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1.592 Aktuelle Fachpublikationen in Journal of Natural Products

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Formononetin Attenuates Osteoclastogenesis via Suppressing the RANKL-Induced Activation of NF-κB, c-Fos, and Nuclear Factor of Activated T-Cells Cytoplasmic 1 Signaling Pathway

14.11.2014 | Jeong-Eun Huh; Wong In Lee; Jung Won Kang; Dongwoo Nam; Do-Young Choi; Dong-Suk Park; Sang Hoon Lee; Jae-Dong Lee, Journal of Natural Products, 2014

Formononetin (1), a plant-derived phytoestrogen, possesses bone protective properties. To address the potential therapeutic efficacy and mechanism of action of 1, we investigated its antiosteoclastogenic activity and its effect on nuclear factor-kappaB ligand (RANKL)-induced bone-marrow-derived ...


Nannozinones and Sorazinones, Unprecedented Pyrazinones from Myxobacteria

14.11.2014 | Rolf Jansen; Sakshi Sood; Kathrin I. Mohr; Brigitte Kunze; Herbert Irschik; Marc Stadler; Rolf Müller, Journal of Natural Products, 2014

Nannozinones A (1) and B (2) were discovered as metabolites of the recently isolated Nannocystis pusilla strain MNa10913 belonging to the poorly studied myxobacterial family Nannocystaceae. In contrast, the structurally related sorazinones A (5) and B (6) were isolated from Sorangium cellulosum ...


Antinociceptive Properties of Physalins from Physalis angulata

14.11.2014 | Milena da Silva Lima; Afrânio Ferreira Evangelista; Gisele Graça Leite dos Santos; Ivone Maria Ribeiro; Therezinha C ..., Journal of Natural Products, 2014

Pain is the most common reason a patient sees a physician. Nevertheless, the use of typical painkillers is not completely effective in controlling all pain syndromes; therefore further attempts have been made to develop improved analgesic drugs. The present study was undertaken to evaluate the ...


Delineation of the Role of Glycosylation in the Cytotoxic Properties of Quercetin using Novel Assays in Living Vertebrates

14.11.2014 | Si-Hwan Park; Hyun Jung Kim; Soon-Ho Yim; Ah-Ra Kim; Nisha Tyagi; Haihong Shen; Kyung Keun Kim; Boo Ahn Shin; Da-Woo ..., Journal of Natural Products, 2014

Quercetin is a plant-derived flavonoid and its cytotoxic properties have been widely reported. However, in nature, quercetin predominantly occurs as various glycosides. Thus far the cytotoxic activity of these glycosides has not been investigated to the same extent as quercetin, especially in ...


Borrelidin B: Isolation, Biological Activity, and Implications for Nitrile Biosynthesis

13.11.2014 | Christopher J. Schulze; Walter M. Bray; Frank Loganzo; My-Hanh Lam; Teresa Szal; Anabella Villalobos; Frank E. Koehn ..., Journal of Natural Products, 2014

Borrelidin (1) is a nitrile-containing bacterially derived polyketide that is a potent inhibitor of bacterial and eukaryotic threonyl-tRNA synthetases. We now report the discovery of borrelidin B (2), a tetrahydro-borrelidin derivative containing an aminomethyl group in place of the nitrile ...


Direct Capture and Heterologous Expression of Salinispora Natural Product Genes for the Biosynthesis of Enterocin

10.11.2014 | Bailey Bonet; Robin Teufel; Max Crüsemann; Nadine Ziemert; Bradley S. Moore, Journal of Natural Products, 2014

Heterologous expression of secondary metabolic pathways is a promising approach for the discovery and characterization of bioactive natural products. Herein we report the first heterologous expression of a natural product from the model marine actinomycete genus Salinispora. Using the recently ...


Protective Mechanisms of Acacetin against d-Galactosamine and Lipopolysaccharide-Induced Fulminant Hepatic Failure in Mice

10.11.2014 | Hong-Ik Cho; Jin-Hyun Park; Hyo-Sun Choi; Jong Hwan Kwak; Dong-Ung Lee; Sang Kook Lee; Sun-Mee Lee, Journal of Natural Products, 2014

This study examined the hepatoprotective effects of acacetin (1), a flavonoid isolated from Agastache rugosa, against d-galactosamine (GalN) and lipopolysaccharide (LPS)-induced fulminant hepatic failure. Mice were given an intraperitoneal injection of 1 (25, 50, and 100 mg/kg), or the vehicle ...


Canthin-6-one Displays Antiproliferative Activity and Causes Accumulation of Cancer Cells in the G2/M Phase

07.11.2014 | Camille Dejos; Pierre Voisin; Marianne Bernard; Matthieu Régnacq; Thierry Bergès, Journal of Natural Products, 2014

Canthinones are natural substances with a wide range of biological activities, including antipyretic, antiparasitic, and antimicrobial. Antiproliferative and/or cytotoxic effects of canthinones on cancer cells have also been described, although their mechanism of action remains ill defined. To ...


Heterodimeric ent-Kauranoids from Isodon tenuifolius

06.11.2014 | Jian-Hong Yang; Wei-Guang Wang; Xue Du; Fei He; Hai-Bo Zhang; Xiao-Nian Li; Yan Li; Jian-Xin Pu; Han-Dong Sun, Journal of Natural Products, 2014

Thirteen new heterodimeric ent-kauranoids, bistenuifolins A–M (1–13), were isolated from the aerial parts of Isodon tenuifolius. The constituent units of compounds 1–6 were linked by a six-membered dihydropyran ring, while those of compounds 7–11 were joined by a rare single carbon–carbon bond ...


Structures and Bioactivities of Dihydrochalcones from Metrodorea stipularis

06.11.2014 | Marcela C. de Melo Burger; João Batista Fernandes; Maria F. das Graças Fernandes da Silva; Aster Escalante; Jacques ..., Journal of Natural Products, 2014

Metrodorea stipularis stem extracts were studied in the search for possible antichagastic, antimalarial, and antitumoral compounds using cruzain from Trypanosoma cruzi, Plasmodium falciparum, and cathepsins B and L, as molecular targets, respectively. Dihydrochalcones 1, 2, 3, and 4 showed ...


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