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1.474 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Suppression of conformational heterogeneity at a protein-protein interface [Biophysics and Computational Biology]

21.07.2015 | Lindsay N. Deis; Qinglin Wu; You Wang; Yang Qi; Kyle G. Daniels; Pei Zhou; Terrence G. Oas, Proceedings of the National Academy of Sciences current issue, 2015

Staphylococcal protein A (SpA) is an important virulence factor from Staphylococcus aureus responsible for the bacterium’s evasion of the host immune system. SpA includes five small three-helix–bundle domains that can each bind with high affinity to many host proteins such as antibodies. The ...

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Novel protein Callipygian defines the back of migrating cells [Cell Biology]

21.07.2015 | Kristen F. Swaney; Jane Borleis; Pablo A. Iglesias; Peter N. Devreotes, Proceedings of the National Academy of Sciences current issue, 2015

Asymmetric protein localization is essential for cell polarity and migration. We report a novel protein, Callipygian (CynA), which localizes to the lagging edge before other proteins and becomes more tightly restricted as cells polarize; additionally, it accumulates in the cleavage furrow during ...

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Intrinsic unfoldase/foldase activity of the chaperonin GroEL directly demonstrated using multinuclear relaxation-based NMR [Biophysics and Computational Biology]

21.07.2015 | David S. Libich; Vitali Tugarinov; G. Marius Clore, Proceedings of the National Academy of Sciences current issue, 2015

The prototypical chaperonin GroEL assists protein folding through an ATP-dependent encapsulation mechanism. The details of how GroEL folds proteins remain elusive, particularly because encapsulation is not an absolute requirement for successful re/folding. Here we make use of a metastable model ...

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Delicate conformational balance of the redox enzyme cytochrome P450cam [Biophysics and Computational Biology]

21.07.2015 | Simon P. Skinner; Wei-Min Liu; Yoshitaka Hiruma; Monika Timmer; Anneloes Blok; Mathias A. S. Hass; Marcellus Ubbink, Proceedings of the National Academy of Sciences current issue, 2015

The energy landscapes of proteins are highly complex and can be influenced by changes in physical and chemical conditions under which the protein is studied. The redox enzyme cytochrome P450cam undergoes a multistep catalytic cycle wherein two electrons are transferred to the heme group and the ...

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Structural characterization of the interaction of Ubp6 with the 26S proteasome [Biophysics and Computational Biology]

14.07.2015 | Antje Aufderheide; Florian Beck; Florian Stengel; Michaela Hartwig; Andreas Schweitzer; Günter Pfeifer; Alfred L. Go ..., Proceedings of the National Academy of Sciences current issue, 2015

In eukaryotic cells, the 26S proteasome is responsible for the regulated degradation of intracellular proteins. Several cofactors interact transiently with this large macromolecular machine and modulate its function. The deubiquitylating enzyme ubiquitin C-terminal hydrolase 6 [Ubp6; ...

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Arabidopsis MZT1 homologs GIP1 and GIP2 are essential for centromere architecture [Cell Biology]

14.07.2015 | Morgane Batzenschlager; Inna Lermontova; Veit Schubert; Jörg Fuchs; Alexandre Berr; Maria A. Koini; Guy Houlné; Etie ..., Proceedings of the National Academy of Sciences current issue, 2015

Centromeres play a pivotal role in maintaining genome integrity by facilitating the recruitment of kinetochore and sister-chromatid cohesion proteins, both required for correct chromosome segregation. Centromeres are epigenetically specified by the presence of the histone H3 variant (CENH3). In ...

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Generating new prions by targeted mutation or segment duplication [Biochemistry]

14.07.2015 | Kacy R. Paul; Connor G. Hendrich; Aubrey Waechter; Madison R. Harman; Eric D. Ross, Proceedings of the National Academy of Sciences current issue, 2015

Yeasts contain various protein-based genetic elements, termed prions, that result from the structural conversion of proteins into self-propagating amyloid forms. Most yeast prion proteins contain glutamine/asparagine (Q/N)-rich prion domains that drive prion activity. Here, we explore two ...

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O-glycans direct selectin ligands to lipid rafts on leukocytes [Cell Biology]

14.07.2015 | Bojing Shao; Tadayuki Yago; Hendra Setiadi; Ying Wang; Padmaja Mehta-D’souza; Jianxin Fu; Paul R. Crocker; William R ..., Proceedings of the National Academy of Sciences current issue, 2015

Palmitoylated cysteines typically target transmembrane proteins to domains enriched in cholesterol and sphingolipids (lipid rafts). P-selectin glycoprotein ligand-1 (PSGL-1), CD43, and CD44 are O-glycosylated proteins on leukocytes that associate with lipid rafts. During inflammation, they ...

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Hydrodynamic collective effects of active protein machines in solution and lipid bilayers [Physics]

14.07.2015 | Alexander S. Mikhailov; Raymond Kapral, Proceedings of the National Academy of Sciences current issue, 2015

The cytoplasm and biomembranes in biological cells contain large numbers of proteins that cyclically change their shapes. They are molecular machines that can function as molecular motors or carry out various other tasks in the cell. Many enzymes also undergo conformational changes within their ...

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The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation [Cell Biology]

07.07.2015 | Chiara Pastori; Philipp Kapranov; Clara Penas; Veronica Peschansky; Claude-Henry Volmar; Jann N. Sarkaria; Amade Bre ..., Proceedings of the National Academy of Sciences current issue, 2015

Bromodomain and extraterminal (BET) domain proteins have emerged as promising therapeutic targets in glioblastoma and many other cancers. Small molecule inhibitors of BET bromodomain proteins reduce expression of several oncogenes required for Glioblastoma Multiforme (GBM) progression. However, ...

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