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22.033 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington’s disease [Neuroscience]

17.05.2016 | Aldrin E. Molero; Eduardo E. Arteaga-Bracho; Christopher H. Chen; Maria Gulinello; Michael L. Winchester; Nandini Pi ..., Proceedings of the National Academy of Sciences current issue, 2016

Recent studies have identified impairments in neural induction and in striatal and cortical neurogenesis in Huntington’s disease (HD) knock-in mouse models and associated embryonic stem cell lines. However, the potential role of these developmental alterations for HD pathogenesis and progression ...

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Reply to Parker: Robust response of AMOC interdecadal variability to future intense warming [Physical Sciences]

17.05.2016 | Jun Cheng; Zhengyu Liu; Shaoqing Zhang; Wei Liu; Lina Dong; Peng Liu; Hongli Li, Proceedings of the National Academy of Sciences current issue, 2016

Based on 19 experiments using five models of the Coupled Model Intercomparison Project Phase 5, our study (1) finds a shortened and weakened interdecadal variability (IV) of Atlantic Meridional Overturning Circulation (AMOC) over a future intense warming period in the 22nd and 23rd centuries, and ...

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Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions [Immunology and Inflammation]

17.05.2016 | Peter Jönsson; Jennifer H. Southcombe; Ana Mafalda Santos; Jiandong Huo; Ricardo A. Fernandes; James McColl; Melissa ..., Proceedings of the National Academy of Sciences current issue, 2016

The αβ T-cell coreceptor CD4 enhances immune responses more than 1 million-fold in some assays, and yet the affinity of CD4 for its ligand, peptide-major histocompatibility class II (pMHC II) on antigen-presenting cells, is so weak that it was previously unquantifiable. Here, we report that a ...

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Drift in ocean currents impacts intergenerational microbial exposure to temperature [Environmental Sciences]

17.05.2016 | Martina A. Doblin; Erik van Sebille, Proceedings of the National Academy of Sciences current issue, 2016

Microbes are the foundation of marine ecosystems [Falkowski PG, Fenchel T, Delong EF (2008) Science 320(5879):1034–1039]. Until now, the analytical framework for understanding the implications of ocean warming on microbes has not considered thermal exposure during transport in dynamic seascapes, ...

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Physical and situational inequality on airplanes predicts air rage [Psychological and Cognitive Sciences]

17.05.2016 | Katherine A. DeCelles; Michael I. Norton, Proceedings of the National Academy of Sciences current issue, 2016

We posit that the modern airplane is a social microcosm of class-based society, and that the increasing incidence of “air rage” can be understood through the lens of inequality. Research on inequality typically examines the effects of relatively fixed, macrostructural forms of inequality, such as ...

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Bacteriocin from epidemic Listeria strains alters the host intestinal microbiota to favor infection [Microbiology]

17.05.2016 | Juan J. Quereda; Olivier Dussurget; Marie-Anne Nahori; Amine Ghozlane; Stevenn Volant; Marie-Agnès Dillies; Béatrice ..., Proceedings of the National Academy of Sciences current issue, 2016

Listeria monocytogenes is responsible for gastroenteritis in healthy individuals and for a severe invasive disease in immunocompromised patients. Among the three identified L. monocytogenes evolutionary lineages, lineage I strains are overrepresented in epidemic listeriosis outbreaks, but the ...

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Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6 [Biochemistry]

17.05.2016 | Anders Allgardsson; Lotta Berg; Christine Akfur; Andreas Hörnberg; Franz Worek; Anna Linusson; Fredrik J. Ekström, Proceedings of the National Academy of Sciences current issue, 2016

Organophosphorus nerve agents interfere with cholinergic signaling by covalently binding to the active site of the enzyme acetylcholinesterase (AChE). This inhibition causes an accumulation of the neurotransmitter acetylcholine, potentially leading to overstimulation of the nervous system and ...

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Tracking marine alien species by ship movements [Ecology]

17.05.2016 | Anthony Ricciardi, Proceedings of the National Academy of Sciences current issue, 2016

Under human influence, plants, animals, and microbes are spreading beyond their native ranges faster and farther than ever before. Rates of invasion are increasing worldwide, especially in large aquatic systems (1). Many of these alien species appear to be innocuous, whereas others cause ...

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Concealed d-wave pairs in the s{+/-} condensate of iron-based superconductors [Applied Physical Sciences]

17.05.2016 | Tzen Ong; Piers Coleman; Jörg Schmalian, Proceedings of the National Academy of Sciences current issue, 2016

A central question in iron-based superconductivity is the mechanism by which the paired electrons minimize their strong mutual Coulomb repulsion. In most unconventional superconductors, Coulomb repulsion is minimized through the formation of higher angular momentum Cooper pairs, with Fermi ...

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Living biofouling-resistant membranes as a model for the beneficial use of engineered biofilms [Environmental Sciences]

17.05.2016 | Thammajun L. Wood; Rajarshi Guha; Li Tang; Michael Geitner; Manish Kumar; Thomas K. Wood, Proceedings of the National Academy of Sciences current issue, 2016

Membrane systems are used increasingly for water treatment, recycling water from wastewater, during food processing, and energy production. They thus are a key technology to ensure water, energy, and food sustainability. However, biofouling, the build-up of microbes and their polymeric matrix, ...

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