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17.430 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Arabidopsis OR proteins are the major posttranscriptional regulators of phytoene synthase in controlling carotenoid biosynthesis [Plant Biology]

17.03.2015 | Xiangjun Zhou; Ralf Welsch; Yong Yang; Daniel Álvarez; Matthias Riediger; Hui Yuan; Tara Fish; Jiping Liu; Theodore ..., Proceedings of the National Academy of Sciences current issue, 2015

Carotenoids are indispensable natural pigments to plants and humans. Phytoene synthase (PSY), the rate-limiting enzyme in the carotenoid biosynthetic pathway, and ORANGE (OR), a regulator of chromoplast differentiation and enhancer of carotenoid biosynthesis, represent two key proteins that ...

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Structure and dynamics of the MKK7-JNK signaling complex [Biophysics and Computational Biology]

17.03.2015 | Jaka Kragelj; Andrés Palencia; Max H. Nanao; Damien Maurin; Guillaume Bouvignies; Martin Blackledge; Malene Ringkjøb ..., Proceedings of the National Academy of Sciences current issue, 2015

Signaling specificity in the mitogen-activated protein kinase (MAPK) pathways is controlled by disordered domains of the MAPK kinases (MKKs) that specifically bind to their cognate MAPKs via linear docking motifs. MKK7 activates the c-Jun N-terminal kinase (JNK) pathway and is the only MKK ...

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KCC2 activity is critical in limiting the onset and severity of status epilepticus [Neuroscience]

17.03.2015 | Liliya Silayeva; Tarek Z. Deeb; Rochelle M. Hines; Matt R. Kelley; Michaelanne B. Munoz; Henry H. C. Lee; Nicholas J ..., Proceedings of the National Academy of Sciences current issue, 2015

The K+/Cl– cotransporter (KCC2) allows adult neurons to maintain low intracellular Cl– levels, which are a prerequisite for efficient synaptic inhibition upon activation of γ-aminobutyric acid receptors. Deficits in KCC2 activity are implicated in epileptogenesis, but how increased neuronal ...

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Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH [Biochemistry]

17.03.2015 | Shangyu Dang; Shenjie Wu; Jiawei Wang; Hongbo Li; Min Huang; Wei He; Yue-Ming Li; Catherine C. L. Wong; Yigong Shi, Proceedings of the National Academy of Sciences current issue, 2015

Aberrant cleavage of amyloid precursor protein (APP) by γ-secretase contributes to the development of Alzheimer’s disease. More than 200 disease-derived mutations have been identified in presenilin (the catalytic subunit of γ-secretase), making modulation of γ-secretase activity a potentially ...

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Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer [Medical Sciences]

17.03.2015 | Anthony C. Faber; Anna F. Farago; Carlotta Costa; Anahita Dastur; Maria Gomez-Caraballo; Rebecca Robbins; Bethany L. ..., Proceedings of the National Academy of Sciences current issue, 2015

BH3 mimetics such as ABT-263 induce apoptosis in a subset of cancer models. However, these drugs have shown limited clinical efficacy as single agents in small-cell lung cancer (SCLC) and other solid tumor malignancies, and rational combination strategies remain underexplored. To develop a novel ...

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Improving recombinant Rubisco biogenesis, plant photosynthesis and growth by coexpressing its ancillary RAF1 chaperone [Plant Biology]

17.03.2015 | Spencer M. Whitney; Rosemary Birch; Celine Kelso; Jennifer L. Beck; Maxim V. Kapralov, Proceedings of the National Academy of Sciences current issue, 2015

Enabling improvements to crop yield and resource use by enhancing the catalysis of the photosynthetic CO2-fixing enzyme Rubisco has been a longstanding challenge. Efforts toward realization of this goal have been greatly assisted by advances in understanding the complexities of Rubisco’s ...

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Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution [Applied Biological Sciences]

17.03.2015 | Alice Tzeng; Byron H. Kwan; Cary F. Opel; Tejas Navaratna; K. Dane Wittrup, Proceedings of the National Academy of Sciences current issue, 2015

Cytokine therapy can activate potent, sustained antitumor responses, but collateral toxicity often limits dosages. Although antibody–cytokine fusions (immunocytokines) have been designed with the intent to localize cytokine activity, systemic dose-limiting side effects are not fully ameliorated ...

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Implantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistance [Medical Sciences]

17.03.2015 | João Conde; Nuria Oliva; Natalie Artzi, Proceedings of the National Academy of Sciences current issue, 2015

Multidrug resistance (MDR) in cancer cells is a substantial limitation to the success of chemotherapy. Here, we describe facile means to overcome resistance by silencing the multidrug resistance protein 1 (MRP1), before chemotherapeutic drug delivery in vivo with a single local application. Our ...

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Vapor hydrogen and oxygen isotopes reflect water of combustion in the urban atmosphere [Environmental Sciences]

17.03.2015 | Galen Gorski; Courtenay Strong; Stephen P. Good; Ryan Bares; James R. Ehleringer; Gabriel J. Bowen, Proceedings of the National Academy of Sciences current issue, 2015

Anthropogenic modification of the water cycle involves a diversity of processes, many of which have been studied intensively using models and observations. Effective tools for measuring the contribution and fate of combustion-derived water vapor in the atmosphere are lacking, however, and this ...

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Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma [Genetics]

17.03.2015 | Kalpana Kannan; Cristian Coarfa; Pei-Wen Chao; Liming Luo; Yan Wang; Amy E. Brinegar; Shannon M. Hawkins; Aleksandar ..., Proceedings of the National Academy of Sciences current issue, 2015

High-grade serous ovarian cancer (HGSC) is among the most lethal forms of cancer in women. Excessive genomic rearrangements, which are expected to create fusion oncogenes, are the hallmark of this cancer. Here we report a cancer-specific gene fusion between BCAM, a membrane adhesion molecule, and ...

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