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391 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress [Neuroscience]

23.06.2015 | Manuella P. Kaster; Nuno J. Machado; Henrique B. Silva; Ana Nunes; Ana Paula Ardais; Magda Santana; Younis Baqi; Chr ..., Proceedings of the National Academy of Sciences current issue, 2015

The consumption of caffeine (an adenosine receptor antagonist) correlates inversely with depression and memory deterioration, and adenosine A2A receptor (A2AR) antagonists emerge as candidate therapeutic targets because they control aberrant synaptic plasticity and afford neuroprotection. ...

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Selective buckling via states of self-stress in topological metamaterials [Applied Physical Sciences]

23.06.2015 | Jayson Paulose; Anne S. Meeussen; Vincenzo Vitelli, Proceedings of the National Academy of Sciences current issue, 2015

States of self-stress—tensions and compressions of structural elements that result in zero net forces—play an important role in determining the load-bearing ability of structures ranging from bridges to metamaterials with tunable mechanical properties. We exploit a class of recently introduced ...

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Microbial invasion of the Caribbean by an Indo-Pacific coral zooxanthella [Ecology]

16.06.2015 | D. Tye Pettay; Drew C. Wham; Robin T. Smith; Roberto Iglesias-Prieto; Todd C. LaJeunesse, Proceedings of the National Academy of Sciences current issue, 2015

Human-induced environmental changes have ushered in the rapid decline of coral reef ecosystems, particularly by disrupting the symbioses between reef-building corals and their photosymbionts. However, escalating stressful conditions enable some symbionts to thrive as opportunists. We present ...

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Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway [Neuroscience]

09.06.2015 | Damien Rei; Xenos Mason; Jinsoo Seo; Johannes Gräff; Andrii Rudenko; Jun Wang; Richard Rueda; Sandra Siegert; Sukhee ..., Proceedings of the National Academy of Sciences current issue, 2015

Repeated stress has been suggested to underlie learning and memory deficits via the basolateral amygdala (BLA) and the hippocampus; however, the functional contribution of BLA inputs to the hippocampus and their molecular repercussions are not well understood. Here we show that repeated stress is ...

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BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress [Cell Biology]

09.06.2015 | Marcos A. Carpio; Michael Michaud; Wenping Zhou; Jill K. Fisher; Loren D. Walensky; Samuel G. Katz, Proceedings of the National Academy of Sciences current issue, 2015

B-cell lymphoma 2 (BCL-2) ovarian killer (BOK) is a BCL-2 family protein with high homology to the multidomain proapoptotic proteins BAX and BAK, yet Bok−/− and even Bax−/−Bok−/− and Bak−/−Bok−/− mice were reported to have no overt phenotype or apoptotic defects in response to a host of classical ...

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Stress and the dynamic genome: Steroids, epigenetics, and the transposome [Colloquium Paper]

02.06.2015 | Richard G. Hunter; Khatuna Gagnidze; Bruce S. McEwen; Donald W. Pfaff, Proceedings of the National Academy of Sciences current issue, 2015

Stress plays a substantial role in shaping behavior and brain function, often with lasting effects. How these lasting effects occur in the context of a fixed postmitotic neuronal genome has been an enduring question for the field. Synaptic plasticity and neurogenesis have provided some of the ...

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Mechanical force effect on the two-state equilibrium of the hyaluronan-binding domain of CD44 in cell rolling [Biophysics and Computational Biology]

02.06.2015 | Takashi Suzuki; Miho Suzuki; Shinji Ogino; Ryo Umemoto; Noritaka Nishida; Ichio Shimada, Proceedings of the National Academy of Sciences current issue, 2015

CD44 is the receptor for hyaluronan (HA) and mediates cell rolling under fluid shear stress. The HA-binding domain (HABD) of CD44 interconverts between a low-affinity, ordered (O) state and a high-affinity, partially disordered (PD) state, by the conformational change of the C-terminal region, ...

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Inverted formin 2 in focal adhesions promotes dorsal stress fiber and fibrillar adhesion formation to drive extracellular matrix assembly [Cell Biology]

12.05.2015 | Colleen T. Skau; Sergey V. Plotnikov; Andrew D. Doyle; Clare M. Waterman, Proceedings of the National Academy of Sciences current issue, 2015

Actin filaments and integrin-based focal adhesions (FAs) form integrated systems that mediate dynamic cell interactions with their environment or other cells during migration, the immune response, and tissue morphogenesis. How adhesion-associated actin structures obtain their functional ...

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Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae [Genetics]

12.05.2015 | Hugo Tapia; Lindsey Young; Douglas Fox; Carolyn R. Bertozzi; Douglas Koshland, Proceedings of the National Academy of Sciences current issue, 2015

Diverse organisms capable of surviving desiccation, termed anhydrobiotes, include species from bacteria, yeast, plants, and invertebrates. However, most organisms are sensitive to desiccation, likely due to an assortment of different stresses such as protein misfolding and aggregation, ...

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Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level [Medical Sciences]

12.05.2015 | Toshihide Takeuchi; Mari Suzuki; Nobuhiro Fujikake; H. Akiko Popiel; Hisae Kikuchi; Shiroh Futaki; Keiji Wada; Yoshi ..., Proceedings of the National Academy of Sciences current issue, 2015

The heat shock response (HSR), a transcriptional response that up-regulates molecular chaperones upon heat shock, is necessary for cell survival in a stressful environment to maintain protein homeostasis (proteostasis). However, there is accumulating evidence that the HSR does not ubiquitously ...

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