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504 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Tetramers reveal IL-17-secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease [Immunology and Inflammation]

10.03.2015 | Nicole H. Kattah; Evan W. Newell; Justin Ansel Jarrell; Alvina D. Chu; Jianming Xie; Michael G. Kattah; Ofir Goldber ..., Proceedings of the National Academy of Sciences current issue, 2015

Antigen-specific CD4+ T cells are implicated in the autoimmune disease systemic lupus erythematosus (SLE), but little is known about the peptide antigens that they recognize and their precise function in disease. We generated a series of MHC class II tetramers of I-Ek–containing peptides from the ...

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Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration [Immunology and Inflammation]

10.03.2015 | Jayendra Kumar Krishnaswamy; Arpita Singh; Uthaman Gowthaman; Renee Wu; Pavane Gorrepati; Manuela Sales Nascimento; ..., Proceedings of the National Academy of Sciences current issue, 2015

Dendritic cells (DCs) are the primary leukocytes responsible for priming T cells. To find and activate naïve T cells, DCs must migrate to lymph nodes, yet the cellular programs responsible for this key step remain unclear. DC migration to lymph nodes and the subsequent T-cell response are ...

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{beta}-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10 [Immunology and Inflammation]

03.03.2015 | Chunmei Fu; Xinjun Liang; Weiguo Cui; Julia L. Ober-Blöbaum; Joseph Vazzana; Protul A. Shrikant; Kelvin P. Lee; Björ ..., Proceedings of the National Academy of Sciences current issue, 2015

Recent studies have demonstrated that β-catenin in DCs serves as a key mediator in promoting both CD4+ and CD8+ T-cell tolerance, although how β-catenin exerts its functions remains incompletely understood. Here we report that activation of β-catenin in DCs inhibits cross-priming of CD8+ T cells ...

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Dendritic cell SIRT1-HIF1{alpha} axis programs the differentiation of CD4+ T cells through IL-12 and TGF-{beta}1 [Immunology and Inflammation]

03.03.2015 | Guangwei Liu; Yujing Bi; Lixiang Xue; Yan Zhang; Hui Yang; Xi Chen; Yun Lu; Zhengguo Zhang; Huanrong Liu; Xiao Wang; ..., Proceedings of the National Academy of Sciences current issue, 2015

The differentiation of naive CD4+ T cells into distinct lineages plays critical roles in mediating adaptive immunity or maintaining immune tolerance. In addition to being a first line of defense, the innate immune system also actively instructs adaptive immunity through antigen presentation and ...

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Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK [Immunology and Inflammation]

03.03.2015 | Idit Sagiv-Barfi; Holbrook E. K. Kohrt; Debra K. Czerwinski; Patrick P. Ng; Betty Y. Chang; Ronald Levy, Proceedings of the National Academy of Sciences current issue, 2015

Monoclonal antibodies can block cellular interactions that negatively regulate T-cell immune responses, such as CD80/CTLA-4 and PD-1/PD1-L, amplifying preexisting immunity and thereby evoking antitumor immune responses. Ibrutinib, an approved therapy for B-cell malignancies, is a covalent ...

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Automated analysis of high-throughput B-cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles [Immunology and Inflammation]

24.02.2015 | Daniel Gadala-Maria; Gur Yaari; Mohamed Uduman; Steven H. Kleinstein, Proceedings of the National Academy of Sciences current issue, 2015

Individual variation in germline and expressed B-cell immunoglobulin (Ig) repertoires has been associated with aging, disease susceptibility, and differential response to infection and vaccination. Repertoire properties can now be studied at large-scale through next-generation sequencing of ...

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Heavy-chain receptor editing: Unbound [Immunology and Inflammation]

24.02.2015 | Garnett Kelsoe, Proceedings of the National Academy of Sciences current issue, 2015

With all of the certainty of death and taxes, questions regarding the mechanisms of immunological tolerance remain fixtures across the landscape of immunology. From Paul Ehlirch’s “horror autotoxicus” (reviewed in ref. 1) to the current synthesis of tolerance by apoptosis, anergy, and receptor ...

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Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8 [Immunology and Inflammation]

24.02.2015 | Suzhao Li; C. Preston Neff; Kristina Barber; Jaewoo Hong; Yuchun Luo; Tania Azam; Brent E. Palmer; Mayumi Fujita; Ce ..., Proceedings of the National Academy of Sciences current issue, 2015

Similar to IL-1α and IL-33, IL-1 family member IL-37b translocates to the nucleus and is associated with suppression of innate and adaptive immunity. Here we demonstrate an extracellular function of the IL-37 precursor and a processed form. Recombinant IL-37 precursor reduced LPS-induced IL-6 by ...

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Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk [Immunology and Inflammation]

17.02.2015 | Mingye Feng; James Y. Chen; Rachel Weissman-Tsukamoto; Jens-Peter Volkmer; Po Yi Ho; Kelly M. McKenna; Samuel Cheshi ..., Proceedings of the National Academy of Sciences current issue, 2015

Macrophage-mediated programmed cell removal (PrCR) is an important mechanism of eliminating diseased and damaged cells before programmed cell death. The induction of PrCR by eat-me signals on tumor cells is countered by don’t-eat-me signals such as CD47, which binds macrophage signal-regulatory ...

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PTEN regulates natural killer cell trafficking in vivo [Immunology and Inflammation]

17.02.2015 | Jeffrey W. Leong; Stephanie E. Schneider; Ryan P. Sullivan; Bijal A. Parikh; Bryan A. Anthony; Anvita Singh; Brea A. ..., Proceedings of the National Academy of Sciences current issue, 2015

Phosphatase and tensin homolog (PTEN) is a critical negative regulator of the phosphoinositide-3 kinase pathway, members of which play integral roles in natural killer (NK) cell development and function. However, the functions of PTEN in NK cell biology remain unknown. Here, we used an NK ...

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