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1.364 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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An early secretory pathway mediated by GNOM-LIKE 1 and GNOM is essential for basal polarity establishment in Arabidopsis thaliana [Plant Biology]

17.02.2015 | Siamsa M. Doyle; Ash Haeger; Thomas Vain; Adeline Rigal; Corrado Viotti; Małgorzata Łangowska; Qian Ma; Jiří Friml; ..., Proceedings of the National Academy of Sciences current issue, 2015

Spatial regulation of the plant hormone indole-3-acetic acid (IAA, or auxin) is essential for plant development. Auxin gradient establishment is mediated by polarly localized auxin transporters, including PIN-FORMED (PIN) proteins. Their localization and abundance at the plasma membrane are ...

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Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum [Biochemistry]

17.02.2015 | Filipa Teixeira; Helena Castro; Tânia Cruz; Eric Tse; Philipp Koldewey; Daniel R. Southworth; Ana M. Tomás; Ursula Jakob, Proceedings of the National Academy of Sciences current issue, 2015

Cytosolic eukaryotic 2-Cys-peroxiredoxins have been widely reported to act as dual-function proteins, either detoxifying reactive oxygen species or acting as chaperones to prevent protein aggregation. Several stimuli, including peroxide-mediated sulfinic acid formation at the active site ...

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Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands [Engineering]

17.02.2015 | Yao Lu; Qiong Xue; Markus R. Eisele; Endah S. Sulistijo; Kara Brower; Lin Han; El-ad David Amir; Dana Pe’er; Kathryn ..., Proceedings of the National Academy of Sciences current issue, 2015

Despite recent advances in single-cell genomic, transcriptional, and mass-cytometric profiling, it remains a challenge to collect highly multiplexed measurements of secreted proteins from single cells for comprehensive analysis of functional states. Herein, we combine spatial and spectral ...

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A conserved amphipathic helix is required for membrane tubule formation by Yop1p [Biochemistry]

17.02.2015 | Jacob P. Brady; Jolyon K. Claridge; Peter G. Smith; Jason R. Schnell, Proceedings of the National Academy of Sciences current issue, 2015

The integral membrane proteins of the DP1 (deleted in polyposis) and reticulon families are responsible for maintaining the high membrane curvature required for both smooth endoplasmic reticulum (ER) tubules and the edges of ER sheets, and mutations in these proteins lead to motor neuron ...

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Inhibition of the {beta}-barrel assembly machine by a peptide that binds BamD [Biochemistry]

17.02.2015 | Christine L. Hagan; Joseph S. Wzorek; Daniel Kahne, Proceedings of the National Academy of Sciences current issue, 2015

The protein complex that assembles integral membrane β-barrel proteins in the outer membranes of Gram-negative bacteria is an attractive target in the development of new antibiotics. This complex, the β-barrel assembly machine (Bam), contains two essential proteins, BamA and BamD. We have ...

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Bacterial proteins pinpoint a single eukaryotic root [Evolution]

17.02.2015 | Romain Derelle; Guifré Torruella; Vladimír Klimeš; Henner Brinkmann; Eunsoo Kim; Čestmír Vlček; B. Franz Lang; Marek ..., Proceedings of the National Academy of Sciences current issue, 2015

The large phylogenetic distance separating eukaryotic genes and their archaeal orthologs has prevented identification of the position of the eukaryotic root in phylogenomic studies. Recently, an innovative approach has been proposed to circumvent this issue: the use as phylogenetic markers of ...

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Absence of knots in known RNA structures [Biophysics and Computational Biology]

17.02.2015 | Cristian Micheletti; Marco Di Stefano; Henri Orland, Proceedings of the National Academy of Sciences current issue, 2015

The ongoing effort to detect and characterize physical entanglement in biopolymers has so far established that knots are present in many globular proteins and also, abound in viral DNA packaged inside bacteriophages. RNA molecules, however, have not yet been systematically screened for the ...

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Tunable control of antibody immobilization using electric field [Applied Biological Sciences]

17.02.2015 | Sam Emaminejad; Mehdi Javanmard; Chaitanya Gupta; Shuai Chang; Ronald W. Davis; Roger T. Howe, Proceedings of the National Academy of Sciences current issue, 2015

The controlled immobilization of proteins on solid-state surfaces can play an important role in enhancing the sensitivity of both affinity-based biosensors and probe-free sensing platforms. Typical methods of controlling the orientation of probe proteins on a sensor surface involve surface ...

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Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase [Biochemistry]

10.02.2015 | Christopher N. Batuello; Paula M. Hauck; Jaimie M. Gendron; Jason A. Lehman; Lindsey D. Mayo, Proceedings of the National Academy of Sciences current issue, 2015

Murine double minute-2 protein (Mdm2) is a multifaceted phosphorylated protein that plays a role in regulating numerous proteins including the tumor suppressor protein p53. Mdm2 binds to and is involved in conjugating either ubiquitin or Nedd8 (Neural precursor cell expressed, developmentally ...

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Correction for Li et al., Arabidopsis ribosomal proteins control vacuole trafficking and developmental programs through the regulation of lipid metabolism [Correction]

10.02.2015 | Proceedings of the National Academy of Sciences current issue, 2015

PLANT BIOLOGY Correction for “Arabidopsis ribosomal proteins control vacuole trafficking and developmental programs through the regulation of lipid metabolism,” by Ruixi Li, Ruobai Sun, Glenn R. Hicks, and Natasha V. Raikhel, which appeared in issue 1, January 6, 2015, of Proc Natl Acad Sci USA ...

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