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21.877 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Gene therapy, CMT1X, and the inherited neuropathies [Neuroscience]

26.04.2016 | Michael E. Shy, Proceedings of the National Academy of Sciences current issue, 2016

In PNAS, Kagiava et al. (1) report their rescue of the X-linked form of Charcot–Marie–Tooth disease (CMT1X) in mice, through the use of a single intrathecal injection with a lentiviral vector. The vector expresses the gap junction beta 1 (GJB1) gene and its encoded protein connexin32 (Cx32), ...

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Moral consequences of becoming unemployed [Economic Sciences]

26.04.2016 | Abigail Barr; Luis Miller; Paloma Ubeda, Proceedings of the National Academy of Sciences current issue, 2016

We test the conjecture that becoming unemployed erodes the extent to which a person acknowledges earned entitlement. We use behavioral experiments to generate incentive-compatible measures of individuals’ tendencies to acknowledge earned entitlement and incorporate these experiments in a ...

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Resolving the HONO formation mechanism in the ionosphere via ab initio molecular dynamic simulations [Chemistry]

26.04.2016 | Rongxing He; Lei Li; Jie Zhong; Chongqin Zhu; Joseph S. Francisco; Xiao Cheng Zeng, Proceedings of the National Academy of Sciences current issue, 2016

Solar emission produces copious nitrosonium ions (NO+) in the D layer of the ionosphere, 60 to 90 km above the Earth’s surface. NO+ is believed to transfer its charge to water clusters in that region, leading to the formation of gaseous nitrous acid (HONO) and protonated water cluster. The ...

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Cotranslational association of mRNA encoding subunits of heteromeric ion channels [Physiology]

26.04.2016 | Fang Liu; David K. Jones; Willem J. de Lange; Gail A. Robertson, Proceedings of the National Academy of Sciences current issue, 2016

Oligomers of homomeric voltage-gated potassium channels associate early in biogenesis as the nascent proteins emerge from the polysome. Less is known about how proteins emerging from different polysomes associate to form hetero-oligomeric channels. Here, we report that alternate mRNA transcripts ...

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Molecular circuits for dynamic noise filtering [Applied Mathematics]

26.04.2016 | Christoph Zechner; Georg Seelig; Marc Rullan; Mustafa Khammash, Proceedings of the National Academy of Sciences current issue, 2016

The invention of the Kalman filter is a crowning achievement of filtering theory—one that has revolutionized technology in countless ways. By dealing effectively with noise, the Kalman filter has enabled various applications in positioning, navigation, control, and telecommunications. In the ...

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Algorithmic handwriting analysis of Judah’s military correspondence sheds light on composition of biblical texts [Applied Mathematics]

26.04.2016 | Shira Faigenbaum-Golovin; Arie Shaus; Barak Sober; David Levin; Nadav Na’aman; Benjamin Sass; Eli Turkel; Eli Piaset ..., Proceedings of the National Academy of Sciences current issue, 2016

The relationship between the expansion of literacy in Judah and composition of biblical texts has attracted scholarly attention for over a century. Information on this issue can be deduced from Hebrew inscriptions from the final phase of the first Temple period. We report our investigation of 16 ...

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Knowledge and innovation relationships in the shrimp industry in Thailand and Mexico [Sustainability Science]

26.04.2016 | Louis Lebel; Po Garden; Amy Luers; David Manuel-Navarrete; Dao Huy Giap, Proceedings of the National Academy of Sciences current issue, 2016

Experts, government officials, and industry leaders concerned about the sustainability of shrimp aquaculture believe they know what farmers need to know and should be doing. They have framed sustainability as a technical problem that, at the farm level, is to be solved by better shrimp and ...

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Striatal structure and function predict individual biases in learning to avoid pain [Psychological and Cognitive Sciences]

26.04.2016 | Eran Eldar; Tobias U. Hauser; Peter Dayan; Raymond J. Dolan, Proceedings of the National Academy of Sciences current issue, 2016

Pain is an elemental inducer of avoidance. Here, we demonstrate that people differ in how they learn to avoid pain, with some individuals refraining from actions that resulted in painful outcomes, whereas others favor actions that helped prevent pain. These individual biases were best explained ...

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In This Issue [This Week in PNAS]

26.04.2016 | Proceedings of the National Academy of Sciences current issue, 2016

Handwriting analysis hints at timing of Hebrew biblical texts Ostraca from Arad, southern Judah, dated to ca. 600 BCE. Image courtesy of the Institute of Archaeology, Tel Aviv University, and of the Israel Antiquities Authority. Scholars have long debated the extent of the Hebrew bible that was ...

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Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system [Immunology and Inflammation]

26.04.2016 | Alexis Vandenbon; Viet H. Dinh; Norihisa Mikami; Yohko Kitagawa; Shunsuke Teraguchi; Naganari Ohkura; Shimon Sakaguchi, Proceedings of the National Academy of Sciences current issue, 2016

High-throughput gene expression data are one of the primary resources for exploring complex intracellular dynamics in modern biology. The integration of large amounts of public data may allow us to examine general dynamical relationships between regulators and target genes. However, obstacles for ...

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