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1.571 Aktuelle Fachpublikationen in Journal of Natural Products

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Protective Effects of Lupeol against d-Galactosamine and Lipopolysaccharide-Induced Fulminant Hepatic Failure in Mice

17.10.2014 | So-Jin Kim; Hong-Ik Cho; Seok-Joo Kim; Joon-Sung Kim; Jong-Hwan Kwak; Dong-Ung Lee; Sang Kook Lee; Sun-Mee Lee, Journal of Natural Products, 2014

This study examined the hepatoprotective effects of lupeol (1, a major active triterpenoid isolated from Adenophora triphylla var. japonica) against d-galactosamine (GalN) and lipopolysaccharide (LPS)-induced fulminant hepatic failure. Mice were orally administered 1 (25, 50, and 100 mg/kg; ...

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Antiproliferative Prenylated Xanthones and Benzophenones from the Roots of Cudrania tricuspidata in HSC-T6 Cells

16.10.2014 | Yang Hee Jo; Bora Shin; Qing Liu; Ki Yong Lee; Dong-Chan Oh; Bang Yeon Hwang; Mi Kyeong Lee, Journal of Natural Products, 2014

Four new prenylated xanthones, cudracuspixanthones A–D (1–4), two new prenylated benzophenones, cudracuspiphenones A (5) and B (6), and 11 known xanthones (7–17) were isolated from the roots of Cudrania tricuspidata. The absolute configurations of compounds 2–4 were deduced by the comparison of ...

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Sensitization of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Resistant Primary Prostate Cancer Cells by Isoegomaketone from Perilla frutescens

16.10.2014 | Ju-Hye Lee; Hyun-Dong Cho; Il-Yun Jeong; Mi-Kyung Lee; Kwon-Il Seo, Journal of Natural Products, 2014

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is currently in clinical trials as a cancer treatment due to its ability to induce apoptosis selectively in cancer cells. Nevertheless, the risk of developing resistance warrants the development of sensitizers that can overcome ...

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Nocatriones A and B, Photoprotective Tetracenediones from a Marine-Derived Nocardiopsis sp.

15.10.2014 | Min Cheol Kim; Eunson Hwang; Taejung Kim; Jungyeob Ham; Sun Yeou Kim; Hak Cheol Kwon, Journal of Natural Products, 2014

Two new tetracenedione derivatives, nocatriones A (1) and B (2), were discovered from the culture broth of a marine actinomycete, Nocardiopsis sp. KMF-002, which was isolated from the tissue of an unidentified dark purple marine sponge. The structures of 1 and 2, which are tetracenediones ...

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Antitrypanosomal Quinoline Alkaloids from the Roots of Waltheria indica

14.10.2014 | Sylvian Cretton; Lise Breant; Lucie Pourrez; Chiara Ambuehl; Laurence Marcourt; Samad Nejad Ebrahimi; Matthias Hambu ..., Journal of Natural Products, 2014

Chemical investigation of the dichloromethane root extract of Waltheria indica led to the isolation and characterization of 10 quinoline alkaloids, namely, 8-deoxoantidesmone (1), waltheriones E–L (2–9), and antidesmone (10). Among these, compounds 2–9 have not yet been described in the ...

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Synthesis of Natural and Non-natural Curcuminoids and Their Neuroprotective Activity against Glutamate-Induced Oxidative Stress in HT-22 Cells

14.10.2014 | Petr Jirásek; Sabine Amslinger; Jörg Heilmann, Journal of Natural Products, 2014

A strategy for the synthesis of natural and non-natural 5-deoxy-6,7-dihydrocurcuminoids (diarylheptanoids) was developed for the preparation of 14 compounds with varying aromatic substituent patterns and a different functionality in the aliphatic seven-carbon chain. The in vitro protective ...

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Cytotoxic Resin Glycosides from Ipomoea aquatica and Their Effects on Intracellular Ca2+ Concentrations

14.10.2014 | Bo-Yi Fan; Yu-Cheng Gu; Ye He; Zhong-Rui Li; Jian-Guang Luo; Ling-Yi Kong, Journal of Natural Products, 2014

Eleven new resin glycosides, aquaterins I–XI (1–11), were isolated from the whole plants of Ipomoea aquatica. The structures of 1–11 were elucidated by a combination of spectroscopic and chemical methods. They were found to be partially acylated tetra- or pentasaccharides derived from simonic ...

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Merremins A–G, Resin Glycosides from Merremia hederacea with Multidrug Resistance Reversal Activity

13.10.2014 | Wen-qiong Wang; Wei-bin Song; Xiao-jing Lan; Min Huang; Li-jiang Xuan, Journal of Natural Products, 2014

Five new pentasaccharide resin glycosides, named merremins A–E (1–5), two new pentasaccharide resin glycoside methyl esters, named merremins F and G (6, 7), and four known resin glycosides, murucoidin IV, murucoidin V, stoloniferin IV, and murucoidin XVII, were obtained from the aerial parts of ...

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Protective Effects of Resveratrol on Hepatotoxicity Induced by Isoniazid and Rifampicin via SIRT1 Modulation

10.10.2014 | Natália F. Nicoletti; Valnês Rodrigues-Junior; André A. Santos, Jr.; Carlos E. Leite; Ana C. O. Dias; Eraldo L. Bati ..., Journal of Natural Products, 2014

Acute liver injury was induced in male BALB/c mice by coadministering isoniazid and rifampicin. In this work, the effects of resveratrol (1) were investigated in the hepatotoxicity caused by isoniazid–rifampicin in mice. Compound 1 was administered 30 min prior to isoniazid–rifampicin. Serum ...

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Identification of Key Structural Characteristics of Schisandra chinensis Lignans Involved in P-Glycoprotein Inhibition

10.10.2014 | Jiří Slanina; Gabriela Páchniková; Martina Čarnecká; Ludmila Porubová Koubíková; Lenka Adámková; Otakar Humpa; Karel ..., Journal of Natural Products, 2014

The aim of the present study was to determine the structural requirements for dibenzocyclooctadiene lignans essential for P-glycoprotein inhibition. Altogether 15 structurally related lignans isolated from Schisandra chinensis or prepared by modification of their backbone were investigated, ...

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