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13.931 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Dynamic gene expression by putative hair-cell progenitors during regeneration in the zebrafish lateral line [Developmental Biology]

08.04.2014 | Aaron B. Steiner; Taeryn Kim; Victoria Cabot; A. J. Hudspeth, Proceedings of the National Academy of Sciences current issue, 2014

Hearing loss is most commonly caused by the destruction of mechanosensory hair cells in the ear. This condition is usually permanent: Despite the presence of putative hair-cell progenitors in the cochlea, hair cells are not naturally replenished in adult mammals. Unlike those of the mammalian ...

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T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation [Immunology]

08.04.2014 | Makoto Inoue; Tomohiro Arikawa; Yu-Hsun Chen; Yasuhiro Moriwaki; Michael Price; Michael Brown; John R. Perfect; Mari ..., Proceedings of the National Academy of Sciences current issue, 2014

Endotoxemia is caused by excessive inflammation, but the immune system has various mechanisms to avoid collateral organ damage in endotoxemia. A handful of reports have shown that innate immune responses are suppressed by the adaptive immune system. However, the molecular mechanism by which ...

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Polydispersity-driven topological defects as order-restoring excitations [Applied Physical Sciences]

08.04.2014 | Zhenwei Yao; Monica Olvera de la Cruz, Proceedings of the National Academy of Sciences current issue, 2014

The engineering of defects in crystalline matter has been extensively exploited to modify the mechanical and electrical properties of many materials. Recent experiments on manipulating extended defects in graphene, for example, show that defects direct the flow of electric charges. The ...

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Understanding environmentally significant consumption [Sustainability Science]

08.04.2014 | Thomas Dietz, Proceedings of the National Academy of Sciences current issue, 2014

Consumer choices can have major impacts on the environment. For example, the United States could reduce its total greenhouse gas emissions by 7% through modest policies to encourage more efficient household energy consumption (1). This “behavioral wedge” would make a substantial and low-cost ...

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Whole-exome sequencing reveals LRP5 mutations and canonical Wnt signaling associated with hepatic cystogenesis [Medical Sciences]

08.04.2014 | Wybrich R. Cnossen; René H. M. te Morsche; Alexander Hoischen; Christian Gilissen; Melissa Chrispijn; Hanka Venselaa ..., Proceedings of the National Academy of Sciences current issue, 2014

Polycystic livers are seen in the rare inherited disorder isolated polycystic liver disease (PCLD) and are recognized as the most common extrarenal manifestation in autosomal dominant polycystic kidney disease. Hepatic cystogenesis is characterized by progressive proliferation of cholangiocytes, ...

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Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes [Applied Biological Sciences]

08.04.2014 | Lynn E. Macdonald; Margaret Karow; Sean Stevens; Wojtek Auerbach; William T. Poueymirou; Jason Yasenchak; David Fren ..., Proceedings of the National Academy of Sciences current issue, 2014

Genetic humanization, which involves replacing mouse genes with their human counterparts, can create powerful animal models for the study of human genes and diseases. One important example of genetic humanization involves mice humanized for their Ig genes, allowing for human antibody responses ...

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Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits [Physiology]

08.04.2014 | Leigh D. Plant; Dazhi Xiong; Hui Dai; Steve A. N. Goldstein, Proceedings of the National Academy of Sciences current issue, 2014

KCNE1 (E1) β-subunits assemble with KCNQ1 (Q1) voltage-gated K+ channel α-subunits to form IKslow (IKs) channels in the heart and ear. The number of E1 subunits in IKs channels has been an issue of ongoing debate. Here, we use single-molecule spectroscopy to demonstrate that surface IKs channels ...

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Knowledge discovery by accuracy maximization [Biophysics and Computational Biology]

08.04.2014 | Stefano Cacciatore; Claudio Luchinat; Leonardo Tenori, Proceedings of the National Academy of Sciences current issue, 2014

Here we describe KODAMA (knowledge discovery by accuracy maximization), an unsupervised and semisupervised learning algorithm that performs feature extraction from noisy and high-dimensional data. Unlike other data mining methods, the peculiarity of KODAMA is that it is driven by an integrated ...

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Protein phosphatase PP1/GLC7 interaction domain in yeast eIF2{gamma} bypasses targeting subunit requirement for eIF2{alpha} dephosphorylation [Biochemistry]

08.04.2014 | Margarito Rojas; Anne-Claude Gingras; Thomas E. Dever, Proceedings of the National Academy of Sciences current issue, 2014

Whereas the protein kinases GCN2, HRI, PKR, and PERK specifically phosphorylate eukaryotic translation initiation factor 2 (eIF2α) on Ser51 to regulate global and gene-specific mRNA translation, eIF2α is dephosphorylated by the broadly acting serine/threonine protein phosphatase 1 (PP1). In ...

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On the mechanism of photoinduced dimer dissociation in the plant UVR8 photoreceptor [Biophysics and Computational Biology]

08.04.2014 | Alexander A. Voityuk; Rudolph A. Marcus; Maria-Elisabeth Michel-Beyerle, Proceedings of the National Academy of Sciences current issue, 2014

UV-B absorption by the photoreceptor UV resistance locus 8 (UVR8) consisting of two identical protein units triggers a signal chain used by plants in connection with protection and repair of UV-B induced damage. X-ray structural analysis of the purified protein [Christie JM, et al. (2012) Science ...

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