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25.191 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis [Microbiology]

14.03.2017 | Susan Puckett; Carolina Trujillo; Zhe Wang; Hyungjin Eoh; Thomas R. Ioerger; Inna Krieger; James Sacchettini; Dirk S ..., Proceedings of the National Academy of Sciences current issue, 2017

The glyoxylate shunt is a metabolic pathway of bacteria, fungi, and plants used to assimilate even-chain fatty acids (FAs) and has been implicated in persistence of Mycobacterium tuberculosis (Mtb). Recent work, however, showed that the first enzyme of the glyoxylate shunt, isocitrate lyase ...

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Legislative coalitions with incomplete information [Political Sciences]

14.03.2017 | Tiberiu Dragu; Michael Laver, Proceedings of the National Academy of Sciences current issue, 2017

In most parliamentary democracies, proportional representation electoral rules mean that no single party controls a majority of seats in the legislature. This in turn means that the formation of majority legislative coalitions in such settings is of critical political importance. Conventional ...

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Synergy of cAMP and calcium signaling pathways in CFTR regulation [Biochemistry]

14.03.2017 | Zoltan Bozoky; Saumel Ahmadi; Tal Milman; Tae Hun Kim; Kai Du; Michelle Di Paola; Stan Pasyk; Roman Pekhletski; Jaco ..., Proceedings of the National Academy of Sciences current issue, 2017

Cystic fibrosis results from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, leading to defective apical chloride transport. Patients also experience overactivation of inflammatory processes, including increased calcium signaling. Many investigations ...

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Localization of the gate and selectivity filter of the full-length P2X7 receptor [Biophysics and Computational Biology]

14.03.2017 | Anja Pippel; Michaela Stolz; Ronja Woltersdorf; Achim Kless; Günther Schmalzing; Fritz Markwardt, Proceedings of the National Academy of Sciences current issue, 2017

The P2X7 receptor (P2X7R) belongs to the P2X family of ATP-gated cation channels. P2X7Rs are expressed in epithelial cells, leukocytes, and microglia, and they play important roles in immunological and inflammatory processes. P2X7Rs are obligate homotrimers, with each subunit having two ...

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In This Issue [This Week in PNAS]

14.03.2017 | Proceedings of the National Academy of Sciences current issue, 2017

Electronic wires and supercapacitors in living plants Electronic wires in the petals of a rose. Image courtesy of Thor Balkhed (Linköping University, Linkoping, Sweden). Researchers recently developed living plants with electronic circuitry integrated into the plant tissues. Previously, the ...

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Co-occurrence of extremes in surface ozone, particulate matter, and temperature over eastern North America [Environmental Sciences]

14.03.2017 | Jordan L. Schnell; Michael J. Prather, Proceedings of the National Academy of Sciences current issue, 2017

Heat waves and air pollution episodes pose a serious threat to human health and may worsen under future climate change. In this paper, we use 15 years (1999–2013) of commensurately gridded (1° x 1°) surface observations of extended summer (April–September) surface ozone (O3), fine particulate ...

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Electron transfer pathways in a multiheme cytochrome MtrF [Chemistry]

14.03.2017 | Hiroshi C. Watanabe; Yuki Yamashita; Hiroshi Ishikita, Proceedings of the National Academy of Sciences current issue, 2017

In MtrF, an outer-membrane multiheme cytochrome, the 10 heme groups are arranged in heme binding domains II and IV along the pseudo-C2 axis, forming the electron transfer (ET) pathways. Previous reports based on molecular dynamics simulations showed that the redox potential (Em) values for the ...

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SM protein Munc18-2 facilitates transition of Syntaxin 11-mediated lipid mixing to complete fusion for T-lymphocyte cytotoxicity [Cell Biology]

14.03.2017 | Waldo A. Spessott; Maria L. Sanmillan; Margaret E. McCormick; Vineet V. Kulkarni; Claudio G. Giraudo, Proceedings of the National Academy of Sciences current issue, 2017

The atypical lipid-anchored Syntaxin 11 (STX11) and its binding partner, the Sec/Munc (SM) protein Munc18-2, facilitate cytolytic granule release by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Patients carrying mutations in these genes develop familial hemophagocytic ...

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In vivo polymerization and manufacturing of wires and supercapacitors in plants [Applied Physical Sciences]

14.03.2017 | Eleni Stavrinidou; Roger Gabrielsson; K. Peter R. Nilsson; Sandeep Kumar Singh; Juan Felipe Franco-Gonzalez; Anton V ..., Proceedings of the National Academy of Sciences current issue, 2017

Electronic plants, e-Plants, are an organic bioelectronic platform that allows electronic interfacing with plants. Recently we have demonstrated plants with augmented electronic functionality. Using the vascular system and organs of a plant, we manufactured organic electronic devices and circuits ...

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Specific phospholipid binding to Na,K-ATPase at two distinct sites [Biochemistry]

14.03.2017 | Michael Habeck; Einat Kapri-Pardes; Michal Sharon; Steven J. D. Karlish, Proceedings of the National Academy of Sciences current issue, 2017

Membrane protein function can be affected by the physical state of the lipid bilayer and specific lipid–protein interactions. For Na,K-ATPase, bilayer properties can modulate pump activity, and, as observed in crystal structures, several lipids are bound within the transmembrane domain. ...

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