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1.578 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification [Biochemistry]

02.02.2016 | Frédéric V. Stanger; Björn M. Burmann; Alexander Harms; Hugo Aragão; Adam Mazur; Timothy Sharpe; Christoph Dehio; Se ..., Proceedings of the National Academy of Sciences current issue, 2016

Filamentation induced by cyclic AMP (FIC)-domain enzymes catalyze adenylylation or other posttranslational modifications of target proteins to control their function. Recently, we have shown that Fic enzymes are autoinhibited by an α-helix (αinh) that partly obstructs the active site. For the ...

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Programmable polyproteams built using twin peptide superglues [Biochemistry]

02.02.2016 | Gianluca Veggiani; Tomohiko Nakamura; Michael D. Brenner; Raphaël V. Gayet; Jun Yan; Carol V. Robinson; Mark Howarth, Proceedings of the National Academy of Sciences current issue, 2016

Programmed connection of amino acids or nucleotides into chains introduced a revolution in control of biological function. Reacting proteins together is more complex because of the number of reactive groups and delicate stability. Here we achieved sequence-programmed irreversible connection of ...

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Folding and assembly of the large molecular machine Hsp90 studied in single-molecule experiments [Biophysics and Computational Biology]

02.02.2016 | Markus Jahn; Johannes Buchner; Thorsten Hugel; Matthias Rief, Proceedings of the National Academy of Sciences current issue, 2016

Folding of small proteins often occurs in a two-state manner and is well understood both experimentally and theoretically. However, many proteins are much larger and often populate misfolded states, complicating their folding process significantly. Here we study the complete folding and assembly ...

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Constant molecular aging rates vs. the exponential acceleration of mortality [Biochemistry]

02.02.2016 | Caleb E. Finch; Eileen M. Crimmins, Proceedings of the National Academy of Sciences current issue, 2016

Laëtitia Gorisse, Philippe Gillery, and their coworkers (1) at the University of Reims elegantly document carbamylation as a biochemical change of aging in long-lived proteins that accumulates progressively across the life span. In human skin samples, the main carbamylation product, homocitruline ...

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Reply to Fernandez-Marrero et al.: Role of BOK at the intersection of endoplasmic reticulum stress and apoptosis regulation [Biological Sciences]

02.02.2016 | Marcos A. Carpio; Michael Michaud; Wenping Zhou; Jill K. Fisher; Loren D. Walensky; Samuel G. Katz, Proceedings of the National Academy of Sciences current issue, 2016

The B-cell lymphoma 2 (BCL-2) ovarian killer (BOK) is an intriguing BCL-2 family protein with highest homology to the multidomain executioner proteins BAX and BAK, yet its role in apoptosis regulation has been questionable because of the reported absence of phenotypic findings in Bok−/− mice (1). ...

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SutA is a bacterial transcription factor expressed during slow growth in Pseudomonas aeruginosa [Microbiology]

02.02.2016 | Brett M. Babin; Megan Bergkessel; Michael J. Sweredoski; Annie Moradian; Sonja Hess; Dianne K. Newman; David A. Tirrell, Proceedings of the National Academy of Sciences current issue, 2016

Microbial quiescence and slow growth are ubiquitous physiological states, but their study is complicated by low levels of metabolic activity. To address this issue, we used a time-selective proteome-labeling method [bioorthogonal noncanonical amino acid tagging (BONCAT)] to identify proteins ...

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Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors [Immunology and Inflammation]

26.01.2016 | Joel Haywood; Jianxun Qi; Chun-Chi Chen; Guangwen Lu; Yingxia Liu; Jinghua Yan; Yi Shi; George F. Gao, Proceedings of the National Academy of Sciences current issue, 2016

Human osteoclast-associated receptor (OSCAR) is an immunoglobulin (Ig)-like collagen receptor that is up-regulated on osteoclasts during osteoclastogenesis and is expressed in a range of myeloid cells. As a member of the leukocyte receptor complex family of proteins, OSCAR shares a high degree of ...

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Altered short-term synaptic plasticity and reduced muscle strength in mice with impaired regulation of presynaptic CaV2.1 Ca2+ channels [Neuroscience]

26.01.2016 | Evanthia Nanou; Jin Yan; Nicholas P. Whitehead; Min Jeong Kim; Stanley C. Froehner; Todd Scheuer; William A. Catterall, Proceedings of the National Academy of Sciences current issue, 2016

Facilitation and inactivation of P/Q-type calcium (Ca2+) currents through the regulation of voltage-gated Ca2+ (CaV) 2.1 channels by Ca2+ sensor (CaS) proteins contributes to the facilitation and rapid depression of synaptic transmission in cultured neurons that transiently express CaV2.1 ...

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Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to short-term synaptic plasticity in hippocampal neurons [Neuroscience]

26.01.2016 | Evanthia Nanou; Jane M. Sullivan; Todd Scheuer; William A. Catterall, Proceedings of the National Academy of Sciences current issue, 2016

Short-term synaptic plasticity is induced by calcium (Ca2+) accumulating in presynaptic nerve terminals during repetitive action potentials. Regulation of voltage-gated CaV2.1 Ca2+ channels by Ca2+ sensor proteins induces facilitation of Ca2+ currents and synaptic facilitation in cultured neurons ...

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Critical roles of Gi/o proteins and phospholipase C-{delta}1 in the activation of receptor-operated TRPC4 channels [Pharmacology]

26.01.2016 | Dhananjay P. Thakur; Jin-bin Tian; Jaepyo Jeon; Jian Xiong; Yu Huang; Veit Flockerzi; Michael X. Zhu, Proceedings of the National Academy of Sciences current issue, 2016

Transient Receptor Potential Canonical (TRPC) proteins form nonselective cation channels commonly known to be activated downstream from receptors that signal through phospholipase C (PLC). Although TRPC3/C6/C7 can be directly activated by diacylglycerols produced by PLC breakdown of ...

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