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1.631 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Extended synaptotagmins are Ca2+-dependent lipid transfer proteins at membrane contact sites [Cell Biology]

19.04.2016 | Haijia Yu; Yinghui Liu; Daniel R. Gulbranson; Alex Paine; Shailendra S. Rathore; Jingshi Shen, Proceedings of the National Academy of Sciences current issue, 2016

Organelles are in constant communication with each other through exchange of proteins (mediated by trafficking vesicles) and lipids [mediated by both trafficking vesicles and lipid transfer proteins (LTPs)]. It has long been known that vesicle trafficking can be tightly regulated by the second ...

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Surface force measurements and simulations of mussel-derived peptide adhesives on wet organic surfaces [Biophysics and Computational Biology]

19.04.2016 | Zachary A. Levine; Michael V. Rapp; Wei Wei; Ryan Gotchy Mullen; Chun Wu; Gül H. Zerze; Jeetain Mittal; J. Herbert W ..., Proceedings of the National Academy of Sciences current issue, 2016

Translating sticky biological molecules—such as mussel foot proteins (MFPs)—into synthetic, cost-effective underwater adhesives with adjustable nano- and macroscale characteristics requires an intimate understanding of the glue’s molecular interactions. To help facilitate the next generation of ...

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Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function [Biochemistry]

19.04.2016 | Sushabhan Sadhukhan; Xiaojing Liu; Dongryeol Ryu; Ornella D. Nelson; John A. Stupinski; Zhi Li; Wei Chen; Sheng Zhan ..., Proceedings of the National Academy of Sciences current issue, 2016

Cellular metabolites, such as acyl-CoA, can modify proteins, leading to protein posttranslational modifications (PTMs). One such PTM is lysine succinylation, which is regulated by sirtuin 5 (SIRT5). Although numerous proteins are modified by lysine succinylation, the physiological significance of ...

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BKCa channel regulates calcium oscillations induced by alpha-2-macroglobulin in human myometrial smooth muscle cells [Physiology]

19.04.2016 | Monali Wakle-Prabagaran; Ramón A. Lorca; Xiaofeng Ma; Susan J. Stamnes; Chinwendu Amazu; Jordy J. Hsiao; Celeste M. ..., Proceedings of the National Academy of Sciences current issue, 2016

The large-conductance, voltage-gated, calcium (Ca2+)-activated potassium channel (BKCa) plays an important role in regulating Ca2+ signaling and is implicated in the maintenance of uterine quiescence during pregnancy. We used immunopurification and mass spectrometry to identify proteins that ...

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Mass-tag labeling reveals site-specific and endogenous levels of protein S-fatty acylation [Biochemistry]

19.04.2016 | Avital Percher; Srinivasan Ramakrishnan; Emmanuelle Thinon; Xiaoqiu Yuan; Jacob S. Yount; Howard C. Hang, Proceedings of the National Academy of Sciences current issue, 2016

Fatty acylation of cysteine residues provides spatial and temporal control of protein function in cells and regulates important biological pathways in eukaryotes. Although recent methods have improved the detection and proteomic analysis of cysteine fatty (S-fatty) acylated proteins, ...

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Heterotrimeric G-protein shuttling via Gip1 extends the dynamic range of eukaryotic chemotaxis [Cell Biology]

19.04.2016 | Yoichiro Kamimura; Yukihiro Miyanaga; Masahiro Ueda, Proceedings of the National Academy of Sciences current issue, 2016

Chemotactic eukaryote cells can sense chemical gradients over a wide range of concentrations via heterotrimeric G-protein signaling; however, the underlying wide-range sensing mechanisms are only partially understood. Here we report that a novel regulator of G proteins, G protein-interacting ...

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Mechanism for accurate, protein-assisted DNA annealing by Deinococcus radiodurans DdrB [Biochemistry]

19.04.2016 | Seiji N. Sugiman-Marangos; Yoni M. Weiss; Murray S. Junop, Proceedings of the National Academy of Sciences current issue, 2016

Accurate pairing of DNA strands is essential for repair of DNA double-strand breaks (DSBs). How cells achieve accurate annealing when large regions of single-strand DNA are unpaired has remained unclear despite many efforts focused on understanding proteins, which mediate this process. Here we ...

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Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe [Biochemistry]

19.04.2016 | Rahul Jaiswal; Malay Choudhury; Shamsu Zaman; Samarendra Singh; Vishaka Santosh; Deepak Bastia; Carlos R. Escalante, Proceedings of the National Academy of Sciences current issue, 2016

Reb1 of Schizosaccharomyces pombe represents a family of multifunctional proteins that bind to specific terminator sites (Ter) and cause polar termination of transcription catalyzed by RNA polymerase I (pol I) and arrest of replication forks approaching the Ter sites from the opposite direction. ...

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Two distinct trimeric conformations of natively membrane-anchored full-length herpes simplex virus 1 glycoprotein B [Microbiology]

12.04.2016 | Tzviya Zeev-Ben-Mordehai; Daven Vasishtan; Anna Hernández Durán; Benjamin Vollmer; Paul White; Arun Prasad Pandurang ..., Proceedings of the National Academy of Sciences current issue, 2016

Many viruses are enveloped by a lipid bilayer acquired during assembly, which is typically studded with one or two types of glycoproteins. These viral surface proteins act as the primary interface between the virus and the host. Entry of enveloped viruses relies on specialized fusogen proteins to ...

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Host-parasite oscillation dynamics and evolution in a compartmentalized RNA replication system [Biochemistry]

12.04.2016 | Yohsuke Bansho; Taro Furubayashi; Norikazu Ichihashi; Tetsuya Yomo, Proceedings of the National Academy of Sciences current issue, 2016

To date, various cellular functions have been reconstituted in vitro such as self-replication systems using DNA, RNA, and proteins. The next important challenges include the reconstitution of the interactive networks of self-replicating species and investigating how such interactions generate ...

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