26.11.2012 | Min-Hee Yi, Young Sook Lee, Joon Won Kang, Soo Jin Kim, Sang-Ha Oh, Yong Min Kim, Young Ho Lee, Sang Do Lee, Dong Wo ..., Cellular and Molecular Neurobiology, 2012

The maintenance of water homeostasis under pathological conditions is mediated by the aquaporin-4 (AQP4) channel in astrocytes. To clarify the transcriptional regulation for AQP4 under conditions of astrocytic swelling, we examined the role of nuclear factor of activated T cells 5 (NFAT5). We ...

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19.11.2012 | Chengcheng Ying, Mei Yang, Xinmin Zheng, Wanli Hu, Xinghuan Wang, Cellular and Molecular Neurobiology, 2012

The aim of this study was to investigate effects of intracavernous injection of adipose-derived stem cells (ADSCs) on cavernous nerve (CN) regeneration and functional status in a nerve-crush rat model. Thirty Sprague–Dawley male rats were randomly divided into three equal groups: one group ...

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19.11.2012 | Xiao-Xia Fang, Xiao-Lin Jiang, Xin-Hua Han, Yu-Ping Peng, Yi-Hua Qiu, Cellular and Molecular Neurobiology, 2012

We have previously shown that interleukin-6 (IL-6) has neuroprotective effect against N-methyl-d-aspartate (NMDA)-induced excitotoxicity. The current study aimed to reveal signal transduction pathways involved in the IL-6 neuroprotection. Cerebellar granule neurons (CGNs) from postnatal 8-day ...

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15.11.2012 | Vedat Ali Yürekli, Semih Gürler, Mustafa Nazıroğlu, Abdülhadi Cihangir Uğuz, Hasan Rifat Koyuncuoğlu, Cellular and Molecular Neurobiology, 2012

Parkinson’s disease is an incurable progressive neurological condition caused by a degeneration of dopamine-producing cells characterized by motor and non-motor symptoms. The major mechanisms of the antiepileptic actions of ZNS are inhibition of voltage-gated Na+ channel, T-type ...

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08.11.2012 | Yong-Gang Jiao, Guo-Cai Li, Jun-Pao Chen, Zhong-Hai Wu, Hong-tian Zhang, Cellular and Molecular Neurobiology, 2012

Dopamine receptor 1 (D1R) plays an essential role in regulating respiratory activity in mammals, however, little is known about how this receptor acts to modulate the basic respiratory rhythmogenesis. Here, by simultaneously recording the discharge activities of biphasic expiratory (biphasic ...

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06.11.2012 | Tadasu Sato, Masatoshi Fujita, Mitsuhiro Kano, Hiroshi Hosokawa, Teruyoshi Kondo, Toshihiko Suzuki, Eriko Kasahara, ..., Cellular and Molecular Neurobiology, 2012

Immunohistochemistry for transient receptor potential melastatin-8 (TRPM8), the cold and menthol receptor, was performed on the rat soft palate, epiglottis and pharynx. TRPM8-immunoreactive (IR) nerve fibers were located beneath the mucous epithelium, and occasionally penetrated the ...

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05.11.2012 | Xiao-Yan Zhu, Chang-Sheng Huang, Qian Li, Qu-Lian Guo, Ying Wang, Xin He, Juan Liao, Cellular and Molecular Neurobiology, 2012

p300 and its homolog cyclic AMP response element binding protein (CBP) are coactivators that were identified to participate in many biological processes including neural development and cognition. Their roles within the rodent spinal cord have not been reported systematically; in this study, ...

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05.11.2012 | Jianhua Cao, Jiao Yang, Youhua Wang, Jian Xu, Zhengming Zhou, Chun Cheng, Xiaojuan Liu, Xinghai Cheng, Long Long, Xi ..., Cellular and Molecular Neurobiology, 2012

As a novel cell cycle protein, Spy1 enhances cell proliferation, promotes the G1/S transition as well as inhibits apoptosis in response to UV irradiation. Spy1 levels are tightly regulated during mammary development, and overexpression of Spy1 accelerates tumorigenesis in vivo. But little is ...

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30.10.2012 | Beatrice Mihaela Radu, Adina Daniela Iancu, Diana Ionela Dumitrescu, Maria Luisa Flonta, Mihai Radu, Cellular and Molecular Neurobiology, 2012

Pharmacological therapies in type 1 diabetes for efficient control of glycemia and changes in pain alterations due to diabetic neuropathy are a continuous challenge. Transient receptor potential vanilloid type 1 (TRPV1) from dorsal root ganglia (DRG) neurons is one of the main pharmacological ...

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28.10.2012 | Nejla Yosef, Eroboghene E. Ubogu, Cellular and Molecular Neurobiology, 2012

Solute and macromolecular transport studies may elucidate nutritional requirements and drug effects in healthy and diseased peripheral nerves. Endoneurial endothelial cells are specialized microvascular cells that form the restrictive blood-nerve barrier (BNB). Primary human endoneurial ...

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