Meine Merkliste
my.bionity.com  
Login  

737 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

rss
mit folgenden Suchkriterien:

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma [Medical Sciences]

21.10.2014 | Stephan Kreher; M. Amine Bouhlel; Pierre Cauchy; Björn Lamprecht; Shuang Li; Michael Grau; Franziska Hummel; Karl Kö ..., Proceedings of the National Academy of Sciences current issue, 2014

Deregulated transcription factor (TF) activities are commonly observed in hematopoietic malignancies. Understanding tumorigenesis therefore requires determining the function and hierarchical role of individual TFs. To identify TFs central to lymphomagenesis, we identified lymphoma type-specific ...

mehr

KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes [Biochemistry]

21.10.2014 | Dong-In Koh; Dohyun Han; Hoon Ryu; Won-Il Choi; Bu-Nam Jeon; Min-Kyeong Kim; Youngsoo Kim; Jin Young Kim; Lee Parry; ..., Proceedings of the National Academy of Sciences current issue, 2014

An unresolved issue in genotoxic stress response is identification of induced regulatory proteins and how these activate tumor suppressor p53 to determine appropriate cell responses. Transcription factor KAISO was previously described to repress transcription following binding to methylated DNA. ...

mehr

Structural studies on the authentic mumps virus nucleocapsid showing uncoiling by the phosphoprotein [Microbiology]

21.10.2014 | Robert Cox; Adrian Pickar; Shihong Qiu; Jun Tsao; Cynthia Rodenburg; Terje Dokland; Andrew Elson; Biao He; Ming Luo, Proceedings of the National Academy of Sciences current issue, 2014

Mumps virus (MuV) is a highly contagious pathogen, and despite extensive vaccination campaigns, outbreaks continue to occur worldwide. The virus has a negative-sense, single-stranded RNA genome that is encapsidated by the nucleocapsid protein (N) to form the nucleocapsid (NC). NC serves as the ...

mehr

Nitrate foraging by Arabidopsis roots is mediated by the transcription factor TCP20 through the systemic signaling pathway [Plant Biology]

21.10.2014 | Peizhu Guan; Rongchen Wang; Philippe Nacry; Ghislain Breton; Steve A. Kay; Jose L. Pruneda-Paz; Ariea Davani; Nigel ..., Proceedings of the National Academy of Sciences current issue, 2014

To compete for nutrients in diverse soil microenvironments, plants proliferate lateral roots preferentially in nutrient-rich zones. For nitrate, root foraging involves local and systemic signaling; however, little is known about the genes that function in the systemic signaling pathway. By using ...

mehr

SPX1 is a phosphate-dependent inhibitor of PHOSPHATE STARVATION RESPONSE 1 in Arabidopsis [Plant Biology]

14.10.2014 | María Isabel Puga; Isabel Mateos; Rajulu Charukesi; Zhiye Wang; José M. Franco-Zorrilla; Laura de Lorenzo; María L. ..., Proceedings of the National Academy of Sciences current issue, 2014

To cope with growth in low-phosphate (Pi) soils, plants have evolved adaptive responses that involve both developmental and metabolic changes. PHOSPHATE STARVATION RESPONSE 1 (PHR1) and related transcription factors play a central role in the control of Pi starvation responses (PSRs). How Pi ...

mehr

Structural basis of cellular dNTP regulation by SAMHD1 [Biochemistry]

14.10.2014 | Xiaoyun Ji; Chenxiang Tang; Qi Zhao; Wei Wang; Yong Xiong, Proceedings of the National Academy of Sciences current issue, 2014

The sterile alpha motif and HD domain-containing protein 1 (SAMHD1), a dNTPase, prevents the infection of nondividing cells by retroviruses, including HIV, by depleting the cellular dNTP pool available for viral reverse transcription. SAMHD1 is a major regulator of cellular dNTP levels in ...

mehr

Precisely modulated pathogenicity island interference with late phage gene transcription [Microbiology]

07.10.2014 | Geeta Ram; John Chen; Hope F. Ross; Richard P. Novick, Proceedings of the National Academy of Sciences current issue, 2014

Having gone to great evolutionary lengths to develop resistance to bacteriophages, bacteria have come up with resistance mechanisms directed at every aspect of the bacteriophage life cycle. Most genes involved in phage resistance are carried by plasmids and other mobile genetic elements, ...

mehr

Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses [Microbiology]

07.10.2014 | Christian Königer; Ida Wingert; Moritz Marsmann; Christine Rösler; Jürgen Beck; Michael Nassal, Proceedings of the National Academy of Sciences current issue, 2014

Hepatitis B virus (HBV), the causative agent of chronic hepatitis B and prototypic hepadnavirus, is a small DNA virus that replicates by protein-primed reverse transcription. The product is a 3-kb relaxed circular DNA (RC-DNA) in which one strand is linked to the viral polymerase (P protein) ...

mehr

Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease [Cell Biology]

07.10.2014 | Yuming Wang; Probir Chakravarty; Michael Ranes; Gavin Kelly; Philip J. Brooks; Edward Neilan; Aengus Stewart; Giampi ..., Proceedings of the National Academy of Sciences current issue, 2014

Cockayne syndrome (CS) is a multisystem disorder with severe neurological symptoms. The majority of CS patients carry mutations in Cockayne syndrome group B (CSB), best known for its role in transcription-coupled nucleotide excision repair. Indeed, because various repair pathways are compromised ...

mehr

p53 suppression partially rescues the mutant phenotype in mouse models of DiGeorge syndrome [Developmental Biology]

16.09.2014 | Cinzia Caprio; Antonio Baldini, Proceedings of the National Academy of Sciences current issue, 2014

T-box 1 (Tbx1), a gene encoding a T-box transcription factor, is required for embryonic development in humans and mice. Half dosage of this gene in humans causes most of the features of the DiGeorge or Velocardiofacial syndrome phenotypes, including aortic arch and cardiac outflow tract ...

mehr

Seite 1 von 74
Suche per e-Mail abonnieren

Sie erhalten passend zu Ihrer Suche die neusten Suchergebnisse per E-Mail. Dieser Service ist für Sie kostenlos und kann jederzeit abbestellt werden.

Ihr Bowser ist nicht aktuell. Microsoft Internet Explorer 6.0 unterstützt einige Funktionen auf Chemie.DE nicht.