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792 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies [Biochemistry]

07.04.2015 | Tetsuya Kawaguchi; Akie Tanigawa; Takao Naganuma; Yasuyuki Ohkawa; Sylvie Souquere; Gerard Pierron; Tetsuro Hirose, Proceedings of the National Academy of Sciences current issue, 2015

Paraspeckles are subnuclear structures that form around nuclear paraspeckle assembly transcript 1 (NEAT1) long noncoding RNA (lncRNA). Recently, paraspeckles were shown to be functional nuclear bodies involved in stress responses and the development of specific organs. Paraspeckle formation is ...

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Structure of the paramyxovirus parainfluenza virus 5 nucleoprotein-RNA complex [Microbiology]

07.04.2015 | Maher Alayyoubi; George P. Leser; Christopher A. Kors; Robert A. Lamb, Proceedings of the National Academy of Sciences current issue, 2015

Parainfluenza virus 5 (PIV5) is a member of the Paramyxoviridae family of membrane-enveloped viruses with a negative-sense RNA genome that is packaged and protected by long filamentous nucleocapsid-helix structures (RNPs). These RNPs, consisting of ∼2,600 protomers of nucleocapsid (N) protein, ...

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ATM prevents DSB formation by coordinating SSB repair and cell cycle progression [Cell Biology]

31.03.2015 | Svetlana V. Khoronenkova; Grigory L. Dianov, Proceedings of the National Academy of Sciences current issue, 2015

DNA single-strand breaks (SSBs) arise as a consequence of spontaneous DNA instability and are also formed as DNA repair intermediates. Their repair is critical because they otherwise terminate gene transcription and generate toxic DNA double-strand breaks (DSBs) on replication. To prevent the ...

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Silencing of end-joining repair for efficient site-specific gene insertion after TALEN/CRISPR mutagenesis in Aedes aegypti [Genetics]

31.03.2015 | Sanjay Basu; Azadeh Aryan; Justin M. Overcash; Glady Hazitha Samuel; Michelle A. E. Anderson; Timothy J. Dahlem; Kev ..., Proceedings of the National Academy of Sciences current issue, 2015

Conventional control strategies for mosquito-borne pathogens such as malaria and dengue are now being complemented by the development of transgenic mosquito strains reprogrammed to generate beneficial phenotypes such as conditional sterility or pathogen resistance. The widespread success of ...

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TALE nickase-mediated SP110 knockin endows cattle with increased resistance to tuberculosis [Agricultural Sciences]

31.03.2015 | Haibo Wu; Yongsheng Wang; Yan Zhang; Mingqi Yang; Jiaxing Lv; Jun Liu; Yong Zhang, Proceedings of the National Academy of Sciences current issue, 2015

Transcription activator-like effector nuclease (TALEN)-mediated genome modification has been applied successfully to create transgenic animals in various species, such as mouse, pig, and even monkey. However, transgenic cattle with gene knockin have yet to be created using TALENs. Here, we report ...

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Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages [Medical Sciences]

31.03.2015 | James Scott McClellan; Christopher Dove; Andrew J. Gentles; Christine E. Ryan; Ravindra Majeti, Proceedings of the National Academy of Sciences current issue, 2015

BCR–ABL1+ precursor B-cell acute lymphoblastic leukemia (BCR–ABL1+ B-ALL) is an aggressive hematopoietic neoplasm characterized by a block in differentiation due in part to the somatic loss of transcription factors required for B-cell development. We hypothesized that overcoming this ...

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Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas [Medical Sciences]

31.03.2015 | M. Kyle Cromer; Murim Choi; Carol Nelson-Williams; Annabelle L. Fonseca; John W. Kunstman; Reju M. Korah; John D. Ov ..., Proceedings of the National Academy of Sciences current issue, 2015

Insulinomas are pancreatic islet tumors that inappropriately secrete insulin, producing hypoglycemia. Exome and targeted sequencing revealed that 14 of 43 insulinomas harbored the identical somatic mutation in the DNA-binding zinc finger of the transcription factor Yin Yang 1 (YY1). Chromatin ...

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STAT3-driven transcription depends upon the dimethylation of K49 by EZH2 [Cell Biology]

31.03.2015 | Maupali Dasgupta; Josephine Kam Tai Dermawan; Belinda Willard; George R. Stark, Proceedings of the National Academy of Sciences current issue, 2015

Several transcription factors, including p53, NF-κB, and STAT3, are modified by the same enzymes that also modify histones, with important functional consequences. We have identified a previously unrecognized dimethylation of K49 of STAT3 that is crucial for the expression of many IL-6–dependent ...

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Identification of FOXO targets that generate diverse features of the diapause phenotype in the mosquito Culex pipiens [Physiology]

24.03.2015 | Cheolho Sim; David S. Kang; Sungshil Kim; Xiaodong Bai; David L. Denlinger, Proceedings of the National Academy of Sciences current issue, 2015

Insulin and juvenile hormone signaling direct entry of the mosquito Culex pipiens into its overwintering adult diapause, and these two critical signaling pathways appear to do so by converging on the regulation of forkhead transcription factor (FOXO). Diapause is a complex phenotype, and FOXO ...

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Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing [Medical Sciences]

17.03.2015 | Saravana P. Selvanathan; Garrett T. Graham; Hayriye V. Erkizan; Uta Dirksen; Thanemozhi G. Natarajan; Aleksandra Dak ..., Proceedings of the National Academy of Sciences current issue, 2015

The synthesis and processing of mRNA, from transcription to translation initiation, often requires splicing of intragenic material. The final mRNA composition varies based on proteins that modulate splice site selection. EWS-FLI1 is an Ewing sarcoma (ES) oncoprotein with an interactome that we ...

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