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1.459 Aktuelle Fachpublikationen in Journal of Natural Products

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2,4-Bis(4-hydroxybenzyl)phenol Inhibits Heat Shock Transcription Factor 1 and Sensitizes Lung Cancer Cells to Conventional Anticancer Modalities

18.04.2014 | Taesook Yoon; Ga-Young Kang; Ah-Reum Han; Eun-Kyoung Seo; Yun-Sil Lee, Journal of Natural Products, 2014

Heat shock factor 1 (HSF1) is a transcription factor that regulates expression of heat shock protein (HSP) genes in response to stress. HSPs are expressed at high levels in a wide range of tumors. It has been reported that HSF1 and HSPs are associated closely in tumorigenesis. In the present ...


Mahorones, Highly Brominated Cyclopentenones from the Red Alga Asparagopsis taxiformis

18.04.2014 | Stéphane Greff; Mayalen Zubia; Grégory Genta-Jouve; Lionel Massi; Thierry Perez; Olivier P. Thomas, Journal of Natural Products, 2014

The red alga Asparagopsis taxiformis (Rhodophyta, Bonnemaisoniaceae) has been shown to produce a large diversity of halogenated volatile organic compounds, with one to four carbons. As the distribution of this alga may expand worldwide, we implemented a research program that aims to understand ...


Cyclohexadepsipeptides of the Isaridin Class from the Marine-Derived Fungus Beauveria felina EN-135

17.04.2014 | Feng-Yu Du; Peng Zhang; Xiao-Ming Li; Chun-Shun Li; Chuan-Ming Cui; Bin-Gui Wang, Journal of Natural Products, 2014

Three new cyclohexadepsipeptides of the isaridin class including isaridin G (1), desmethylisaridin G (2), and desmethylisaridin C1 (3), along with three related known metabolites (4–6), were isolated and identified from the marine bryozoan-derived fungus Beauveria felina EN-135. The structures of ...


Diterpenoids from Croton laui and Their Cytotoxic and Antimicrobial Activities

15.04.2014 | Cui-Ping Liu; Jin-Biao Xu; Jin-Xin Zhao; Cheng-Hui Xu; Lei Dong; Jian Ding; Jian-Min Yue, Journal of Natural Products, 2014

Fourteen new diterpenoids including clerodane (1–12), labdane (13), and norlabdane (14) types, as well as nine known analogues were isolated from the aerial parts of Croton laui. Their structures were established on the basis of spectroscopic analysis, and that of crotonolide H (11) was confirmed ...


Cytotoxic Constituents from Lobaria scrobiculata and a Comparison of Two Bioassays for Their Evaluation

11.04.2014 | Andreas Schinkovitz; Aman Kaur; Ernst Urban; Martin Zehl; Gabriela Páchniková; Yuehong Wang; Nadine Kretschmer; Iva ..., Journal of Natural Products, 2014

Lichens are resilient organisms, known for their unique profiles of secondary metabolites and for exhibiting antioxidative, antibacterial, and cytotoxic effects. Analyzing the cytotoxic potential of Lobaria scrobiculata, a bioassay-guided fractionation strategy yielded seven known metabolites, ...


Voacamine Modulates the Sensitivity to Doxorubicin of Resistant Osteosarcoma and Melanoma Cells and Does Not Induce Toxicity in Normal Fibroblasts

10.04.2014 | Maria Condello; Dario Cosentino; Silvia Corinti; Gabriella Di Felice; Giuseppina Multari; Francesca Romana Gallo; Gi ..., Journal of Natural Products, 2014

In previous studies it has been demonstrated that the plant alkaloid voacamine (1), used at noncytotoxic concentrations, enhanced the cytotoxicity of doxorubicin and exerted a chemosensitizing effect on cultured multidrug-resistant (MDR) U-2 OS-DX osteosarcoma cells. The in vitro investigations ...


Antimicrobial Peptides from Skin Secretions of Hypsiboas pulchellus (Anura: Hylidae)

09.04.2014 | Alvaro Siano; María Verónica Húmpola; Eliandre de Oliveira; Fernando Albericio; Arturo C. Simonetta; Rafael Lajmanov ..., Journal of Natural Products, 2014

The skin of many amphibians produces a large repertoire of antimicrobial peptides that are crucial in the first line of defense against microbial invasion. Despite the immense richness of wild amphibians in Argentina, knowledge about peptides with antimicrobial properties is limited to a few ...


Anti-inflammatory Labdane Diterpenoids from Lagopsis supina

08.04.2014 | Hui Li; Man-Man Li; Xiao-Qin Su; Jing Sun; Yu-Fan Gu; Ke-Wu Zeng; Qian Zhang; Yun-Fang Zhao; Daneel Ferreira; Jordan ..., Journal of Natural Products, 2014

Journal of Natural Products DOI: 10.1021/np5001329


Absolute Configuration of (13R)- and (13S)-Labdane Diterpenes Coexisting in Ageratina jocotepecana

04.04.2014 | Edgar García-Sánchez; César B. Ramírez-López; Armando Talavera-Alemán; Alejandra León-Hernández; Rosa E. Martínez-Mu ..., Journal of Natural Products, 2014

Chemical investigation of the hexanes extracts of Ageratina jocotepecana afforded (−)-(5S,9S,10S,13S)-labd-7-en-15-oic acid (1), methyl (−)-(5S,9S,10S,13S)-labd-7-en-15-oate (2), (+)-(5S,8R,9R,10S,13R)-8-hydroxylabdan-15-oic acid (3), and (−)-(5S,9S,10S,13Z)-labda-7,13-dien-15-oic acid (5). The ...


Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides

03.04.2014 | Hai-Yan Wu; Rui Zhan; Wei-Guang Wang; Hua-Yi Jiang; Xue Du; Xiao-Nian Li; Yan Li; Jian-Xin Pu; Han-Dong Sun, Journal of Natural Products, 2014

Phytochemical investigation of EtOAc extracts of the aerial parts of Isodon wikstroemioides afforded 18 new ent-kaurane diterpenoids (wikstroemioidins E–V, 1–18), along with 17 known analogues (19–35). The absolute configurations of 1 and 16 were confirmed by single-crystal X-ray diffraction ...


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