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767 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Structural basis for transcription reactivation by RapA [Biochemistry]

17.02.2015 | Bin Liu; Yuhong Zuo; Thomas A. Steitz, Proceedings of the National Academy of Sciences current issue, 2015

RNA polymerase (RNAP) loses activity during transcription as it stalls at various inactive states due to erratic translocation. Reactivation of these stalled RNAPs is essential for efficient RNA synthesis. Here we report a 4.7-Å resolution crystal structure of the Escherichia coli RNAP core ...

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Retraction for Zhang et al., Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex [Retractions]

17.02.2015 | Proceedings of the National Academy of Sciences current issue, 2015

CELL BIOLOGY Retraction for “Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex,” by Qinghong Zhang, Su-Yan Wang, Capucine Fleuriel, Dominique Leprince, Jonathan V. Rocheleau, David W. Piston, and Richard H. Goodman, which appeared in issue 3, January 16, 2007, of ...

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Distinct pathways of RNA polymerase regulation by a phage-encoded factor [Biochemistry]

17.02.2015 | Daria Esyunina; Evgeny Klimuk; Konstantin Severinov; Andrey Kulbachinskiy, Proceedings of the National Academy of Sciences current issue, 2015

Transcription antitermination is a common strategy of gene expression regulation, but only a few transcription antitermination factors have been studied in detail. Here, we dissect the transcription antitermination mechanism of Xanthomonas oryzae virus Xp10 protein p7, which binds host RNA ...

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Network-based metaanalysis identifies HNF4A and PTBP1 as longitudinally dynamic biomarkers for Parkinson's disease [Neuroscience]

17.02.2015 | Jose A. Santiago; Judith A. Potashkin, Proceedings of the National Academy of Sciences current issue, 2015

Environmental and genetic factors are likely to be involved in the pathogenesis of Parkinson’s disease (PD), the second most prevalent neurodegenerative disease among the elderly. Network-based metaanalysis of four independent microarray studies identified the hepatocyte nuclear factor 4 alpha ...

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Bordetella pertussis fim3 gene regulation by BvgA: Phosphorylation controls the formation of inactive vs. active transcription complexes [Biochemistry]

10.02.2015 | Alice Boulanger; Kyung Moon; Kimberly B. Decker; Qing Chen; Leslie Knipling; Scott Stibitz; Deborah M. Hinton, Proceedings of the National Academy of Sciences current issue, 2015

Two-component systems [sensor kinase/response regulator (RR)] are major tools used by microorganisms to adapt to environmental conditions. RR phosphorylation is typically required for gene activation, but few studies have addressed how and if phosphorylation affects specific steps during ...

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MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells [Cell Biology]

03.02.2015 | Diego Ploper; Vincent F. Taelman; Lidia Robert; Brian S. Perez; Björn Titz; Hsiao-Wang Chen; Thomas G. Graeber; Erik ..., Proceedings of the National Academy of Sciences current issue, 2015

Canonical Wnt signaling plays an important role in development and disease, regulating transcription of target genes and stabilizing many proteins phosphorylated by glycogen synthase kinase 3 (GSK3). We observed that the MiT family of transcription factors, which includes the melanoma oncogene ...

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Endostatin: A novel inhibitor of androgen receptor function in prostate cancer [Biochemistry]

03.02.2015 | Joo Hyoung Lee; Tatyana Isayeva; Matthew R. Larson; Anandi Sawant; Ha-Ram Cha; Diptiman Chanda; Igor N. Chesnokov; S ..., Proceedings of the National Academy of Sciences current issue, 2015

Acquired resistance to androgen receptor (AR)-targeted therapies compels the development of novel treatment strategies for castration-resistant prostate cancer (CRPC). Here, we report a profound effect of endostatin on prostate cancer cells by efficient intracellular trafficking, direct ...

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TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin [Genetics]

03.02.2015 | Lavinia Arseni; Manuela Lanzafame; Emmanuel Compe; Paola Fortugno; António Afonso-Barroso; Fiorenzo A. Peverali; Ala ..., Proceedings of the National Academy of Sciences current issue, 2015

Mutations in the XPD subunit of the DNA repair/transcription factor TFIIH result in distinct clinical entities, including the cancer-prone xeroderma pigmentosum (XP) and the multisystem disorder trichothiodystrophy (TTD), which share only cutaneous photosensitivity. Gene-expression profiles of ...

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T box riboswitches in Actinobacteria: Translational regulation via novel tRNA interactions [Genetics]

27.01.2015 | Anna V. Sherwood; Frank J. Grundy; Tina M. Henkin, Proceedings of the National Academy of Sciences current issue, 2015

The T box riboswitch regulates many amino acid-related genes in Gram-positive bacteria. T box riboswitch-mediated gene regulation was shown previously to occur at the level of transcription attenuation via structural rearrangements in the 5′ untranslated (leader) region of the mRNA in response to ...

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Impaired Hippo signaling promotes Rho1-JNK-dependent growth [Developmental Biology]

27.01.2015 | Xianjue Ma; Yujun Chen; Wenyan Xu; Nana Wu; Maoquan Li; Ying Cao; Shian Wu; Qiutang Li; Lei Xue, Proceedings of the National Academy of Sciences current issue, 2015

The Hippo and c-Jun N-terminal kinase (JNK) pathway both regulate growth and contribute to tumorigenesis when dysregulated. Whereas the Hippo pathway acts via the transcription coactivator Yki/YAP to regulate target gene expression, JNK signaling, triggered by various modulators including Rho ...

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