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1.597 Aktuelle Fachpublikationen in Journal of Natural Products

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Jiangrines A–F and Jiangolide from an Actinobacterium, Jiangella gansuensis

20.11.2014 | Li Han; Chun Gao; Yi Jiang; Peipei Guan; Jiang Liu; Liya Li; Lihua Xu; Xueshi Huang, Journal of Natural Products, 2014

Seven new compounds, including five pyrrol-2-aldehyde derivatives, jiangrines A–E (1–5), one indolizine derivative, jiangrine F (7), and one glycolipid, jiangolide (8), along with a known compound, pyrrolezanthine (6), were isolated from the fermentation broth of Jiangella gansuensis, an ...

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Identification of the Biosynthetic Gene Clusters for the Lipopeptides Fusaristatin A and W493 B in Fusarium graminearum and F. pseudograminearum

20.11.2014 | Jens Laurids Sørensen; Teis Esben Sondergaard; Lorenzo Covarelli; Patricia Romans Fuertes; Frederik Teilfeldt Hansen ..., Journal of Natural Products, 2014

The closely related species Fusarium graminearum and Fusarium pseudograminearum differ in that each contains a gene cluster with a polyketide synthase (PKS) and a nonribosomal peptide synthetase (NRPS) that is not present in the other species. To identify their products, we deleted PKS6 and NRPS7 ...

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Solving the Supply of Resveratrol Tetramers from Papua New Guinean Rainforest Anisoptera Species That Inhibit Bacterial Type III Secretion Systems

18.11.2014 | Rohan A. Davis; Karren D. Beattie; Min Xu; Xinzhou Yang; Sheng Yin; Harish Holla; Peter C. Healy; Melissa Sykes; Tod ..., Journal of Natural Products, 2014

The supply of (−)-hopeaphenol (1) was achieved via enzymatic biotransformation in order to provide material for preclinical investigation. High-throughput screening of a prefractionated natural product library aimed to identify compounds that inhibit the bacterial virulence type III secretion ...

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Karwinaphthopyranones from the Fruits of Karwinskia parvifolia and Their Cytotoxic Activities

17.11.2014 | Claudia Rojas-Flores; María Yolanda Rios; Rebeca López-Marure; Horacio F. Olivo, Journal of Natural Products, 2014

The new 2-acetyl-8-methoxynaphthol (1) and five new “dimeric” napthopyranones, karwinaphthopyranones A1 and A2 (2 and 3) and karwinaphthopyranones B1–B3 (4–6), possessing a methoxy group at C-5′, were isolated together with four other known compounds from the dried fruits of Karwinskia ...

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Structure of a Putative Fluorinated Natural Product from Streptomyces sp. TC1

17.11.2014 | Hülya Aldemir; Stefanie V. Kohlhepp; Tanja Gulder; Tobias A. M. Gulder, Journal of Natural Products, 2014

Fluorine-containing natural products are extremely rare. The recent report on the isolation and biological activity of the bacterial secondary metabolite 3-(3,5-di-tert-butyl-4-fluorophenyl)propionic acid was thus highly remarkable. The compound contained the first aromatic fluorine substituent ...

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Formononetin Attenuates Osteoclastogenesis via Suppressing the RANKL-Induced Activation of NF-κB, c-Fos, and Nuclear Factor of Activated T-Cells Cytoplasmic 1 Signaling Pathway

14.11.2014 | Jeong-Eun Huh; Wong In Lee; Jung Won Kang; Dongwoo Nam; Do-Young Choi; Dong-Suk Park; Sang Hoon Lee; Jae-Dong Lee, Journal of Natural Products, 2014

Formononetin (1), a plant-derived phytoestrogen, possesses bone protective properties. To address the potential therapeutic efficacy and mechanism of action of 1, we investigated its antiosteoclastogenic activity and its effect on nuclear factor-kappaB ligand (RANKL)-induced bone-marrow-derived ...

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Nannozinones and Sorazinones, Unprecedented Pyrazinones from Myxobacteria

14.11.2014 | Rolf Jansen; Sakshi Sood; Kathrin I. Mohr; Brigitte Kunze; Herbert Irschik; Marc Stadler; Rolf Müller, Journal of Natural Products, 2014

Nannozinones A (1) and B (2) were discovered as metabolites of the recently isolated Nannocystis pusilla strain MNa10913 belonging to the poorly studied myxobacterial family Nannocystaceae. In contrast, the structurally related sorazinones A (5) and B (6) were isolated from Sorangium cellulosum ...

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Antinociceptive Properties of Physalins from Physalis angulata

14.11.2014 | Milena da Silva Lima; Afrânio Ferreira Evangelista; Gisele Graça Leite dos Santos; Ivone Maria Ribeiro; Therezinha C ..., Journal of Natural Products, 2014

Pain is the most common reason a patient sees a physician. Nevertheless, the use of typical painkillers is not completely effective in controlling all pain syndromes; therefore further attempts have been made to develop improved analgesic drugs. The present study was undertaken to evaluate the ...

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Delineation of the Role of Glycosylation in the Cytotoxic Properties of Quercetin using Novel Assays in Living Vertebrates

14.11.2014 | Si-Hwan Park; Hyun Jung Kim; Soon-Ho Yim; Ah-Ra Kim; Nisha Tyagi; Haihong Shen; Kyung Keun Kim; Boo Ahn Shin; Da-Woo ..., Journal of Natural Products, 2014

Quercetin is a plant-derived flavonoid and its cytotoxic properties have been widely reported. However, in nature, quercetin predominantly occurs as various glycosides. Thus far the cytotoxic activity of these glycosides has not been investigated to the same extent as quercetin, especially in ...

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Borrelidin B: Isolation, Biological Activity, and Implications for Nitrile Biosynthesis

13.11.2014 | Christopher J. Schulze; Walter M. Bray; Frank Loganzo; My-Hanh Lam; Teresa Szal; Anabella Villalobos; Frank E. Koehn ..., Journal of Natural Products, 2014

Borrelidin (1) is a nitrile-containing bacterially derived polyketide that is a potent inhibitor of bacterial and eukaryotic threonyl-tRNA synthetases. We now report the discovery of borrelidin B (2), a tetrahydro-borrelidin derivative containing an aminomethyl group in place of the nitrile ...

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