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20.920 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution [Immunology and Inflammation]

26.01.2016 | Yun-Hee Youm; Tamas L. Horvath; David J. Mangelsdorf; Steven A. Kliewer; Vishwa Deep Dixit, Proceedings of the National Academy of Sciences current issue, 2016

Age-related thymic degeneration is associated with loss of naïve T cells, restriction of peripheral T-cell diversity, and reduced healthspan due to lower immune competence. The mechanistic basis of age-related thymic demise is unclear, but prior evidence suggests that caloric restriction (CR) can ...

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Megafauna and ecosystem function from the Pleistocene to the Anthropocene [Biological Sciences]

26.01.2016 | Yadvinder Malhi; Christopher E. Doughty; Mauro Galetti; Felisa A. Smith; Jens-Christian Svenning; John W. Terborgh, Proceedings of the National Academy of Sciences current issue, 2016

Large herbivores and carnivores (the megafauna) have been in a state of decline and extinction since the Late Pleistocene, both on land and more recently in the oceans. Much has been written on the timing and causes of these declines, but only recently has scientific attention focused on the ...

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Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors [Immunology and Inflammation]

26.01.2016 | Joel Haywood; Jianxun Qi; Chun-Chi Chen; Guangwen Lu; Yingxia Liu; Jinghua Yan; Yi Shi; George F. Gao, Proceedings of the National Academy of Sciences current issue, 2016

Human osteoclast-associated receptor (OSCAR) is an immunoglobulin (Ig)-like collagen receptor that is up-regulated on osteoclasts during osteoclastogenesis and is expressed in a range of myeloid cells. As a member of the leukocyte receptor complex family of proteins, OSCAR shares a high degree of ...

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Correction for Chen et al., Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution [Correction]

26.01.2016 | Proceedings of the National Academy of Sciences current issue, 2016

APPLIED BIOLOGICAL SCIENCES Correction for “Genome sequence of the Asian Tiger mosquito, Aedes albopictus, reveals insights into its biology, genetics, and evolution,” by Xiao-Guang Chen, Xuanting Jiang, Jinbao Gu, Meng Xu, Yang Wu, Yuhua Deng, Chi Zhang, Mariangela Bonizzoni, Wannes Dermauw, ...

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The impact of large terrestrial carnivores on Pleistocene ecosystems [Evolution]

26.01.2016 | Blaire Van Valkenburgh; Matthew W. Hayward; William J. Ripple; Carlo Meloro; V. Louise Roth, Proceedings of the National Academy of Sciences current issue, 2016

Large mammalian terrestrial herbivores, such as elephants, have dramatic effects on the ecosystems they inhabit and at high population densities their environmental impacts can be devastating. Pleistocene terrestrial ecosystems included a much greater diversity of megaherbivores (e.g., mammoths, ...

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Discontinuity in the genetic and environmental causes of the intellectual disability spectrum [Psychological and Cognitive Sciences]

26.01.2016 | Abraham Reichenberg; Martin Cederlöf; Andrew McMillan; Maciej Trzaskowski; Ori Kapara; Eyal Fruchter; Karen Ginat; M ..., Proceedings of the National Academy of Sciences current issue, 2016

Intellectual disability (ID) occurs in almost 3% of newborns. Despite substantial research, a fundamental question about its origin and links to intelligence (IQ) still remains. ID has been shown to be inherited and has been accepted as the extreme low of the normal IQ distribution. However, ID ...

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Reply to Panero: Robust phylogenetic placement of fossil pollen grains: The case of Asteraceae [Biological Sciences]

26.01.2016 | Viviana D. Barreda; Luis Palazzesi; Maria C. Tellería; Eduardo B. Olivero; J. Ian Raine; Félix Forest, Proceedings of the National Academy of Sciences current issue, 2016

We thank Panero (1) for his interest in our paper (2). However, we consider his interpretations (1) somewhat incomplete and misleading, principally because he reports results using methods that we did not apply in our study, and underestimates the importance of pollen morphological characters in ...

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Pedothem carbonates reveal anomalous North American atmospheric circulation 70,000-55,000 years ago [Earth, Atmospheric, and Planetary Sciences]

26.01.2016 | Erik J. Oerter; Warren D. Sharp; Jessica L. Oster; Angela Ebeling; John W. Valley; Reinhard Kozdon; Ian J. Orland; J ..., Proceedings of the National Academy of Sciences current issue, 2016

Our understanding of climatic conditions, and therefore forcing factors, in North America during the past two glacial cycles is limited in part by the scarcity of long, well-dated, continuous paleoclimate records. Here, we present the first, to our knowledge, continuous, millennial-resolution ...

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Correction to Supporting Information for Wilcox et al., Threat of plastic pollution to seabirds is global, pervasive, and increasing [SI Corrections]

26.01.2016 | Proceedings of the National Academy of Sciences current issue, 2016

ENVIRONMENTAL SCIENCES Correction to Supporting Information for “Threat of plastic pollution to seabirds is global, pervasive, and increasing,” by Chris Wilcox, Erik Van Sebille, and Britta Denise Hardesty, which appeared in issue 38, September 22, 2015, of Proc Natl Acad Sci USA ...

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Origin of the p-process radionuclides 92Nb and 146Sm in the early solar system and inferences on the birth of the Sun [Astronomy]

26.01.2016 | Maria Lugaro; Marco Pignatari; Ulrich Ott; Kai Zuber; Claudia Travaglio; György Gyürky; Zsolt Fülöp, Proceedings of the National Academy of Sciences current issue, 2016

The abundances of 92Nb and 146Sm in the early solar system are determined from meteoritic analysis, and their stellar production is attributed to the p process. We investigate if their origin from thermonuclear supernovae deriving from the explosion of white dwarfs with mass above the ...

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