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520 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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IL-33 activates tumor stroma to promote intestinal polyposis [Immunology and Inflammation]

12.05.2015 | Rebecca L. Maywald; Stephanie K. Doerner; Luca Pastorelli; Carlo De Salvo; Susan M. Benton; Emily P. Dawson; Denise ..., Proceedings of the National Academy of Sciences current issue, 2015

Tumor epithelial cells develop within a microenvironment consisting of extracellular matrix, growth factors, and cytokines produced by nonepithelial stromal cells. In response to paracrine signals from tumor epithelia, stromal cells modify the microenvironment to promote tumor growth and ...

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Targeted noninvasive imaging of the innate immune response [Immunology and Inflammation]

12.05.2015 | Melissa N. McCracken; Caius G. Radu, Proceedings of the National Academy of Sciences current issue, 2015

Monitoring the immune system is complicated by its enormous cellular heterogeneity and by the continuous flux in the phenotypes and numbers of immune cells throughout the body. Measurements can be performed on tissue biopsies or peripheral blood, but these methods do not provide whole-body ...

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Noninvasive imaging of immune responses [Immunology and Inflammation]

12.05.2015 | Mohammad Rashidian; Edmund J. Keliher; Angelina M. Bilate; Joao N. Duarte; Gregory R. Wojtkiewicz; Johanne Tracey Ja ..., Proceedings of the National Academy of Sciences current issue, 2015

At their margins, tumors often contain neutrophils, dendritic cells, and activated macrophages, which express class II MHC and CD11b products. The interplay between stromal cells, tumor cells, and migratory cells such as lymphocytes creates opportunities for noninvasive imaging of immune ...

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NK cells require IL-28R for optimal in vivo activity [Immunology and Inflammation]

05.05.2015 | Fernando Souza-Fonseca-Guimaraes; Arabella Young; Deepak Mittal; Ludovic Martinet; Claudia Bruedigam; Kazuyoshi Take ..., Proceedings of the National Academy of Sciences current issue, 2015

Natural killer (NK) cells are naturally circulating innate lymphoid cells that protect against tumor initiation and metastasis and contribute to immunopathology during inflammation. The signals that prime NK cells are not completely understood, and, although the importance of IFN type I is well ...

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Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs [Immunology and Inflammation]

05.05.2015 | Benjamin M. Fiebiger; Jad Maamary; Andrew Pincetic; Jeffrey V. Ravetch, Proceedings of the National Academy of Sciences current issue, 2015

The antiinflammatory activity of intravenous immunoglobulin (IVIG) is dependent on the presence of sialic acid in the core IgG fragment crystallizable domain (Fc) glycan, resulting in increased conformational flexibility of the CH2 domain with corresponding modulation of Fc receptor (FcR) binding ...

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Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase [Immunology and Inflammation]

05.05.2015 | Wenjun Hu; Nasim A. Begum; Samiran Mondal; Andre Stanlie; Tasuku Honjo, Proceedings of the National Academy of Sciences current issue, 2015

Activation-induced cytidine deaminase (AID) is essential for antibody class switch recombination (CSR) and somatic hypermutation (SHM). AID originally was postulated to function as an RNA-editing enzyme, based on its strong homology with apolipoprotein B mRNA-editing enzyme, catalytic polypeptide ...

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Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain [Immunology and Inflammation]

28.04.2015 | Pragnesh Mistry; Michelle H. W. Laird; Ryan S. Schwarz; Shannon Greene; Tristan Dyson; Greg A. Snyder; Tsan Sam Xiao ..., Proceedings of the National Academy of Sciences current issue, 2015

Toll-like receptor (TLR) signaling is initiated by dimerization of intracellular Toll/IL-1 receptor resistance (TIR) domains. For all TLRs except TLR3, recruitment of the adapter, myeloid differentiation primary response gene 88 (MyD88), to TLR TIR domains results in downstream signaling ...

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PLZF expression maps the early stages of ILC1 lineage development [Immunology and Inflammation]

21.04.2015 | Michael G. Constantinides; Herman Gudjonson; Benjamin D. McDonald; Isabel E. Ishizuka; Philip A. Verhoef; Aaron R. D ..., Proceedings of the National Academy of Sciences current issue, 2015

Among the variety of tissue-resident NK-like populations recently distinguished from recirculating classical NK (cNK) cells, liver innate lymphoid cells (ILC) type 1 (ILC1s) have been shown to represent a distinct lineage that originates from a novel promyelocytic leukaemia zinc finger ...

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Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response [Immunology and Inflammation]

21.04.2015 | Emilie K. Grasset; Amanda Duhlin; Hanna E. Agardh; Olga Ovchinnikova; Thomas Hägglöf; Mattias N. Forsell; Gabrielle ..., Proceedings of the National Academy of Sciences current issue, 2015

The B-cell response in atherosclerosis is directed toward oxidation-specific epitopes such as phosphorylcholine (PC) that arise during disease-driven oxidation of self-antigens. PC-bearing antigens have been used to induce atheroprotective antibodies against modified low-density lipoproteins ...

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G{alpha}i1 and G{alpha}i3 regulate macrophage polarization by forming a complex containing CD14 and Gab1 [Immunology and Inflammation]

14.04.2015 | Xianjing Li; Duowei Wang; Zhen Chen; Ermei Lu; Zhuo Wang; Jingjing Duan; Wei Tian; Yun Wang; Linjun You; Yulian Zou; ..., Proceedings of the National Academy of Sciences current issue, 2015

Heterotrimeric G proteins have been implicated in Toll-like receptor 4 (TLR4) signaling in macrophages and endothelial cells. However, whether guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Gαi1/3) are required for LPS responses remains unclear, and if so, the underlying ...

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