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1.571 Aktuelle Fachpublikationen in Journal of Natural Products

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Protective Effects of Lupeol against d-Galactosamine and Lipopolysaccharide-Induced Fulminant Hepatic Failure in Mice

17.10.2014 | So-Jin Kim; Hong-Ik Cho; Seok-Joo Kim; Joon-Sung Kim; Jong-Hwan Kwak; Dong-Ung Lee; Sang Kook Lee; Sun-Mee Lee, Journal of Natural Products, 2014

This study examined the hepatoprotective effects of lupeol (1, a major active triterpenoid isolated from Adenophora triphylla var. japonica) against d-galactosamine (GalN) and lipopolysaccharide (LPS)-induced fulminant hepatic failure. Mice were orally administered 1 (25, 50, and 100 mg/kg; ...


Antiproliferative Prenylated Xanthones and Benzophenones from the Roots of Cudrania tricuspidata in HSC-T6 Cells

16.10.2014 | Yang Hee Jo; Bora Shin; Qing Liu; Ki Yong Lee; Dong-Chan Oh; Bang Yeon Hwang; Mi Kyeong Lee, Journal of Natural Products, 2014

Four new prenylated xanthones, cudracuspixanthones A–D (1–4), two new prenylated benzophenones, cudracuspiphenones A (5) and B (6), and 11 known xanthones (7–17) were isolated from the roots of Cudrania tricuspidata. The absolute configurations of compounds 2–4 were deduced by the comparison of ...


Sensitization of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Resistant Primary Prostate Cancer Cells by Isoegomaketone from Perilla frutescens

16.10.2014 | Ju-Hye Lee; Hyun-Dong Cho; Il-Yun Jeong; Mi-Kyung Lee; Kwon-Il Seo, Journal of Natural Products, 2014

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is currently in clinical trials as a cancer treatment due to its ability to induce apoptosis selectively in cancer cells. Nevertheless, the risk of developing resistance warrants the development of sensitizers that can overcome ...


Nocatriones A and B, Photoprotective Tetracenediones from a Marine-Derived Nocardiopsis sp.

15.10.2014 | Min Cheol Kim; Eunson Hwang; Taejung Kim; Jungyeob Ham; Sun Yeou Kim; Hak Cheol Kwon, Journal of Natural Products, 2014

Two new tetracenedione derivatives, nocatriones A (1) and B (2), were discovered from the culture broth of a marine actinomycete, Nocardiopsis sp. KMF-002, which was isolated from the tissue of an unidentified dark purple marine sponge. The structures of 1 and 2, which are tetracenediones ...


Antitrypanosomal Quinoline Alkaloids from the Roots of Waltheria indica

14.10.2014 | Sylvian Cretton; Lise Breant; Lucie Pourrez; Chiara Ambuehl; Laurence Marcourt; Samad Nejad Ebrahimi; Matthias Hambu ..., Journal of Natural Products, 2014

Chemical investigation of the dichloromethane root extract of Waltheria indica led to the isolation and characterization of 10 quinoline alkaloids, namely, 8-deoxoantidesmone (1), waltheriones E–L (2–9), and antidesmone (10). Among these, compounds 2–9 have not yet been described in the ...


Synthesis of Natural and Non-natural Curcuminoids and Their Neuroprotective Activity against Glutamate-Induced Oxidative Stress in HT-22 Cells

14.10.2014 | Petr Jirásek; Sabine Amslinger; Jörg Heilmann, Journal of Natural Products, 2014

A strategy for the synthesis of natural and non-natural 5-deoxy-6,7-dihydrocurcuminoids (diarylheptanoids) was developed for the preparation of 14 compounds with varying aromatic substituent patterns and a different functionality in the aliphatic seven-carbon chain. The in vitro protective ...


Cytotoxic Resin Glycosides from Ipomoea aquatica and Their Effects on Intracellular Ca2+ Concentrations

14.10.2014 | Bo-Yi Fan; Yu-Cheng Gu; Ye He; Zhong-Rui Li; Jian-Guang Luo; Ling-Yi Kong, Journal of Natural Products, 2014

Eleven new resin glycosides, aquaterins I–XI (1–11), were isolated from the whole plants of Ipomoea aquatica. The structures of 1–11 were elucidated by a combination of spectroscopic and chemical methods. They were found to be partially acylated tetra- or pentasaccharides derived from simonic ...


Merremins A–G, Resin Glycosides from Merremia hederacea with Multidrug Resistance Reversal Activity

13.10.2014 | Wen-qiong Wang; Wei-bin Song; Xiao-jing Lan; Min Huang; Li-jiang Xuan, Journal of Natural Products, 2014

Five new pentasaccharide resin glycosides, named merremins A–E (1–5), two new pentasaccharide resin glycoside methyl esters, named merremins F and G (6, 7), and four known resin glycosides, murucoidin IV, murucoidin V, stoloniferin IV, and murucoidin XVII, were obtained from the aerial parts of ...


Protective Effects of Resveratrol on Hepatotoxicity Induced by Isoniazid and Rifampicin via SIRT1 Modulation

10.10.2014 | Natália F. Nicoletti; Valnês Rodrigues-Junior; André A. Santos, Jr.; Carlos E. Leite; Ana C. O. Dias; Eraldo L. Bati ..., Journal of Natural Products, 2014

Acute liver injury was induced in male BALB/c mice by coadministering isoniazid and rifampicin. In this work, the effects of resveratrol (1) were investigated in the hepatotoxicity caused by isoniazid–rifampicin in mice. Compound 1 was administered 30 min prior to isoniazid–rifampicin. Serum ...


Identification of Key Structural Characteristics of Schisandra chinensis Lignans Involved in P-Glycoprotein Inhibition

10.10.2014 | Jiří Slanina; Gabriela Páchniková; Martina Čarnecká; Ludmila Porubová Koubíková; Lenka Adámková; Otakar Humpa; Karel ..., Journal of Natural Products, 2014

The aim of the present study was to determine the structural requirements for dibenzocyclooctadiene lignans essential for P-glycoprotein inhibition. Altogether 15 structurally related lignans isolated from Schisandra chinensis or prepared by modification of their backbone were investigated, ...


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