25.11.2012 | Zhenpeng Qin, Jing Jiang, Gary Long, Bruce Lindgren, John C. Bischof, Annals of Biomedical Engineering, 2012

Irreversible electroporation (IRE) has been proposed to destroy large amounts of tumorous tissue and shows advantages over thermal therapies. Unfortunately, carefully constructed studies assessing impact in in vivo tumor systems and a direct comparison of IRE with thermal therapy are lacking. ...

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25.11.2012 | Shane R. Wurdeman, Sara A. Myers, Nicholas Stergiou, Annals of Biomedical Engineering, 2012

The amputation and subsequent prosthetic rehabilitation of a lower leg affects gait. Dynamical systems theory would predict the use of a prosthetic device should alter the functional attractor dynamics to which the system self-organizes. Therefore, the purpose of this study was to compare the ...

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25.11.2012 | Laura Hansen, Ivana Parker, Roy L. Sutliff, Manu O. Platt, Rudolph L. Gleason Jr., Annals of Biomedical Engineering, 2012

HIV patients on highly active antiretroviral therapy (HAART) exhibit elevated incidence of cardiovascular disease (CVD), including a higher risk of myocardial infarction and prevalence of atherosclerotic lesions, as well as increases in markers of subclinical atherosclerosis including ...

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25.11.2012 | Costin D. Untaroiu, Neng Yue, Jaeho Shin, Annals of Biomedical Engineering, 2012

A finite element (FE) model of a vehicle occupant’s lower limb was developed in this study to improve understanding of injury mechanisms during traffic crashes. The reconstructed geometry of a male volunteer close to the anthropometry of a 50th percentile male was meshed using mostly ...

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25.11.2012 | Jiankun Liu, Jin-Oh Hahn, Ramakrishna Mukkamala, Annals of Biomedical Engineering, 2012

The oscillometric fixed-ratio method is widely employed for non-invasive measurement of systolic and diastolic pressures (SP and DP) but is heuristic and prone to error. We investigated the accuracy of this method using an established mathematical model of oscillometry. First, to determine ...

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25.11.2012 | Kibaek Lee, Junjun Zhu, Judy Shum, Yongjie Zhang, Satish C. Muluk, Ankur Chandra, Mark K. Eskandari, Ender A. Finol, Annals of Biomedical Engineering, 2012

An abdominal aortic aneurysm (AAA) carries one of the highest mortality rates among vascular diseases when it ruptures. To predict the role of surface curvature in rupture risk assessment, a discriminatory analysis of aneurysm geometry characterization was conducted. Data was obtained from ...

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25.11.2012 | Scott T. Wood, Brian C. Dean, Delphine Dean, Annals of Biomedical Engineering, 2012

The goal of this study is to construct a representative 3D finite element model (FEM) of individual cells based on their sub-cellular structures that predicts cell mechanical behavior. The FEM simulations replicate atomic force microscopy (AFM) nanoindentation experiments on live vascular ...

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25.11.2012 | S. Hamed Alavi, Victor Ruiz, Tatiana Krasieva, Elliot L. Botvinick, Arash Kheradvar, Annals of Biomedical Engineering, 2012

When implanted inside the body, bioprosthetic heart valve leaflets experience a variety of cyclic mechanical stresses such as shear stress due to blood flow when the valve is open, flexural stress due to cyclic opening and closure of the valve, and tensile stress when the valve is closed. ...

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19.11.2012 | Jessie M. Huisinga, Martina Mancini, Rebecca J. St. George, Fay B. Horak, Annals of Biomedical Engineering, 2012

Variability of movement reflects important information for the maintenance of the health of the system. For pathological populations, changes in variability during gait signal the presence of abnormal motor control strategies. For persons with multiple sclerosis (PwMS), extensive gait ...

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19.11.2012 | Bradford J. Smith, Kara A. Grant, Jason H. T. Bates, Annals of Biomedical Engineering, 2012

Management of ALI/ARDS involves supportive ventilation at low tidal volumes (V t) to minimize the rate at which ventilator induced lung injury (VILI) develops while the lungs heal. However, we currently have few details to guide the minimization of VILI in the ALI/ARDS patient. The goal of ...

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