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28.294 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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How T cells grasp mycobacterial lipid antigens [Immunology and Inflammation]

19.12.2017 | D. Branch Moody, Proceedings of the National Academy of Sciences current issue, 2017

Solving the mechanism by which MHC I and II proteins capture protein fragments represented a triumph for T cell biologists. This discovery highlighted the peptidic nature of antigens for T cells. Investigation of MHC-peptide–T cell receptor (TCR) interactions provides the basis for epitope ...

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Aminoglycoside interactions and impacts on the eukaryotic ribosome [Biochemistry]

19.12.2017 | Irina Prokhorova; Roger B. Altman; Muminjon Djumagulov; Jaya P. Shrestha; Alexandre Urzhumtsev; Angelica Ferguson; C ..., Proceedings of the National Academy of Sciences current issue, 2017

Aminoglycosides are chemically diverse, broad-spectrum antibiotics that target functional centers within the bacterial ribosome to impact all four principle stages (initiation, elongation, termination, and recycling) of the translation mechanism. The propensity of aminoglycosides to induce ...

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Correction for Gerth et al., Intersectin associates with synapsin and regulates its nanoscale localization and function [Correction]

19.12.2017 | Proceedings of the National Academy of Sciences current issue, 2017

NEUROSCIENCE Correction for “Intersectin associates with synapsin and regulates its nanoscale localization and function,” by Fabian Gerth, Maria Jäpel, Arndt Pechstein, Gaga Kochlamazashvili, Martin Lehmann, Dmytro Puchkov, Franco Onofri, Fabio Benfenati, Alexander G. Nikonenko, Tanja Maritzen, ...

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Dynamics of translation can determine the spatial organization of membrane-bound proteins and their mRNA [Biophysics and Computational Biology]

19.12.2017 | Elgin Korkmazhan; Hamid Teimouri; Neil Peterman; Erel Levine, Proceedings of the National Academy of Sciences current issue, 2017

Unlike most macromolecules that are homogeneously distributed in the bacterial cell, mRNAs that encode inner-membrane proteins can be concentrated near the inner membrane. Cotranslational insertion of the nascent peptide into the membrane brings the translating ribosome and the mRNA close to the ...

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Specific cation effects at aqueous solution-vapor interfaces: Surfactant-like behavior of Li+ revealed by experiments and simulations [Chemistry]

19.12.2017 | Kathryn A. Perrine; Krista M. Parry; Abraham C. Stern; Marijke H. C. Van Spyk; Michael J. Makowski; J. Alfredo Freit ..., Proceedings of the National Academy of Sciences current issue, 2017

It is now well established by numerous experimental and computational studies that the adsorption propensities of inorganic anions conform to the Hofmeister series. The adsorption propensities of inorganic cations, such as the alkali metal cations, have received relatively little attention. Here ...

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In This Issue [This Week in PNAS]

19.12.2017 | Proceedings of the National Academy of Sciences current issue, 2017

How alkali flies thrive in Mono Lake Alkali fly. To feed and lay their eggs, alkali flies (Ephydra hians) crawl down calcium carbonate rocks into California’s Mono Lake, where the water is both highly alkaline and three times as salty as the Pacific Ocean. The flies stay dry during their...

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Musical training sharpens and bonds ears and tongue to hear speech better [Psychological and Cognitive Sciences]

19.12.2017 | Yi Du; Robert J. Zatorre, Proceedings of the National Academy of Sciences current issue, 2017

The idea that musical training improves speech perception in challenging listening environments is appealing and of clinical importance, yet the mechanisms of any such musician advantage are not well specified. Here, using functional magnetic resonance imaging (fMRI), we found that musicians ...

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Chemical physics of water [Introductions]

19.12.2017 | Pablo G. Debenedetti; Michael L. Klein, Proceedings of the National Academy of Sciences current issue, 2017

There is hardly any aspect of our lives that is not profoundly influenced by water. From climate to commerce and agriculture to health, water shapes our physical environment, regulates the major energy exchanges that determine climate on Earth, and is the matrix that supports the physical and ...

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Transverse fields to tune an Ising-nematic quantum phase transition [Physics]

19.12.2017 | Akash V. Maharaj; Elliott W. Rosenberg; Alexander T. Hristov; Erez Berg; Rafael M. Fernandes; Ian R. Fisher; Steven ..., Proceedings of the National Academy of Sciences current issue, 2017

The paradigmatic example of a continuous quantum phase transition is the transverse field Ising ferromagnet. In contrast to classical critical systems, whose properties depend only on symmetry and the dimension of space, the nature of a quantum phase transition also depends on the dynamics. In ...

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Structural insights into how GTP-dependent conformational changes in a metallochaperone UreG facilitate urease maturation [Biochemistry]

19.12.2017 | Man Hon Yuen; Yu Hang Fong; Yap Shing Nim; Pak Ho Lau; Kam-Bo Wong, Proceedings of the National Academy of Sciences current issue, 2017

The ability of metallochaperones to allosterically regulate the binding/release of metal ions and to switch protein-binding partners along the metal delivery pathway is essential to the metallation of the metalloenzymes. Urease, catalyzing the hydrolysis of urea into ammonia and carbon dioxide, ...

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