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22.972 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) [Biochemistry]

16.08.2016 | Zhe Li Salie; Karen A. Kirby; Eleftherios Michailidis; Bruno Marchand; Kamalendra Singh; Lisa C. Rohan; Eiichi N. Ko ..., Proceedings of the National Academy of Sciences current issue, 2016

4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is the most potent nucleoside analog inhibitor of HIV reverse transcriptase (RT). It retains a 3′-OH yet acts as a chain-terminating agent by diminishing translocation from the pretranslocation nucleotide-binding site (N site) to the posttranslocation ...

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Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen [Biochemistry]

16.08.2016 | Rebecca S. Levin; Nicholas T. Hertz; Alma L. Burlingame; Kevan M. Shokat; Shaeri Mukherjee, Proceedings of the National Academy of Sciences current issue, 2016

TGF-β activated kinase 1 (TAK1) is a critical signaling hub responsible for translating antigen binding signals to immune receptors for the activation of the AP-1 and NF-κB master transcriptional programs. Despite its importance, known substrates of TAK1 are limited to kinases of the MAPK and IKK ...

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Cross-linguistic patterns in the acquisition of quantifiers [Psychological and Cognitive Sciences]

16.08.2016 | Napoleon Katsos; Chris Cummins; Maria-José Ezeizabarrena; Anna Gavarró; Jelena Kuvač Kraljević; Gordana Hrzica; Klea ..., Proceedings of the National Academy of Sciences current issue, 2016

Learners of most languages are faced with the task of acquiring words to talk about number and quantity. Much is known about the order of acquisition of number words as well as the cognitive and perceptual systems and cultural practices that shape it. Substantially less is known about the ...

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O-linked GlcNAcylation elevated by HPV E6 mediates viral oncogenesis [Medical Sciences]

16.08.2016 | Qinghua Zeng; Rui-Xun Zhao; Jianfeng Chen; Yining Li; Xiang-Dong Li; Xiao-Long Liu; Wei-Ming Zhang; Cheng-Shi Quan; ..., Proceedings of the National Academy of Sciences current issue, 2016

High-risk human papillomaviruses (HPVs) are causative agents of anogenital cancers and a fraction of head and neck cancers. The mechanisms involved in the progression of HPV neoplasias to cancers remain largely unknown. Here, we report that O-linked GlcNAcylation (O-GlcNAc) and O-GlcNAc ...

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FAR-RED ELONGATED HYPOCOTYL3 activates SEPALLATA2 but inhibits CLAVATA3 to regulate meristem determinacy and maintenance in Arabidopsis [Plant Biology]

16.08.2016 | Dongming Li; Xing Fu; Lin Guo; Zhigang Huang; Yongpeng Li; Yang Liu; Zishan He; Xiuwei Cao; Xiaohan Ma; Meicheng Zha ..., Proceedings of the National Academy of Sciences current issue, 2016

Plant meristems are responsible for the generation of all plant tissues and organs. Here we show that the transcription factor (TF) FAR-RED ELONGATED HYPOCOTYL3 (FHY3) plays an important role in both floral meristem (FM) determinacy and shoot apical meristem maintenance in Arabidopsis, in ...

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Axitinib blocks Wnt/{beta}-catenin signaling and directs asymmetric cell division in cancer [Medical Sciences]

16.08.2016 | Yi Qu; Naouel Gharbi; Xing Yuan; Jan Roger Olsen; Pernille Blicher; Bjørn Dalhus; Karl A. Brokstad; Biaoyang Lin; An ..., Proceedings of the National Academy of Sciences current issue, 2016

Oncogenic mutations of the Wnt (wingless)/β-catenin pathway are frequently observed in major cancer types. Thus far, however, no therapeutic agent targeting Wnt/β-catenin signaling is available for clinical use. Here we demonstrate that axitinib, a clinically approved drug, strikingly blocks ...

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Structure and genome release of Twort-like Myoviridae phage with a double-layered baseplate [Microbiology]

16.08.2016 | Jiří Nováček; Marta Šiborová; Martin Benešík; Roman Pantůček; Jiří Doškař; Pavel Plevka, Proceedings of the National Academy of Sciences current issue, 2016

Bacteriophages from the family Myoviridae use double-layered contractile tails to infect bacteria. Contraction of the tail sheath enables the tail tube to penetrate through the bacterial cell wall and serve as a channel for the transport of the phage genome into the cytoplasm. However, the ...

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In This Issue [This Week in PNAS]

16.08.2016 | Proceedings of the National Academy of Sciences current issue, 2016

Menopause and biological aging Menopause might accelerate biological aging. Epidemiological studies have suggested a negative link between women’s age at menopause and mortality risk. Morgan Levine et al. (pp. 9327–9332) used a previously established method called the epigenetic clock, which can ...

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Reported violations of rationality may be aggregation artifacts [Biological Sciences]

16.08.2016 | Clintin P. Davis-Stober; Sanghyuk Park; Nicholas Brown; Michel Regenwetter, Proceedings of the National Academy of Sciences current issue, 2016

In PNAS, Tsetsos et al. (1) report intransitive preferences consistent with selective integration (SI) theory. The Condorcet paradox warns that aggregating transitive (rational) preferences readily creates intransitive (irrational) collective preferences (2). Therefore, any study reporting ...

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On the solution of the Helmholtz equation on regions with corners [Applied Mathematics]

16.08.2016 | Kirill Serkh; Vladimir Rokhlin, Proceedings of the National Academy of Sciences current issue, 2016

In this paper we solve several boundary value problems for the Helmholtz equation on polygonal domains. We observe that when the problems are formulated as the boundary integral equations of potential theory, the solutions are representable by series of appropriately chosen Bessel functions. In ...

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