14.06.2013 | Michael Bodd, Melinda Ráki, Elin Bergseng, Jørgen Jahnsen, Knut E.A. Lundin, Ludvig M. Sollid, European Journal of Immunology, 2013

Knowledge of the frequency of disease‐driving CD4+ T cells in lesions of chronic human inflammatory diseases is limited. In celiac disease, intestinal gluten‐reactive CD4+ T cells, which recognize gluten peptides only in the context of the disease‐associated HLA‐DQ molecules, are key ...

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14.06.2013 | Ursula M. D'Souza, Georgia Powell‐Smith, Kate Haddley, Timothy R. Powell, Vivien J. Bubb, Tom Price, Peter McGuffin, ..., American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2013

Abstract Lamotrigine, a mood stabilizer used clinically in the treatment of bipolar disorder, is thought to exert actions on the serotonin system. However lamotrigine's exact mechanism of action remains unclear. The current study investigated whether lamotrigine might exert its effects ...

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14.06.2013 | Amélie Marsot, Véronique Brevaut‐Malaty, Renaud Vialet, Audrey Boulamery, Bernard Bruguerolle, Nicolas Simon, Fundamental & Clinical Pharmacology, 2013

Abstract Phenobarbital is widely used for treatment of neonatal seizures. Its optimal use in neonates and young infants requires information regarding pharmacokinetics. The objective of this study is to characterize the absolute bioavailability of phenobarbital in neonates and young ...

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14.06.2013 | Obi Egbuniwe, Andrew D. Grant, Tara Renton, Lucy Di Silvio, Macromolecular Bioscience, 2013

An immortalized human dental pulp stem cell (DPSC) line of an odontoblastic phenotype is established to circumvent the normal programmed senescence and to maintain the cell line's usefulness as a tool for further study of cellular activity. DPSCs are isolated from human dental pulp tissues ...

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14.06.2013 | Talwinder Kaur, Rajesh Kumari Manhas, Journal of Basic Microbiology, 2013

In the present study, an actinobacterium strain, possessing antagonistic activity against different fungal phytopathogens viz. Colletotrichum acutatum, Cladosporium herbarum, Alternaria brassicicola, Exserohilum sp., Alternaria mali, Colletotrichum gleospoiroides, Alternaria alternata, ...

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14.06.2013 | Karen C. Dannemiller, Darryl Reeves, Kyle Bibby, Naomichi Yamamoto, Jordan Peccia, Journal of Basic Microbiology, 2013

Abstract Improvements in DNA sequencing technology provide unprecedented opportunities to explore fungal diversity, but also present challenges in data analysis due to the large number of sequences generated. Here, we describe an open source software program “FHiTINGS” that utilizes the ...

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14.06.2013 | Gaëlle H. Martin, Sylvie Grégoire, Dan A. Landau, Caroline Pilon, Yenkel Grinberg‐Bleyer, Frédéric Charlotte, Jean‐P ..., European Journal of Immunology, 2013

Treg cells hold enormous promise for therapeutic application in GVH disease, a lethal complication of allogeneic HSC transplantation. Mouse studies showed that donor‐derived recipient‐specific Treg (rsTreg) cells are far more efficient than polyclonal Treg cells in suppressing GVH disease. ...

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14.06.2013 | T. Norén, K. Johansson, M. Unemo, Clinical Microbiology and Infection, 2013

Abstract Clostridium difficile PCR ribotype 046 was found in 67% of neonatal piglets (45/67) sampled from three separate pig‐breeding farms in Sweden. Sows from the same farms were colonized by 50% in faeces and 30% on skin. Environmental source was suggested because identical PCR ...

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14.06.2013 | Alberto Camacho, Jeffrey K. Huang, Ilse Delint‐Ramirez, Chong Yew Tan, Maria Fuller, Christopher J. Lelliott, Antoni ..., European Journal of Neuroscience, 2013

Abstract Peroxisome proliferator‐activated receptor gamma‐coactivator‐1 alpha (PGC1a) is involved in energy and lipid metabolism, and its loss leads to neurodegenerative changes in the striatum. Here we performed lipidomic analysis on brain extracts from PGC1a mutant and wild‐type mice. ...

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14.06.2013 | David J Hodson, Patrice Mollard, Journal of Neuroendocrinology, 2013

Summary The human pituitary gland may be the size of a pea, but it punches well above its weight due to secretion of hormones that regulate essential homeostatic processes ranging from growth to stress. Recent advances in imaging and genetics have allowed large‐scale interrogation of ...

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