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650 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Nuclear transfer nTreg model reveals fate-determining TCR-{beta} and novel peripheral nTreg precursors [Immunology and Inflammation]

19.04.2016 | Manching Ku; Shih-En Chang; Julio Hernandez; Justin R. Abadejos; Mohsen Sabouri-Ghomi; Niklas J. Muenchmeier; Anna S ..., Proceedings of the National Academy of Sciences current issue, 2016

To study the development and function of “natural-arising” T regulatory (nTreg) cells, we developed a novel nTreg model on pure nonobese diabetic background using epigenetic reprogramming via somatic cell nuclear transfer. On RAG1-deficient background, we found that monoclonal FoxP3+ CD4+ Treg ...

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NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1{beta}-mediated osteomyelitis [Immunology and Inflammation]

19.04.2016 | Prajwal Gurung; Amanda Burton; Thirumala-Devi Kanneganti, Proceedings of the National Academy of Sciences current issue, 2016

Missense mutation in the proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2) gene results in the development of spontaneous chronic bone disease characterized by bone deformity and inflammation that is reminiscent of patients with chronic multifocal osteomyelitis (cmo). ...

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Monoclonal antibody therapy for Junin virus infection [Immunology and Inflammation]

19.04.2016 | Larry Zeitlin; Joan B. Geisbert; Daniel J. Deer; Karla A. Fenton; Ognian Bohorov; Natasha Bohorova; Charles Goodman; ..., Proceedings of the National Academy of Sciences current issue, 2016

Countermeasures against potential biothreat agents remain important to US Homeland Security, and many of these pharmaceuticals could have dual use in the improvement of global public health. Junin virus, the causative agent of Argentine hemorrhagic fever (AHF), is an arenavirus identified as a ...

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PGE2 induced in and released by dying cells functions as an inhibitory DAMP [Immunology and Inflammation]

05.04.2016 | Sho Hangai; Tomoka Ao; Yoshitaka Kimura; Kosuke Matsuki; Takeshi Kawamura; Hideo Negishi; Junko Nishio; Tatsuhiko Ko ..., Proceedings of the National Academy of Sciences current issue, 2016

Cellular components released into the external milieu as a result of cell death and sensed by the body are generally termed damage-associated molecular patterns (DAMPs). Although DAMPs are conventionally thought to be protective to the host by evoking inflammatory responses important for immunity ...

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Correction for Gaiser et al., Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo [Correction]

05.04.2016 | Proceedings of the National Academy of Sciences current issue, 2016

IMMUNOLOGY Correction for “Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo,” by Maria R. Gaiser, Tim Lämmermann, Xu Feng, Botond Z. Igyarto, Daniel H. Kaplan, Lino Tessarollo, Ronald N. Germain, and Mark C. Udey, ...

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Correction to Supporting Information for Wang et al., TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS [SI Correction]

05.04.2016 | Proceedings of the National Academy of Sciences current issue, 2016

IMMUNOLOGY AND INFLAMMATION Correction to Supporting Information for “TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS,” by Ying Wang, Lijing Su, Matthew D. Morin, Brian T. Jones, Landon R. Whitby, Murali M. R. P. Surakattula, Hua Huang, Hexin Shi, Jin Huk Choi, Kuan-wen ...

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Detection, phenotyping, and quantification of antigen-specific T cells using a peptide-MHC dodecamer [Immunology and Inflammation]

29.03.2016 | Jun Huang; Xun Zeng; Natalia Sigal; Peder J. Lund; Laura F. Su; Huang Huang; Yueh-hsiu Chien; Mark M. Davis, Proceedings of the National Academy of Sciences current issue, 2016

Here we report a peptide-MHC (pMHC) dodecamer as a “next generation” technology that is a significantly more sensitive and versatile alternative to pMHC tetramers for the detection, isolation, and phenotypic analysis of antigen-specific T cells. In particular, dodecamers are able to detect two- ...

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Autoantibody-boosted T-cell reactivation in the target organ triggers manifestation of autoimmune CNS disease [Immunology and Inflammation]

22.03.2016 | Anne-Christine Flach; Tanja Litke; Judith Strauss; Michael Haberl; César Cordero Gómez; Markus Reindl; Albert Saiz; ..., Proceedings of the National Academy of Sciences current issue, 2016

Multiple sclerosis (MS) is caused by T cells that are reactive for brain antigens. In experimental autoimmune encephalomyelitis, the animal model for MS, myelin-reactive T cells initiate the autoimmune process when entering the nervous tissue and become reactivated upon local encounter of their ...

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Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis [Immunology and Inflammation]

15.03.2016 | Xiaonan Dong; Adam Cheng; Zhongju Zou; Yih-Sheng Yang; Rhea M. Sumpter Jr.; Chou-Long Huang; Govind Bhagat; Herbert ..., Proceedings of the National Academy of Sciences current issue, 2016

The ubiquitin-proteasome system degrades viral oncoproteins and other microbial virulence factors; however, the role of endolysosomal degradation pathways in these processes is unclear. Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi’s sarcoma, and a constitutively ...

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Cell-type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source [Immunology and Inflammation]

15.03.2016 | Grigory A. Efimov; Andrei A. Kruglov; Zoya V. Khlopchatnikova; Fedor N. Rozov; Vladislav V. Mokhonov; Stefan Rose-Jo ..., Proceedings of the National Academy of Sciences current issue, 2016

Overexpression of TNF contributes to pathogenesis of multiple autoimmune diseases, accounting for a remarkable success of anti-TNF therapy. TNF is produced by a variety of cell types, and it can play either a beneficial or a deleterious role. In particular, in autoimmunity pathogenic TNF may be ...

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