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1.730 Aktuelle Fachpublikationen in Journal of Natural Products

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Isolation and Pharmacological Evaluation of Minor Cannabinoids from High-Potency Cannabis sativa

22.05.2015 | Mohamed M. Radwan; Mahmoud A. ElSohly; Abir T. El-Alfy; Safwat A. Ahmed; Desmond Slade; Afeef S. Husni; Susan P. Man ..., Journal of Natural Products, 2015

Seven new naturally occurring hydroxylated cannabinoids (1–7), along with the known cannabiripsol (8), have been isolated from the aerial parts of high-potency Cannabis sativa. The structures of the new compounds were determined by 1D and 2D NMR spectroscopic analysis, GC-MS, and HRESIMS as ...

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Sweet Poisons: Honeys Contaminated with Glycosides of the Neurotoxin Tutin

21.05.2015 | Lesley Larsen; Nigel I. Joyce; Catherine E. Sansom; Janine M. Cooney; Dwayne J. Jensen; Nigel B. Perry, Journal of Natural Products, 2015

Poisonings due to consumption of honeys containing plant toxins have been reported widely. One cause is the neurotoxin tutin, an oxygenated sesquiterpene picrotoxane, traced back to honeybees (Apis mellifera) collecting honeydew produced by passionvine hoppers (Scolypopa australis) feeding on sap ...

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α- and β-Santalols Directly Interact with Tubulin and Cause Mitotic Arrest and Cytotoxicity in Oral Cancer Cells

20.05.2015 | Brigette Lee; Jonathan Bohmann; Tony Reeves; Corey Levenson; April L. Risinger, Journal of Natural Products, 2015

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, with no major advancements in treatment over the past 40 years. The current study explores the biological effects of East Indian sandalwood oil (EISO) and its two major constituents, α- and β-santalol, ...

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Lumiquinone A, an α-Aminomalonate-Derived Aminobenzoquinone from Photorhabdus luminescens

19.05.2015 | Hyun Bong Park; Jason M. Crawford, Journal of Natural Products, 2015

Lumiquinone A (1), an unusual aminobenzoquinone member within the phenylpropanoid class of natural products, together with the known compound 3,5-dihydroxy-4-isopropyl-trans-stilbene (2), was isolated from the entomopathogenic bacterium Photorhabdus luminescens TT01. On the basis of the analysis ...

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Dirigent Protein-Mediated Lignan and Cyanogenic Glucoside Formation in Flax Seed: Integrated Omics and MALDI Mass Spectrometry Imaging

17.05.2015 | Doralyn S. Dalisay; Kye Won Kim; Choonseok Lee; Hong Yang; Oliver Rübel; Benjamin P. Bowen; Laurence B. Davin; Norma ..., Journal of Natural Products, 2015

An integrated omics approach using genomics, transcriptomics, metabolomics (MALDI mass spectrometry imaging, MSI), and bioinformatics was employed to study spatiotemporal formation and deposition of health-protecting polymeric lignans and plant defense cyanogenic glucosides. Intact flax (Linum ...

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Photochemical Synthesis of Nepetanudone

15.05.2015 | Swapna Jayan; Paul B. Jones, Journal of Natural Products, 2015

Journal of Natural Products DOI: 10.1021/np500832h

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Identification of Oxaphenalenone Ketals from the Ascomycete Fungus Neonectria sp.

15.05.2015 | Jinwei Ren; Shubing Niu; Li Li; Zhufeng Geng; Xingzhong Liu; Yongsheng Che, Journal of Natural Products, 2015

Neonectrolides B–E (4–7), four new oxaphenalenone ketals incorporating the new furo[2,3-b]isochromeno[3,4,5-def]chromen-11(6aH)-one skeleton, were isolated from the fermentation extract of the ascomycete fungus Neonectria sp. in an in-depth investigation guided by HPLC fingerprint and a ...

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Tetranorsesquiterpenoids and Santalane-Type Sesquiterpenoids from Illicium lanceolatum and Their Antimicrobial Activity against the Oral Pathogen Porphyromonas gingivalis

13.05.2015 | Miwa Kubo; Yuri Nishikawa; Kenichi Harada; Masataka Oda; Jian-Mei Huang; Hisanori Domon; Yutaka Terao; Yoshiyasu Fuk ..., Journal of Natural Products, 2015

The methanol extract of the leaves of Illicium lanceolatum, indigenous to Fujian Province, People’s Republic of China, was found to exhibit antimicrobial activity against the periodontal pathogen Porphyromonas gingivalis, and a bioassay-guided fractionation led to the isolation of two new ...

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Limonoids with Anti-HIV Activity from Cipadessa cinerascens

13.05.2015 | Jin-Hai Yu; Guo-Cai Wang; Ying-Shan Han; Yan Wu; Mark A. Wainberg; Jian-Min Yue, Journal of Natural Products, 2015

Journal of Natural Products DOI: 10.1021/acs.jnatprod.5b00025

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Diterpenoids and Triterpenoids from the Resin of Bursera microphylla and Their Cytotoxic Activity

12.05.2015 | Federica Messina; Massimo Curini; Chiara Di Sano; Claudia Zadra; Giulia Gigliarelli; Luisa Alondra Rascón-Valenzuela ..., Journal of Natural Products, 2015

A chemical study of the nonpolar fraction of a methanol-soluble extract of Bursera microphylla resin yielded a variety of di- and triterpenoids. In total, 15 compounds were isolated, of which three are new, namely, malabaricatrienone (1), malabaricatrienol (2), and microphyllanin (3). The ...

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