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15.804 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans [Genetics]

21.10.2014 | Ara B. Hwang; Eun-A Ryu; Murat Artan; Hsin-Wen Chang; Mohammad Humayun Kabir; Hyun-Jun Nam; Dongyeop Lee; Jae-Seong ..., Proceedings of the National Academy of Sciences current issue, 2014

Mild inhibition of mitochondrial respiration extends the lifespan of many species. In Caenorhabditis elegans, reactive oxygen species (ROS) promote longevity by activating hypoxia-inducible factor 1 (HIF-1) in response to reduced mitochondrial respiration. However, the physiological role and ...

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Human TLR10 is an anti-inflammatory pattern-recognition receptor [Immunology and Inflammation]

21.10.2014 | Marije Oosting; Shih-Chin Cheng; Judith M. Bolscher; Rachel Vestering-Stenger; Theo S. Plantinga; Ineke C. Verschuer ..., Proceedings of the National Academy of Sciences current issue, 2014

Toll-like receptor (TLR)10 is the only pattern-recognition receptor without known ligand specificity and biological function. We demonstrate that TLR10 is a modulatory receptor with mainly inhibitory effects. Blocking TLR10 by antagonistic antibodies enhanced proinflammatory cytokine production, ...

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Neutral molecular cluster formation of sulfuric acid-dimethylamine observed in real time under atmospheric conditions [Environmental Sciences]

21.10.2014 | Andreas Kürten; Tuija Jokinen; Mario Simon; Mikko Sipilä; Nina Sarnela; Heikki Junninen; Alexey Adamov; João Almeida ..., Proceedings of the National Academy of Sciences current issue, 2014

For atmospheric sulfuric acid (SA) concentrations the presence of dimethylamine (DMA) at mixing ratios of several parts per trillion by volume can explain observed boundary layer new particle formation rates. However, the concentration and molecular composition of the neutral (uncharged) clusters ...

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From fear recognition to kidney donation [Psychological and Cognitive Sciences]

21.10.2014 | Joshua D. Greene, Proceedings of the National Academy of Sciences current issue, 2014

Valerie Maupin’s best friend had a loved one who needed a kidney. In an act of extraordinary altruism, Maupin offered one of hers, but she was not a match. Then she wondered: If I’m willing to do this for someone I know, why not for someone else whose need is...

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Estrogen-related receptor {alpha} decreases RHOA stability to induce orientated cell migration [Cell Biology]

21.10.2014 | Juliette Sailland; Violaine Tribollet; Christelle Forcet; Cyrielle Billon; Bruno Barenton; Julie Carnesecchi; Alice ..., Proceedings of the National Academy of Sciences current issue, 2014

Several physiopathological processes require orientated cellular migration. This phenomenon highly depends on members of the RHO family of GTPases. Both excessive and deficient RHO activity impair directional migration. A tight control is thus exerted on these proteins through the regulation of ...

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Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma [Medical Sciences]

21.10.2014 | Stephan Kreher; M. Amine Bouhlel; Pierre Cauchy; Björn Lamprecht; Shuang Li; Michael Grau; Franziska Hummel; Karl Kö ..., Proceedings of the National Academy of Sciences current issue, 2014

Deregulated transcription factor (TF) activities are commonly observed in hematopoietic malignancies. Understanding tumorigenesis therefore requires determining the function and hierarchical role of individual TFs. To identify TFs central to lymphomagenesis, we identified lymphoma type-specific ...

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Visualization and quantification of nascent RAD51 filament formation at single-monomer resolution [Biophysics and Computational Biology]

21.10.2014 | Andrea Candelli; Jan Thomas Holthausen; Martin Depken; Ineke Brouwer; Mariëlla A. M. Franker; Margherita Marchetti; ..., Proceedings of the National Academy of Sciences current issue, 2014

During recombinational repair of double-stranded DNA breaks, RAD51 recombinase assembles as a nucleoprotein filament around single-stranded DNA to form a catalytically proficient structure able to promote homology recognition and strand exchange. Mediators and accessory factors guide the action ...

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Single-molecule packaging initiation in real time by a viral DNA packaging machine from bacteriophage T4 [Biophysics and Computational Biology]

21.10.2014 | Reza Vafabakhsh; Kiran Kondabagil; Tyler Earnest; Kyung Suk Lee; Zhihong Zhang; Li Dai; Karin A. Dahmen; Venigalla B ..., Proceedings of the National Academy of Sciences current issue, 2014

Viral DNA packaging motors are among the most powerful molecular motors known. A variety of structural, biochemical, and single-molecule biophysical approaches have been used to understand their mechanochemistry. However, packaging initiation has been difficult to analyze because of its transient ...

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The high heritability of educational achievement reflects many genetically influenced traits, not just intelligence [Psychological and Cognitive Sciences]

21.10.2014 | Eva Krapohl; Kaili Rimfeld; Nicholas G. Shakeshaft; Maciej Trzaskowski; Andrew McMillan; Jean-Baptiste Pingault; Kat ..., Proceedings of the National Academy of Sciences current issue, 2014

Because educational achievement at the end of compulsory schooling represents a major tipping point in life, understanding its causes and correlates is important for individual children, their families, and society. Here we identify the general ingredients of educational achievement using a ...

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Label-free electrochemical detection of human methyltransferase from tumors [Biochemistry]

21.10.2014 | Ariel L. Furst; Natalie B. Muren; Michael G. Hill; Jacqueline K. Barton, Proceedings of the National Academy of Sciences current issue, 2014

The role of abnormal DNA methyltransferase activity in the development and progression of cancer is an essential and rapidly growing area of research, both for improved diagnosis and treatment. However, current technologies for the assessment of methyltransferase activity, particularly from crude ...

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