03.05.2013 | Stephen J. Glatt, Daniel S. Tylee, Sharon D. Chandler, Joel Pazol, Caroline M. Nievergelt, Christopher H. Woelk, Dew ..., American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2013

Abstract Susceptibility to PTSD is determined by both genes and environment. Similarly, gene‐expression levels in peripheral blood are influenced by both genes and environment, and expression levels of many genes show good correspondence between peripheral blood and brain. Therefore, our ...

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03.05.2013 | Michele T. Pato, Janet L. Sobell, Helena Medeiros, Colony Abbott, Brooke M. Sklar, Peter F. Buckley, Evelyn J. Brome ..., American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2013

Abstract The Genomic Psychiatry Cohort (GPC) is a longitudinal resource designed to provide the necessary population‐based sample for large‐scale genomic studies, studies focusing on Research Domain Criteria (RDoC) and/or other alternate phenotype constructs, clinical and interventional ...

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03.05.2013 | Ximena Goldberg, Silvia Alemany, Araceli Rosa, Marco Picchioni, Igor Nenadic, Sheena F. Owens, Fruhling Rijsdijk, Ir ..., American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2013

Abstract While evidence is accumulating to support specific neurocognitive deficits as putative endophenotypes for schizophrenia, the heritability of these deficits in healthy subjects and whether they share common genetic influences, is not well established. In the present study, 529 ...

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03.05.2013 | Reka Kovacs‐Nagy, Zsuzsanna Elek, Anna Szekely, Tibor Nanasi, Maria Sasvari‐Szekely, Zsolt Ronai, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2013

Abstract Rare mutations in the WFS1 gene lead to Wolfram syndrome, a severe multisystem disorder with progressive neurodegeneration and diabetes mellitus causing life‐threatening complications and premature death. Only a few association studies using small clinical samples tested the ...

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03.05.2013 | Dimitrios I. Zafeiriou, Athina Ververi, Vaios Dafoulis, Efrosini Kalyva, Euthymia Vargiami, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2013

Abstract Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disabilities with various etiologies, but with a heritability estimate of more than 90%. Although the strong correlation between autism and genetic factors has been long established, the exact ...

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18.04.2013 | S.E. Stewart, C. Mayerfeld, P.D. Arnold, J.R. Crane, C. O'Dushlaine, J.A. Fagerness, D. Yu, J.M. Scharf, E. Chan, F. ..., American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2013

Abstract The neuronal glutamate transporter gene SLC1A1 is a candidate gene for obsessive‐compulsive disorder (OCD) based on linkage studies and convergent evidence implicating glutamate in OCD etiology. The 3′ end of SLC1A1 is the only genomic region with consistently demonstrated OCD ...

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26.03.2013 | Özgür Albayrak, Carolin Pütter, Anna‐Lena Volckmar, Sven Cichon, Per Hoffmann, Markus M. Nöthen, Karl‐Heinz Jöckel, ..., American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2013

Abstract Children with attention‐deficit/hyperactivity disorder (ADHD) have a higher rate of obesity than children without ADHD. Obesity risk alleles may overlap with those relevant for ADHD. We examined whether risk alleles for an increased body mass index (BMI) are associated with ADHD ...

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26.03.2013 | Ashley E. Nordsletten, Benedetta Monzani, Lorena Fernández de la Cruz, Alessandra C. Iervolino, Miquel A. Fullana, J ..., American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2013

Abstract A reluctance to discard items, leading to severely cluttered living spaces, is the landmark feature of hoarding disorder (HD). Many, but not all, individuals with HD also excessively acquire, buy or even steal items that they do not need and for which no space is available. In ...

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26.03.2013 | Frédérique Béna, Damien L. Bruno, Mats Eriksson, Conny van Ravenswaaij‐Arts, Zornitza Stark, Trijnie Dijkhuizen, Eri ..., American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2013

Abstract This study aimed to elucidate the observed variable phenotypic expressivity associated with NRXN1 (Neurexin 1) haploinsufficiency by analyses of the largest cohort of patients with NRXN1 exonic deletions described to date and by comprehensively reviewing all comparable copy ...

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15.03.2013 | Charles F. Gillespie, Lynn M. Almli, Alicia K. Smith, Bekh Bradley, Kimberly Kerley, Daniel F. Crain, Kristina B. Me ..., American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2013

Abstract A non‐synonymous, single nucleotide polymorphism (SNP) in the gene coding for steroid 5‐α‐reductase type 2 (SRD5A2) is associated with reduced conversion of testosterone to dihydrotestosterone (DHT). Because SRD5A2 participates in the regulation of testosterone and cortisol ...

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