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1.635 Aktuelle Fachpublikationen in Journal of Natural Products

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Xerophilusin B Induces Cell Cycle Arrest and Apoptosis in Esophageal Squamous Cell Carcinoma Cells and Does Not Cause Toxicity in Nude Mice

02.01.2015 | Ran Yao; Zhaoli Chen; Chengcheng Zhou; Mei Luo; Xuejiao Shi; Jiagen Li; Yibo Gao; Fang Zhou; Jianxin Pu; Handong Sun ..., Journal of Natural Products, 2015

Esophageal cancer is the eighth most common cancer in the world and ranks as the sixth leading cause of cancer-related mortality. Esophageal cancer has a poor prognosis partially due to its low sensitivity to chemotherapy agents, and the development of new therapeutic agents is urgently needed. ...

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Eight Pairs of Epimeric Triterpenoids Involving a Characteristic Spiro-E/F Ring from Abies faxoniana

02.01.2015 | Guo-Wei Wang; Chao Lv; Xin Fang; Xin-Hui Tian; Ji Ye; Hui-Liang Li; Lei Shan; Yun-Heng Shen; Wei-Dong Zhang, Journal of Natural Products, 2015

Five pairs of new epimeric lanostane-type triterpenoids, abiespirones A–D (1–4) and G (7), two pairs of new epimeric cycloartane-type triterpenoids, abiespirones E and F (5, 6), and a pair of new epimeric 7(8→9)abeo-spirolanostane abiespirones H (8) with spiro-B/C and -E/F ring systems were ...

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Hypocoprins A–C: New Sesquiterpenoids from the Coprophilous Fungus Hypocopra rostrata

30.12.2014 | Dinith R. Jayanetti; Qun Yue; Gerald F. Bills; James B. Gloer, Journal of Natural Products, 2014

Studies of the coprophilous fungus Hypocopra rostrata (TTI-0009, NRRL 66178) isolated from a sample of horse dung collected in Texas led to the isolation of three new sesquiterpenoids that we named hypocoprins A–C (1–3), together with the known fungal metabolite helvolic acid. The new metabolites ...

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Phylum-Specific Regulation of Resistomycin Production in a Streptomyces sp. via Microbial Coculture

24.12.2014 | Skylar Carlson; Urszula Tanouye; Sesselja Omarsdottir; Brian T. Murphy, Journal of Natural Products, 2014

Actinomycete genomes are encoded with immense potential to produce secondary metabolites, however standard laboratory culture experiments rarely provide the conditions under which associated biosynthetic pathways are expressed. Despite years of research attempting to access these pathways and ...

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Carriebowlinol, an Antimicrobial Tetrahydroquinolinol from an Assemblage of Marine Cyanobacteria Containing a Novel Taxon

23.12.2014 | Angélica R. Soares; Niclas Engene; Sarath P. Gunasekera; Jennifer M. Sneed; Valerie J. Paul, Journal of Natural Products, 2014

A combined biodiversity- and bioassay-guided natural products discovery approach was used to explore new groups of marine cyanobacteria for novel secondary metabolites with ecologically relevant bioactivities. Phylogenetic analysis of cyanobacterial collections from Belize revealed a new taxon ...

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Jalapinoside, a Macrocyclic Bisdesmoside from the Resin Glycosides of Ipomea purga, as a Modulator of Multidrug Resistance in Human Cancer Cells

23.12.2014 | Elihú Bautista; Mabel Fragoso-Serrano; Rogelio Pereda-Miranda, Journal of Natural Products, 2014

The first macrocyclic bisdesmoside resin glycoside, jalapinoside (4), was purified by preparative-scale recycling HPLC from the MeOH-soluble extracts of Ipomoea purga roots, the officinal jalap. Purgic acid C (3), a new glycosidic acid of ipurolic acid, was identified as ...

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Erinaceolactones A to C, from the Culture Broth of Hericium erinaceus

23.12.2014 | Jing Wu; Taiki Tokunaga; Mitsuru Kondo; Kota Ishigami; Shinji Tokuyama; Tomohiro Suzuki; Jae-Hoon Choi; Hirofumi Hir ..., Journal of Natural Products, 2014

Three novel compounds, erinaceolactones A to C (1–3), and a known compound (4) were isolated from the culture broth of Hericium erinaceus. The planar structures of 1–3 were determined by the interpretation of spectroscopic data. The absolute configuration of 3 was determined by X-ray ...

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Batatins VIII–XI, Glycolipid Ester-Type Dimers from Ipomoea batatas

22.12.2014 | Daniel Rosas-Ramírez; Rogelio Pereda-Miranda, Journal of Natural Products, 2014

Sweet potato (Ipomoea batatas) is native to the tropics of Central and South America, where many varieties have been consumed for more that 5000 years. In developing countries, this crop is a recognized effective food for fighting malnutrition. Purification of the minor lipophilic glicolipids ...

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Bioactive Sesquiterpene Aryl Esters from the Culture Broth of Armillaria sp.

19.12.2014 | Hajime Kobori; Atsushi Sekiya; Tomohiro Suzuki; Jae-Hoon Choi; Hirofumi Hirai; Hirokazu Kawagishi, Journal of Natural Products, 2014

Journal of Natural Products DOI: 10.1021/np500322t

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Matrix-Bound 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone in Tobacco: Quantification and Evidence for an Origin from Lignin-Incorporated Alkaloids

19.12.2014 | Gerhard Lang; Aline Vuarnoz, Journal of Natural Products, 2014

Substantial quantities of the carcinogenic tobacco-specific N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (1; NNK) are still found in the mainstream smoke of tobacco exhaustively extracted with water, indicating the presence of an insoluble, matrix-bound form. Soluble and ...

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