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1.651 Aktuelle Fachpublikationen in Journal of Natural Products

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Effects of Resveratrol on Benign Prostatic Hyperplasia by the Regulation of Inflammatory and Apoptotic Proteins

25.02.2015 | Kyung-Sook Chung; Se-Yun Cheon; Hyo-Jin An, Journal of Natural Products, 2015

Resveratrol (1) is a natural polyphenolic compound that has cardioprotective, anticancer, and anti-inflammatory properties. Although diverse biological studies of compound 1 have been conducted, no antiproliferative effects of 1 have been reported in benign prostatic hyperplasia (BPH). BPH is a ...

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Biosynthetic Products from a Nearshore-Derived Gram-Negative Bacterium Enable Reassessment of the Kailuin Depsipeptides

20.02.2015 | Christine M. Theodore; Nicholas Lorig-Roach; Patrick C. Still; Tyler A. Johnson; Marija Drašković; Joshua A. Schwoch ..., Journal of Natural Products, 2015

Sampling of California nearshore sediments resulted in the isolation of a Gram-negative bacterium, Photobacterium halotolerans, capable of producing unusual biosynthetic products. Liquid culture in artificial seawater-based media provided cyclic depsipeptides including four known compounds, ...

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Gulypyrones A and B and Phomentrioloxins B and C Produced by Diaporthe gulyae, a Potential Mycoherbicide for Saffron Thistle (Carthamus lanatus)

20.02.2015 | Anna Andolfi; Angela Boari; Marco Evidente; Alessio Cimmino; Maurizio Vurro; Gavin Ash; Antonio Evidente, Journal of Natural Products, 2015

A virulent strain of Diaporthe gulyae, isolated from stem cankers of sunflower and known to be pathogenic to saffron thistle, has been shown to produce both known and previously undescribed metabolites when grown in either static liquid culture or a bioreactor. Together with phomentrioloxin, a ...

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Ribifolin, an Orbitide from Jatropha ribifolia, and Its Potential Antimalarial Activity

20.02.2015 | Meri Emili F. Pinto; João M. Batista, Jr.; Johannes Koehbach; Pratibha Gaur; Abhinay Sharma; Myna Nakabashi; Eduardo ..., Journal of Natural Products, 2015

Journal of Natural Products DOI: 10.1021/np5007668

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Correction to Prenylated Flavonoids and Resveratrol Derivatives Isolated from Artocarpus communis with the Ability to Overcome TRAIL Resistance

20.02.2015 | Kazufumi Toume; Tadashi Habu; Midori A. Arai; Takashi Koyano; Thaworn Kowithayakorn; Masami Ishibashi, Journal of Natural Products, 2015

Journal of Natural Products DOI: 10.1021/acs.jnatprod.5b00061

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Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors

19.02.2015 | Sudharshan Madapa; Wayne W. Harding, Journal of Natural Products, 2015

N-Methyllaurotetanine (1) has been reported to display good affinity for the 5-HT1A receptor, but no structure–affinity studies have been performed to date. The commercially available alkaloid boldine (2) was used as the starting material for synthesis of various C-9 alkoxy analogues of ...

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Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-β-agarofuran Sesquiterpenes from Celastrus vulcanicola

19.02.2015 | Oliver Callies; María P. Sánchez-Cañete; Francisco Gamarro; Ignacio A. Jiménez; Santiago Castanys; Isabel L. Bazzocchi, Journal of Natural Products, 2015

Multidrug resistance (MDR) caused by the overexpression of ABC drug transporters is a major obstacle in clinical cancer chemotherapy and underlines the urgent need for the development of new, potent, and safe reversal agents. Toward this goal, reported herein are the structure elucidation and ...

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Sesamol Reduces the Atherogenicity of Electronegative L5 LDL in Vivo and in Vitro

18.02.2015 | Wei-Yu Chen; Fang-Yu Chen; An-Sheng Lee; Kuan-Hsiang Ting; Chia-Ming Chang; Jing-Fang Hsu; Wei-Shine Lee; Joen-Rong ..., Journal of Natural Products, 2015

Highly electronegative low-density lipoprotein (LDL) L5 induces endothelial cell (EC) apoptosis, which leads to the development of atherosclerosis. We examined the effects of sesamol (1), a natural organic component of sesame oil, on plasma L5 levels and atherosclerosis development in a rodent ...

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Antineoplastic Agents. 600. From the South Pacific Ocean to the Silstatins

17.02.2015 | George R. Pettit; Pablo M. Arce; Jean-Charles Chapuis; Christian B. Macdonald, Journal of Natural Products, 2015

The recent advances in the development of antibody and other drug conjugates for targeted cancer treatment have further increased the need for powerful cancer cell growth inhibitors. Toward that objective we have extended our earlier discovery of the remarkable anticancer bacillistatins 1 and 2 ...

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Correction to Balticidins A–D, Antifungal Hassallidin-like Lipopeptides from the Baltic Sea Cyanobacterium Anabaena cylindrica Bio33

17.02.2015 | Thanh-Huong Bui; Victor Wray; Manfred Nimtz; Torgils Fossen; Michael Preisitsch; Gudrun Schröder; Kristian Wende; St ..., Journal of Natural Products, 2015

Journal of Natural Products DOI: 10.1021/acs.jnatprod.5b00138

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