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472 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Epigenetic targeting of activation-induced cytidine deaminase [Immunology and Inflammation]

30.12.2014 | Qiao Wang; Thiago Oliveira; Mila Jankovic; Israel T. Silva; Ofir Hakim; Kaihui Yao; Anna Gazumyan; Christian T. Maye ..., Proceedings of the National Academy of Sciences current issue, 2014

Activation-induced cytidine deaminase (AID) initiates class switch recombination (CSR) and somatic hypermutation (SHM) by deaminating cytosine residues in immunoglobulin genes (Igh, Igκ, and Igλ). At a lower frequency, AID also causes collateral DNA damage at non-Ig loci, including genes that are ...

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Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT [Immunology and Inflammation]

30.12.2014 | Tim D. Holmes; Erica B. Wilson; Emma V. I. Black; Andrew V. Benest; Candida Vaz; Betty Tan; Vivek M. Tanavde; Graham ..., Proceedings of the National Academy of Sciences current issue, 2014

Interactions between natural killer (NK) cells and dendritic cells (DCs) aid DC maturation and promote T-cell responses. Here, we have analyzed the response of human NK cells to tumor cells, and we identify a pathway by which NK–DC interactions occur. Gene expression profiling of tumor-responsive ...

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Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection [Immunology and Inflammation]

23.12.2014 | Michael R. Yeaman; Scott G. Filler; Siyang Chaili; Kevin Barr; Huiyuan Wang; Deborah Kupferwasser; John P. Hennessey ..., Proceedings of the National Academy of Sciences current issue, 2014

Increasing rates of life-threatening infections and decreasing susceptibility to antibiotics urge development of an effective vaccine targeting Staphylococcus aureus. This study evaluated the efficacy and immunologic mechanisms of a vaccine containing a recombinant glycoprotein antigen (NDV-3) in ...

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Fc{gamma}RIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis [Immunology and Inflammation]

16.12.2014 | Menna R. Clatworthy; Sarah K. Harford; Rebeccah J. Mathews; Kenneth G. C. Smith, Proceedings of the National Academy of Sciences current issue, 2014

IgG immune complexes (ICs) are generated during immune responses to infection and self-antigen and have been implicated in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE). Their role, and that of the fragment crystallizable (Fc) receptors that bind them, in ...

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Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination [Immunology and Inflammation]

16.12.2014 | Marissa Rashkovan; Charles Vadnais; Julie Ross; Mathieu Gigoux; Woong-Kyung Suh; Wei Gu; Christian Kosan; Tarik Möröy, Proceedings of the National Academy of Sciences current issue, 2014

To be effective, the adaptive immune response requires a large repertoire of antigen receptors, which are generated through V(D)J recombination in lymphoid precursors. These precursors must be protected from DNA damage-induced cell death, however, because V(D)J recombination generates ...

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Molecular architecture of the {alpha}{beta} T cell receptor-CD3 complex [Immunology and Inflammation]

09.12.2014 | Michael E. Birnbaum; Richard Berry; Yu-Shan Hsiao; Zhenjun Chen; Miguel A. Shingu-Vazquez; Xiaoling Yu; Deepa Waghra ..., Proceedings of the National Academy of Sciences current issue, 2014

αβ T-cell receptor (TCR) activation plays a crucial role for T-cell function. However, the TCR itself does not possess signaling domains. Instead, the TCR is noncovalently coupled to a conserved multisubunit signaling apparatus, the CD3 complex, that comprises the CD3εγ, CD3εδ, and CD3ζζ dimers. ...

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Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis [Immunology and Inflammation]

09.12.2014 | Emma Reeves; Alexandra Colebatch-Bourn; Tim Elliott; Christopher J. Edwards; Edward James, Proceedings of the National Academy of Sciences current issue, 2014

For more than 40 y, expression of HLA-B27 has been strongly associated with the chronic inflammatory disease Ankylosing Spondylitis (AS); however, the mechanisms underlying this association are still unknown. Single nucleotide polymorphisms within the aminopeptidase endoplasmic reticulum ...

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Optimal T-cell receptor affinity for inducing autoimmunity [Immunology and Inflammation]

02.12.2014 | Sabrina Koehli; Dieter Naeher; Virginie Galati-Fournier; Dietmar Zehn; Ed Palmer, Proceedings of the National Academy of Sciences current issue, 2014

T-cell receptor affinity for self-antigen has an important role in establishing self-tolerance. Three transgenic mouse strains expressing antigens of variable affinity for the OVA transgenic-I T-cell receptor were generated to address how TCR affinity affects the efficiency of negative selection, ...

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Going viral and the fatal vulnerability of neurons from immunity, not from infection [Immunology and Inflammation]

02.12.2014 | Lawrence Steinman, Proceedings of the National Academy of Sciences current issue, 2014

Clinicians are often faced with life and death choices in treating patients with viral infections. Often, consideration focuses on viral eradication with antiviral therapies, akin to bacterial antibiotics or to immune-based strategies, involving either active immunization or passive immunization ...

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Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function [Immunology and Inflammation]

02.12.2014 | Baptiste Guey; Mélanie Bodnar; Serge N. Manié; Aubry Tardivel; Virginie Petrilli, Proceedings of the National Academy of Sciences current issue, 2014

Inflammasomes are caspase-1–activating multiprotein complexes. The mouse nucleotide-binding domain and leucine rich repeat pyrin containing 1b (NLRP1b) inflammasome was identified as the sensor of Bacillus anthracis lethal toxin (LT) in mouse macrophages from sensitive strains such as BALB/c. ...

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