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1.283 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion [Biophysics and Computational Biology]

14.10.2014 | Damian C. Ekiert; Jeffery S. Cox, Proceedings of the National Academy of Sciences current issue, 2014

Nearly 10% of the coding capacity of the Mycobacterium tuberculosis genome is devoted to two highly expanded and enigmatic protein families called PE and PPE, some of which are important virulence/immunogenicity factors and are secreted during infection via a unique alternative secretory system ...

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Transient conformational fluctuation of TePixD during a reaction [Biophysics and Computational Biology]

14.10.2014 | Kunisato Kuroi; Koji Okajima; Masahiko Ikeuchi; Satoru Tokutomi; Masahide Terazima, Proceedings of the National Academy of Sciences current issue, 2014

Knowledge of the dynamical behavior of proteins, and in particular their conformational fluctuations, is essential to understanding the mechanisms underlying their reactions. Here, transient enhancement of the isothermal partial molar compressibility, which is directly related to the ...

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Transmembrane domain of surface-exposed outer membrane lipoprotein RcsF is threaded through the lumen of {beta}-barrel proteins [Microbiology]

14.10.2014 | Anna Konovalova; David H. Perlman; Charles E. Cowles; Thomas J. Silhavy, Proceedings of the National Academy of Sciences current issue, 2014

RcsF (regulator of capsule synthesis) is an outer membrane (OM) lipoprotein that functions to sense defects such as changes in LPS. However, LPS is found in the outer leaflet, and RcsF was thought to be tethered to the inner leaflet by its lipidated N terminus, raising the question of how...

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Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis [Cell Biology]

14.10.2014 | Xian Jiang; Hui Jiang; Zhirong Shen; Xiaodong Wang, Proceedings of the National Academy of Sciences current issue, 2014

Intrinsic apoptotic stimuli initiate mammalian cells’ apoptotic program by first activating the proteins that have only Bcl-2 homology domain 3 (BH3), such as Bcl-2 interacting mediator of cell death (Bim) and truncated BH3 interacting death domain agonist (tBid), which in turn trigger ...

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Dynamic measurements for funny channels [Physiology]

07.10.2014 | Michael C. Puljung, Proceedings of the National Academy of Sciences current issue, 2014

Proteins possess the uncanny ability to telegraph signals over long distances. The presence of a ligand, snugly bound to a site on one end of a molecule, can be “felt” by an effector domain several nanometers away. Determining precisely how this task is accomplished is a major challenge for ...

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Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor [Developmental Biology]

07.10.2014 | Thomas R. Gawriluk; CheMyong Ko; Xiaoman Hong; Lane K. Christenson; Edmund B. Rucker III, Proceedings of the National Academy of Sciences current issue, 2014

Autophagy is an important cellular process that serves as a companion pathway to the ubiquitin-proteasome system to degrade long-lived proteins and organelles to maintain cell homeostasis. Although initially characterized in yeast, autophagy is being realized as an important regulator of ...

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Structural insights into the role of iron-histidine bond cleavage in nitric oxide-induced activation of H-NOX gas sensor proteins [Biochemistry]

07.10.2014 | Mark A. Herzik, Jr.; Rohan Jonnalagadda; John Kuriyan; Michael A. Marletta, Proceedings of the National Academy of Sciences current issue, 2014

Heme-nitric oxide/oxygen (H-NOX) binding domains are a recently discovered family of heme-based gas sensor proteins that are conserved across eukaryotes and bacteria. Nitric oxide (NO) binding to the heme cofactor of H-NOX proteins has been implicated as a regulatory mechanism for processes ...

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Mixtures of opposing phosphorylations within hexamers precisely time feedback in the cyanobacterial circadian clock [Systems Biology]

16.09.2014 | Jenny Lin; Justin Chew; Udaysankar Chockanathan; Michael J. Rust, Proceedings of the National Academy of Sciences current issue, 2014

Circadian oscillations are generated by the purified cyanobacterial clock proteins, KaiA, KaiB, and KaiC, through rhythmic interactions that depend on multisite phosphorylation of KaiC. However, the mechanisms that allow these phosphorylation reactions to robustly control the timing of ...

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Two apextrin-like proteins mediate extracellular and intracellular bacterial recognition in amphioxus [Immunology and Inflammation]

16.09.2014 | Guangrui Huang; Shengfeng Huang; Xinyu Yan; Ping Yang; Jun Li; Weiya Xu; Lingling Zhang; Ruihua Wang; Yingcai Yu; Sh ..., Proceedings of the National Academy of Sciences current issue, 2014

Animals exploit different germ-line-encoded proteins with various domain structures to detect the signature molecules of pathogenic microbes. These molecules are known as pathogen-associated molecular patterns (PAMPs), and the host proteins that react with PAMPs are called pattern recognition ...

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Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase [Microbiology]

16.09.2014 | Jie Zhang; Hongchuan Liu; Kongkai Zhu; Shouzhe Gong; Shaynoor Dramsi; Ya-Ting Wang; Jiafei Li; Feifei Chen; Ruihan Z ..., Proceedings of the National Academy of Sciences current issue, 2014

Methicillin-resistant Staphylococcus aureus (MRSA) is the most frequent cause of hospital-acquired infection, which manifests as surgical site infections, bacteremia, and sepsis. Due to drug-resistance, prophylaxis of MRSA infection with antibiotics frequently fails or incites nosocomial diseases ...

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