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458 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Ancestral genetic diversity associated with the rapid spread of stress-tolerant coral symbionts in response to Holocene climate change [Evolution]

19.04.2016 | Benjamin C. C. Hume; Christian R. Voolstra; Chatchanit Arif; Cecilia D’Angelo; John A. Burt; Gal Eyal; Yossi Loya; J ..., Proceedings of the National Academy of Sciences current issue, 2016

Coral communities in the Persian/Arabian Gulf (PAG) withstand unusually high salinity levels and regular summer temperature maxima of up to ∼35 °C that kill conspecifics elsewhere. Due to the recent formation of the PAG and its subsequent shift to a hot climate, these corals have had ...

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Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNF{alpha}/NF-{kappa}B response [Biochemistry]

19.04.2016 | Anja Reintjes; Julian E. Fuchs; Leopold Kremser; Herbert H. Lindner; Klaus R. Liedl; Lukas A. Huber; Taras Valovka, Proceedings of the National Academy of Sciences current issue, 2016

Nuclear factor kappa B (NF-κB) is an inducible transcription factor that plays critical roles in immune and stress responses and is often implicated in pathologies, including chronic inflammation and cancer. Although much has been learned about NF-κB–activating pathways, the specific repression ...

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Response of single bacterial cells to stress gives rise to complex history dependence at the population level [Population Biology]

12.04.2016 | Roland Mathis; Martin Ackermann, Proceedings of the National Academy of Sciences current issue, 2016

Most bacteria live in ever-changing environments where periods of stress are common. One fundamental question is whether individual bacterial cells have an increased tolerance to stress if they recently have been exposed to lower levels of the same stressor. To address this question, we worked ...

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Stress management strategies in single bacterial cells [Population Biology]

12.04.2016 | Siv G. E. Andersson, Proceedings of the National Academy of Sciences current issue, 2016

Microbial genomes are highly adaptable to changing environmental conditions (1). Mechanisms such as duplications, deletions, and horizontal gene transfer events generate diversity in bacterial gene repertoires. In effect, most free-living bacterial populations contain myriads of individual cells ...

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Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress [Pharmacology]

29.03.2016 | Qian Ren; Min Ma; Tamaki Ishima; Christophe Morisseau; Jun Yang; Karen M. Wagner; Ji-chun Zhang; Chun Yang; Wei Yao; ..., Proceedings of the National Academy of Sciences current issue, 2016

Depression is a severe and chronic psychiatric disease, affecting 350 million subjects worldwide. Although multiple antidepressants have been used in the treatment of depressive symptoms, their beneficial effects are limited. The soluble epoxide hydrolase (sEH) plays a key role in the ...

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Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein [Biophysics and Computational Biology]

29.03.2016 | Alexander S. Krois; Josephine C. Ferreon; Maria A. Martinez-Yamout; H. Jane Dyson; Peter E. Wright, Proceedings of the National Academy of Sciences current issue, 2016

An important component of the activity of p53 as a tumor suppressor is its interaction with the transcriptional coactivators cyclic-AMP response element-binding protein (CREB)-binding protein (CBP) and p300, which activate transcription of p53-regulated stress response genes and stabilize p53 ...

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LSD1 modulates stress-evoked transcription of immediate early genes and emotional behavior [Neuroscience]

29.03.2016 | Francesco Rusconi; Barbara Grillo; Luisa Ponzoni; Silvia Bassani; Emanuela Toffolo; Leda Paganini; Alessandra Mallei ..., Proceedings of the National Academy of Sciences current issue, 2016

Behavioral changes in response to stressful stimuli can be controlled via adaptive epigenetic changes in neuronal gene expression. Here we indicate a role for the transcriptional corepressor Lysine-Specific Demethylase 1 (LSD1) and its dominant-negative splicing isoform neuroLSD1, in the ...

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ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria [Microbiology]

22.03.2016 | Rebecca M. Corrigan; Lauren E. Bellows; Alison Wood; Angelika Gründling, Proceedings of the National Academy of Sciences current issue, 2016

The stringent response is a survival mechanism used by bacteria to deal with stress. It is coordinated by the nucleotides guanosine tetraphosphate and pentaphosphate [(p)ppGpp], which interact with target proteins to promote bacterial survival. Although this response has been well characterized ...

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A mutualistic symbiosis between a parasitic mite and a pathogenic virus undermines honey bee immunity and health [Agricultural Sciences]

22.03.2016 | Gennaro Di Prisco; Desiderato Annoscia; Marina Margiotta; Rosalba Ferrara; Paola Varricchio; Virginia Zanni; Emilio ..., Proceedings of the National Academy of Sciences current issue, 2016

Honey bee colony losses are triggered by interacting stress factors consistently associated with high loads of parasites and/or pathogens. A wealth of biotic and abiotic stressors are involved in the induction of this complex multifactorial syndrome, with the parasitic mite Varroa destructor and ...

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Fiber networks amplify active stress [Biophysics and Computational Biology]

15.03.2016 | Pierre Ronceray; Chase P. Broedersz; Martin Lenz, Proceedings of the National Academy of Sciences current issue, 2016

Large-scale force generation is essential for biological functions such as cell motility, embryonic development, and muscle contraction. In these processes, forces generated at the molecular level by motor proteins are transmitted by disordered fiber networks, resulting in large-scale active ...

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