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733 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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SPX1 is a phosphate-dependent inhibitor of PHOSPHATE STARVATION RESPONSE 1 in Arabidopsis [Plant Biology]

14.10.2014 | María Isabel Puga; Isabel Mateos; Rajulu Charukesi; Zhiye Wang; José M. Franco-Zorrilla; Laura de Lorenzo; María L. ..., Proceedings of the National Academy of Sciences current issue, 2014

To cope with growth in low-phosphate (Pi) soils, plants have evolved adaptive responses that involve both developmental and metabolic changes. PHOSPHATE STARVATION RESPONSE 1 (PHR1) and related transcription factors play a central role in the control of Pi starvation responses (PSRs). How Pi ...

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Structural basis of cellular dNTP regulation by SAMHD1 [Biochemistry]

14.10.2014 | Xiaoyun Ji; Chenxiang Tang; Qi Zhao; Wei Wang; Yong Xiong, Proceedings of the National Academy of Sciences current issue, 2014

The sterile alpha motif and HD domain-containing protein 1 (SAMHD1), a dNTPase, prevents the infection of nondividing cells by retroviruses, including HIV, by depleting the cellular dNTP pool available for viral reverse transcription. SAMHD1 is a major regulator of cellular dNTP levels in ...

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Precisely modulated pathogenicity island interference with late phage gene transcription [Microbiology]

07.10.2014 | Geeta Ram; John Chen; Hope F. Ross; Richard P. Novick, Proceedings of the National Academy of Sciences current issue, 2014

Having gone to great evolutionary lengths to develop resistance to bacteriophages, bacteria have come up with resistance mechanisms directed at every aspect of the bacteriophage life cycle. Most genes involved in phage resistance are carried by plasmids and other mobile genetic elements, ...

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Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses [Microbiology]

07.10.2014 | Christian Königer; Ida Wingert; Moritz Marsmann; Christine Rösler; Jürgen Beck; Michael Nassal, Proceedings of the National Academy of Sciences current issue, 2014

Hepatitis B virus (HBV), the causative agent of chronic hepatitis B and prototypic hepadnavirus, is a small DNA virus that replicates by protein-primed reverse transcription. The product is a 3-kb relaxed circular DNA (RC-DNA) in which one strand is linked to the viral polymerase (P protein) ...

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Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease [Cell Biology]

07.10.2014 | Yuming Wang; Probir Chakravarty; Michael Ranes; Gavin Kelly; Philip J. Brooks; Edward Neilan; Aengus Stewart; Giampi ..., Proceedings of the National Academy of Sciences current issue, 2014

Cockayne syndrome (CS) is a multisystem disorder with severe neurological symptoms. The majority of CS patients carry mutations in Cockayne syndrome group B (CSB), best known for its role in transcription-coupled nucleotide excision repair. Indeed, because various repair pathways are compromised ...

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p53 suppression partially rescues the mutant phenotype in mouse models of DiGeorge syndrome [Developmental Biology]

16.09.2014 | Cinzia Caprio; Antonio Baldini, Proceedings of the National Academy of Sciences current issue, 2014

T-box 1 (Tbx1), a gene encoding a T-box transcription factor, is required for embryonic development in humans and mice. Half dosage of this gene in humans causes most of the features of the DiGeorge or Velocardiofacial syndrome phenotypes, including aortic arch and cardiac outflow tract ...

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C-terminal domain small phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation [Neuroscience]

16.09.2014 | Edmund Nesti; Glen M. Corson; Maxwell McCleskey; Jon A. Oyer; Gail Mandel, Proceedings of the National Academy of Sciences current issue, 2014

The repressor element 1 (RE1) silencing transcription factor (REST) in stem cells represses hundreds of genes essential to neuronal function. During neurogenesis, REST is degraded in neural progenitors to promote subsequent elaboration of a mature neuronal phenotype. Prior studies indicate that ...

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One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities [Microbiology]

16.09.2014 | Lorenzo Subissi; Clara C. Posthuma; Axelle Collet; Jessika C. Zevenhoven-Dobbe; Alexander E. Gorbalenya; Etienne Dec ..., Proceedings of the National Academy of Sciences current issue, 2014

In addition to members causing milder human infections, the Coronaviridae family includes potentially lethal zoonotic agents causing severe acute respiratory syndrome (SARS) and the recently emerged Middle East respiratory syndrome. The ∼30-kb positive-stranded RNA genome of coronaviruses encodes ...

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Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET [Cell Biology]

16.09.2014 | Erinn B. Rankin; Katherine C. Fuh; Laura Castellini; Kartik Viswanathan; Elizabeth C. Finger; Anh N. Diep; Edward L. ..., Proceedings of the National Academy of Sciences current issue, 2014

Dysregulation of the von Hippel–Lindau/hypoxia-inducible transcription factor (HIF) signaling pathway promotes clear cell renal cell carcinoma (ccRCC) progression and metastasis. The protein kinase GAS6/AXL signaling pathway has recently been implicated as an essential mediator of metastasis and ...

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Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for {beta}-globin gene expression [Biochemistry]

16.09.2014 | Shefali Soni; Nikolay Pchelintsev; Peter D. Adams; James J. Bieker, Proceedings of the National Academy of Sciences current issue, 2014

The binding of chromatin-associated proteins and incorporation of histone variants correlates with alterations in gene expression. These changes have been particularly well analyzed at the mammalian β-globin locus, where transcription factors such as erythroid Krüppel-like factor (EKLF), which is ...

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