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829 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells [Cell Biology]

23.06.2015 | Muhammad Akhtar Ali; Shady Younis; Ola Wallerman; Rajesh Gupta; Leif Andersson; Tobias Sjöblom, Proceedings of the National Academy of Sciences current issue, 2015

The transcription factor ZBED6 (zinc finger, BED-type containing 6) is a repressor of IGF2 whose action impacts development, cell proliferation, and growth in placental mammals. In human colorectal cancers, IGF2 overexpression is mutually exclusive with somatic mutations in PI3K signaling ...

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Inference of transcriptional regulation in cancers [Biophysics and Computational Biology]

23.06.2015 | Peng Jiang; Matthew L. Freedman; Jun S. Liu; Xiaole Shirley Liu, Proceedings of the National Academy of Sciences current issue, 2015

Despite the rapid accumulation of tumor-profiling data and transcription factor (TF) ChIP-seq profiles, efforts integrating TF binding with the tumor-profiling data to understand how TFs regulate tumor gene expression are still limited. To systematically search for cancer-associated TFs, we ...

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Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas [Immunology and Inflammation]

23.06.2015 | Hyung-Ok Lee; Xiao He; Jayati Mookerjee-Basu; Dai Zhongping; Xiang Hua; Emmanuelle Nicolas; Maria Luisa Sulis; Adolf ..., Proceedings of the National Academy of Sciences current issue, 2015

The transcription factor T-helper-inducing POZ/Krueppel-like factor (ThPOK, encoded by the Zbtb7b gene) plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. Here we show that mice expressing a constitutive T-cell–specific ThPOK ...

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Two-level inhibition of galK expression by Spot 42: Degradation of mRNA mK2 and enhanced transcription termination before the galK gene [Microbiology]

16.06.2015 | Xun Wang; Sang Chun Ji; Heung Jin Jeon; Yonho Lee; Heon M. Lim, Proceedings of the National Academy of Sciences current issue, 2015

The Escherichia coli gal operon has the structure Pgal-galE-galT-galK-galM. During early log growth, a gradient in gene expression, named type 2 polarity, is established, as follows: galE > galT > galK > galM. However, during late-log growth, type 1 polarity is established in which galK is ...

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Transgenic songbirds with suppressed or enhanced activity of CREB transcription factor [Neuroscience]

16.06.2015 | Kentaro Abe; Sumiko Matsui; Dai Watanabe, Proceedings of the National Academy of Sciences current issue, 2015

Songbirds postnatally develop their skill to utter and to perceive a vocal signal for communication. How genetic and environmental influences act in concert to regulate the development of such skill is not fully understood. Here, we report the phenotype of transgenic songbirds with altered ...

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Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability [Medical Sciences]

09.06.2015 | Qi Qi; Dean Y. Li; Hongbo R. Luo; Kun-Liang Guan; Keqiang Ye, Proceedings of the National Academy of Sciences current issue, 2015

Yes-associated protein (YAP), a transcription coactivator, is the major downstream effector of the Hippo pathway, which plays a critical role in organ size control and cancer development. However, how YAP is regulated by extracellular stimuli in tumorigenesis remains incompletely understood. ...

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Transcription factor PRDM8 is required for rod bipolar and type 2 OFF-cone bipolar cell survival and amacrine subtype identity [Developmental Biology]

09.06.2015 | Cynthia C. Jung; Denize Atan; David Ng; Lynda Ploder; Sarah E. Ross; Martin Klein; David G. Birch; Eduardo Diez; Rod ..., Proceedings of the National Academy of Sciences current issue, 2015

Retinal bipolar (BP) cells mediate the earliest steps in image processing in the visual system, but the genetic pathways that regulate their development and function are incompletely known. We identified PRDI-BF1 and RIZ homology domain containing 8 (PRDM8) as a highly conserved transcription ...

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Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition [Medical Sciences]

09.06.2015 | Tung-Hung Su; Chung-Wai Shiau; Ping Jao; Chen-Hua Liu; Chun-Jen Liu; Wei-Tien Tai; Yung-Ming Jeng; Hung-Chih Yang; T ..., Proceedings of the National Academy of Sciences current issue, 2015

Signal transducer and activator of transcription 3 (STAT3) had been involved in liver fibrogenesis. We aimed to explore the antifibrotic activities of sorafenib and its derivative SC-1 (devoid of Raf kinase inhibition activity) both in vivo and in vitro with special focus on the STAT3 pathway in ...

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Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3high regulatory T cells in humans [Immunology and Inflammation]

09.06.2015 | Makoto Miyara; Driss Chader; Edouard Sage; Daisuke Sugiyama; Hiroyoshi Nishikawa; Diane Bouvry; Laetitia Claër; Ravi ..., Proceedings of the National Academy of Sciences current issue, 2015

CD4+ regulatory T (Treg) cells expressing CD25 and the transcription factor forkhead box P3 (FOXP3) are indispensable for immunological self-tolerance and homeostasis. FOXP3+CD25+CD4+ T cells in humans, however, are heterogeneous in function and differentiation status, including suppressive or ...

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Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA [Biochemistry]

09.06.2015 | Elizabeth A. Hubin; Aline Tabib-Salazar; Laurence J. Humphrey; Joshua E. Flack; Paul Dominic B. Olinares; Seth A. Da ..., Proceedings of the National Academy of Sciences current issue, 2015

Gene expression is highly regulated at the step of transcription initiation, and transcription activators play a critical role in this process. RbpA, an actinobacterial transcription activator that is essential in Mycobacterium tuberculosis (Mtb), binds selectively to group 1 and certain group 2 ...

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