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1.761 Aktuelle Fachpublikationen in Journal of Natural Products

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hERG Channel Inhibitory Daphnane Diterpenoid Orthoesters and Polycephalones A and B with Unprecedented Skeletons from Gnidia polycephala

19.06.2015 | Maria De Mieri; Kun Du; Markus Neuburger; Priyanka Saxena; Pieter C. Zietsman; Steffen Hering; Jan H. van der Westhu ..., Journal of Natural Products, 2015

The hERG channel is an important antitarget in safety pharmacology. Several drugs have been withdrawn from the market or received severe usage restrictions because of hERG-related cardiotoxicity. In a screening of medicinal plants for hERG channel inhibition using a two-microelectrode voltage ...

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Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest1

19.06.2015 | Yixi Liu; Kelly Young; L. Harinantenaina Rakotondraibe; Peggy J. Brodie; Jessica D. Wiley; Maria B. Cassera; Martin ..., Journal of Natural Products, 2015

The two new lignans 3α-O-(β-d-glucopyranosyl)desoxypodophyllotoxin (1) and 4-O-(β-d-glucopyranosyl)dehydropodophyllotoxin (2) were isolated from Cleistanthus boivinianus, together with the known lignans deoxypicropodophyllotoxin (3), (±)-β-apopicropodophyllin (4), (−)-desoxypodophyllotoxin (5), ...

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HPLC-NMR and HPLC-MS Profiling and Bioassay-Guided Identification of Secondary Metabolites from the Australian Plant Haemodorum spicatum

19.06.2015 | Robert Brkljača; Sylvia Urban, Journal of Natural Products, 2015

Phytochemical dereplication was undertaken on the bioactive crude CH2Cl2 extract of the bulbs of the Australian plant Haemodorum spicatum employing HPLC-NMR and HPLC-MS methodologies. Subsequent bioassay-guided isolation resulted in the identification of two new phenylphenalenones [haemoxiphidone ...

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Neolignans with a Rare 2-Oxaspiro[4.5]deca-6,9-dien-8-one Motif from the Stem Bark of Cinnamomum subavenium

18.06.2015 | Yongji Lai; Tingting Liu; Rongjian Sa; Xialan Wei; Yongbo Xue; Zhaodi Wu; Zengwei Luo; Ming Xiang; Yonghui Zhang; Gu ..., Journal of Natural Products, 2015

Two pairs of racemic spirodienone neolignans with a rare 2-oxaspiro[4.5]deca-6,9-dien-8-one motif, named (±)-subaveniumins A (1) and B (2), were isolated from the bark of Cinnamomum subavenium. The chiral separation of the (+)-1, (−)-1, (+)-2, and (−)-2 enantiomers was accomplished via ...

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An Isoflavone from Leiophyllum buxifolium and Its Antiproliferative Effect

18.06.2015 | Dan Tian; John R. Porter, Journal of Natural Products, 2015

Journal of Natural Products DOI: 10.1021/acs.jnatprod.5b00100

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Structures and Biological Evaluations of Agelasines Isolated from the Okinawan Marine Sponge Agelas nakamurai

17.06.2015 | Delfly B. Abdjul; Hiroyuki Yamazaki; Syu-ichi Kanno; Ohgi Takahashi; Ryota Kirikoshi; Kazuyo Ukai; Michio Namikoshi, Journal of Natural Products, 2015

Three new N-methyladenine-containing diterpenes, 2-oxoagelasines A (1) and F (2) and 10-hydro-9-hydroxyagelasine F (3), were isolated from the Okinawan marine sponge Agelas nakamurai Hoshino together with eight known agelasine derivatives, 2-oxoagelasine B (4), agelasines A (5), B (6), D (7), E ...

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Chemo- and Regioselective Functionalization of Nortrilobolide: Application for Semisynthesis of the Natural Product 2-Acetoxytrilobolide

16.06.2015 | Nhu Thi Quynh Doan; François Crestey; Carl Erik Olsen; Søren Brøgger Christensen, Journal of Natural Products, 2015

The difference in reactivity of the hexaoxygenated natural product thapsigargin (1) and the pentaoxygenated nortrilobolide (3) was compared in order to develop a chemo- and regioselective method for the conversion of nortrilobolide (3) into the natural product 2-acetoxytrilobolide (4). For the ...

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Suncheonosides A–D, Benzothioate Glycosides from a Marine-Derived Streptomyces sp.

16.06.2015 | Bora Shin; Seyeon Ahn; Minsoo Noh; Jongheon Shin; Dong-Chan Oh, Journal of Natural Products, 2015

A marine-derived Streptomyces strain, SSC21, was isolated from the sediment of Suncheon Bay, Republic of Korea. Chemical analysis of the bacterial strain resulted in the isolation of four new metabolites, suncheonosides A–D (1–4, respectively), each bearing a sulfur atom. The planar structures of ...

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(−)-α-Bisabolol, a Promising Oral Compound for the Treatment of Visceral Leishmaniasis

15.06.2015 | Victoriano Corpas-López; Francisco Morillas-Márquez; M. Concepción Navarro-Moll; Gemma Merino-Espinosa; Victoriano D ..., Journal of Natural Products, 2015

The aim of the present study was to assess the in vitro and in vivo activity of (−)-α-bisabolol (1) against the etiological agents of visceral leishmaniasis. Bone-marrow-derived macrophages were infected with Leishmania infantum or L. donovani promastigotes and incubated with (−)-α-bisabolol at ...

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Chemical Characterization and Botanical Origin of French Ambers

12.06.2015 | Youssef A. Nohra; Vincent Perrichot; Laurent Jeanneau; Laurent Le Pollès; Dany Azar, Journal of Natural Products, 2015

The molecular composition of 10 Cretaceous and one Eocene ambers from France was analyzed by infrared spectroscopy, solid-state 13C nuclear magnetic resonance spectroscopy, and thermochemolysis gas chromatography–mass spectrometry. The terpenoids identified in the samples were used as biomarkers ...

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