27.03.2013 | M Golubovskaya, Vita, Anti-Cancer Agents in Medicinal Chemistry , 2013

Abstract: This review is focused on the role of Focal Adhesion Kinase (FAK) signaling in cancer stem cells. The recent data demonstrate the important role of FAK in cancer stem cell proliferation, differentiation, motility, and invasion. We showed recently that the transcription factor ...

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27.03.2013 | L Megison, Michael; A Gillory, Lauren; A Beierle, Elizabeth, Anti-Cancer Agents in Medicinal Chemistry , 2013

Abstract: Neuroblastoma is the most common extracranial solid tumor of childhood and is responsible for over 15% of pediatric cancer deaths. Neuroblastoma tumorigenesis and malignant transformation is driven by overexpression and dominance of cell survival pathways and a lack of normal ...

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27.03.2013 | Shen, Wei; Deng, Huimin; Gao, Zhiqiang, Anti-Cancer Agents in Medicinal Chemistry , 2013

Abstract: A series of naphthalene diimide (ND)-based mono-, bis-, and tris-intercalators are synthesized and evaluated for their anticancer activities. All compounds show anticancer activities in the micromolar range. Among them the bis-intercalator is the most promising. Experimental ...

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27.03.2013 | A Ucar, Deniz; T Magis, Andrew; He, Di-Hua; J Lawrence, Nicholas; M Sebti, Said; Kurenova, Elena; Zajac-Kaye, Maria; ..., Anti-Cancer Agents in Medicinal Chemistry , 2013

Abstract: Pancreatic cancer is one of the most lethal diseases with no effective treatment. Previously, we have shown that FAK is overexpressed in pancreatic cancer and plays a key role in cancer cell survival and proliferation. FAK has been shown to interact with growth factor ...

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27.03.2013 | Ko, Bor-Sheng; Jan, Yee-Jee; Chang, Tzu-Ching; Liang, Shu-Man; Chen, Shyh-Chang; Liu, Tzu-An; Wu, Yao-Ming; Wang, Jo ..., Anti-Cancer Agents in Medicinal Chemistry , 2013

Abstract: Focal adhesion kinase (FAK) is implicated in cancer cell survival, proliferation and migration. Expression of FAK expression is elevated and associated with tumor progression and metastasis in various tumors, including hepatocellular carcinoma (HCC). Increased 14-3-3ε ...

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27.03.2013 | M Golubovskaya, Vita; L Palma, Nadia; Zheng, Min; Ho, Baotran; Magis, Andrew; Ostrov, David; G Cance, William, Anti-Cancer Agents in Medicinal Chemistry , 2013

Abstract: Focal Adhesion Kinase (FAK) is overexpressed in many types of tumors and plays an important role in survival. We developed a novel approach, targeting FAK-protein interactions by computer modeling and screening of NCI small molecule drug database. In this report we targeted ...

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27.03.2013 | Lee, Jin; Lim, Kye-Taek, Anti-Cancer Agents in Medicinal Chemistry , 2013

Abstract: The initiation stage of liver cancer is closely related to abnormal cell proliferation as observed for other types of carcinogenesis. Recently, we isolated a glycoprotein from Styrax japonica Siebold et al Zuccarini (SJSZ glycoprotein), which consists of a carbohydrate moiety ...

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27.03.2013 | M Golubovskaya, Vita; Ho, Baotran; Zheng, Min; Magis, Andrew; Ostrov, David; G Cance, William, Anti-Cancer Agents in Medicinal Chemistry , 2013

Abstract: Focal Adhesion Kinase (FAK) is a non-receptor kinase that is overexpressed in many types of tumors and plays a key role in cell adhesion, spreading, motility, proliferation, invasion, angiogenesis, and survival. Recently, FAK has been proposed as a target for cancer therapy, ...

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27.03.2013 | Brandi, Giorgio; Fraternale, Alessandra; Lucarini, Simone; Paiardini, Mirko; De Santi, Mauro; Cervasi, Barbara; F Pa ..., Anti-Cancer Agents in Medicinal Chemistry , 2013

Abstract: Indole-3-carbinol (I3C) and its oligomeric derivatives have been widely studied for their chemopreventive and chemotherapeutic properties. We have previously shown that the I3C cyclic tetrameric derivative CTet inhibits breast cancer cell proliferation in vitro and in ...

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27.03.2013 | Castiglioni, Sara; Casati, Silvana; Ottria, Roberta; Ciuffreda, Pierangela; AM Maier, Jeanette, Anti-Cancer Agents in Medicinal Chemistry , 2013

Abstract: Cytokinins are phytohormones critically involved in the regulation of plant growth and development. They also affect the proliferation and differentiation of animal cells, thus representing new tools to treat diseases that involve dysfunctional cell growth and/or ...

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