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384 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Inverted formin 2 in focal adhesions promotes dorsal stress fiber and fibrillar adhesion formation to drive extracellular matrix assembly [Cell Biology]

12.05.2015 | Colleen T. Skau; Sergey V. Plotnikov; Andrew D. Doyle; Clare M. Waterman, Proceedings of the National Academy of Sciences current issue, 2015

Actin filaments and integrin-based focal adhesions (FAs) form integrated systems that mediate dynamic cell interactions with their environment or other cells during migration, the immune response, and tissue morphogenesis. How adhesion-associated actin structures obtain their functional ...

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Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae [Genetics]

12.05.2015 | Hugo Tapia; Lindsey Young; Douglas Fox; Carolyn R. Bertozzi; Douglas Koshland, Proceedings of the National Academy of Sciences current issue, 2015

Diverse organisms capable of surviving desiccation, termed anhydrobiotes, include species from bacteria, yeast, plants, and invertebrates. However, most organisms are sensitive to desiccation, likely due to an assortment of different stresses such as protein misfolding and aggregation, ...

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Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level [Medical Sciences]

12.05.2015 | Toshihide Takeuchi; Mari Suzuki; Nobuhiro Fujikake; H. Akiko Popiel; Hisae Kikuchi; Shiroh Futaki; Keiji Wada; Yoshi ..., Proceedings of the National Academy of Sciences current issue, 2015

The heat shock response (HSR), a transcriptional response that up-regulates molecular chaperones upon heat shock, is necessary for cell survival in a stressful environment to maintain protein homeostasis (proteostasis). However, there is accumulating evidence that the HSR does not ubiquitously ...

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Plastid-produced interorgannellar stress signal MEcPP potentiates induction of the unfolded protein response in endoplasmic reticulum [Plant Biology]

12.05.2015 | Justin Walley; Yanmei Xiao; Jin-Zheng Wang; Edward E. Baidoo; Jay D. Keasling; Zhouxin Shen; Steven P. Briggs; Katay ..., Proceedings of the National Academy of Sciences current issue, 2015

Cellular homeostasis in response to internal and external stimuli requires a tightly coordinated interorgannellar communication network. We recently identified methylerythritol cyclodiphosphate (MEcPP) as a novel stress-specific retrograde signaling metabolite that accumulates in response to ...

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Emergence of homeostatic epithelial packing and stress dissipation through divisions oriented along the long cell axis [Developmental Biology]

05.05.2015 | Tom P. J. Wyatt; Andrew R. Harris; Maxine Lam; Qian Cheng; Julien Bellis; Andrea Dimitracopoulos; Alexandre J. Kabla ..., Proceedings of the National Academy of Sciences current issue, 2015

Cell division plays an important role in animal tissue morphogenesis, which depends, critically, on the orientation of divisions. In isolated adherent cells, the orientation of mitotic spindles is sensitive to interphase cell shape and the direction of extrinsic mechanical forces. In epithelia, ...

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Causal effects of the early caregiving environment on development of stress response systems in children [Psychological and Cognitive Sciences]

05.05.2015 | Katie A. McLaughlin; Margaret A. Sheridan; Florin Tibu; Nathan A. Fox; Charles H. Zeanah; Charles A. Nelson III, Proceedings of the National Academy of Sciences current issue, 2015

Disruptions in stress response system functioning are thought to be a central mechanism by which exposure to adverse early-life environments influences human development. Although early-life adversity results in hyperreactivity of the sympathetic nervous system (SNS) and ...

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Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress [Genetics]

05.05.2015 | Zhiji Ren; Victor R. Ambros, Proceedings of the National Academy of Sciences current issue, 2015

Animals maintain their developmental robustness against natural stresses through numerous regulatory mechanisms, including the posttranscriptional regulation of gene expression by microRNAs (miRNAs). Caenorhabditis elegans miRNAs of the let-7 family (let-7-Fam) function semiredundantly to confer ...

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Potential role for snoRNAs in PKR activation during metabolic stress [Biochemistry]

21.04.2015 | Osama A. Youssef; Sarah A. Safran; Takahisa Nakamura; David A. Nix; Gökhan S. Hotamisligil; Brenda L. Bass, Proceedings of the National Academy of Sciences current issue, 2015

Protein kinase RNA-activated (PKR) has long been known to be activated by viral double-stranded RNA (dsRNA) as part of the mammalian immune response. However, in mice PKR is also activated by metabolic stress in the absence of viral infection, and this requires a functional kinase domain, as well ...

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Stress sigma factor RpoS degradation and translation are sensitive to the state of central metabolism [Microbiology]

21.04.2015 | Aurelia Battesti; Nadim Majdalani; Susan Gottesman, Proceedings of the National Academy of Sciences current issue, 2015

RpoS, the stationary phase/stress sigma factor of Escherichia coli, regulates a large cohort of genes important for the cell to deal with suboptimal conditions. Its level increases quickly in the cell in response to many stresses and returns to low levels when growth resumes. Increased RpoS ...

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Autoinhibition of MDMX by intramolecular p53 mimicry [Biochemistry]

14.04.2015 | Lihong Chen; Wade Borcherds; Shaofang Wu; Andreas Becker; Ernst Schonbrunn; Gary W. Daughdrill; Jiandong Chen, Proceedings of the National Academy of Sciences current issue, 2015

The p53 inhibitor MDMX is controlled by multiple stress signaling pathways. Using a proteolytic fragment release (PFR) assay, we detected an intramolecular interaction in MDMX that mechanistically mimics the interaction with p53, resulting in autoinhibition of MDMX. This mimicry is mediated by a ...

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