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1.574 Aktuelle Fachpublikationen in Journal of Natural Products

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Detailed Analysis of (−)-Palmyrolide A and Some Synthetic Derivatives as Voltage-Gated Sodium Channel Antagonists

24.10.2014 | Suneet Mehrotra; Brendan M. Duggan; Rodolfo Tello-Aburto; Tara D. Newar; William H. Gerwick; Thomas F. Murray; Willi ..., Journal of Natural Products, 2014

A small library of synthetic (−)-palmyrolide A diastereomers, analogues, and acyclic precursors have been examined with respect to their interaction with voltage-gated sodium channels (VGSCs). Toward this goal, the ability of (−)-palmyrolide A and analogues to antagonize veratridine-stimulated ...

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Correction to Acylated Iridoids with Cytotoxicity from Valeriana jatamansi

23.10.2014 | Sheng Lin; Yun-Heng Shen; Hui-Liang Li; Xian-Wen Yang; Tao Chen; Long-Hai Lu; Zheng-Sheng Huang; Run-Hui Liu; Xi-Ke ..., Journal of Natural Products, 2014

Journal of Natural Products DOI: 10.1021/np500821g

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Synthesis of Cyclocaric Acid A and Comparison to Material from Cyclocarya paliurus

23.10.2014 | Matthew E. Wright; Jonathan Byrd; Chunnian He; Norma Dunlap, Journal of Natural Products, 2014

Journal of Natural Products DOI: 10.1021/np500575q

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Steroidal Alkaloids from the Marine Sponge Corticium niger That Inhibit Growth of Human Colon Carcinoma Cells

22.10.2014 | Suthananda N. Sunassee; Tanya Ransom; Curtis J. Henrich; John A. Beutler; David G. Covell; James B. McMahon; Kirk R. ..., Journal of Natural Products, 2014

Bioinformatic analysis of data from the NCI-60 cell cytotoxicity screen revealed a subset of extracts that showed selective cytotoxic activity toward human colon carcinoma cell lines. Bioassay-guided fractionation of a colon cancer selective extract from a Philippines collection of the marine ...

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Terpenoids from the Root Bark of Pterolobium macropterum

22.10.2014 | Jittra Suthiwong; Siripit Pitchuanchom; Wareeporn Wattanawongdon; Chariya Hahnvajanawong; Chavi Yenjai, Journal of Natural Products, 2014

Journal of Natural Products DOI: 10.1021/np500476h

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Anti-inflammatory Diterpenoids from the Root Bark of Acanthopanax gracilistylus

22.10.2014 | Zhi-Yuan Wu; Yi-Bei Zhang; Kong-Kai Zhu; Cheng Luo; Jing-Xian Zhang; Chun-Ru Cheng; Rui-Hong Feng; Wen-Zhi Yang; Fen ..., Journal of Natural Products, 2014

Three new ent-kaurane (1–3) and five new ent-pimarane diterpenoids (4–8) and a new oleanane triterpene acid (9), together with 22 known compounds, were isolated from the root bark of the medicinal herb Acanthopanax gracilistylus. The structures of 1–9 were established based on the interpretation ...

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Chlorinated Polyketide Obtained from a Daldinia sp. Treated with the Epigenetic Modifier Suberoylanilide Hydroxamic Acid

22.10.2014 | Lin Du; Jarrod B. King; Robert H. Cichewicz, Journal of Natural Products, 2014

A new chlorinated pentacyclic polyketide, daldinone E (1), was purified from a Daldinia sp. fungal isolate treated with the epigenetic modifier suberoylanilide hydroxamic acid (SAHA). A biosynthetically related epoxide-containing daldinone analogue, 2, was also purified from the same fungus. The ...

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Folded Structure and Insertion Depth of the Frog-Skin Antimicrobial Peptide Esculentin-1b(1–18) in the Presence of Differently Charged Membrane-Mimicking Micelles

22.10.2014 | Giorgia Manzo; Mariano Casu; Andrea C. Rinaldi; Nicola P. Montaldo; Anna Luganini; Giorgio Gribaudo; Mariano A. Scor ..., Journal of Natural Products, 2014

Antimicrobial peptides (AMPs) are effectors of the innate immunity of most organisms. Their role in the defense against pathogen attack and their high selectivity for bacterial cells make them attractive for the development of a new class of antimicrobial drugs. The N-terminal fragment of the ...

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Polyyne Hybrid Compounds from Notopterygium incisum with Peroxisome Proliferator-Activated Receptor Gamma Agonistic Effects

21.10.2014 | Xin Liu; Olaf Kunert; Martina Blunder; Nanang Fakhrudin; Stefan M. Noha; Clemens Malainer; Andreas Schinkovitz; Elke ..., Journal of Natural Products, 2014

In the search for peroxisome proliferator-activated receptor gamma (PPARγ) active constituents from the roots and rhizomes of Notopterygium incisum, 11 new polyacetylene derivatives (1–11) were isolated. Their structures were elucidated by NMR and HRESIMS as new polyyne hybrid molecules of ...

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Cytotoxic Vobasine, Tacaman, and Corynanthe-Tryptamine Bisindole Alkaloids from Tabernaemontana and Structure Revision of Tronoharine

21.10.2014 | Dawn Su-Yin Sim; Kam-Weng Chong; Choy-Eng Nge; Yun-Yee Low; Kae-Shin Sim; Toh-Seok Kam, Journal of Natural Products, 2014

Journal of Natural Products DOI: 10.1021/np500589u

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