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1.287 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Estrogen-related receptor {alpha} decreases RHOA stability to induce orientated cell migration [Cell Biology]

21.10.2014 | Juliette Sailland; Violaine Tribollet; Christelle Forcet; Cyrielle Billon; Bruno Barenton; Julie Carnesecchi; Alice ..., Proceedings of the National Academy of Sciences current issue, 2014

Several physiopathological processes require orientated cellular migration. This phenomenon highly depends on members of the RHO family of GTPases. Both excessive and deficient RHO activity impair directional migration. A tight control is thus exerted on these proteins through the regulation of ...

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Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway [Genetics]

21.10.2014 | Matthias Drosten; Eleanor Y. M. Sum; Carmen G. Lechuga; Lucía Simón-Carrasco; Harrys K. C. Jacob; Raquel García-Medi ..., Proceedings of the National Academy of Sciences current issue, 2014

The Ras family of small GTPases constitutes a central node in the transmission of mitogenic stimuli to the cell cycle machinery. The ultimate receptor of these mitogenic signals is the retinoblastoma (Rb) family of pocket proteins, whose inactivation is a required step to license cell ...

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Computational design of a self-assembling symmetrical {beta}-propeller protein [Biophysics and Computational Biology]

21.10.2014 | Arnout R. D. Voet; Hiroki Noguchi; Christine Addy; David Simoncini; Daiki Terada; Satoru Unzai; Sam-Yong Park; Kam Y ..., Proceedings of the National Academy of Sciences current issue, 2014

The modular structure of many protein families, such as β-propeller proteins, strongly implies that duplication played an important role in their evolution, leading to highly symmetrical intermediate forms. Previous attempts to create perfectly symmetrical propeller proteins have failed, however. ...

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KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes [Biochemistry]

21.10.2014 | Dong-In Koh; Dohyun Han; Hoon Ryu; Won-Il Choi; Bu-Nam Jeon; Min-Kyeong Kim; Youngsoo Kim; Jin Young Kim; Lee Parry; ..., Proceedings of the National Academy of Sciences current issue, 2014

An unresolved issue in genotoxic stress response is identification of induced regulatory proteins and how these activate tumor suppressor p53 to determine appropriate cell responses. Transcription factor KAISO was previously described to repress transcription following binding to methylated DNA. ...

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Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion [Biophysics and Computational Biology]

14.10.2014 | Damian C. Ekiert; Jeffery S. Cox, Proceedings of the National Academy of Sciences current issue, 2014

Nearly 10% of the coding capacity of the Mycobacterium tuberculosis genome is devoted to two highly expanded and enigmatic protein families called PE and PPE, some of which are important virulence/immunogenicity factors and are secreted during infection via a unique alternative secretory system ...

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Transient conformational fluctuation of TePixD during a reaction [Biophysics and Computational Biology]

14.10.2014 | Kunisato Kuroi; Koji Okajima; Masahiko Ikeuchi; Satoru Tokutomi; Masahide Terazima, Proceedings of the National Academy of Sciences current issue, 2014

Knowledge of the dynamical behavior of proteins, and in particular their conformational fluctuations, is essential to understanding the mechanisms underlying their reactions. Here, transient enhancement of the isothermal partial molar compressibility, which is directly related to the ...

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Transmembrane domain of surface-exposed outer membrane lipoprotein RcsF is threaded through the lumen of {beta}-barrel proteins [Microbiology]

14.10.2014 | Anna Konovalova; David H. Perlman; Charles E. Cowles; Thomas J. Silhavy, Proceedings of the National Academy of Sciences current issue, 2014

RcsF (regulator of capsule synthesis) is an outer membrane (OM) lipoprotein that functions to sense defects such as changes in LPS. However, LPS is found in the outer leaflet, and RcsF was thought to be tethered to the inner leaflet by its lipidated N terminus, raising the question of how...

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Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis [Cell Biology]

14.10.2014 | Xian Jiang; Hui Jiang; Zhirong Shen; Xiaodong Wang, Proceedings of the National Academy of Sciences current issue, 2014

Intrinsic apoptotic stimuli initiate mammalian cells’ apoptotic program by first activating the proteins that have only Bcl-2 homology domain 3 (BH3), such as Bcl-2 interacting mediator of cell death (Bim) and truncated BH3 interacting death domain agonist (tBid), which in turn trigger ...

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Dynamic measurements for funny channels [Physiology]

07.10.2014 | Michael C. Puljung, Proceedings of the National Academy of Sciences current issue, 2014

Proteins possess the uncanny ability to telegraph signals over long distances. The presence of a ligand, snugly bound to a site on one end of a molecule, can be “felt” by an effector domain several nanometers away. Determining precisely how this task is accomplished is a major challenge for ...

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Beclin-1 deficiency in the murine ovary results in the reduction of progesterone production to promote preterm labor [Developmental Biology]

07.10.2014 | Thomas R. Gawriluk; CheMyong Ko; Xiaoman Hong; Lane K. Christenson; Edmund B. Rucker III, Proceedings of the National Academy of Sciences current issue, 2014

Autophagy is an important cellular process that serves as a companion pathway to the ubiquitin-proteasome system to degrade long-lived proteins and organelles to maintain cell homeostasis. Although initially characterized in yeast, autophagy is being realized as an important regulator of ...

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