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1.455 Aktuelle Fachpublikationen in Journal of Natural Products

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Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation

11.04.2014 | Andreas Schinkovitz; Aman Kaur; Ernst Urban; Martin Zehl; Gabriela Páchniková; Yuehong Wang; Nadine Kretschmer; Iva ..., Journal of Natural Products, 2014

Lichens are resilient organisms, known for their unique profiles of secondary metabolites and for exhibiting antioxidative, antibacterial, and cytotoxic effects. Analyzing the cytotoxic potential of Lobaria scrobiculata, a bioassay-guided fractionation strategy yielded seven known metabolites, ...

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Voacamine Modulates the Sensitivity to Doxorubicin of Resistant Osteosarcoma and Melanoma Cells and Does Not Induce Toxicity in Normal Fibroblasts

10.04.2014 | Maria Condello; Dario Cosentino; Silvia Corinti; Gabriella Di Felice; Giuseppina Multari; Francesca Romana Gallo; Gi ..., Journal of Natural Products, 2014

In previous studies it has been demonstrated that the plant alkaloid voacamine (1), used at noncytotoxic concentrations, enhanced the cytotoxicity of doxorubicin and exerted a chemosensitizing effect on cultured multidrug-resistant (MDR) U-2 OS-DX osteosarcoma cells. The in vitro investigations ...

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Antimicrobial Peptides from Skin Secretions of Hypsiboas pulchellus (Anura: Hylidae)

09.04.2014 | Alvaro Siano; María Verónica Húmpola; Eliandre de Oliveira; Fernando Albericio; Arturo C. Simonetta; Rafael Lajmanov ..., Journal of Natural Products, 2014

The skin of many amphibians produces a large repertoire of antimicrobial peptides that are crucial in the first line of defense against microbial invasion. Despite the immense richness of wild amphibians in Argentina, knowledge about peptides with antimicrobial properties is limited to a few ...

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Anti-inflammatory Labdane Diterpenoids from Lagopsis supina

08.04.2014 | Hui Li; Man-Man Li; Xiao-Qin Su; Jing Sun; Yu-Fan Gu; Ke-Wu Zeng; Qian Zhang; Yun-Fang Zhao; Daneel Ferreira; Jordan ..., Journal of Natural Products, 2014

Journal of Natural Products DOI: 10.1021/np5001329

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Absolute Configuration of (13R)- and (13S)-Labdane Diterpenes Coexisting in Ageratina jocotepecana

04.04.2014 | Edgar García-Sánchez; César B. Ramírez-López; Armando Talavera-Alemán; Alejandra León-Hernández; Rosa E. Martínez-Mu ..., Journal of Natural Products, 2014

Chemical investigation of the hexanes extracts of Ageratina jocotepecana afforded (−)-(5S,9S,10S,13S)-labd-7-en-15-oic acid (1), methyl (−)-(5S,9S,10S,13S)-labd-7-en-15-oate (2), (+)-(5S,8R,9R,10S,13R)-8-hydroxylabdan-15-oic acid (3), and (−)-(5S,9S,10S,13Z)-labda-7,13-dien-15-oic acid (5). The ...

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Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides

03.04.2014 | Hai-Yan Wu; Rui Zhan; Wei-Guang Wang; Hua-Yi Jiang; Xue Du; Xiao-Nian Li; Yan Li; Jian-Xin Pu; Han-Dong Sun, Journal of Natural Products, 2014

Phytochemical investigation of EtOAc extracts of the aerial parts of Isodon wikstroemioides afforded 18 new ent-kaurane diterpenoids (wikstroemioidins E–V, 1–18), along with 17 known analogues (19–35). The absolute configurations of 1 and 16 were confirmed by single-crystal X-ray diffraction ...

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Indothiazinone, an Indolyl Thiazolyl Ketone from a Novel Myxobacterium Belonging to the Sorangiineae

03.04.2014 | Rolf Jansen; Kathrin I. Mohr; Steffen Bernecker; Marc Stadler; Rolf Müller, Journal of Natural Products, 2014

Indothiazinone (1), an indolyl thiazolyl ketone, was discovered in cultures of novel myxobacterial strain 706, recently isolated from compost in Germany. Molecular phylogenetic studies based on 16S rRNA gene sequences revealed strain 706 to be a representative of a new family of the Sorangiineae. ...

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Antineoplastic Agents. 595. Structural Modifications of Betulin and the X-ray Crystal Structure of an Unusual Betulin Amine Dimer1

02.04.2014 | George R. Pettit; Noeleen Melody; Frank Hempenstall; Jean-Charles Chapuis; Thomas L. Groy; Lee Williams, Journal of Natural Products, 2014

The lupane-type triterpene betulin (1) has been subjected to a series of structural modifications for the purpose of evaluating resultant cancer cell growth inhibitory activity. The reaction sequence 7 → 11 → 12 was especially noteworthy in providing a betulin-derived amine dimer. Other ...

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Inhibitory Effect of Turmeric Curcuminoids on FLT3 Expression and Cell Cycle Arrest in the FLT3-Overexpressing EoL-1 Leukemic Cell Line

01.04.2014 | Singkome Tima; Hideki Ichikawa; Chadarat Ampasavate; Siriporn Okonogi; Songyot Anuchapreeda, Journal of Natural Products, 2014

Leukemia is a hematologic malignancy with a frequent incidence and high mortality rate. Previous studies have shown that the FLT3 gene is overexpressed in leukemic blast cells, especially in acute myeloid leukemia. In this study, a commercially available curcuminoid mixture (1), pure curcumin ...

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Suppression of Inflammatory Responses by Handelin, a Guaianolide Dimer from Chrysanthemum boreale, via Downregulation of NF-κB Signaling and Pro-inflammatory Cytokine Production

01.04.2014 | Yuna Pyee; Hwa-Jin Chung; Tae Jun Choi; Hyen Joo Park; Ji-Young Hong; Ju Sun Kim; Sam Sik Kang; Sang Kook Lee, Journal of Natural Products, 2014

The anti-inflammatory activity of handelin (1), a guaianolide dimer from Chrysanthemum boreale flowers, was evaluated in vivo, and the effects on mediators nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) and the nuclear factor-κB (NF-κB) and ...

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