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1.398 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors [Neuroscience]

14.04.2015 | Chris R. Bye; Marie E. Jönsson; Anders Björklund; Clare L. Parish; Lachlan H. Thompson, Proceedings of the National Academy of Sciences current issue, 2015

An important challenge for the continued development of cell therapy for Parkinson’s disease (PD) is the establishment of procedures that better standardize cell preparations for use in transplantation. Although cell sorting has been an anticipated strategy, its application has been limited by ...

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Structural basis for the geometry-driven localization of a small protein [Microbiology]

14.04.2015 | Richard L. Gill Jr.; Jean-Philippe Castaing; Jen Hsin; Irene S. Tan; Xingsheng Wang; Kerwyn Casey Huang; Fang Tian; ..., Proceedings of the National Academy of Sciences current issue, 2015

In bacteria, certain shape-sensing proteins localize to differently curved membranes. During sporulation in Bacillus subtilis, the only convex (positively curved) surface in the cell is the forespore, an approximately spherical internal organelle. Previously, we demonstrated that SpoVM localizes ...

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An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis [Microbiology]

07.04.2015 | Jordan B. Jastrab; Tong Wang; J. Patrick Murphy; Lin Bai; Kuan Hu; Remco Merkx; Jessica Huang; Champak Chatterjee; H ..., Proceedings of the National Academy of Sciences current issue, 2015

Mycobacterium tuberculosis encodes a proteasome that is highly similar to eukaryotic proteasomes and is required to cause lethal infections in animals. The only pathway known to target proteins for proteasomal degradation in bacteria is pupylation, which is functionally analogous to eukaryotic ...

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Molecular ruler determines needle length for the Salmonella Spi-1 injectisome [Microbiology]

31.03.2015 | Daniel H. Wee; Kelly T. Hughes, Proceedings of the National Academy of Sciences current issue, 2015

The type-III secretion (T3S) systems of bacteria are part of self-assembling nanomachines: the bacterial flagellum that enables cells to propel themselves through liquid and across hydrated surfaces, and the injectisome that delivers pathogenic effector proteins into eukaryotic host cells. ...

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Genome-wide analysis of thylakoid-bound ribosomes in maize reveals principles of cotranslational targeting to the thylakoid membrane [Plant Biology]

31.03.2015 | Reimo Zoschke; Alice Barkan, Proceedings of the National Academy of Sciences current issue, 2015

Chloroplast genomes encode ∼37 proteins that integrate into the thylakoid membrane. The mechanisms that target these proteins to the membrane are largely unexplored. We used ribosome profiling to provide a comprehensive, high-resolution map of ribosome positions on chloroplast mRNAs in separated ...

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PAB is an assembly chaperone that functions downstream of chaperonin 60 in the assembly of chloroplast ATP synthase coupling factor 1 [Plant Biology]

31.03.2015 | Juan Mao; Wei Chi; Min Ouyang; Baoye He; Fan Chen; Lixin Zhang, Proceedings of the National Academy of Sciences current issue, 2015

The chloroplast ATP synthase, a multisubunit complex in the thylakoid membrane, catalyzes the light-driven synthesis of ATP, thereby supplying the energy for carbon fixation during photosynthesis. The chloroplast ATP synthase is composed of both nucleus- and chloroplast-encoded proteins that have ...

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Immunomodulatory spherical nucleic acids [Immunology and Inflammation]

31.03.2015 | Aleksandar F. Radovic-Moreno; Natalia Chernyak; Christopher C. Mader; Subbarao Nallagatla; Richard S. Kang; Lianglia ..., Proceedings of the National Academy of Sciences current issue, 2015

Immunomodulatory nucleic acids have extraordinary promise for treating disease, yet clinical progress has been limited by a lack of tools to safely increase activity in patients. Immunomodulatory nucleic acids act by agonizing or antagonizing endosomal toll-like receptors (TLR3, TLR7/8, and ...

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ORMDL orosomucoid-like proteins are degraded by free-cholesterol-loading-induced autophagy [Cell Biology]

24.03.2015 | Shuhui Wang; Peggy Robinet; Jonathan D. Smith; Kailash Gulshan, Proceedings of the National Academy of Sciences current issue, 2015

Eukaryotic cells have evolved robust mechanisms to counter excess cholesterol including redistribution of lipids into different compartments and compensatory up-regulation of phospholipid biosynthesis. We demonstrate here that excess cellular cholesterol increased the activity of the endoplasmic ...

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Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions [Systems Biology]

24.03.2015 | Xiong Ji; Daniel B. Dadon; Brian J. Abraham; Tong Ihn Lee; Rudolf Jaenisch; James E. Bradner; Richard A. Young, Proceedings of the National Academy of Sciences current issue, 2015

More than a thousand proteins are thought to contribute to mammalian chromatin and its regulation, but our understanding of the genomic occupancy and function of most of these proteins is limited. Here we describe an approach, which we call “chromatin proteomic profiling,” to identify proteins ...

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The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer [Chemistry]

24.03.2015 | Fang Bai; Faruck Morcos; Yang-Sung Sohn; Merav Darash-Yahana; Celso O. Rezende; Colin H. Lipper; Mark L. Paddock; Lu ..., Proceedings of the National Academy of Sciences current issue, 2015

Identification of novel drug targets and chemotherapeutic agents is a high priority in the fight against cancer. Here, we report that MAD-28, a designed cluvenone (CLV) derivative, binds to and destabilizes two members of a unique class of mitochondrial and endoplasmic reticulum (ER) 2Fe-2S ...

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