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700 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Burkholderia pseudomallei suppresses Caenorhabditis elegans immunity by specific degradation of a GATA transcription factor [Microbiology]

10.09.2013 | Song-Hua Lee; Rui-Rui Wong; Chui-Yoke Chin; Tian-Yeh Lim; Su-Anne Eng; Cin Kong; Nur Afifah Ijap; Ming-Seong Lau; Me ..., Proceedings of the National Academy of Sciences current issue, 2013

Burkholderia pseudomallei is a Gram-negative soil bacterium that infects both humans and animals. Although cell culture studies have revealed significant insights into factors contributing to virulence and host defense, the interactions between this pathogen and its intact host remain to be ...

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The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells [Immunology]

10.09.2013 | Friederike Raczkowski; Josephine Ritter; Kira Heesch; Valéa Schumacher; Anna Guralnik; Lena Höcker; Hartmann Raifer; ..., Proceedings of the National Academy of Sciences current issue, 2013

Robust cytotoxic CD8+ T-cell response is important for immunity to intracellular pathogens. Here, we show that the transcription factor IFN Regulatory Factor 4 (IRF4) is crucial for the protective CD8+ T-cell response to the intracellular bacterium Listeria monocytogenes. IRF4-deficient (Irf4−/−) ...

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Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle [Biochemistry]

03.09.2013 | Rebecca Gupte; Ginger W. Muse; Yurii Chinenov; Karen Adelman; Inez Rogatsky, Proceedings of the National Academy of Sciences current issue, 2013

Widespread anti-inflammatory actions of glucocorticoid hormones are mediated by the glucocorticoid receptor (GR), a ligand-dependent transcription factor of the nuclear receptor superfamily. In conjunction with its corepressor GR-interacting protein-1 (GRIP1), GR tethers to the DNA-bound ...

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Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells [Cell Biology]

03.09.2013 | Anniina Vihervaara; Christian Sergelius; Jenni Vasara; Malin A. H. Blom; Alexandra N. Elsing; Pia Roos-Mattjus; Lea ..., Proceedings of the National Academy of Sciences current issue, 2013

Heat shock factors (HSFs) are the master regulators of transcription under protein-damaging conditions, acting in an environment where the overall transcription is silenced. We determined the genomewide transcriptional program that is rapidly provoked by HSF1 and HSF2 under acute stress in human ...

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Attenuation of the posttranslational oscillator via transcription-translation feedback enhances circadian-phase shifts in Synechococcus [Plant Biology]

27.08.2013 | Norimune Hosokawa; Hiroko Kushige; Hideo Iwasaki, Proceedings of the National Academy of Sciences current issue, 2013

Circadian rhythms are endogenous biological timing processes that are ubiquitous in organisms ranging from cyanobacteria to humans. In the photoautotrophic unicellular cyanobacterium Synechococcus elongatus PCC 7942, under continuous light (LL) conditions, the transcription–translation feedback ...

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Transcription termination controls prophage maintenance in Escherichia coli genomes [Microbiology]

27.08.2013 | Rachid Menouni; Stéphanie Champ; Leon Espinosa; Marc Boudvillain; Mireille Ansaldi, Proceedings of the National Academy of Sciences current issue, 2013

Prophages represent a large fraction of prokaryotic genomes and often provide new functions to their hosts, in particular virulence and fitness. How prokaryotic cells maintain such gene providers is central for understanding bacterial genome evolution by horizontal transfer. Prophage excision ...

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Subset of heat-shock transcription factors required for the early response of Arabidopsis to excess light [Plant Biology]

27.08.2013 | Hou-Sung Jung; Peter A. Crisp; Gonzalo M. Estavillo; Benjamin Cole; Fangxin Hong; Todd C. Mockler; Barry J. Pogson; ..., Proceedings of the National Academy of Sciences current issue, 2013

Sunlight provides energy for photosynthesis and is essential for nearly all life on earth. However, too much or too little light or rapidly fluctuating light conditions cause stress to plants. Rapid changes in the amount of light are perceived as a change in the reduced/oxidized (redox) state of ...

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T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance [Immunology]

20.08.2013 | Kira Rubtsova; Anatoly V. Rubtsov; Linda F. van Dyk; John W. Kappler; Philippa Marrack, Proceedings of the National Academy of Sciences current issue, 2013

IgG2a is known to be the most efficient antibody isotype for viral clearance. Here, we demonstrate a unique pathway of B-cell activation, leading to IgG2a production, and involving synergistic stimulation via B-cell antigen receptors, toll-like receptor 7 (TLR7), and IFNγ receptors on B cells. ...

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Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells [Immunology]

20.08.2013 | Lewis Zhichang Shi; Nishan S. Kalupahana; Meghan E. Turnis; Geoffrey Neale; Hanno Hock; Dario A. A. Vignali; Hongbo Chi, Proceedings of the National Academy of Sciences current issue, 2013

Foxp3+ regulatory T (Treg) cells are essential for the maintenance of self-tolerance and immune homeostasis. The majority of Treg cells is generated in the thymus as a specific subset of CD4+ T cells, known as thymus-derived or natural Treg (nTreg) cells, in response to signals from T-cell ...

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Mod5 protein binds to tRNA gene complexes and affects local transcriptional silencing [Biochemistry]

13.08.2013 | Matthew Pratt-Hyatt; Dave A. Pai; Rebecca A. Haeusler; Glenn G. Wozniak; Paul D. Good; Erin L. Miller; Ian X. McLeod ..., Proceedings of the National Academy of Sciences current issue, 2013

The tRNA gene-mediated (tgm) silencing of RNA polymerase II promoters is dependent on subnuclear clustering of the tRNA genes, but genetic analysis shows that the silencing requires additional mechanisms. We have identified proteins that bind tRNA gene transcription complexes and are required for ...

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