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2.032 Aktuelle Fachpublikationen in Journal of Natural Products

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Natural Products as Sources of New Drugs from 1981 to 2014

07.02.2016 | David J. Newman; Gordon M. Cragg, Journal of Natural Products, 2016

This contribution is a completely updated and expanded version of the four prior analogous reviews that were published in this journal in 1997, 2003, 2007, and 2012. In the case of all approved therapeutic agents, the time frame has been extended to cover the 34 years from January 1, 1981, to ...

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Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi

05.02.2016 | Minni Pirttimaa; Abedelmajeed Nasereddin; Dmitry Kopelyanskiy; Marcel Kaiser; Jari Yli-Kauhaluoma; Kirsi-Marja Oksma ..., Journal of Natural Products, 2016

Dehydroabietylamine (1) was used as a starting material to synthesize a small library of dehydroabietyl amides by simple and facile methods, and their activities against two disease-causing trypanosomatids, namely, Leishmania donovani and Trypanosoma cruzi, were assayed. The most potent compound, ...

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Anti-hepatitis C Virus Natural Product from a Fungus, Penicillium herquei

05.02.2016 | Shu Nishikori; Kenji Takemoto; Shinji Kamisuki; Syo Nakajima; Kouji Kuramochi; Senko Tsukuda; Masashi Iwamoto; Yuri ..., Journal of Natural Products, 2016

New diazabicyclo[2.2.2]octane derivatives, peniciherquamides A–C (1–3), and a novel herqueinone derivative, neoherqueinone (5), were isolated from a fungal culture broth of Penicillium herquei. The structures of these novel compounds were determined by interpretation of spectroscopic data (1D/2D ...

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Antifungal Quinoline Alkaloids from Waltheria indica

05.02.2016 | Sylvian Cretton; Stéphane Dorsaz; Antonio Azzollini; Quentin Favre-Godal; Laurence Marcourt; Samad Nejad Ebrahimi; F ..., Journal of Natural Products, 2016

Chemical investigation of a dichloromethane extract of the aerial parts of Waltheria indica led to the isolation and characterization of five polyhydroxymethoxyflavonoids, namely, oxyanin A (1), vitexicarpin (3), chrysosplenol E (4), flindulatin (5), 5-hydroxy-3,7,4′-trimethoxyflavone (6), and ...

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Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine

03.02.2016 | Shuai Ji; Ziwei Li; Wei Song; Yongrui Wang; Wenfei Liang; Kai Li; Shunan Tang; Qi Wang; Xue Qiao; Demin Zhou; Siwang ..., Journal of Natural Products, 2016

Traditional herbal medicines have been reported to possess significant bioactivities. In this investigation, a combined strategy using both phytochemical and biological approaches was conducted to discern the effective components of licorice, a widely used herbal medicine. Altogether, 122 ...

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Biochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds

03.02.2016 | Joshua J. Kellogg; Daniel A. Todd; Joseph M. Egan; Huzefa A. Raja; Nicholas H. Oberlies; Olav M. Kvalheim; Nadja B. Cech, Journal of Natural Products, 2016

A central challenge of natural products research is assigning bioactive compounds from complex mixtures. The gold standard approach to address this challenge, bioassay-guided fractionation, is often biased toward abundant, rather than bioactive, mixture components. This study evaluated the ...

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Correction to Antiproliferative Trihydroxyalkylcyclohexenones from Pleiogynium timoriense

02.02.2016 | Alexander L. Eaton; L. Harinantenaina Rakotondraibe; Peggy J. Brodie; Michael Goetz; David G. I. Kingston, Journal of Natural Products, 2016

Journal of Natural Products DOI: 10.1021/acs.jnatprod.6b00073

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Evolution of the Cannabinoid and Terpene Content during the Growth of Cannabis sativa Plants from Different Chemotypes

02.02.2016 | Oier Aizpurua-Olaizola; Umut Soydaner; Ekin Öztürk; Daniele Schibano; Yilmaz Simsir; Patricia Navarro; Nestor Etxeba ..., Journal of Natural Products, 2016

The evolution of major cannabinoids and terpenes during the growth of Cannabis sativa plants was studied. In this work, seven different plants were selected: three each from chemotypes I and III and one from chemotype II. Fifty clones of each mother plant were grown indoors under controlled ...

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Morusin Induces TRAIL Sensitization by Regulating EGFR and DR5 in Human Glioblastoma Cells

01.02.2016 | Dain Park; In Jin Ha; Sang-Yoon Park; Minji Choi; Sung-Lyul Lim; Sung-Hoon Kim; Jun-Hee Lee; Kwang Seok Ahn; Miyong ..., Journal of Natural Products, 2016

Glioblastoma is one of the most malignant primary tumors, and the prognosis for glioblastoma patients remains poor. Tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL) is considered a promising anticancer agent due to its remarkable ability to selectively kill tumor cells. However, ...

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N-Acyl Dehydrotyrosines, Tyrosinase Inhibitors from the Marine Bacterium Thalassotalea sp. PP2-459

29.01.2016 | Robert W. Deering; Jianwei Chen; Jiadong Sun; Hang Ma; Javier Dubert; Juan L. Barja; Navindra P. Seeram; Hong Wang; ..., Journal of Natural Products, 2016

Thalassotalic acids A–C and thalassotalamides A and B are new N-acyl dehydrotyrosine derivatives produced by Thalassotalea sp. PP2-459, a Gram-negative bacterium isolated from a marine bivalve aquaculture facility. The structures were elucidated via a combination of spectroscopic analyses ...

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