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1.563 Aktuelle Fachpublikationen in Journal of Natural Products

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Protective Effects of Resveratrol on Hepatotoxicity Induced by Isoniazid and Rifampicin via SIRT1 Modulation

10.10.2014 | Natália F. Nicoletti; Valnês Rodrigues-Junior; André A. Santos, Jr.; Carlos E. Leite; Ana C. O. Dias; Eraldo L. Bati ..., Journal of Natural Products, 2014

Acute liver injury was induced in male BALB/c mice by coadministering isoniazid and rifampicin. In this work, the effects of resveratrol (1) were investigated in the hepatotoxicity caused by isoniazid–rifampicin in mice. Compound 1 was administered 30 min prior to isoniazid–rifampicin. Serum ...


Identification of Key Structural Characteristics of Schisandra chinensis Lignans Involved in P-Glycoprotein Inhibition

10.10.2014 | Jiří Slanina; Gabriela Páchniková; Martina Čarnecká; Ludmila Porubová Koubíková; Lenka Adámková; Otakar Humpa; Karel ..., Journal of Natural Products, 2014

The aim of the present study was to determine the structural requirements for dibenzocyclooctadiene lignans essential for P-glycoprotein inhibition. Altogether 15 structurally related lignans isolated from Schisandra chinensis or prepared by modification of their backbone were investigated, ...


Indazole-Type Alkaloids from Nigella sativa Seeds Exhibit Antihyperglycemic Effects via AMPK Activation in Vitro

09.10.2014 | Tao Yuan; Pragati Nahar; Meenakshi Sharma; Ke Liu; Angela Slitt; H. A. Aisa; Navindra P. Seeram, Journal of Natural Products, 2014

Journal of Natural Products DOI: 10.1021/np500398m


Chemopreventive Effects of (−)-Hinokinin against 1,2-Dimethylhydrazine-Induced Genotoxicity and Preneoplastic Lesions in Rat Colon

09.10.2014 | Lilian C. Barbosa; Ricardo A. Furtado; Humberto C. C. Bertanha; Iara M. Tomazella; Eveline S. Costa; Jairo K. Bastos ..., Journal of Natural Products, 2014

(−)-Hinokinin (1) is a dibenzylbutyrolactone lignan obtained by the partial synthesis of (−)-cubebin. This study reports the antigenotoxic and anticarcinogenic potential of 1 by the comet and aberrant crypt focus assays in the peripheral blood and colon of 4–5-week-old Wistar rats, respectively. ...


Bioactive Clerodane Diterpenoids from the Twigs of Casearia balansae

06.10.2014 | Jing Xu; Qiang Zhang; Meicheng Wang; Quanhui Ren; Yihang Sun; Da-Qing Jin; Chunfeng Xie; Hongqiang Chen; Yasushi Ohi ..., Journal of Natural Products, 2014

Eight new clerodane diterpenes, balanspenes A–H (1–8), along with two known analogues (9 and 10), were isolated from the twigs of Casearia balansae. The structures of 1–8 were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analysis, and the absolute configurations of ...


iNOS Inhibitory Activity of Sesquiterpenoids and a Monoterpenoid from the Rhizomes of Curcuma wenyujin

02.10.2014 | Guo-Ping Yin; Liang-Chun Li; Qing-Zhe Zhang; Yue-Wei An; Jing-Jing Zhu; Zhi-Min Wang; Gui-Xin Chou; Zheng-tao Wang, Journal of Natural Products, 2014

Eleven new sesquiterpenoids, wenyujinins A–K (1–11), and a new monoterpenoid, wenyujinin L (12), were isolated from the rhizomes of Curcuma wenyujin. Their structures and relative configurations were elucidated using 1D and 2D NMR, X-ray crystallographic analysis, and HRESIMS data. The absolute ...


The Oxeatamides: Nitrogenous Spongian Diterpenes from the New Zealand Marine Sponge Darwinella oxeata

01.10.2014 | Joanna M. Wojnar; Katie O. Dowle; Peter T. Northcote, Journal of Natural Products, 2014

Journal of Natural Products DOI: 10.1021/np500549g


Acylphloroglucinol Derivatives from Hypericum andinum: Antidepressant-like Activity of Andinin A

29.09.2014 | Gari V. Ccana-Ccapatinta; Eveline D. Stolz; Paola F. da Costa; Stela M. K. Rates; Gilsane L. von Poser, Journal of Natural Products, 2014

Journal of Natural Products DOI: 10.1021/np500426m


Bioactive Sulfur-Containing Sulochrin Dimers and Other Metabolites from an Alternaria sp. Isolate from a Hawaiian Soil Sample

29.09.2014 | Shengxin Cai; Jarrod B. King; Lin Du; Douglas R. Powell; Robert H. Cichewicz, Journal of Natural Products, 2014

Polluxochrin (1) and dioschrin (2), two new dimers of sulochrin linked by thioether bonds, were purified from an Alternaria sp. isolate obtained from a Hawaiian soil sample. The structures of the two metabolites were established by NMR, mass spectrometry data, and X-ray analysis. Metabolite 1 was ...


Autumnalamide, a Prenylated Cyclic Peptide from the Cyanobacterium Phormidium autumnale, Acts on SH-SY5Y Cells at the Mitochondrial Level

29.09.2014 | Coralie Audoin; Jon Andoni Sánchez; Grégory Genta-Jouve; Amparo Alfonso; Laurent Rios; Carmen Vale; Olivier P. Thoma ..., Journal of Natural Products, 2014

Filamentous cyanobacteria of the genus Phormidium have been rarely studied for their chemical diversity. For the first time, the cultivable Phormidium autumnale was shown to produce a prenylated cyclic peptide named autumnalamide (1). The structure of this peptide was fully determined after a ...


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