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334 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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GABAB(1) receptor subunit isoforms differentially regulate stress resilience [Neuroscience]

21.10.2014 | Olivia F. O’Leary; Daniela Felice; Stefano Galimberti; Hélène M. Savignac; Javier A. Bravo; Tadhg Crowley; Malika El ..., Proceedings of the National Academy of Sciences current issue, 2014

Stressful life events increase the susceptibility to developing psychiatric disorders such as depression; however, many individuals are resilient to such negative effects of stress. Determining the neurobiology underlying this resilience is instrumental to the development of novel and more ...

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KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes [Biochemistry]

21.10.2014 | Dong-In Koh; Dohyun Han; Hoon Ryu; Won-Il Choi; Bu-Nam Jeon; Min-Kyeong Kim; Youngsoo Kim; Jin Young Kim; Lee Parry; ..., Proceedings of the National Academy of Sciences current issue, 2014

An unresolved issue in genotoxic stress response is identification of induced regulatory proteins and how these activate tumor suppressor p53 to determine appropriate cell responses. Transcription factor KAISO was previously described to repress transcription following binding to methylated DNA. ...

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Structural basis of the regulatory mechanism of the plant CIPK family of protein kinases controlling ion homeostasis and abiotic stress [Plant Biology]

21.10.2014 | Antonio Chaves-Sanjuan; Maria Jose Sanchez-Barrena; Juana Maria Gonzalez-Rubio; Maria Moreno; Paula Ragel; Marta Jim ..., Proceedings of the National Academy of Sciences current issue, 2014

Plant cells have developed specific protective molecular machinery against environmental stresses. The family of CBL-interacting protein kinases (CIPK) and their interacting activators, the calcium sensors calcineurin B-like (CBLs), work together to decode calcium signals elicited by stress ...

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Delayed Ras/PKA signaling augments the unfolded protein response [Cell Biology]

14.10.2014 | David Pincus; Andrés Aranda-Díaz; Ignacio A. Zuleta; Peter Walter; Hana El-Samad, Proceedings of the National Academy of Sciences current issue, 2014

During environmental, developmental, or genetic stress, the cell’s folding capacity can become overwhelmed, and misfolded proteins can accumulate in all cell compartments. Eukaryotes evolved the unfolded protein response (UPR) to counteract proteotoxic stress in the endoplasmic reticulum (ER). ...

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Scaling description of the yielding transition in soft amorphous solids at zero temperature [Physics]

07.10.2014 | Jie Lin; Edan Lerner; Alberto Rosso; Matthieu Wyart, Proceedings of the National Academy of Sciences current issue, 2014

Yield stress materials flow if a sufficiently large shear stress is applied. Although such materials are ubiquitous and relevant for industry, there is no accepted microscopic description of how they yield, even in the simplest situations in which temperature is negligible and in which flow ...

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Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes [Neuroscience]

16.09.2014 | Nikolaos P. Daskalakis; Hagit Cohen; Guiqing Cai; Joseph D. Buxbaum; Rachel Yehuda, Proceedings of the National Academy of Sciences current issue, 2014

Delineating the molecular basis of individual differences in the stress response is critical to understanding the pathophysiology and treatment of posttraumatic stress disorder (PTSD). In this study, 7 d after predator-scent-stress (PSS) exposure, male and female rats were classified into ...

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Xylella fastidiosa outer membrane vesicles modulate plant colonization by blocking attachment to surfaces [Microbiology]

16.09.2014 | Michael Ionescu; Paulo A. Zaini; Clelia Baccari; Sophia Tran; Aline M. da Silva; Steven E. Lindow, Proceedings of the National Academy of Sciences current issue, 2014

Outer membrane vesicles (OMVs) of Gram-negative bacteria have been studied intensively in recent years, primarily in their role in delivering virulence factors and antigens during pathogenesis. However, the near ubiquity of their production suggests that they may play other roles, such as ...

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Blood-brain biomarkers for stress susceptibility [Neuroscience]

16.09.2014 | Sumantra Chattarji; Rajnish P. Rao, Proceedings of the National Academy of Sciences current issue, 2014

Posttraumatic stress disorder (PTSD) is a debilitating condition that arises in the aftermath of a highly traumatic event and was initially described as “shell shock” in combatants (1). Patients display three primary sets of symptoms: repeated flashbacks of the trauma, hyperarousal, and ...

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Drought stress variability in ancient Near Eastern agricultural systems evidenced by {delta}13C in barley grain [Anthropology]

26.08.2014 | Simone Riehl; Konstantin E. Pustovoytov; Heike Weippert; Stefan Klett; Frank Hole, Proceedings of the National Academy of Sciences current issue, 2014

The collapse and resilience of political systems in the ancient Near East and their relationship with agricultural development have been of wide interest in archaeology and anthropology. Despite attempts to link the archaeological evidence to local paleoclimate data, the precise role of ...

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Intergenerational transmission of emotional trauma through amygdala-dependent mother-to-infant transfer of specific fear [Neuroscience]

19.08.2014 | Jacek Debiec; Regina Marie Sullivan, Proceedings of the National Academy of Sciences current issue, 2014

Emotional trauma is transmitted across generations. For example, children witnessing their parent expressing fear to specific sounds or images begin to express fear to those cues. Within normal range, this is adaptive, although pathological fear, such as occurs in posttraumatic stress disorder or ...

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