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361 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Reply to Tichenor: Proposed update to beef greenhouse gas footprint is numerically questionable and well within current uncertainty bounds [Physical Sciences]

24.02.2015 | Gidon Eshel; Alon Shepon; Tamar Makov; Ron Milo, Proceedings of the National Academy of Sciences current issue, 2015

We thank Tichenor (1) for the attention to our paper (2). In it, we repeatedly stress the need for augmented and more refined data, and it is in this spirit we welcome Tichenor’s letter. However, as shown in Fig. 1, Tichenor’s approach, based on analyzing a single farm in Sweden...

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Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress [Neuroscience]

24.02.2015 | Benjamin D. Sachs; Jason R. Ni; Marc G. Caron, Proceedings of the National Academy of Sciences current issue, 2015

Brain serotonin (5-HT) deficiency and exposure to psychosocial stress have both been implicated in the etiology of depression and anxiety disorders, but whether 5-HT deficiency influences susceptibility to depression- and anxiety-like phenotypes induced by psychosocial stress has not been ...

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Gustatory and metabolic perception of nutrient stress in Drosophila [Neuroscience]

24.02.2015 | Nancy J. Linford; Jennifer Ro; Brian Y. Chung; Scott D. Pletcher, Proceedings of the National Academy of Sciences current issue, 2015

Sleep loss is an adaptive response to nutrient deprivation that alters behavior to maximize the chances of feeding before imminent death. Organisms must maintain systems for detecting the quality of the food source to resume healthy levels of sleep when the stress is alleviated. We determined ...

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Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome [Neuroscience]

20.01.2015 | Meiyu Xu; Andrew Kobets; Jung-Chieh Du; Jessica Lennington; Lina Li; Mounira Banasr; Ronald S. Duman; Flora M. Vacca ..., Proceedings of the National Academy of Sciences current issue, 2015

Gilles de la Tourette syndrome (TS) is characterized by tics, which are transiently worsened by stress, acute administration of dopaminergic drugs, and by subtle deficits in motor coordination and sensorimotor gating. It represents the most severe end of a spectrum of tic disorders that, in ...

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Direct measurement of oxidative and nitrosative stress dynamics in Salmonella inside macrophages [Microbiology]

13.01.2015 | Joris van der Heijden; Else S. Bosman; Lisa A. Reynolds; B. Brett Finlay, Proceedings of the National Academy of Sciences current issue, 2015

Many significant bacterial pathogens have evolved virulence mechanisms to evade degradation and exposure to reactive oxygen (ROS) and reactive nitrogen species (RNS), allowing them to survive and replicate inside their hosts. Due to the highly reactive and short-lived nature of ROS and RNS, ...

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Reply to Tan et al.: Differences between real and simulated proteins in multiple sequence alignments [Biological Sciences]

13.01.2015 | Kieran Boyce; Fabian Sievers; Desmond G. Higgins, Proceedings of the National Academy of Sciences current issue, 2015

Tan et al. (1) comment on our earlier paper regarding the accuracy of multiple sequence alignments (MSAs) using different guide tree topologies (2). We stress that the scope of our result was confined to alignments of very large numbers of protein sequences with known structures, where accuracy ...

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Nitric oxide negatively regulates abscisic acid signaling in guard cells by S-nitrosylation of OST1 [Plant Biology]

13.01.2015 | Pengcheng Wang; Yanyan Du; Yueh-Ju Hou; Yang Zhao; Chuan-Chih Hsu; Feijuan Yuan; Xiaohong Zhu; W. Andy Tao; Chun-Pen ..., Proceedings of the National Academy of Sciences current issue, 2015

The phytohormone abscisic acid (ABA) plays important roles in plant development and adaptation to environmental stress. ABA induces the production of nitric oxide (NO) in guard cells, but how NO regulates ABA signaling is not understood. Here, we show that NO negatively regulates ABA signaling in ...

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Correction for Hodes et al., Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress [Correction]

30.12.2014 | Proceedings of the National Academy of Sciences current issue, 2014

NEUROSCIENCE Correction for “Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress,” by Georgia E. Hodes, Madeline L. Pfau, Marylene Leboeuf, Sam A. Golden, Daniel J. Christoffel, Dana Bregman, Nicole Rebusi, Mitra Heshmati, Hossein ...

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Identification of a pheromone that increases anxiety in rats [Neuroscience]

30.12.2014 | Hideaki Inagaki; Yasushi Kiyokawa; Shigeyuki Tamogami; Hidenori Watanabe; Yukari Takeuchi; Yuji Mori, Proceedings of the National Academy of Sciences current issue, 2014

Chemical communication plays an important role in the social lives of various mammalian species. Some of these chemicals are called pheromones. Rats release a specific odor into the air when stressed. This stress-related odor increases the anxiety levels of other rats; therefore, it is possible ...

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Responses to social and environmental stress are attenuated by strong male bonds in wild macaques [Anthropology]

23.12.2014 | Christopher Young; Bonaventura Majolo; Michael Heistermann; Oliver Schülke; Julia Ostner, Proceedings of the National Academy of Sciences current issue, 2014

In humans and obligatory social animals, individuals with weak social ties experience negative health and fitness consequences. The social buffering hypothesis conceptualizes one possible mediating mechanism: During stressful situations the presence of close social partners buffers against the ...

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