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550 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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NLRP12 provides a critical checkpoint for osteoclast differentiation [Immunology and Inflammation]

18.08.2015 | Jennifer L. Krauss; Rong Zeng; Cynthia L. Hickman-Brecks; Justin E. Wilson; Jenny P.-Y. Ting; Deborah V. Novack, Proceedings of the National Academy of Sciences current issue, 2015

The alternative or noncanonical nuclear factor kappa B (NF-κB) pathway regulates the osteoclast (OC) response to receptor activator of nuclear factor kappa B ligand (RANKL) and thus bone metabolism. Although several lines of evidence support the emerging concept that nucleotide-binding ...

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MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation [Immunology and Inflammation]

18.08.2015 | Amit Lahiri; Matija Hedl; Clara Abraham, Proceedings of the National Academy of Sciences current issue, 2015

Inflammatory bowel disease (IBD) is characterized by dysregulated host:microbial interactions and cytokine production. Host pattern recognition receptors (PRRs) are critical in regulating these interactions. Multiple genetic loci are associated with IBD, but altered functions for most, including ...

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Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities [Immunology and Inflammation]

11.08.2015 | Danica A. Helb; Kevin K. A. Tetteh; Philip L. Felgner; Jeff Skinner; Alan Hubbard; Emmanuel Arinaitwe; Harriet Mayan ..., Proceedings of the National Academy of Sciences current issue, 2015

Tools to reliably measure Plasmodium falciparum (Pf) exposure in individuals and communities are needed to guide and evaluate malaria control interventions. Serologic assays can potentially produce precise exposure estimates at low cost; however, current approaches based on responses to a few ...

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Correction for Tackenberg et al., Impaired inhibitory Fc{gamma} receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy [Correction]

04.08.2015 | Proceedings of the National Academy of Sciences current issue, 2015

IMMUNOLOGY Correction for “Impaired inhibitory Fcγ receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy,” by Björn Tackenberg, Ilijas Jelčić, Anne Baerenwaldt, Wolfgang H. Oertel, Norbert Sommer, Falk Nimmerjahn, and Jan D. Lünemann, which appeared in issue 12, ...

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Complement membrane attack complexes activate noncanonical NF-{kappa}B by forming an Akt+NIK+ signalosome on Rab5+ endosomes [Immunology and Inflammation]

04.08.2015 | Dan Jane-wit; Yulia V. Surovtseva; Lingfeng Qin; Guangxin Li; Rebecca Liu; Pamela Clark; Thomas D. Manes; Chen Wang; ..., Proceedings of the National Academy of Sciences current issue, 2015

Complement membrane attack complexes (MACs) promote inflammatory functions in endothelial cells (ECs) by stabilizing NF-κB–inducing kinase (NIK) and activating noncanonical NF-κB signaling. Here we report a novel endosome-based signaling complex induced by MACs to stabilize NIK. We found that, in ...

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Correction for Baerenwaldt et al., Fc{gamma} receptor IIB (Fc{gamma}RIIB) maintains humoral tolerance in the human immune system in vivo [Correction]

04.08.2015 | Proceedings of the National Academy of Sciences current issue, 2015

IMMUNOLOGY Correction for “Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo,” by Anne Baerenwaldt, Anja Lux, Heike Danzer, Bernd M. Spriewald, Evelyn Ullrich, Gordon Heidkamp, Diana Dudziak, and Falk Nimmerjahn, which appeared in issue 46, November 15, ...

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Correction for Seeling et al., Inflammatory monocytes and Fc{gamma} receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice [Correction]

04.08.2015 | Proceedings of the National Academy of Sciences current issue, 2015

IMMUNOLOGY Correction for “Inflammatory monocytes and Fcγ receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice,” by Michaela Seeling, Ulrike Hillenhoff, Jean Pierre David, Georg Schett, Jan Tuckermann, Anja Lux, and Falk Nimmerjahn, which appeared in ...

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Erlotinib protects against LPS-induced Endotoxicity because TLR4 needs EGFR to signal [Immunology and Inflammation]

04.08.2015 | Sarmishtha De; Hao Zhou; David DeSantis; Colleen M. Croniger; Xiaoxia Li; George R. Stark, Proceedings of the National Academy of Sciences current issue, 2015

Several components of the canonical pathway of response to lipopolysaccharide (LPS) are required for the EGF-dependent activation of NFκB. Conversely, the ability of Toll-like Receptor 4 (TLR4) to activate NFκB in response to LPS is impaired by down regulating EGF receptor (EGFR) expression or by ...

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Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium [Immunology and Inflammation]

04.08.2015 | Yoji Murata; Takenori Kotani; Yana Supriatna; Yasuaki Kitamura; Shinya Imada; Kohichi Kawahara; Miki Nishio; Edwin W ..., Proceedings of the National Academy of Sciences current issue, 2015

Intestinal epithelial cells contribute to regulation of intestinal immunity in mammals, but the detailed molecular mechanisms of such regulation have remained largely unknown. Stomach-cancer–associated protein tyrosine phosphatase 1 (SAP-1, also known as PTPRH) is a receptor-type protein tyrosine ...

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TACI deficiency leads to alternatively activated macrophage phenotype and susceptibility to Leishmania infection [Immunology and Inflammation]

28.07.2015 | Windy R. Allman; Ranadhir Dey; Lunhua Liu; Shafiuddin Siddiqui; Adam S. Coleman; Parna Bhattacharya; Masahide Yano; ..., Proceedings of the National Academy of Sciences current issue, 2015

The TNF family member, transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), is a key molecule for plasma cell maintenance and is required in infections where protection depends on antibody response. Here, we report that compared with WT mouse, TACI KO Μϕs ...

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