Meine Merkliste
my.bionity.com  
Login  

927 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

rss
mit folgenden Suchkriterien:

Interallelic interaction and gene regulation in budding yeast [Genetics]

19.04.2016 | Daoyong Zhang; Lu Bai, Proceedings of the National Academy of Sciences current issue, 2016

In Drosophila, homologous chromosome pairing leads to “transvection,” in which the enhancer of a gene can regulate the allelic transcription in trans. Interallelic interactions were also observed in vegetative diploid budding yeast, but their functional significance is unknown. Here, we show that ...

mehr

Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNF{alpha}/NF-{kappa}B response [Biochemistry]

19.04.2016 | Anja Reintjes; Julian E. Fuchs; Leopold Kremser; Herbert H. Lindner; Klaus R. Liedl; Lukas A. Huber; Taras Valovka, Proceedings of the National Academy of Sciences current issue, 2016

Nuclear factor kappa B (NF-κB) is an inducible transcription factor that plays critical roles in immune and stress responses and is often implicated in pathologies, including chronic inflammation and cancer. Although much has been learned about NF-κB–activating pathways, the specific repression ...

mehr

Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe [Biochemistry]

19.04.2016 | Rahul Jaiswal; Malay Choudhury; Shamsu Zaman; Samarendra Singh; Vishaka Santosh; Deepak Bastia; Carlos R. Escalante, Proceedings of the National Academy of Sciences current issue, 2016

Reb1 of Schizosaccharomyces pombe represents a family of multifunctional proteins that bind to specific terminator sites (Ter) and cause polar termination of transcription catalyzed by RNA polymerase I (pol I) and arrest of replication forks approaching the Ter sites from the opposite direction. ...

mehr

Structures of E. coli {sigma}S-transcription initiation complexes provide new insights into polymerase mechanism [Biochemistry]

12.04.2016 | Bin Liu; Yuhong Zuo; Thomas A. Steitz, Proceedings of the National Academy of Sciences current issue, 2016

In bacteria, multiple σ factors compete to associate with the RNA polymerase (RNAP) core enzyme to form a holoenzyme that is required for promoter recognition. During transcription initiation RNAP remains associated with the upstream promoter DNA via sequence-specific interactions between the σ ...

mehr

Rethinking progesterone regulation of female reproductive cyclicity [Physiology]

12.04.2016 | Kaiyu Kubota; Wei Cui; Pramod Dhakal; Michael W. Wolfe; M. A. Karim Rumi; Jay L. Vivian; Katherine F. Roby; Michael ..., Proceedings of the National Academy of Sciences current issue, 2016

The progesterone receptor (PGR) is a ligand-activated transcription factor with key roles in the regulation of female fertility. Much has been learned of the actions of PGR signaling through the use of pharmacologic inhibitors and genetic manipulation, using mouse mutagenesis. Characterization of ...

mehr

GOLDEN 2-LIKE transcription factors for chloroplast development affect ozone tolerance through the regulation of stomatal movement [Plant Biology]

12.04.2016 | Yukari Nagatoshi; Nobutaka Mitsuda; Maki Hayashi; Shin-ichiro Inoue; Eiji Okuma; Akihiro Kubo; Yoshiyuki Murata; Mit ..., Proceedings of the National Academy of Sciences current issue, 2016

Stomatal movements regulate gas exchange, thus directly affecting the efficiency of photosynthesis and the sensitivity of plants to air pollutants such as ozone. The GARP family transcription factors GOLDEN 2-LIKE1 (GLK1) and GLK2 have known functions in chloroplast development. Here, we show ...

mehr

Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2 [Medical Sciences]

05.04.2016 | Daniel J. Hodson; Arthur L. Shaffer; Wenming Xiao; George W. Wright; Roland Schmitz; James D. Phelan; Yandan Yang; D ..., Proceedings of the National Academy of Sciences current issue, 2016

The requirement for the B-cell transcription factor OCT2 (octamer-binding protein 2, encoded by Pou2f2) in germinal center B cells has proved controversial. Here, we report that germinal center B cells are formed normally after depletion of OCT2 in a conditional knockout mouse, but their ...

mehr

Putative oncogene Brachyury (T) is essential to specify cell fate but dispensable for notochord progenitor proliferation and EMT [Developmental Biology]

05.04.2016 | Jianjian Zhu; Kin Ming Kwan; Susan Mackem, Proceedings of the National Academy of Sciences current issue, 2016

The transcription factor Brachyury (T) gene is expressed throughout primary mesoderm (primitive streak and notochord) during early embryonic development and has been strongly implicated in the genesis of chordoma, a sarcoma of notochord cell origin. Additionally, T expression has been found in ...

mehr

Identification of three LRR-RKs involved in perception of root meristem growth factor in Arabidopsis [Plant Biology]

05.04.2016 | Hidefumi Shinohara; Ayaka Mori; Naoko Yasue; Kumiko Sumida; Yoshikatsu Matsubayashi, Proceedings of the National Academy of Sciences current issue, 2016

A peptide hormone, root meristem growth factor (RGF), regulates root meristem development through the PLETHORA (PLT) stem cell transcription factor pathway, but it remains to be uncovered how extracellular RGF signals are transduced to the nucleus. Here we identified, using a combination of a ...

mehr

Epigenome confrontation triggers immediate reprogramming of DNA methylation and transposon silencing in Arabidopsis thaliana F1 epihybrids [Plant Biology]

05.04.2016 | Mélanie Rigal; Claude Becker; Thierry Pélissier; Romain Pogorelcnik; Jane Devos; Yoko Ikeda; Detlef Weigel; Olivier ..., Proceedings of the National Academy of Sciences current issue, 2016

Genes and transposons can exist in variable DNA methylation states, with potentially differential transcription. How these epialleles emerge is poorly understood. Here, we show that crossing an Arabidopsis thaliana plant with a hypomethylated genome and a normally methylated WT individual ...

mehr

Seite 1 von 93
Suche per e-Mail abonnieren

Sie erhalten passend zu Ihrer Suche die neusten Suchergebnisse per E-Mail. Dieser Service ist für Sie kostenlos und kann jederzeit abbestellt werden.

Ihr Bowser ist nicht aktuell. Microsoft Internet Explorer 6.0 unterstützt einige Funktionen auf Chemie.DE nicht.