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1.231 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Protoribosome by quantum kernel energy method [Biochemistry]

10.09.2013 | Lulu Huang; Miri Krupkin; Anat Bashan; Ada Yonath; Lou Massa, Proceedings of the National Academy of Sciences current issue, 2013

Experimental evidence suggests the existence of an RNA molecular prebiotic entity, called by us the “protoribosome,” which may have evolved in the RNA world before evolution of the genetic code and proteins. This vestige of the RNA world, which possesses all of the capabilities required for ...

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Structure of the transition state for the binding of c-Myb and KIX highlights an unexpected order for a disordered system [Biophysics and Computational Biology]

10.09.2013 | Rajanish Giri; Angela Morrone; Angelo Toto; Maurizio Brunori; Stefano Gianni, Proceedings of the National Academy of Sciences current issue, 2013

A classical dogma of molecular biology dictates that the 3D structure of a protein is necessary for its function. However, a considerable fraction of the human proteome, although functional, does not adopt a defined folded state under physiological conditions. These intrinsically disordered ...

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Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections [Developmental Biology]

10.09.2013 | Kyungmoo Yea; Hongkai Zhang; Jia Xie; Teresa M. Jones; Guang Yang; Byeong Doo Song; Richard A. Lerner, Proceedings of the National Academy of Sciences current issue, 2013

When combinatorial antibody libraries are rendered infectious for eukaryotic cells, the integrated antibody genotype and cellular phenotype become permanently linked and each cell becomes a selection system unto itself. These systems should be ideal for the identification of proteins and pathways ...

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An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa [Microbiology]

10.09.2013 | Jeremiah N. Marden; Manisha R. Diaz; William G. Walton; Cindy J. Gode; Laurie Betts; Mark L. Urbanowski; Matthew R. ..., Proceedings of the National Academy of Sciences current issue, 2013

Members of the CsrA family of prokaryotic mRNA-binding proteins alter the translation and/or stability of transcripts needed for numerous global physiological processes. The previously described CsrA family member in Pseudomonas aeruginosa (RsmA) plays a central role in determining infection ...

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SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver [Cell Biology]

10.09.2013 | Masaaki Yamamoto; Genzo Iguchi; Hidenori Fukuoka; Kentaro Suda; Hironori Bando; Michiko Takahashi; Hitoshi Nishizawa ..., Proceedings of the National Academy of Sciences current issue, 2013

Adaptation under fasting conditions is critical for survival in animals. Sirtuin 1 (SIRT1), a protein deacetylase, plays an essential role in adaptive metabolic and endocrine responses under fasting conditions by modifying the acetylation status of various proteins. Fasting induces growth hormone ...

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In vivo imaging of alphaherpesvirus infection reveals synchronized activity dependent on axonal sorting of viral proteins [Microbiology]

10.09.2013 | Andrea E. Granstedt; Jens B. Bosse; Stephan Y. Thiberge; Lynn W. Enquist, Proceedings of the National Academy of Sciences current issue, 2013

A clinical hallmark of human alphaherpesvirus infections is peripheral pain or itching. Pseudorabies virus (PRV), a broad host range alphaherpesvirus, causes violent pruritus in many different animals, but the mechanism is unknown. Previous in vitro studies have shown that infected, cultured ...

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Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation [Cell Biology]

10.09.2013 | Jaerak Chang; Seongju Lee; Craig Blackstone, Proceedings of the National Academy of Sciences current issue, 2013

Hereditary spastic paraplegias are inherited neurological disorders characterized by progressive lower-limb spasticity and weakness. Although more than 50 genetic loci are known [spastic gait (SPG)1 to -57], over half of hereditary spastic paraplegia cases are caused by pathogenic mutations in ...

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Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity [Medical Sciences]

10.09.2013 | Fusako Usuki; Akio Yamashita; Tadafumi Shiraishi; Atsushi Shiga; Osamu Onodera; Itsuro Higuchi; Shigeo Ohno, Proceedings of the National Academy of Sciences current issue, 2013

Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that eliminates aberrant mRNAs containing premature termination codons (PTCs). NMD inhibits the production of aberrant proteins that still retain, at least in part, wild-type function as well as dominant-negative peptides. ...

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Human {alpha}-l-iduronidase uses its own N-glycan as a substrate-binding and catalytic module [Biochemistry]

03.09.2013 | Nobuo Maita; Takahiro Tsukimura; Takako Taniguchi; Seiji Saito; Kazuki Ohno; Hisaaki Taniguchi; Hitoshi Sakuraba, Proceedings of the National Academy of Sciences current issue, 2013

N-glycosylation is a major posttranslational modification that endows proteins with various functions. It is established that N-glycans are essential for the correct folding and stability of some enzymes; however, the actual effects of N-glycans on their activities are poorly understood. Here, we ...

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Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A [Biophysics and Computational Biology]

03.09.2013 | Daohua Jiang; Yan Zhao; Xianping Wang; Junping Fan; Jie Heng; Xuehui Liu; Wei Feng; Xusheng Kang; Bo Huang; Jianfeng ..., Proceedings of the National Academy of Sciences current issue, 2013

The major facilitator superfamily (MFS) is the largest family of secondary active transporters and is present in all life kingdoms. Detailed structural basis of the substrate transport and energy-coupling mechanisms of these proteins remain to be elucidated. YajR is a putative proton-driven MFS ...

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