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1.947 Aktuelle Fachpublikationen in Journal of Natural Products

mit folgenden Suchkriterien:

Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors

20.11.2015 | Mehrdad Iranshahi; Maria Giovanna Chini; Milena Masullo; Amirhossein Sahebkar; Azita Javidnia; Mahsa Chitsazian Yazd ..., Journal of Natural Products, 2015

Curcumin, or diferuloylmethane, a polyphenolic molecule isolated from the rhizome of Curcuma longa, is reported to modulate multiple molecular targets involved in cancer and inflammatory processes. On the basis of its pan-inhibitory characteristics, here we show that simple chemical modifications ...


1,9-seco-Bicyclic Polyprenylated Acylphloroglucinols from Hypericum uralum

19.11.2015 | Jing-Jing Zhang; Xing-Wei Yang; Xia Liu; Jun-Zeng Ma; Yang Liao; Gang Xu, Journal of Natural Products, 2015

Hyperuralones C–H (1–6), six new 1,9-seco-bicyclic polyprenylated acylphloroglucinols (1,9-seco-BPAPs) derived from the normal polyprenylated acylphloroglucinols with a bicyclo[3.3.1]nonane-2,4,9-trione core, together with six known analogues, were isolated from the aerial parts of Hypericum ...


Cytotoxic Illudane Sesquiterpenes from the Fungus Granulobasidium vellereum (Ellis and Cragin) Jülich

17.11.2015 | Christina Nord; Audrius Menkis; Anders Broberg, Journal of Natural Products, 2015

Eight illudane sesquiterpenes were obtained from the wood-decomposing fungus Granulobasidium vellereum (Ellis and Cragin) Jülich; among them were the enantiomers of the known compounds illudin M (1) and dihydroilludin M (4) and the diastereomers of illudin M (2) and illudin S (3), as well as two ...


Chemical Constituents from the Fruiting Bodies of Hexagonia apiaria and Their Anti-inflammatory Activity

17.11.2015 | Tran Dinh Thang; Ping-Chung Kuo; Nguyen Thi Bich Ngoc; Tsong-Long Hwang; Mei-Lin Yang; Shih-Huang Ta; E-Jian Lee; Da ..., Journal of Natural Products, 2015

Journal of Natural Products DOI: 10.1021/acs.jnatprod.5b00449


Arthroamide, a Cyclic Depsipeptide with Quorum Sensing Inhibitory Activity from Arthrobacter sp.

17.11.2015 | Yasuhiro Igarashi; Kazuki Yamamoto; Takao Fukuda; Akane Shojima; Jiro Nakayama; Lorena Carro; Martha E. Trujillo, Journal of Natural Products, 2015

Journal of Natural Products DOI: 10.1021/acs.jnatprod.5b00540


Synergistic Antifungal Meroterpenes and Dioxolanone Derivatives from the Endophytic Fungus Guignardia sp.

13.11.2015 | Tian-Xiao Li; Ming-Hua Yang; Xiao-Bing Wang; Ying Wang; Ling-Yi Kong, Journal of Natural Products, 2015

Nine new meroterpenes (1–9) and one new dioxolanone derivative (10), along with seven known compounds (11–17), were isolated from solid cultures of the endophytic fungus Guignardia sp., obtained from Euphorbia sieboldiana. Their structures were elucidated by analysis of UV, IR, 1D and 2D NMR, and ...


Cadinane-Type Sesquiterpenoids from Heterotheca inuloides: Absolute Configuration and Anti-inflammatory Activity

13.11.2015 | Verónica Egas; Rubén A. Toscano; Edelmira Linares; Robert Bye; Francisco J. Espinosa-García; Guillermo Delgado, Journal of Natural Products, 2015

Eight cadinane-type sesquiterpenoids (1–8) together with some triterpenoids, flavonoids, and sterols were isolated from the aerial parts of Heterotheca inuloides. The structures of the new compounds (1–4) were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analysis. The ...


Absolute Configuration of (−)-Centratherin, a Sesquiterpenoid Lactone, Defined by Means of Chiroptical Spectroscopy

13.11.2015 | Fernando M. S. Junior; Cody L. Covington; Ana Carolina F. de Albuquerque; Jonathas F. R. Lobo; Ricardo M. Borges; Ma ..., Journal of Natural Products, 2015

(−)-Centratherin is a bioactive sesquiterpenoid lactone, whose absolute configuration (AC) was not established, but has been proposed based on those of germacrane precursors. To verify this proposal, the experimental electronic circular dichroism (ECD), electronic dissymmetry factor (EDF), ...


Indoline Amide Glucosides from Portulaca oleracea: Isolation, Structure, and DPPH Radical Scavenging Activity

12.11.2015 | Ze-Zhao Jiao; Su Yue; Hong-Xiang Sun; Tian-Yun Jin; Hai-Na Wang; Rong-Xiu Zhu; Lan Xiang, Journal of Natural Products, 2015

A polyamide column chromatography method using an aqueous ammonia mobile phase was developed for large-scale accumulation of water-soluble indoline amide glucosides from a medicinal plant, Portulaca oleracea. Ten new [oleraceins H, I, K, L, N, O, P, Q, R, S (1–10)] and four known [oleraceins A–D ...


Cytotoxic Orbitide from the Latex of Croton urucurana

12.11.2015 | Priscila de M. Cândido-Bacani; Patrícia de O. Figueiredo; Maria de F. C. Matos; Fernanda R. Garcez; Walmir S. Garcez, Journal of Natural Products, 2015

The bioactive ethyl acetate phase obtained from the latex of Croton urucurana Baillon afforded a novel orbitide (1), [1–9-NαC]-crourorb A1, that proved active against NCI-ADR/RES (ovary, multidrug-resistance phenotype) cells with the same potency as doxorubicin (positive control) and inactive up ...


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