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901 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Unstable FoxP3+ T regulatory cells in NZW mice [Immunology and Inflammation]

02.02.2016 | Fabien Dépis; Ho-Keun Kwon; Diane Mathis; Christophe Benoist, Proceedings of the National Academy of Sciences current issue, 2016

Regulatory T (Treg) cells that express the transcription factor FoxP3 play a key role in self-tolerance and the control of inflammation. In mice and humans, there is a wide interindividual range in Treg frequency, but little is known about the underlying genetic or epigenetic mechanisms. We ...

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GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepression [Pharmacology]

02.02.2016 | Guoqiang Hua; Laetitia Paulen; Pierre Chambon, Proceedings of the National Academy of Sciences current issue, 2016

Unique among the nuclear receptor superfamily, the glucocorticoid (GC) receptor (GR) can exert three distinct transcriptional regulatory functions on binding of a single natural (cortisol in human and corticosterone in mice) and synthetic [e.g., dexamethasone (Dex)] hormone. The molecular ...

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Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1 [Immunology and Inflammation]

02.02.2016 | Joseph D. Dekker; Daechan Park; Arthur L. Shaffer III; Holger Kohlhammer; Wei Deng; Bum-Kyu Lee; Gregory C. Ippolito ..., Proceedings of the National Academy of Sciences current issue, 2016

High expression of the forkhead box P1 (FOXP1) transcription factor distinguishes the aggressive activated B cell (ABC) diffuse large B-cell lymphoma (DLBCL) subtype from the better prognosis germinal center B-cell (GCB)-DLBCL subtype and is highly correlated with poor outcomes. A genetic or ...

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Antagonistic roles for the ubiquitin ligase Asr1 and the ubiquitin-specific protease Ubp3 in subtelomeric gene silencing [Genetics]

02.02.2016 | Tyler S. McCann; Yan Guo; W. Hayes McDonald; William P. Tansey, Proceedings of the National Academy of Sciences current issue, 2016

Ubiquitin, and components of the ubiquitin–proteasome system, feature extensively in the regulation of gene transcription. Although there are many examples of how ubiquitin controls the activity of transcriptional regulators and coregulators, there are few examples of core components of the ...

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SutA is a bacterial transcription factor expressed during slow growth in Pseudomonas aeruginosa [Microbiology]

02.02.2016 | Brett M. Babin; Megan Bergkessel; Michael J. Sweredoski; Annie Moradian; Sonja Hess; Dianne K. Newman; David A. Tirrell, Proceedings of the National Academy of Sciences current issue, 2016

Microbial quiescence and slow growth are ubiquitous physiological states, but their study is complicated by low levels of metabolic activity. To address this issue, we used a time-selective proteome-labeling method [bioorthogonal noncanonical amino acid tagging (BONCAT)] to identify proteins ...

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Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans [Developmental Biology]

02.02.2016 | Carles Gaston-Massuet; Mark J. McCabe; Valeria Scagliotti; Rodrigo M. Young; Gabriela Carreno; Louise C. Gregory; Su ..., Proceedings of the National Academy of Sciences current issue, 2016

Aberrant embryonic development of the hypothalamus and/or pituitary gland in humans results in congenital hypopituitarism (CH). Transcription factor 7-like 1 (TCF7L1), an important regulator of the WNT/β-catenin signaling pathway, is expressed in the developing forebrain and pituitary gland, but ...

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Bacterial RNA polymerase can retain {sigma}70 throughout transcription [Biochemistry]

19.01.2016 | Timothy T. Harden; Christopher D. Wells; Larry J. Friedman; Robert Landick; Ann Hochschild; Jane Kondev; Jeff Gelles, Proceedings of the National Academy of Sciences current issue, 2016

Production of a messenger RNA proceeds through sequential stages of transcription initiation and transcript elongation and termination. During each of these stages, RNA polymerase (RNAP) function is regulated by RNAP-associated protein factors. In bacteria, RNAP-associated σ factors are strictly ...

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Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis [Medical Sciences]

19.01.2016 | Olaia A. Martínez-Iglesias; Elvira Alonso-Merino; Sara Gómez-Rey; Juan Pedro Velasco-Martín; Rosa Martín Orozco; Enr ..., Proceedings of the National Academy of Sciences current issue, 2016

Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leading to transcriptional repression. We show here that NCoR depletion enhances cancer cell invasion and increases tumor growth and metastatic potential in nude mice. These changes are related to ...

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Correction for Yan et al., Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3 [Corrections]

12.01.2016 | Proceedings of the National Academy of Sciences current issue, 2016

IMMUNOLOGY AND INFLAMMATION Correction for “Imbalanced signal transduction in regulatory T cells expressing the transcription factor FoxP3,” by Dapeng Yan, Julia Farache, Diane Mathis, and Christophe Benoist, which appeared in issue 48, December 1, 2015, of Proc Natl Acad Sci USA ...

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Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin [Biophysics and Computational Biology]

12.01.2016 | Khaled Elokely; Phanindra Velisetty; Lucie Delemotte; Eugene Palovcak; Michael L. Klein; Tibor Rohacs; Vincenzo Carn ..., Proceedings of the National Academy of Sciences current issue, 2016

The transient receptor potential cation channel subfamily V member 1 (TRPV1) or vanilloid receptor 1 is a nonselective cation channel that is involved in the detection and transduction of nociceptive stimuli. Inflammation and nerve damage result in the up-regulation of TRPV1 transcription, and, ...

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