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16.028 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Prevalence of cycling genes and drug targets calls for prospective chronotherapeutics [Systems Biology]

11.11.2014 | Nimish D. Kathale; Andrew C. Liu, Proceedings of the National Academy of Sciences current issue, 2014

There are two main threads in biomedical research: One is to discover how biological systems work, basic science; and the other is to use knowledge obtained from basic research in medicine, translation. The availability of genome sequences has brought an unprecedented opportunity for discovery ...

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Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brain [Engineering]

11.11.2014 | Urvashi M. Upadhyay; Betty Tyler; Yoda Patta; Robert Wicks; Kevin Spencer; Alexander Scott; Byron Masi; Lee Hwang; R ..., Proceedings of the National Academy of Sciences current issue, 2014

Metastases represent the most common brain tumors in adults. Surgical resection alone results in 45% recurrence and is usually accompanied by radiation and chemotherapy. Adequate chemotherapy delivery to the CNS is hindered by the blood–brain barrier. Efforts at delivering chemotherapy locally to ...

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The general mode of translation inhibition by macrolide antibiotics [Biochemistry]

11.11.2014 | Krishna Kannan; Pinal Kanabar; David Schryer; Tanja Florin; Eugene Oh; Neil Bahroos; Tanel Tenson; Jonathan S. Weiss ..., Proceedings of the National Academy of Sciences current issue, 2014

Macrolides are clinically important antibiotics thought to inhibit bacterial growth by impeding the passage of newly synthesized polypeptides through the nascent peptide exit tunnel of the bacterial ribosome. Recent data challenged this view by showing that macrolide antibiotics can ...

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Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers [Applied Mathematics]

11.11.2014 | Ivana Bozic; Martin A. Nowak, Proceedings of the National Academy of Sciences current issue, 2014

Targeted therapies provide an exciting new approach to combat human cancer. The immediate effect is a dramatic reduction in disease burden, but in most cases, the tumor returns as a consequence of resistance. Various mechanisms for the evolution of resistance have been implicated, including ...

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Unconscious information changes decision accuracy but not confidence [Psychological and Cognitive Sciences]

11.11.2014 | Alexandra Vlassova; Chris Donkin; Joel Pearson, Proceedings of the National Academy of Sciences current issue, 2014

The controversial idea that information can be processed and evaluated unconsciously to change behavior has had a particularly impactful history. Here, we extend a simple model of conscious decision-making to explain both conscious and unconscious accumulation of decisional evidence. Using a ...

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Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila [Developmental Biology]

11.11.2014 | Kai Jiang; Yajuan Liu; Junkai Fan; Garretson Epperly; Tianyan Gao; Jin Jiang; Jianhang Jia, Proceedings of the National Academy of Sciences current issue, 2014

Smoothened (Smo) is essential for transduction of the Hedgehog (Hh) signal in both insects and vertebrates. Cell surface/cilium accumulation of Smo is thought to play an important role in Hh signaling, but how the localization of Smo is controlled remains poorly understood. In this study, we ...

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Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress [Neuroscience]

11.11.2014 | Yayoi Kinoshita; Richard G. Hunter; Jason D. Gray; Roxana Mesias; Bruce S. McEwen; Deanna L. Benson; D. Stave Kohtz, Proceedings of the National Academy of Sciences current issue, 2014

Genetic evidence suggests cell-type–specific functions for certain nucleoporins, and gene expression profiling has revealed that nucleoporin p62 (NUP62) transcripts are decreased in the prefrontal cortex of major depressives. Chronic stress, which can precipitate depression, induces changes in ...

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Arabidopsis protein arginine methyltransferase 3 is required for ribosome biogenesis by affecting precursor ribosomal RNA processing [Plant Biology]

11.11.2014 | Runlai Hang; Chunyan Liu; Ayaz Ahmad; Yong Zhang; Falong Lu; Xiaofeng Cao, Proceedings of the National Academy of Sciences current issue, 2014

Ribosome biogenesis is a fundamental and tightly regulated cellular process, including synthesis, processing, and assembly of rRNAs with ribosomal proteins. Protein arginine methyltransferases (PRMTs) have been implicated in many important biological processes, such as ribosome biogenesis. Two ...

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Dynamic population mapping using mobile phone data [Environmental Sciences]

11.11.2014 | Pierre Deville; Catherine Linard; Samuel Martin; Marius Gilbert; Forrest R. Stevens; Andrea E. Gaughan; Vincent D. B ..., Proceedings of the National Academy of Sciences current issue, 2014

During the past few decades, technologies such as remote sensing, geographical information systems, and global positioning systems have transformed the way the distribution of human population is studied and modeled in space and time. However, the mapping of populations remains constrained by the ...

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Benchmarking all-atom simulations using hydrogen exchange [Biophysics and Computational Biology]

11.11.2014 | John J. Skinner; Wookyung Yu; Elizabeth K. Gichana; Michael C. Baxa; James R. Hinshaw; Karl F. Freed; Tobin R. Sosnick, Proceedings of the National Academy of Sciences current issue, 2014

Long-time molecular dynamics (MD) simulations are now able to fold small proteins reversibly to their native structures [Lindorff-Larsen K, Piana S, Dror RO, Shaw DE (2011) Science 334(6055):517–520]. These results indicate that modern force fields can reproduce the energy surface near the native ...

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