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1.325 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Distinct roles of FKF1, GIGANTEA, and ZEITLUPE proteins in the regulation of CONSTANS stability in Arabidopsis photoperiodic flowering [Plant Biology]

09.12.2014 | Young Hun Song; Daniel A. Estrada; Richard S. Johnson; Somi K. Kim; Sang Yeol Lee; Michael J. MacCoss; Takato Imaizumi, Proceedings of the National Academy of Sciences current issue, 2014

Many plants measure changes in day length to synchronize their flowering time with appropriate seasons for maximum reproductive success. In Arabidopsis, the day-length–dependent regulation of CONSTANS (CO) protein stability is crucial to induce FLOWERING LOCUS T (FT) expression for flowering in ...

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A model for the generation and interconversion of ER morphologies [Cell Biology]

09.12.2014 | Tom Shemesh; Robin W. Klemm; Fabian B. Romano; Songyu Wang; Joshua Vaughan; Xiaowei Zhuang; Hanna Tukachinsky; Micha ..., Proceedings of the National Academy of Sciences current issue, 2014

The peripheral endoplasmic reticulum (ER) forms different morphologies composed of tubules and sheets. Proteins such as the reticulons shape the ER by stabilizing the high membrane curvature in cross-sections of tubules and sheet edges. Here, we show that membrane curvature along the edge lines ...

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Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy [Genetics]

09.12.2014 | Ye Liu; Jakob S. Satz; My-Nuong Vo; Leslie A. Nangle; Paul Schimmel; Susan L. Ackerman, Proceedings of the National Academy of Sciences current issue, 2014

Misfolded proteins are an emerging hallmark of cardiac diseases. Although some misfolded proteins, such as desmin, are associated with mutations in the genes encoding these disease-associated proteins, little is known regarding more general mechanisms that contribute to the generation of ...

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MAGUKs end a tale of promiscuity [Biochemistry]

09.12.2014 | Carsten Reissner; Markus Missler, Proceedings of the National Academy of Sciences current issue, 2014

Membrane-associated guanylate kinases (MAGUKs) constitute a family of scaffold molecules involved in diverse cellular processes, such as cell–cell communication, cell polarity, and signal transduction (1). MAGUKs are multidomain proteins with a core structure consisting of PSD-95/DLG/ZO-1 (PDZ), ...

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Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein [Microbiology]

02.12.2014 | Jianbo Chen; David Grunwald; Luca Sardo; Andrea Galli; Sergey Plisov; Olga A. Nikolaitchik; De Chen; Stephen Lockett ..., Proceedings of the National Academy of Sciences current issue, 2014

Full-length HIV-1 RNA plays a central role in viral replication by serving as the mRNA for essential viral proteins and as the genome packaged into infectious virions. Proper RNA trafficking is required for the functions of RNA and its encoded proteins; however, the mechanism by which HIV-1 RNA ...

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Global structural changes of an ion channel during its gating are followed by ion mobility mass spectrometry [Biophysics and Computational Biology]

02.12.2014 | Albert Konijnenberg; Duygu Yilmaz; Helgi I. Ingólfsson; Anna Dimitrova; Siewert J. Marrink; Zhuolun Li; Catherine Vé ..., Proceedings of the National Academy of Sciences current issue, 2014

Mechanosensitive ion channels are sensors probing membrane tension in all species; despite their importance and vital role in many cell functions, their gating mechanism remains to be elucidated. Here, we determined the conditions for releasing intact mechanosensitive channel of large conductance ...

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An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein [Applied Biological Sciences]

02.12.2014 | Johan Seijsing; Malin Lindborg; Ingmarie Höidén-Guthenberg; Heiko Bönisch; Elin Guneriusson; Fredrik Y. Frejd; Lars ..., Proceedings of the National Academy of Sciences current issue, 2014

Proteins endocytosed from serum are degraded in the lysosomes. However, serum albumin (SA) and IgG, through its Fc part, bind to the neonatal Fc receptor (FcRn) at low pH in the endosome after endocytosis, and are transported back to the cellular surface, where they are released into the ...

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RecQ helicase and RecJ nuclease provide complementary functions to resect DNA for homologous recombination [Biochemistry]

02.12.2014 | Katsumi Morimatsu; Stephen C. Kowalczykowski, Proceedings of the National Academy of Sciences current issue, 2014

Recombinational DNA repair by the RecF pathway of Escherichia coli requires the coordinated activities of RecA, RecFOR, RecQ, RecJ, and single-strand DNA binding (SSB) proteins. These proteins facilitate formation of homologously paired joint molecules between linear double-stranded (dsDNA) and ...

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Nep1-like proteins from three kingdoms of life act as a microbe-associated molecular pattern in Arabidopsis [Plant Biology]

25.11.2014 | Stan Oome; Tom M. Raaymakers; Adriana Cabral; Simon Samwel; Hannah Böhm; Isabell Albert; Thorsten Nürnberger; Guido ..., Proceedings of the National Academy of Sciences current issue, 2014

Necrosis and ethylene-inducing peptide 1 (Nep1)-like proteins (NLPs) are secreted by a wide range of plant-associated microorganisms. They are best known for their cytotoxicity in dicot plants that leads to the induction of rapid tissue necrosis and plant immune responses. The biotrophic downy ...

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Polyspecific pyrrolysyl-tRNA synthetases from directed evolution [Biochemistry]

25.11.2014 | Li-Tao Guo; Yane-Shih Wang; Akiyoshi Nakamura; Daniel Eiler; Jennifer M. Kavran; Margaret Wong; Laura L. Kiessling; ..., Proceedings of the National Academy of Sciences current issue, 2014

Pyrrolysyl-tRNA synthetase (PylRS) and its cognate tRNAPyl have emerged as ideal translation components for genetic code innovation. Variants of the enzyme facilitate the incorporation >100 noncanonical amino acids (ncAAs) into proteins. PylRS variants were previously selected to acylate ...

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