19.11.2012 | Sowmya Soman, Rajesh Raju, Varot K. Sandhya, Jayshree Advani, Aafaque Ahmad Khan, H. C. Harsha, T. S. Keshava Prasad ..., Journal of Cell Communication and Signaling, 2012

A multicellular signal transduction network of AGE/RAGE signaling Content Type Journal Article Category Nuts and Bolts Pages 1-5 DOI 10.1007/s12079-012-0181-3 Authors Sowmya Soman, Institute of Bioinformatics, International Technology Park, Bangalore, 560066 India Rajesh Raju, ...

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19.11.2012 | Vincenza Rita Lo Vasco, Lucia Longo, Patrizia Polonia, Journal of Cell Communication and Signaling, 2012

The involvement of phosphoinositides (PI) signal transduction pathway and related molecules, such as the Phosphoinositide-specific Phospholipase C (PI-PLC) enzymes, in the pathophysiology of mood disorders is corroborated by a number of recent evidences. Our previous works identified the ...

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19.11.2012 | Tarak Srivastava, Mukut Sharma, Kok-Hooi Yew, Ram Sharma, R. Scott Duncan, Moin A. Saleem, Ellen T. McCarthy, Alexan ..., Journal of Cell Communication and Signaling, 2012

Minimal change disease (MCD), the most common idiopathic nephrotic syndrome in children, is characterized by proteinuria and loss of glomerular visceral epithelial cell (podocyte) ultrastructure. Lipopolysaccharide (LPS) and puromycin aminonucleoside (PAN) are used to study podocyte injury in ...

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13.10.2012 | Tarek Abd El Kader, Satoshi Kubota, Danilo Janune, Takashi Nishida, Takako Hattori, Eriko Aoyama, Bernard Perbal, Ta ..., Journal of Cell Communication and Signaling, 2012

CCN family proteins 2 and 3 (CCN2 and CCN3) belong to the CCN family of proteins, all having a high level of structural similarity. It is widely known that CCN2 is a profibrotic molecule that mediates the development of fibrotic disorders in many different tissues and organs. In contrast, ...

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08.10.2012 | Michael Jewer, Scott D. Findlay, Lynne-Marie Postovit, Journal of Cell Communication and Signaling, 2012

The microenvironment acts as a conduit for cellular communication, delivering signals that direct development and sustain tissue homeostasis. In pathologies such as cancer, this integral function of the microenvironment is hijacked to support tumor growth and progression. Cells sense the ...

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02.10.2012 | Rob J. Van Geest, Ingeborg Klaassen, Sarit Y. Lesnik-Oberstein, H. Stevie Tan, Marco Mura, Roel Goldschmeding, Corne ..., Journal of Cell Communication and Signaling, 2012

In proliferative diabetic retinopathy (PDR), vascular endothelial growth factor (VEGF) and CCN2 (connective tissue growth factor; CTGF) cause blindness by neovascularization and subsequent fibrosis. This angio-fibrotic switch is associated with a shift in the balance between vitreous levels ...

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07.09.2012 | Tadashi Honjo, Satoshi Kubota, Hiroshi Kamioka, Yasuyo Sugawara, Yoshihito Ishihara, Takashi Yamashiro, Masaharu Tak ..., Journal of Cell Communication and Signaling, 2012

Fluid flow stress (FSS) is a major mechanical stress that induces bone remodeling upon orthodontic tooth movement, whereas CCN family protein 2 (CCN2) is a potent regenerator of bone defects. In this study, we initially evaluated the effect of laminar FSS on Ccn2 expression and investigated ...

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28.08.2012 | Ronald B. Myers, Kibibi Rwayitare, Lauren Richey, Janis Lem, John J. Castellot Jr., Journal of Cell Communication and Signaling, 2012

CCN proteins play crucial roles in development, angiogenesis, cell motility, matrix turnover, proliferation, and other fundamental cell processes. Early embryonic lethality in CCN5 knockout and over-expressing mice led us to characterize CCN5 distribution in early development. Previous papers ...

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10.08.2012 | Denis J. Dupré, Marek Rola-Pleszczynski, Jana Stankova, Journal of Cell Communication and Signaling, 2012

Platelet-activating factor (PAF) is a potent phospholipid mediator involved in specific disease states such as allergic asthma, atherosclerosis and psoriasis. The human PAF receptor (PAFR) is a member of the G protein-coupled receptor (GPCR) family. Following PAF stimulation, cells become ...

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04.08.2012 | Bernard Perbal, Journal of Cell Communication and Signaling, 2012

A critical look at a recently published manuscript reporting the role of CCN3 in the regulation of clear cell renal cell carcinoma (RCC) biology raises several scientific concerns, and reveals flaws in the reviewing process which appear to have resulted in the dissemination of conclusions ...

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