01.06.2013 | Danielle L Aldredge; Maria R Geronimo; Serenus Hua; Charles C Nwosu; Carlito B Lebrilla; Daniela Barile, Glycobiology , 2013

Bovine milk oligosaccharides (BMOs) are recognized by the dairy and food industries, as well as by infant formula manufacturers, as novel, high-potential bioactive food ingredients. Recent studies revealed that bovine milk contains complex oligosaccharides structurally related to those ...

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01.06.2013 | Alison C MacKinnon; Xiaojun Liu; Patrick WF Hadoke; Mark R Miller; David E Newby; Tariq Sethi, Glycobiology , 2013

Atherosclerosis is a major risk factor for cardiovascular disease (CVD) and stroke. Galectin-3 is a carbohydrate-binding lectin implicated in the pathophysiology of CVD and is highly expressed within atherosclerotic lesions in mice and humans. The object of this present study was to use ...

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01.06.2013 | Shui-Hua Wang; Chih-Ming Tsai; Kuo-I Lin; Kay-Hooi Khoo, Glycobiology , 2013

The occurrence of a terminal disialyl motif on mammalian O-glycans is increasingly being identified through recent mass spectrometry (MS)-based glycomic profiling. In most cases, it is carried on simple core 1 structures in which both the galactose and N-acetyl galactosamine can be ...

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01.06.2013 | David W Scott; Rakesh P Patel, Glycobiology , 2013

Inflammation is a major contributing element to a host of diseases with the interaction between leukocytes and the endothelium being key in this process. Much is understood about the nature of the adhesion molecule proteins expressed on any given leukocyte and endothelial cell that modulates ...

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01.06.2013 | Xinping Yue; Jingning Lu; Linda Auduong; Mark D Sides; Joseph A Lasky, Glycobiology , 2013

Previously, we have shown that heparan sulfate (HS) 6-O-endosulfatase 1 (Sulf1) is a transforming growth factor-β1 (TGF-β1)-responsive gene in normal human lung fibroblasts and functions as a negative feedback regulator of TGF-β1 and that TGF-β1 induces the expression of Sulf1 as well as ...

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01.06.2013 | Masahiko Yabu; Hiroaki Korekane; Koji Hatano; Yasufumi Kaneda; Norio Nonomura; Chihiro Sato; Ken Kitajima; Yasuhide ..., Glycobiology , 2013

We previously reported on the accumulation of a substantial amount of free N-acetylneuraminic acid (Neu5Ac)-containing complex-type N-glycans in human pancreatic cancer cells (Yabu M, Korekane H, Takahashi H, Ohigashi H, Ishikawa O, Miyamoto Y. 2013. Accumulation of free Neu5Ac-containing ...

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01.06.2013 | Armen Petrosyan; Pi-Wan Cheng, Glycobiology , 2013

The Golgi apparatus undergoes morphological changes under stress or malignant transformation, but the precise mechanisms are not known. We recently showed that non-muscle myosin IIA (NMIIA) binds to the cytoplasmic tail of Core 2 N-acetylglucosaminyltransferase mucus-type (C2GnT-M) and ...

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01.06.2013 | Linda Lindberg; Jining Liu; Stefan Gaunitz; Anki Nilsson; Tomas Johansson; Niclas G Karlsson; Jan Holgersson, Glycobiology , 2013

Assays for quantification, and methods for removal, of anti-A and anti-B antibodies are the key for the success of ABO incompatible organ transplantation programs. In order to produce tools that can be used as substrates in tests for anti-A/anti-B quantification and specificity determination ...

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01.06.2013 | Iris Meisen; Regina Rosenbrück; Hans-Joachim Galla; Sabine Hüwel; Ivan U Kouzel; Michael Mormann; Helge Karch; Johan ..., Glycobiology , 2013

Shiga toxin (Stx) 2e, released by certain Stx-producing Escherichia coli, is presently the best characterized virulence factor responsible for pig edema disease, which is characterized by hemorrhagic lesions, neurological disorders and often fatal outcomes. Although Stx2e-mediated brain ...

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01.06.2013 | Satoshi Murakami; Yuki Takaoka; Hisashi Ashida; Kenji Yamamoto; Hisashi Narimatsu; Yasunori Chiba, Glycobiology , 2013

In four yeast strains, Ogataea minuta, Candida parapolymorpha, Pichia anomala and Zygosaccharomyces rouxii, we identified endo-β-N-acetylglucosaminidase (ENGase) homologous sequences by database searches; in each of the four species, a corresponding enzyme activity was also confirmed in ...

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