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369 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Steric clashes with bound OMP peptides activate the DegS stress-response protease [Biochemistry]

17.03.2015 | Anna K. de Regt; Tania A. Baker; Robert T. Sauer, Proceedings of the National Academy of Sciences current issue, 2015

Escherichia coli senses envelope stress using a signaling cascade initiated when DegS cleaves a transmembrane inhibitor of a transcriptional activator for response genes. Each subunit of the DegS trimer contains a protease domain and a PDZ domain. During stress, unassembled outer-membrane ...

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Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis [Neuroscience]

10.03.2015 | Yiguo Shen; Woo-Ping Ge; Yulong Li; Arisa Hirano; Hsien-Yang Lee; Astrid Rohlmann; Markus Missler; Richard W. Tsien; ..., Proceedings of the National Academy of Sciences current issue, 2015

Paroxysmal nonkinesigenic dyskinesia (PNKD) is an autosomal dominant episodic movement disorder precipitated by coffee, alcohol, and stress. We previously identified the causative gene but the function of the encoded protein remains unknown. We also generated a PNKD mouse model that revealed ...

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Vacuoles protect plants from high magnesium stress [Plant Biology]

10.03.2015 | Caiji Gao; Qiong Zhao; Liwen Jiang, Proceedings of the National Academy of Sciences current issue, 2015

A sufficient and balanced supply of mineral nutrients is crucial for plant growth and development. However, excessive amounts of minerals in the soil are harmful to most plants. To reduce the toxic levels of ions in the cytoplasm caused by environmental mineral stress, plants have evolved ...

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Insect capa neuropeptides impact desiccation and cold tolerance [Physiology]

03.03.2015 | Selim Terhzaz; Nicholas M. Teets; Pablo Cabrero; Louise Henderson; Michael G. Ritchie; Ronald J. Nachman; Julian A. ..., Proceedings of the National Academy of Sciences current issue, 2015

The success of insects is linked to their impressive tolerance to environmental stress, but little is known about how such responses are mediated by the neuroendocrine system. Here we show that the capability (capa) neuropeptide gene is a desiccation- and cold stress-responsive gene in diverse ...

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Stress and telomere shortening among central Indian conservation refugees [Anthropology]

03.03.2015 | Sammy Zahran; Jeffrey G. Snodgrass; David G. Maranon; Chakrapani Upadhyay; Douglas A. Granger; Susan M. Bailey, Proceedings of the National Academy of Sciences current issue, 2015

Research links psychosocial stress to premature telomere shortening and accelerated human aging; however, this association has only been demonstrated in so-called “WEIRD” societies (Western, educated, industrialized, rich, and democratic), where stress is typically lower and life expectancies ...

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Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance [Medical Sciences]

03.03.2015 | Sonia Carta; Federica Penco; Rosa Lavieri; Alberto Martini; Charles Anthony Dinarello; Marco Gattorno; Anna Rubartelli, Proceedings of the National Academy of Sciences current issue, 2015

Cell stress is implicated in triggering bouts of systemic inflammation in patients with autoinflammatory disorders. Blood monocytes from patients affected by NLRP3-mediated cryopyrin-associated periodic syndromes (CAPS) release greater amounts of IL-1β than monocytes from unaffected subjects. ...

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Transcription factor interaction with COMPASS-like complex regulates histone H3K4 trimethylation for specific gene expression in plants [Plant Biology]

03.03.2015 | Ze-Ting Song; Le Sun; Sun-Jie Lu; Yongke Tian; Yong Ding; Jian-Xiang Liu, Proceedings of the National Academy of Sciences current issue, 2015

Accumulation of unfolded or misfolded proteins causes endoplasmic reticulum (ER) stress, which activates a set of ER membrane-associated transcription factors for protein homeostasis regulation. Previous genome-wide chromatin immunoprecipitation analysis shows a strong correlation between histone ...

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iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death [Medical Sciences]

03.03.2015 | Mario Notari; Ying Hu; Gopinath Sutendra; Zinaida Dedeić; Min Lu; Laurent Dupays; Arash Yavari; Carolyn A. Carr; Sha ..., Proceedings of the National Academy of Sciences current issue, 2015

Desmosomes are anchoring junctions that exist in cells that endure physical stress such as cardiac myocytes. The importance of desmosomes in maintaining the homeostasis of the myocardium is underscored by frequent mutations of desmosome components found in human patients and animal models. ...

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Reply to Tichenor: Proposed update to beef greenhouse gas footprint is numerically questionable and well within current uncertainty bounds [Physical Sciences]

24.02.2015 | Gidon Eshel; Alon Shepon; Tamar Makov; Ron Milo, Proceedings of the National Academy of Sciences current issue, 2015

We thank Tichenor (1) for the attention to our paper (2). In it, we repeatedly stress the need for augmented and more refined data, and it is in this spirit we welcome Tichenor’s letter. However, as shown in Fig. 1, Tichenor’s approach, based on analyzing a single farm in Sweden...

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Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress [Neuroscience]

24.02.2015 | Benjamin D. Sachs; Jason R. Ni; Marc G. Caron, Proceedings of the National Academy of Sciences current issue, 2015

Brain serotonin (5-HT) deficiency and exposure to psychosocial stress have both been implicated in the etiology of depression and anxiety disorders, but whether 5-HT deficiency influences susceptibility to depression- and anxiety-like phenotypes induced by psychosocial stress has not been ...

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