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1.311 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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The general mode of translation inhibition by macrolide antibiotics [Biochemistry]

11.11.2014 | Krishna Kannan; Pinal Kanabar; David Schryer; Tanja Florin; Eugene Oh; Neil Bahroos; Tanel Tenson; Jonathan S. Weiss ..., Proceedings of the National Academy of Sciences current issue, 2014

Macrolides are clinically important antibiotics thought to inhibit bacterial growth by impeding the passage of newly synthesized polypeptides through the nascent peptide exit tunnel of the bacterial ribosome. Recent data challenged this view by showing that macrolide antibiotics can ...

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Arabidopsis protein arginine methyltransferase 3 is required for ribosome biogenesis by affecting precursor ribosomal RNA processing [Plant Biology]

11.11.2014 | Runlai Hang; Chunyan Liu; Ayaz Ahmad; Yong Zhang; Falong Lu; Xiaofeng Cao, Proceedings of the National Academy of Sciences current issue, 2014

Ribosome biogenesis is a fundamental and tightly regulated cellular process, including synthesis, processing, and assembly of rRNAs with ribosomal proteins. Protein arginine methyltransferases (PRMTs) have been implicated in many important biological processes, such as ribosome biogenesis. Two ...

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Benchmarking all-atom simulations using hydrogen exchange [Biophysics and Computational Biology]

11.11.2014 | John J. Skinner; Wookyung Yu; Elizabeth K. Gichana; Michael C. Baxa; James R. Hinshaw; Karl F. Freed; Tobin R. Sosnick, Proceedings of the National Academy of Sciences current issue, 2014

Long-time molecular dynamics (MD) simulations are now able to fold small proteins reversibly to their native structures [Lindorff-Larsen K, Piana S, Dror RO, Shaw DE (2011) Science 334(6055):517–520]. These results indicate that modern force fields can reproduce the energy surface near the native ...

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New approach to capture and characterize synaptic proteome [Neuroscience]

11.11.2014 | Xin-An Liu; Beena Kadakkuzha; Bruce Pascal; Caitlin Steckler; Komolitdin Akhmedov; Long Yan; Michael Chalmers; Sathy ..., Proceedings of the National Academy of Sciences current issue, 2014

Little is known regarding the identity of the population of proteins that are transported and localized to synapses. Here we describe a new approach that involves the isolation and systematic proteomic characterization of molecular motor kinesins to identify the populations of proteins ...

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Self-assembled MmsF proteinosomes control magnetite nanoparticle formation in vitro [Chemistry]

11.11.2014 | Andrea E. Rawlings; Jonathan P. Bramble; Robyn Walker; Jennifer Bain; Johanna M. Galloway; Sarah S. Staniland, Proceedings of the National Academy of Sciences current issue, 2014

Magnetotactic bacteria synthesize highly uniform intracellular magnetite nanoparticles through the action of several key biomineralization proteins. These proteins are present in a unique lipid-bound organelle (the magnetosome) that functions as a nanosized reactor in which the particle is ...

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Folding pathway of a multidomain protein depends on its topology of domain connectivity [Biophysics and Computational Biology]

11.11.2014 | Takashi Inanami; Tomoki P. Terada; Masaki Sasai, Proceedings of the National Academy of Sciences current issue, 2014

How do the folding mechanisms of multidomain proteins depend on protein topology? We addressed this question by developing an Ising-like structure-based model and applying it for the analysis of free-energy landscapes and folding kinetics of an example protein, Escherichia coli dihydrofolate ...

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The nature of protein folding pathways [Biophysics and Computational Biology]

11.11.2014 | S. Walter Englander; Leland Mayne, Proceedings of the National Academy of Sciences current issue, 2014

How do proteins fold, and why do they fold in that way? This Perspective integrates earlier and more recent advances over the 50-y history of the protein folding problem, emphasizing unambiguously clear structural information. Experimental results show that, contrary to prior belief, proteins are ...

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Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells [Biochemistry]

04.11.2014 | Mariano Alló; Eneritz Agirre; Sergey Bessonov; Paola Bertucci; Luciana Gómez Acuña; Valeria Buggiano; Nicolás Bellor ..., Proceedings of the National Academy of Sciences current issue, 2014

The roles of Argonaute proteins in cytoplasmic microRNA and RNAi pathways are well established. However, their implication in small RNA-mediated transcriptional gene silencing in the mammalian cell nucleus is less understood. We have recently shown that intronic siRNAs cause chromatin ...

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Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex [Cell Biology]

04.11.2014 | Jun Yong Ha; Irina D. Pokrovskaya; Leslie K. Climer; Gregory R. Shimamura; Tetyana Kudlyk; Philip D. Jeffrey; Vladim ..., Proceedings of the National Academy of Sciences current issue, 2014

The conserved oligomeric Golgi (COG) complex is required, along with SNARE and Sec1/Munc18 (SM) proteins, for vesicle docking and fusion at the Golgi. COG, like other multisubunit tethering complexes (MTCs), is thought to function as a scaffold and/or chaperone to direct the assembly of ...

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Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome [Biochemistry]

04.11.2014 | Hongbing Zhang; Lily I. Pao; Aileen Zhou; Arthur D. Brace; Robert Halenbeck; Amy W. Hsu; Thomas L. Bray; Kevin Hesti ..., Proceedings of the National Academy of Sciences current issue, 2014

There are many transmembrane receptor-like proteins whose ligands have not been identified. A strategy for finding ligands when little is known about their tissue source is to screen each extracellular protein individually expressed in an array format by using a sensitive functional readout. ...

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