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1.850 Aktuelle Fachpublikationen in Journal of Natural Products

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Saccharothrixones A–D, Tetracenomycin-Type Polyketides from the Marine-Derived Actinomycete Saccharothrix sp. 10-10

28.08.2015 | Maoluo Gan; Bin Liu; Yi Tan; Qiang Wang; Hongxia Zhou; Hongwei He; Yuhui Ping; Zhaoyong Yang; Yiguang Wang; Chunling ..., Journal of Natural Products, 2015

Saccharothrixones A–C (1–3), three new aromatic polyketide seco-tetracenomycins, and saccharothrixone D (4), a new tetracenomycin analogue possessing opposite configurations at all of the stereogenic centers, were isolated from the marine-derived actinomycete Saccharothrix sp. 10-10. Compounds ...

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Harpagoside Inhibits RANKL-Induced Osteoclastogenesis via Syk-Btk-PLCγ2-Ca2+ Signaling Pathway and Prevents Inflammation-Mediated Bone Loss

26.08.2015 | Ju-Young Kim; Sun-Hyang Park; Jong Min Baek; Munkhsoyol Erkhembaatar; Min Seuk Kim; Kwon-Ha Yoon; Jaemin Oh; Myeung ..., Journal of Natural Products, 2015

Harpagoside (HAR) is a natural compound isolated from Harpagophytum procumbens (devil’s claw) that is reported to have anti-inflammatory effects; however, these effects have not been investigated in the context of bone development. The current study describes for the first time that HAR inhibits ...

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Carbon Multiplicity Editing in Long-Range Heteronuclear Correlation NMR Experiments: A Valuable Tool for the Structure Elucidation of Natural Products

25.08.2015 | Josep Saurí; Michel Frédérich; Alembert T. Tchinda; Teodor Parella; R. Thomas Williamson; Gary E. Martin, Journal of Natural Products, 2015

A recently developed NMR method to simultaneously obtain both long-range heteronuclear correlations and carbon multiplicity information in a single experiment, ME-selHSQMBC, is demonstrated as a potentially useful technique for chemical shift assignment and structure elucidation of natural ...

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(±)-Acortatarinowins A–F, Norlignan, Neolignan, and Lignan Enantiomers from Acorus tatarinowii

25.08.2015 | Yuanyuan Lu; Yongbo Xue; Junjun Liu; Guangmin Yao; Dongyan Li; Bin Sun; Jinwen Zhang; Yanfei Liu; Changxing Qi; Ming ..., Journal of Natural Products, 2015

Three pairs of new 8-O-4′-type dinorneolignan enantiomers, (±)-acortatarinowins A–C (1a/1b–3a/3b), a pair of new 8-O-4′-type (4a/4b) and a pair of rare C7–C8′-type (5a/5b) neolignan enantiomers, (±)-acortatarinowins D and E, and a pair of new furofuran-type lignan enantiomers, (±)-acortatarinowin ...

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Lepidotol A from Mesua lepidota Inhibits Inflammatory and Immune Mediators in Human Endothelial Cells

24.08.2015 | Caroline Rouger; Séverine Derbré; Béatrice Charreau; Angélique Pabois; Thomas Cauchy; Marc Litaudon; Khalijah Awang; ..., Journal of Natural Products, 2015

Phytochemical investigation on the fruits of Mesua lepidota (Calophyllaceae) led to the isolation of seven new phenylcoumarin derivatives named lepidotols A–E (1–5) and lepidotins A and B (6, 7). These structures were elucidated by spectroscopic and spectrometric methods including UV, NMR, and ...

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Active Constituents from Drynaria fortunei Rhizomes on the Attenuation of Aβ25–35-Induced Axonal Atrophy

24.08.2015 | Zhi-You Yang; Tomoharu Kuboyama; Kohei Kazuma; Katsuhiro Konno; Chihiro Tohda, Journal of Natural Products, 2015

Axonal regeneration might contribute to the restoration of damaged neuronal networks and improvement of memory deficits in a murine Alzheimer’s disease (AD) model. A search for axonal regenerative drugs was performed to discover novel therapeutic options for AD. In this study, an aqueous extract ...

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Complementary Flavonoid Prenylations by Fungal Indole Prenyltransferases

21.08.2015 | Kang Zhou; Xia Yu; Xiulan Xie; Shu-Ming Li, Journal of Natural Products, 2015

Flavonoids are found mainly in plants and exhibit diverse biological and pharmacological activities, which can often be enhanced by prenylations. In plants, such reactions are catalyzed by membrane-bound prenyltransferases. In this study, the prenylation of nine flavonoids from different classes ...

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Phenotype-Guided Natural Products Discovery Using Cytological Profiling

21.08.2015 | Jessica L. Ochoa; Walter M. Bray; R. Scott Lokey; Roger G. Linington, Journal of Natural Products, 2015

Phenotype-guided natural products discovery is emerging as a useful new discovery tool that addresses challenges in early, unbiased natural product biological annotation. These high-content approaches yield screening results that report directly on the impact of test compounds on cellular ...

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Citrifelins A and B, Citrinin Adducts with a Tetracyclic Framework from Cocultures of Marine-Derived Isolates of Penicillium citrinum and Beauveria felina

21.08.2015 | Ling-Hong Meng; Yang Liu; Xiao-Ming Li; Gang-Ming Xu; Nai-Yun Ji; Bin-Gui Wang, Journal of Natural Products, 2015

Citrifelins A (1) and B (2), two citrinin adducts possessing a unique tetracyclic framework, were characterized from a coculture of marine-derived fungal isolates of Penicillium citrinum and Beauveria felina. Neither fungus produced these compounds when cultured alone under the same conditions. ...

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Bisacremines A–D, Dimeric Acremines Produced by a Soil-Derived Acremonium persicinum Strain

21.08.2015 | Ping Wu; Lei Yao; Liangxiong Xu; Jinghua Xue; Xiaoyi Wei, Journal of Natural Products, 2015

Journal of Natural Products DOI: 10.1021/np501037x

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