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498 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Automated analysis of high-throughput B-cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles [Immunology and Inflammation]

24.02.2015 | Daniel Gadala-Maria; Gur Yaari; Mohamed Uduman; Steven H. Kleinstein, Proceedings of the National Academy of Sciences current issue, 2015

Individual variation in germline and expressed B-cell immunoglobulin (Ig) repertoires has been associated with aging, disease susceptibility, and differential response to infection and vaccination. Repertoire properties can now be studied at large-scale through next-generation sequencing of ...

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Heavy-chain receptor editing: Unbound [Immunology and Inflammation]

24.02.2015 | Garnett Kelsoe, Proceedings of the National Academy of Sciences current issue, 2015

With all of the certainty of death and taxes, questions regarding the mechanisms of immunological tolerance remain fixtures across the landscape of immunology. From Paul Ehlirch’s “horror autotoxicus” (reviewed in ref. 1) to the current synthesis of tolerance by apoptosis, anergy, and receptor ...

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Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk [Immunology and Inflammation]

17.02.2015 | Mingye Feng; James Y. Chen; Rachel Weissman-Tsukamoto; Jens-Peter Volkmer; Po Yi Ho; Kelly M. McKenna; Samuel Cheshi ..., Proceedings of the National Academy of Sciences current issue, 2015

Macrophage-mediated programmed cell removal (PrCR) is an important mechanism of eliminating diseased and damaged cells before programmed cell death. The induction of PrCR by eat-me signals on tumor cells is countered by don’t-eat-me signals such as CD47, which binds macrophage signal-regulatory ...

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PTEN regulates natural killer cell trafficking in vivo [Immunology and Inflammation]

17.02.2015 | Jeffrey W. Leong; Stephanie E. Schneider; Ryan P. Sullivan; Bijal A. Parikh; Bryan A. Anthony; Anvita Singh; Brea A. ..., Proceedings of the National Academy of Sciences current issue, 2015

Phosphatase and tensin homolog (PTEN) is a critical negative regulator of the phosphoinositide-3 kinase pathway, members of which play integral roles in natural killer (NK) cell development and function. However, the functions of PTEN in NK cell biology remain unknown. Here, we used an NK ...

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Overlapping hotspots in CDRs are critical sites for V region diversification [Immunology and Inflammation]

17.02.2015 | Lirong Wei; Richard Chahwan; Shanzhi Wang; Xiaohua Wang; Phuong T. Pham; Myron F. Goodman; Aviv Bergman; Matthew D. ..., Proceedings of the National Academy of Sciences current issue, 2015

Activation-induced deaminase (AID) mediates the somatic hypermutation (SHM) of Ig variable (V) regions that is required for the affinity maturation of the antibody response. An intensive analysis of a published database of somatic hypermutations that arose in the IGHV3-23*01 human V region ...

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Suppression of systemic autoimmunity by the innate immune adaptor STING [Immunology and Inflammation]

17.02.2015 | Shruti Sharma; Allison M. Campbell; Jennie Chan; Stefan A. Schattgen; Gregory M. Orlowski; Ribhu Nayar; Annie H. Huy ..., Proceedings of the National Academy of Sciences current issue, 2015

Cytosolic DNA-sensing pathways that signal via Stimulator of interferon genes (STING) mediate immunity to pathogens and also promote autoimmune pathology in DNaseII- and DNaseIII-deficient mice. In contrast, we report here that STING potently suppresses inflammation in a model of systemic lupus ...

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Effector V{gamma}9V{delta}2 T cells dominate the human fetal {gamma}{delta} T-cell repertoire [Immunology and Inflammation]

10.02.2015 | Tanya Dimova; Margreet Brouwer; Françoise Gosselin; Joël Tassignon; Oberdan Leo; Catherine Donner; Arnaud Marchant; ..., Proceedings of the National Academy of Sciences current issue, 2015

γδ T cells are unconventional T cells recognizing antigens via their γδ T-cell receptor (TCR) in a way that is fundamentally different from conventional αβ T cells. γδ T cells usually are divided into subsets according the type of Vγ and/or Vδ chain they express in their TCR. T cells...

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Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions [Immunology and Inflammation]

10.02.2015 | Marc Seifert; Martina Przekopowitz; Sarah Taudien; Anna Lollies; Viola Ronge; Britta Drees; Monika Lindemann; Uwe Hi ..., Proceedings of the National Academy of Sciences current issue, 2015

The generation and functions of human peripheral blood (PB) IgM+IgD+CD27+ B lymphocytes with somatically mutated IgV genes are controversially discussed. We determined their differential gene expression to naive B cells and to IgM-only and IgG+ memory B cells. This analysis revealed a high ...

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CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination [Immunology and Inflammation]

10.02.2015 | Sherry G. Lin; Chunguang Guo; Arthur Su; Yu Zhang; Frederick W. Alt, Proceedings of the National Academy of Sciences current issue, 2015

Ig heavy chain (IgH) variable region exons are assembled from V, D, and J gene segments during early B-lymphocyte differentiation. A several megabase region at the “distal” end of the mouse IgH locus (Igh) contains hundreds of VHs, separated by an intergenic region from Igh Ds, JHs, and constant ...

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VH replacement in primary immunoglobulin repertoire diversification [Immunology and Inflammation]

03.02.2015 | Amy Sun; Tatiana I. Novobrantseva; Maryaline Coffre; Susannah L. Hewitt; Kari Jensen; Jane A. Skok; Klaus Rajewsky; ..., Proceedings of the National Academy of Sciences current issue, 2015

The genes encoding the variable (V) region of the B-cell antigen receptor (BCR) are assembled from V, D (diversity), and J (joining) elements through a RAG-mediated recombination process that relies on the recognition of recombination signal sequences (RSSs) flanking the individual elements. ...

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