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1.334 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Structural basis of HIV-1 capsid recognition by PF74 and CPSF6 [Biophysics and Computational Biology]

30.12.2014 | Akash Bhattacharya; Steven L. Alam; Thomas Fricke; Kaneil Zadrozny; Jaroslaw Sedzicki; Alexander B. Taylor; Borries ..., Proceedings of the National Academy of Sciences current issue, 2014

Upon infection of susceptible cells by HIV-1, the conical capsid formed by ∼250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplasm. The capsid shields the RNA genome and proteins required for reverse transcription. In addition, the surface of the capsid mediates numerous ...

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A divergent Pumilio repeat protein family for pre-rRNA processing and mRNA localization [Biochemistry]

30.12.2014 | Chen Qiu; Kathleen L. McCann; Robert N. Wine; Susan J. Baserga; Traci M. Tanaka Hall, Proceedings of the National Academy of Sciences current issue, 2014

Pumilio/feminization of XX and XO animals (fem)-3 mRNA-binding factor (PUF) proteins bind sequence specifically to mRNA targets using a single-stranded RNA-binding domain comprising eight Pumilio (PUM) repeats. PUM repeats have now been identified in proteins that function in pre-rRNA processing, ...

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Thermotropic liquid crystals from biomacromolecules [Physics]

30.12.2014 | Kai Liu; Dong Chen; Alessio Marcozzi; Lifei Zheng; Juanjuan Su; Diego Pesce; Wojciech Zajaczkowski; Anke Kolbe; Wojc ..., Proceedings of the National Academy of Sciences current issue, 2014

Complexation of biomacromolecules (e.g., nucleic acids, proteins, or viruses) with surfactants containing flexible alkyl tails, followed by dehydration, is shown to be a simple generic method for the production of thermotropic liquid crystals. The anhydrous smectic phases that result exhibit ...

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Structure of a pantothenate transporter and implications for ECF module sharing and energy coupling of group II ECF transporters [Biochemistry]

30.12.2014 | Minhua Zhang; Zhihao Bao; Qin Zhao; Hui Guo; Ke Xu; Chengcheng Wang; Peng Zhang, Proceedings of the National Academy of Sciences current issue, 2014

Energy-coupling factor (ECF) transporters are a unique group of ATP-binding cassette (ABC) transporters responsible for micronutrient uptake from the environment. Each ECF transporter is composed of an S component (or EcfS protein) and T/A/A′ components (or EcfT/A/A′ proteins; ECF module). Among ...

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Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome [Biochemistry]

23.12.2014 | Leslie Ripaud; Victoria Chumakova; Matthias Antonin; Alex R. Hastie; Stefan Pinkert; Roman Körner; Kiersten M. Ruff; ..., Proceedings of the National Academy of Sciences current issue, 2014

Expansion of a poly-glutamine (polyQ) repeat in a group of functionally unrelated proteins is the cause of several inherited neurodegenerative disorders, including Huntington’s disease. The polyQ length-dependent aggregation and toxicity of these disease proteins can be reproduced in ...

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Folding kinetics of WW domains with the united residue force field for bridging microscopic motions and experimental measurements [Biophysics and Computational Biology]

23.12.2014 | Rui Zhou; Gia G. Maisuradze; David Suñol; Toni Todorovski; Maria J. Macias; Yi Xiao; Harold A. Scheraga; Cezary Czap ..., Proceedings of the National Academy of Sciences current issue, 2014

To demonstrate the utility of the coarse-grained united-residue (UNRES) force field to compare experimental and computed kinetic data for folding proteins, we have performed long-time millisecond-timescale canonical Langevin molecular dynamics simulations of the triple β-strand from the Formin ...

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Direct interactions promote eviction of the Sir3 heterochromatin protein by the SWI/SNF chromatin remodeling enzyme [Biochemistry]

16.12.2014 | Benjamin J. Manning; Craig L. Peterson, Proceedings of the National Academy of Sciences current issue, 2014

Heterochromatin is a specialized chromatin structure that is central to eukaryotic transcriptional regulation and genome stability. Despite its globally repressive role, heterochromatin must also be dynamic, allowing for its repair and replication. In budding yeast, heterochromatin formation ...

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Computational design of a leucine-rich repeat protein with a predefined geometry [Biophysics and Computational Biology]

16.12.2014 | Sebastian Rämisch; Ulrich Weininger; Jonas Martinsson; Mikael Akke; Ingemar André, Proceedings of the National Academy of Sciences current issue, 2014

Structure-based protein design offers a possibility of optimizing the overall shape of engineered binding scaffolds to match their targets better. We developed a computational approach for the structure-based design of repeat proteins that allows for adjustment of geometrical features like ...

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Structural interactions of a voltage sensor toxin with lipid membranes [Physiology]

16.12.2014 | Mihaela Mihailescu; Dmitriy Krepkiy; Mirela Milescu; Klaus Gawrisch; Kenton J. Swartz; Stephen White, Proceedings of the National Academy of Sciences current issue, 2014

Protein toxins from tarantula venom alter the activity of diverse ion channel proteins, including voltage, stretch, and ligand-activated cation channels. Although tarantula toxins have been shown to partition into membranes, and the membrane is thought to play an important role in their activity, ...

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Distinct roles of FKF1, GIGANTEA, and ZEITLUPE proteins in the regulation of CONSTANS stability in Arabidopsis photoperiodic flowering [Plant Biology]

09.12.2014 | Young Hun Song; Daniel A. Estrada; Richard S. Johnson; Somi K. Kim; Sang Yeol Lee; Michael J. MacCoss; Takato Imaizumi, Proceedings of the National Academy of Sciences current issue, 2014

Many plants measure changes in day length to synchronize their flowering time with appropriate seasons for maximum reproductive success. In Arabidopsis, the day-length–dependent regulation of CONSTANS (CO) protein stability is crucial to induce FLOWERING LOCUS T (FT) expression for flowering in ...

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