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782 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing [Medical Sciences]

17.03.2015 | Saravana P. Selvanathan; Garrett T. Graham; Hayriye V. Erkizan; Uta Dirksen; Thanemozhi G. Natarajan; Aleksandra Dak ..., Proceedings of the National Academy of Sciences current issue, 2015

The synthesis and processing of mRNA, from transcription to translation initiation, often requires splicing of intragenic material. The final mRNA composition varies based on proteins that modulate splice site selection. EWS-FLI1 is an Ewing sarcoma (ES) oncoprotein with an interactome that we ...

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Epigenetic modification of the oxytocin receptor gene influences the perception of anger and fear in the human brain [Genetics]

17.03.2015 | Meghan H. Puglia; Travis S. Lillard; James P. Morris; Jessica J. Connelly, Proceedings of the National Academy of Sciences current issue, 2015

In humans, the neuropeptide oxytocin plays a critical role in social and emotional behavior. The actions of this molecule are dependent on a protein that acts as its receptor, which is encoded by the oxytocin receptor gene (OXTR). DNA methylation of OXTR, an epigenetic modification, directly ...

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Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2 [Medical Sciences]

10.03.2015 | Shurei Sugita; Yoko Hosaka; Keita Okada; Daisuke Mori; Fumiko Yano; Hiroshi Kobayashi; Yuki Taniguchi; Yoshifumi Mor ..., Proceedings of the National Academy of Sciences current issue, 2015

Notch signaling modulates skeletal formation and pathogenesis of osteoarthritis (OA) through induction of catabolic factors. Here we examined roles of Hes1, a transcription factor and important target of Notch signaling, in these processes. SRY-box containing gene 9 (Sox9)-Cre mice were mated ...

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Multicolor CRISPR labeling of chromosomal loci in human cells [Cell Biology]

10.03.2015 | Hanhui Ma; Ardalan Naseri; Pablo Reyes-Gutierrez; Scot A. Wolfe; Shaojie Zhang; Thoru Pederson, Proceedings of the National Academy of Sciences current issue, 2015

The intranuclear location of genomic loci and the dynamics of these loci are important parameters for understanding the spatial and temporal regulation of gene expression. Recently it has proven possible to visualize endogenous genomic loci in live cells by the use of transcription activator-like ...

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Histone titration against the genome sets the DNA-to-cytoplasm threshold for the Xenopus midblastula transition [Developmental Biology]

10.03.2015 | Amanda A. Amodeo; David Jukam; Aaron F. Straight; Jan M. Skotheim, Proceedings of the National Academy of Sciences current issue, 2015

During early development, animal embryos depend on maternally deposited RNA until zygotic genes become transcriptionally active. Before this maternal-to-zygotic transition, many species execute rapid and synchronous cell divisions without growth phases or cell cycle checkpoints. The coordinated ...

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Transcription factor interaction with COMPASS-like complex regulates histone H3K4 trimethylation for specific gene expression in plants [Plant Biology]

03.03.2015 | Ze-Ting Song; Le Sun; Sun-Jie Lu; Yongke Tian; Yong Ding; Jian-Xiang Liu, Proceedings of the National Academy of Sciences current issue, 2015

Accumulation of unfolded or misfolded proteins causes endoplasmic reticulum (ER) stress, which activates a set of ER membrane-associated transcription factors for protein homeostasis regulation. Previous genome-wide chromatin immunoprecipitation analysis shows a strong correlation between histone ...

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Rectifying RNA splicing errors in hereditary neurodegenerative disease [Cell Biology]

03.03.2015 | Maurice S. Swanson, Proceedings of the National Academy of Sciences current issue, 2015

The normal pattern of human gene expression requires precise coordination between the transcriptional and RNA processing machineries (1). During and following transcription, nascent RNAs may be modified by 5′-end capping, splicing, and 3′-end cleavage/polyadenylation to generate the vast ...

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Constraints on the evolution of a doublesex target gene arising from doublesex's pleiotropic deployment [Genetics]

24.02.2015 | Shengzhan D. Luo; Bruce S. Baker, Proceedings of the National Academy of Sciences current issue, 2015

“Regulatory evolution,” that is, changes in a gene’s expression pattern through changes at its regulatory sequence, rather than changes at the coding sequence of the gene or changes of the upstream transcription factors, has been increasingly recognized as a pervasive evolution mechanism. Many ...

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Structural basis for transcription reactivation by RapA [Biochemistry]

17.02.2015 | Bin Liu; Yuhong Zuo; Thomas A. Steitz, Proceedings of the National Academy of Sciences current issue, 2015

RNA polymerase (RNAP) loses activity during transcription as it stalls at various inactive states due to erratic translocation. Reactivation of these stalled RNAPs is essential for efficient RNA synthesis. Here we report a 4.7-Å resolution crystal structure of the Escherichia coli RNAP core ...

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Retraction for Zhang et al., Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex [Retractions]

17.02.2015 | Proceedings of the National Academy of Sciences current issue, 2015

CELL BIOLOGY Retraction for “Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex,” by Qinghong Zhang, Su-Yan Wang, Capucine Fleuriel, Dominique Leprince, Jonathan V. Rocheleau, David W. Piston, and Richard H. Goodman, which appeared in issue 3, January 16, 2007, of ...

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