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342 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress [Neuroscience]

11.11.2014 | Yayoi Kinoshita; Richard G. Hunter; Jason D. Gray; Roxana Mesias; Bruce S. McEwen; Deanna L. Benson; D. Stave Kohtz, Proceedings of the National Academy of Sciences current issue, 2014

Genetic evidence suggests cell-type–specific functions for certain nucleoporins, and gene expression profiling has revealed that nucleoporin p62 (NUP62) transcripts are decreased in the prefrontal cortex of major depressives. Chronic stress, which can precipitate depression, induces changes in ...

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HsfB2b-mediated repression of PRR7 directs abiotic stress responses of the circadian clock [Plant Biology]

11.11.2014 | Elsebeth Kolmos; Brenda Y. Chow; Jose L. Pruneda-Paz; Steve A. Kay, Proceedings of the National Academy of Sciences current issue, 2014

The circadian clock perceives environmental signals to reset to local time, but the underlying molecular mechanisms are not well understood. Here we present data revealing that a member of the heat shock factor (Hsf) family is involved in the input pathway to the plant circadian clock. Using the ...

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Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress [Neuroscience]

11.11.2014 | Georgia E. Hodes; Madeline L. Pfau; Marylene Leboeuf; Sam A. Golden; Daniel J. Christoffel; Dana Bregman; Nicole Reb ..., Proceedings of the National Academy of Sciences current issue, 2014

Depression and anxiety disorders are associated with increased release of peripheral cytokines; however, their functional relevance remains unknown. Using a social stress model in mice, we find preexisting individual differences in the sensitivity of the peripheral immune system that predict and ...

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The protein Compromised Hydrolysis of Triacylglycerols 7 (CHT7) acts as a repressor of cellular quiescence in Chlamydomonas [Plant Biology]

04.11.2014 | Chia-Hong Tsai; Jaruswan Warakanont; Tomomi Takeuchi; Barb B. Sears; Eric R. Moellering; Christoph Benning, Proceedings of the National Academy of Sciences current issue, 2014

Microalgae are prolific photosynthetic organisms that have the potential to sustainably produce high-value chemical feedstocks. However, an industry based on microalgal biomass still is faced with challenges. For example, microalgae tend to accumulate valuable compounds, such as triacylglycerols, ...

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Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing [Cell Biology]

04.11.2014 | Mei-Chong Wendy Lee; Fernando J. Lopez-Diaz; Shahid Yar Khan; Muhammad Akram Tariq; Yelena Dayn; Charles Joseph Vask ..., Proceedings of the National Academy of Sciences current issue, 2014

The acute cellular response to stress generates a subpopulation of reversibly stress-tolerant cells under conditions that are lethal to the majority of the population. Stress tolerance is attributed to heterogeneity of gene expression within the population to ensure survival of a minority. We ...

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Disruption of multisystem responses to stress in type 2 diabetes: Investigating the dynamics of allostatic load [Medical Sciences]

04.11.2014 | Andrew Steptoe; Ruth A. Hackett; Antonio I. Lazzarino; Sophie Bostock; Roberto La Marca; Livia A. Carvalho; Mark Hamer, Proceedings of the National Academy of Sciences current issue, 2014

Psychological stress-related processes are thought to contribute to the development and progression of type 2 diabetes, but the biological mechanisms involved are poorly understood. Here, we tested the notion that people with type 2 diabetes experience chronic allostatic load, manifest as dynamic ...

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Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy [Immunology and Inflammation]

28.10.2014 | Jiujiu Yu; Hajime Nagasu; Tomohiko Murakami; Hai Hoang; Lori Broderick; Hal M. Hoffman; Tiffany Horng, Proceedings of the National Academy of Sciences current issue, 2014

Inflammasomes are intracellular sensors that couple detection of pathogens and cellular stress to activation of Caspase-1, and consequent IL-1β and IL-18 maturation and pyroptotic cell death. Here, we show that the absent in melanoma 2 (AIM2) and nucleotide-binding oligomerization domain-like ...

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Highly cooperative stress relaxation in two-dimensional soft colloidal crystals [Physics]

28.10.2014 | Berend van der Meer; Weikai Qi; Remco G. Fokkink; Jasper van der Gucht; Marjolein Dijkstra; Joris Sprakel, Proceedings of the National Academy of Sciences current issue, 2014

Stress relaxation in crystalline solids is mediated by the formation and diffusion of defects. Although it is well established how externally generated stresses relax, through the proliferation and motion of dislocations in the lattice, it remains relatively unknown how crystals cope with ...

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GABAB(1) receptor subunit isoforms differentially regulate stress resilience [Neuroscience]

21.10.2014 | Olivia F. O’Leary; Daniela Felice; Stefano Galimberti; Hélène M. Savignac; Javier A. Bravo; Tadhg Crowley; Malika El ..., Proceedings of the National Academy of Sciences current issue, 2014

Stressful life events increase the susceptibility to developing psychiatric disorders such as depression; however, many individuals are resilient to such negative effects of stress. Determining the neurobiology underlying this resilience is instrumental to the development of novel and more ...

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KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes [Biochemistry]

21.10.2014 | Dong-In Koh; Dohyun Han; Hoon Ryu; Won-Il Choi; Bu-Nam Jeon; Min-Kyeong Kim; Youngsoo Kim; Jin Young Kim; Lee Parry; ..., Proceedings of the National Academy of Sciences current issue, 2014

An unresolved issue in genotoxic stress response is identification of induced regulatory proteins and how these activate tumor suppressor p53 to determine appropriate cell responses. Transcription factor KAISO was previously described to repress transcription following binding to methylated DNA. ...

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