from the aquatic hyphomycete Tricladium castaneicola. The structures of these compounds were determined by spectroscopic analysis, and all were ...


Deconins A–E: Cuparenic and Mevalonic or Propionic Acid Conjugates from the Basidiomycete Deconica sp. 471

14.04.2015 | Frank Surup; Benjarong Thongbai; Eric Kuhnert; Enge Sudarman; Kevin D. Hyde; Marc Stadler, Journal of Natural Products, 2015

Bioassay-guided fractionation of antibacterial extracts from cultures of a basidiomycete from Northern Thailand, which represents a new species of the genus Deconica, yielded the terpenoid deconin A (1), whose structure was elucidated by spectral methods (NMR, HRMS) as a cuparenic/mevalonic acid ...


Hikiamides A–C, Cyclic Pentadepsipeptides from Fusarium sp. TAMA 456

14.04.2015 | Takao Fukuda; Yuri Sudoh; Yuki Tsuchiya; Toru Okuda; Nobuyasu Matsuura; Atsuko Motojima; Tsutomu Oikawa; Yasuhiro Ig ..., Journal of Natural Products, 2015

Three new cyclic pentadepsipeptides, hikiamides A–C (1–3), were isolated from the culture extract of Fusarium sp. TAMA 456. The structures were determined by spectroscopic analysis using NMR and MS, and the absolute configurations were established by using Marfey’s method and chiral HPLC ...


Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi

14.04.2015 | Xing-Wei Yang; Ming-Ming Li; Xia Liu; Daneel Ferreira; Yuanqing Ding; Jing-Jing Zhang; Yang Liao; Hong-Bo Qin; Gang Xu, Journal of Natural Products, 2015

Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways and showing considerable structural and bioactive diversity. In a systematic phytochemical investigation of Hypericum ...


Antiplasmodial and Cytotoxic Triterpenoids from the Bark of the Cameroonian Medicinal Plant Entandrophragma congoënse

14.04.2015 | Gervais Mouthé Happi; Simeon Fogue Kouam; Ferdinand Mouafo Talontsi; Marc Lamshöft; Sebastian Zühlke; Jonathan O. Ba ..., Journal of Natural Products, 2015

Eight new triterpenoids, prototiamins A–G (1–6, 9) and seco-tiaminic acid A (10), were isolated along with four known compounds from the bark of Entandrophragma congoënse. Their structures were elucidated by means of HRMS and different NMR techniques and chemical transformations. Assignments of ...


Steroidal Alkaloids from Veratrum nigrum Enhance Glucose Uptake in Skeletal Muscle Cells

02.04.2015 | ChuHyun Kang; Joo-Hui Han; Joonseok Oh; Roshan Kulkarni; Wei Zhou; Daneel Ferreira; Tae Su Jang; Chang-Seon Myung; M ..., Journal of Natural Products, 2015

Veratrum nigrum is recognized as a medicinal plant used for the treatment of hypertension, stroke, and excessive phlegm. Chemical investigation of the roots and rhizomes led to the isolation of five new steroidal alkaloids, jervine-3-yl formate (1), veramarine-3-yl formate (2), ...


NMR Spectroscopic Method for the Assignment of 3,5-Dioxygenated Aromatic Rings in Natural Products

31.03.2015 | Ya-Nan Yang; Hui Zhu; Zhong Chen; Fu Liu; Ya-Wen An; Zi-Ming Feng; Jian-Shuang Jiang; Pei-Cheng Zhang, Journal of Natural Products, 2015

In recent years, certain “new” naturally occurring compounds (1–28) with 3,5-dioxygenated aromatic rings have been reported. A comparison of the NMR data of these compounds with the data of four model compounds (A–D) indicated that the structures of these “new” compounds were erroneous. The ...


Biotransformation of Curcumenol by Mucor polymorphosporus

30.03.2015 | Li-Xia Chen; Qian Zhao; Meng Zhang; Yan-Yan Liang; Jiang-Hao Ma; Xue Zhang; Li-Qin Ding; Feng Zhao; Feng Qiu, Journal of Natural Products, 2015

Biocatalysis of curcumenol (1) was performed by Mucor polymorphosporus AS 3.3443. Six metabolites including five new compounds were obtained, and their structures were elucidated as 10β-hydroxy-9,10-dihydrocurcumenol (2), 2β-hydroxycurcumenol (3), 15-hydroxycurcumenol (4), 12-hydroxycurcumenol ...


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