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375 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Autoinhibition of MDMX by intramolecular p53 mimicry [Biochemistry]

14.04.2015 | Lihong Chen; Wade Borcherds; Shaofang Wu; Andreas Becker; Ernst Schonbrunn; Gary W. Daughdrill; Jiandong Chen, Proceedings of the National Academy of Sciences current issue, 2015

The p53 inhibitor MDMX is controlled by multiple stress signaling pathways. Using a proteolytic fragment release (PFR) assay, we detected an intramolecular interaction in MDMX that mechanistically mimics the interaction with p53, resulting in autoinhibition of MDMX. This mimicry is mediated by a ...

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SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies [Biochemistry]

07.04.2015 | Tetsuya Kawaguchi; Akie Tanigawa; Takao Naganuma; Yasuyuki Ohkawa; Sylvie Souquere; Gerard Pierron; Tetsuro Hirose, Proceedings of the National Academy of Sciences current issue, 2015

Paraspeckles are subnuclear structures that form around nuclear paraspeckle assembly transcript 1 (NEAT1) long noncoding RNA (lncRNA). Recently, paraspeckles were shown to be functional nuclear bodies involved in stress responses and the development of specific organs. Paraspeckle formation is ...

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Constraints, independence, and evolution of thermal plasticity: Probing genetic architecture of long- and short-term thermal acclimation [Evolution]

07.04.2015 | Alison R. Gerken; Olivia C. Eller; Daniel A. Hahn; Theodore J. Morgan, Proceedings of the National Academy of Sciences current issue, 2015

Seasonal and daily thermal variation can limit species distributions because of physiological tolerances. Low temperatures are particularly challenging for ectotherms, which use both basal thermotolerance and acclimation, an adaptive plastic response, to mitigate thermal stress. Both basal ...

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Acyl-CoA oxidase complexes control the chemical message produced by Caenorhabditis elegans [Biochemistry]

31.03.2015 | Xinxing Zhang; Likui Feng; Satya Chinta; Prashant Singh; Yuting Wang; Joshawna K. Nunnery; Rebecca A. Butcher, Proceedings of the National Academy of Sciences current issue, 2015

Caenorhabditis elegans uses ascaroside pheromones to induce development of the stress-resistant dauer larval stage and to coordinate various behaviors. Peroxisomal β-oxidation cycles are required for the biosynthesis of the fatty acid-derived side chains of the ascarosides. Here we show that ...

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Regulation of Nrf2 signaling and longevity in naturally long-lived rodents [Cell Biology]

24.03.2015 | Kaitlyn N. Lewis; Emily Wason; Yael H. Edrey; Deborah M. Kristan; Eviatar Nevo; Rochelle Buffenstein, Proceedings of the National Academy of Sciences current issue, 2015

The preternaturally long-lived naked mole-rat, like other long-lived species and experimental models of extended longevity, is resistant to both endogenous (e.g., reactive oxygen species) and environmental stressors and also resists age-related diseases such as cancer, cardiovascular disease, and ...

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Environmental stress induces trinucleotide repeat mutagenesis in human cells [Genetics]

24.03.2015 | Nimrat Chatterjee; Yunfu Lin; Beatriz A. Santillan; Patricia Yotnda; John H. Wilson, Proceedings of the National Academy of Sciences current issue, 2015

The dynamic mutability of microsatellite repeats is implicated in the modification of gene function and disease phenotype. Studies of the enhanced instability of long trinucleotide repeats (TNRs)—the cause of multiple human diseases—have revealed a remarkable complexity of mutagenic mechanisms. ...

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Steric clashes with bound OMP peptides activate the DegS stress-response protease [Biochemistry]

17.03.2015 | Anna K. de Regt; Tania A. Baker; Robert T. Sauer, Proceedings of the National Academy of Sciences current issue, 2015

Escherichia coli senses envelope stress using a signaling cascade initiated when DegS cleaves a transmembrane inhibitor of a transcriptional activator for response genes. Each subunit of the DegS trimer contains a protease domain and a PDZ domain. During stress, unassembled outer-membrane ...

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Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis [Neuroscience]

10.03.2015 | Yiguo Shen; Woo-Ping Ge; Yulong Li; Arisa Hirano; Hsien-Yang Lee; Astrid Rohlmann; Markus Missler; Richard W. Tsien; ..., Proceedings of the National Academy of Sciences current issue, 2015

Paroxysmal nonkinesigenic dyskinesia (PNKD) is an autosomal dominant episodic movement disorder precipitated by coffee, alcohol, and stress. We previously identified the causative gene but the function of the encoded protein remains unknown. We also generated a PNKD mouse model that revealed ...

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Vacuoles protect plants from high magnesium stress [Plant Biology]

10.03.2015 | Caiji Gao; Qiong Zhao; Liwen Jiang, Proceedings of the National Academy of Sciences current issue, 2015

A sufficient and balanced supply of mineral nutrients is crucial for plant growth and development. However, excessive amounts of minerals in the soil are harmful to most plants. To reduce the toxic levels of ions in the cytoplasm caused by environmental mineral stress, plants have evolved ...

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Insect capa neuropeptides impact desiccation and cold tolerance [Physiology]

03.03.2015 | Selim Terhzaz; Nicholas M. Teets; Pablo Cabrero; Louise Henderson; Michael G. Ritchie; Ronald J. Nachman; Julian A. ..., Proceedings of the National Academy of Sciences current issue, 2015

The success of insects is linked to their impressive tolerance to environmental stress, but little is known about how such responses are mediated by the neuroendocrine system. Here we show that the capability (capa) neuropeptide gene is a desiccation- and cold stress-responsive gene in diverse ...

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