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354 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Correction for Hodes et al., Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress [Correction]

30.12.2014 | Proceedings of the National Academy of Sciences current issue, 2014

NEUROSCIENCE Correction for “Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress,” by Georgia E. Hodes, Madeline L. Pfau, Marylene Leboeuf, Sam A. Golden, Daniel J. Christoffel, Dana Bregman, Nicole Rebusi, Mitra Heshmati, Hossein ...

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Identification of a pheromone that increases anxiety in rats [Neuroscience]

30.12.2014 | Hideaki Inagaki; Yasushi Kiyokawa; Shigeyuki Tamogami; Hidenori Watanabe; Yukari Takeuchi; Yuji Mori, Proceedings of the National Academy of Sciences current issue, 2014

Chemical communication plays an important role in the social lives of various mammalian species. Some of these chemicals are called pheromones. Rats release a specific odor into the air when stressed. This stress-related odor increases the anxiety levels of other rats; therefore, it is possible ...

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Responses to social and environmental stress are attenuated by strong male bonds in wild macaques [Anthropology]

23.12.2014 | Christopher Young; Bonaventura Majolo; Michael Heistermann; Oliver Schülke; Julia Ostner, Proceedings of the National Academy of Sciences current issue, 2014

In humans and obligatory social animals, individuals with weak social ties experience negative health and fitness consequences. The social buffering hypothesis conceptualizes one possible mediating mechanism: During stressful situations the presence of close social partners buffers against the ...

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G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments [Applied Biological Sciences]

23.12.2014 | Pavel Ivanov; Elizabeth O’Day; Mohamed M. Emara; Gerhard Wagner; Judy Lieberman; Paul Anderson, Proceedings of the National Academy of Sciences current issue, 2014

Angiogenin (ANG) is a stress-activated ribonuclease that promotes the survival of motor neurons. Ribonuclease inactivating point mutations are found in a subset of patients with ALS, a fatal neurodegenerative disease with no cure. We recently showed that ANG cleaves tRNA within anticodon loops to ...

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Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy [Medical Sciences]

16.12.2014 | Tony Jourdan; Gergő Szanda; Avi Z. Rosenberg; Joseph Tam; Brian James Earley; Grzegorz Godlewski; Resat Cinar; Ziyi ..., Proceedings of the National Academy of Sciences current issue, 2014

Diabetic nephropathy is a major cause of end-stage kidney disease, and overactivity of the endocannabinoid/cannabinoid 1 receptor (CB1R) system contributes to diabetes and its complications. Zucker diabetic fatty (ZDF) rats develop type 2 diabetic nephropathy with albuminuria, reduced glomerular ...

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p53 prevents neurodegeneration by regulating synaptic genes [Neuroscience]

16.12.2014 | Paola Merlo; Bess Frost; Shouyong Peng; Yawei J. Yang; Peter J. Park; Mel Feany, Proceedings of the National Academy of Sciences current issue, 2014

DNA damage has been implicated in neurodegenerative disorders, including Alzheimer’s disease and other tauopathies, but the consequences of genotoxic stress to postmitotic neurons are poorly understood. Here we demonstrate that p53, a key mediator of the DNA damage response, plays a ...

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A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton [Cell Biology]

09.12.2014 | Matthew R. Stachowiak; Mark A. Smith; Elizabeth Blankman; Laura M. Chapin; Hayri E. Balcioglu; Shuyuan Wang; Mary C. ..., Proceedings of the National Academy of Sciences current issue, 2014

Cytoskeletal actin assemblies transmit mechanical stresses that molecular sensors transduce into biochemical signals to trigger cytoskeletal remodeling and other downstream events. How mechanical and biochemical signaling cooperate to orchestrate complex remodeling tasks has not been elucidated. ...

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Actin stress in cell reprogramming [Cell Biology]

09.12.2014 | Jun Guo; Yuexiu Wang; Frederick Sachs; Fanjie Meng, Proceedings of the National Academy of Sciences current issue, 2014

Cell mechanics plays a role in stem cell reprogramming and differentiation. To understand this process better, we created a genetically encoded optical probe, named actin–cpstFRET–actin (AcpA), to report forces in actin in living cells in real time. We showed that stemness was associated with ...

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Critical slowing down as early warning for the onset of collapse in mutualistic communities [Environmental Sciences]

09.12.2014 | Vasilis Dakos; Jordi Bascompte, Proceedings of the National Academy of Sciences current issue, 2014

Tipping points are crossed when small changes in external conditions cause abrupt unexpected responses in the current state of a system. In the case of ecological communities under stress, the risk of approaching a tipping point is unknown, but its stakes are high. Here, we test recently ...

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Structural model of an mRNA in complex with the bacterial chaperone Hfq [Biochemistry]

02.12.2014 | Yi Peng; Joseph E. Curtis; Xianyang Fang; Sarah A. Woodson, Proceedings of the National Academy of Sciences current issue, 2014

The Sm-like protein Hfq (host factor Q-beta phage) facilitates regulation by bacterial small noncoding RNAs (sRNAs) in response to stress and other environmental signals. Here, we present a low-resolution model of Escherichia coli Hfq bound to the rpoS mRNA, a bacterial stress response gene that ...

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