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17.217 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Dysregulation of Escherichia coli {alpha}-hemolysin expression alters the course of acute and persistent urinary tract infection [Microbiology]

24.02.2015 | Kanna Nagamatsu; Thomas J. Hannan; Randi L. Guest; Maria Kostakioti; Maria Hadjifrangiskou; Jana Binkley; Karen Dods ..., Proceedings of the National Academy of Sciences current issue, 2015

Urinary tract infections (UTIs) are among the most common bacterial infections, causing considerable morbidity in females. Infection is highly recurrent despite appropriate antibiotic treatment. Uropathogenic Escherichia coli (UPEC), the most common causative agent of UTIs, invades bladder ...

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Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt [Neuroscience]

24.02.2015 | Aalim M. Weljie; Peter Meerlo; Namni Goel; Arjun Sengupta; Matthew S. Kayser; Ted Abel; Morris J. Birnbaum; David F. ..., Proceedings of the National Academy of Sciences current issue, 2015

Sleep is an essential biological process that is thought to have a critical role in metabolic regulation. In humans, reduced sleep duration has been associated with risk for metabolic disorders, including weight gain, diabetes, obesity, and cardiovascular disease. However, our understanding of ...

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Erosion during extreme flood events dominates Holocene canyon evolution in northeast Iceland [Earth, Atmospheric, and Planetary Sciences]

24.02.2015 | Edwin R. C. Baynes; Mikaël Attal; Samuel Niedermann; Linda A. Kirstein; Andrew J. Dugmore; Mark Naylor, Proceedings of the National Academy of Sciences current issue, 2015

Extreme flood events have the potential to cause catastrophic landscape change in short periods of time (100 to 103 h). However, their impacts are rarely considered in studies of long-term landscape evolution (>103 y), because the mechanisms of erosion during such floods are poorly constrained. ...

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Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc [Biochemistry]

24.02.2015 | Parameswaran Hariharan; Dhandayuthapani Balasubramaniam; Alan Peterkofsky; H. Ronald Kaback; Lan Guan, Proceedings of the National Academy of Sciences current issue, 2015

In a variety of bacteria, the phosphotransferase protein IIAGlc plays a key regulatory role in catabolite repression in addition to its role in the vectorial phosphorylation of glucose catalyzed by the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). The lactose permease (LacY) ...

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Reply to Tichenor: Proposed update to beef greenhouse gas footprint is numerically questionable and well within current uncertainty bounds [Physical Sciences]

24.02.2015 | Gidon Eshel; Alon Shepon; Tamar Makov; Ron Milo, Proceedings of the National Academy of Sciences current issue, 2015

We thank Tichenor (1) for the attention to our paper (2). In it, we repeatedly stress the need for augmented and more refined data, and it is in this spirit we welcome Tichenor’s letter. However, as shown in Fig. 1, Tichenor’s approach, based on analyzing a single farm in Sweden...

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Towards link predictability of complex networks [Applied Physical Sciences]

24.02.2015 | Linyuan Lü; Liming Pan; Tao Zhou; Yi-Cheng Zhang; H. Eugene Stanley, Proceedings of the National Academy of Sciences current issue, 2015

The organization of real networks usually embodies both regularities and irregularities, and, in principle, the former can be modeled. The extent to which the formation of a network can be explained coincides with our ability to predict missing links. To understand network organization, we should ...

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Inner Workings: Endoliths hunker down and survive in extreme environments [Inner Workings]

24.02.2015 | Amber Dance, Proceedings of the National Academy of Sciences current issue, 2015

Henry Sun works where other biologists fear to tread, or maybe they just don’t want to bother. Antarctica’s McMurdo Dry Valleys feature temperatures as low as minus 68 °C, winds up to 200 miles per hour, and less than 10% relative humidity. Early polar explorer Robert Scott dubbed them the...

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Neuroinflammation triggered by {beta}-glucan/dectin-1 signaling enables CNS axon regeneration [Neuroscience]

24.02.2015 | Katherine T. Baldwin; Kevin S. Carbajal; Benjamin M. Segal; Roman J. Giger, Proceedings of the National Academy of Sciences current issue, 2015

Innate immunity can facilitate nervous system regeneration, yet the underlying cellular and molecular mechanisms are not well understood. Here we show that intraocular injection of lipopolysaccharide (LPS), a bacterial cell wall component, or the fungal cell wall extract zymosan both lead to ...

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Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress [Neuroscience]

24.02.2015 | Benjamin D. Sachs; Jason R. Ni; Marc G. Caron, Proceedings of the National Academy of Sciences current issue, 2015

Brain serotonin (5-HT) deficiency and exposure to psychosocial stress have both been implicated in the etiology of depression and anxiety disorders, but whether 5-HT deficiency influences susceptibility to depression- and anxiety-like phenotypes induced by psychosocial stress has not been ...

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Automated analysis of high-throughput B-cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles [Immunology and Inflammation]

24.02.2015 | Daniel Gadala-Maria; Gur Yaari; Mohamed Uduman; Steven H. Kleinstein, Proceedings of the National Academy of Sciences current issue, 2015

Individual variation in germline and expressed B-cell immunoglobulin (Ig) repertoires has been associated with aging, disease susceptibility, and differential response to infection and vaccination. Repertoire properties can now be studied at large-scale through next-generation sequencing of ...

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