03.05.2013 | Dirk de Bruyn Oubotér, Thomas Schuster, Vijay Shanker, Markus Heim, Wolfgang Meier, Journal of Biomedical Materials Research Part A, 2013

Abstract Self‐assembled, biodegradable materials that embed fragile, soluble or insoluble compounds of therapeutic interest have potential use as drug delivery systems. The bead‐forming peptide Ac‐X3‐gT can embed hydrophobic and hydrophilic payloads. Loaded peptide beads were internalized ...

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03.05.2013 | Lin Sang, Zhiyong Wei, Keliang Liu, Xinhui Wang, Kedong Song, Hong Wang, Min Qi, Journal of Biomedical Materials Research Part A, 2013

Abstract Biodegradable radiopaque iodinated poly(ester‐urethane) (PU), consisting of poly(ε‐caprolactone)‐diol (PCL) and 4,4′‐isopropylidinedi‐(2,6‐diiodophenol) (IBPA), has been successfully synthesized via a coupling reaction of PCL‐diisocyanate and IBPA with varying compositions. The ...

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03.05.2013 | Anusuya Das, Shaun Tanner, Daniel A. Barker, David Green, Edward A. Botchwey, Journal of Biomedical Materials Research Part A, 2013

Abstract Biodegradable polymer scaffolds can be used to deliver soluble factors to enhance osseous remodeling in bone defects. To this end, we designed a poly(lactic‐co‐glycolic acid) (PLAGA) microsphere scaffold to sustain the release of FTY720, a selective agonist for sphingosine ...

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03.05.2013 | Arnold W. G. Nijhuis, Jeroen J. J. P. van den Beucken, John A. Jansen, Sander C. G. Leeuwenburgh, Journal of Biomedical Materials Research Part A, 2013

Abstract Immobilization of biomolecules onto implant surfaces is one of the most straightforward strategies to control the interaction between an implant and its biological environment. Recently, it was shown that the enzyme alkaline phosphatase (ALP) could be efficiently immobilized onto ...

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02.05.2013 | Jinling Ma, Sanne K Both, Wei Ji, Fang Yang, Henk‐Jan Prins, Marco N Helder, Juli Pan, Fu‐Zhai Cui, John A Jansen, J ..., Journal of Biomedical Materials Research Part A, 2013

Abstract The aim of this study was to compare the osteogenic capacity between human adipose tissue‐derived mesenchymal stem cells (AT‐MSCs) and their cocultures with human umbilical vein endothelial cells (HUVECs) in vitro and their biological performance in vivo. Firstly, the optimal ...

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02.05.2013 | Pingguo Duan, Zhen Pan, Lu Cao, Yao He, Huiren Wang, Zehua Qu, Jian Dong, Jiandong Ding, Journal of Biomedical Materials Research Part A, 2013

Abstract Bilayered porous scaffolds have recently attracted interest because of their considerable promise for repairing osteochondral defects. However, determination of optimal pore size in bilayered porous scaffolds remains an important issue. This study investigated the in vivo effects ...

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30.04.2013 | Emmanuel E. Sadava, David M. Krpata, Yue Gao, Michael J. Rosen, Yuri W. Novitsky, Journal of Biomedical Materials Research Part A, 2013

Abstract In recent years, major advances have been accomplished in abdominal wall reconstruction. Introduction of newer prostheses have improved outcomes, but elimination of mesh‐related morbidity is still an elusive issue. It is believed that host foreign body reaction to prosthesis ...

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30.04.2013 | Silvia Panzavolta, Paola Torricelli, Sofia Amadori, Annapaola Parrilli, Katia Rubini, Elena della Bella, Milena Fini ..., Journal of Biomedical Materials Research Part A, 2013

Abstract Bone cell response to 3D bioinspired scaffolds was tested on osteoblast culture supernatants and by means of quantitative polymerase chain reaction (qPCR). Foaming and freeze‐drying method was optimized in order to obtain three‐dimensional interconnected porous scaffolds of ...

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30.04.2013 | Francisco J. Martínez‐Vázquez, Pedro Miranda, Fernando Guiberteau, Antonia Pajares, Journal of Biomedical Materials Research Part A, 2013

Abstract In situ ring‐opening polymerization of ε‐caprolactone (ε‐CL) was performed to coat β‐tricalcium phosphate (β‐TCP) scaffolds fabricated by robocasting in order to enhance their mechanical performance while preserving the predesigned macropore architecture. Concentrated colloidal ...

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30.04.2013 | Kwang Ho Lee, Ki Hwa Lee, Jeonghoon Lee, Hyuk Choi, Donghee Lee, Yongdoo Park, Sang‐Hoon Lee, Journal of Biomedical Materials Research Part A, 2013

ABSTRACT A biomimetic hydrogel was integrated into microfluidic chips to monitor glioma cell alignment and migration. The extracellular matrix‐based biomimetic hydrogel was remodeled by matrix metalloprotease (MMP) secreted by glioma cells and the hydrogel could thus be used to assess ...

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