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509 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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G{alpha}i1 and G{alpha}i3 regulate macrophage polarization by forming a complex containing CD14 and Gab1 [Immunology and Inflammation]

14.04.2015 | Xianjing Li; Duowei Wang; Zhen Chen; Ermei Lu; Zhuo Wang; Jingjing Duan; Wei Tian; Yun Wang; Linjun You; Yulian Zou; ..., Proceedings of the National Academy of Sciences current issue, 2015

Heterotrimeric G proteins have been implicated in Toll-like receptor 4 (TLR4) signaling in macrophages and endothelial cells. However, whether guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Gαi1/3) are required for LPS responses remains unclear, and if so, the underlying ...

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AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3 [Immunology and Inflammation]

31.03.2015 | Adam Denes; Graham Coutts; Nikolett Lénárt; Sheena M. Cruickshank; Pablo Pelegrin; Joanne Skinner; Nancy Rothwell; S ..., Proceedings of the National Academy of Sciences current issue, 2015

Inflammation that contributes to acute cerebrovascular disease is driven by the proinflammatory cytokine interleukin-1 and is known to exacerbate resulting injury. The activity of interleukin-1 is regulated by multimolecular protein complexes called inflammasomes. There are multiple potential ...

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The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck [Immunology and Inflammation]

31.03.2015 | Kyung-Ho Roh; Björn F. Lillemeier; Feng Wang; Mark M. Davis, Proceedings of the National Academy of Sciences current issue, 2015

CD4 molecules on the surface of T lymphocytes greatly augment the sensitivity and activation process of these cells, but how it functions is not fully understood. Here we studied the spatial organization of CD4, and its relationship to T-cell antigen receptor (TCR) and the active form of Src ...

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Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor [Immunology and Inflammation]

31.03.2015 | Ruijun Tian; Haopeng Wang; Gerald D. Gish; Evangelia Petsalaki; Adrian Pasculescu; Yu Shi; Marianne Mollenauer; Rich ..., Proceedings of the National Academy of Sciences current issue, 2015

Systematic characterization of intercellular signaling approximating the physiological conditions of stimulation that involve direct cell–cell contact is challenging. We describe a proteomic strategy to analyze physiological signaling mediated by the T-cell costimulatory receptor CD28. We ...

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L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro [Immunology and Inflammation]

24.03.2015 | Karolina Rzeniewicz; Abigail Newe; Angela Rey Gallardo; Jessica Davies; Mark R. Holt; Ashish Patel; Guillaume T. Cha ..., Proceedings of the National Academy of Sciences current issue, 2015

L-selectin is a cell adhesion molecule that tethers free-flowing leukocytes from the blood to luminal vessel walls, facilitating the initial stages of their emigration from the circulation toward an extravascular inflammatory insult. Following shear-resistant adhesion to the vessel wall, ...

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Tetramers reveal IL-17-secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease [Immunology and Inflammation]

10.03.2015 | Nicole H. Kattah; Evan W. Newell; Justin Ansel Jarrell; Alvina D. Chu; Jianming Xie; Michael G. Kattah; Ofir Goldber ..., Proceedings of the National Academy of Sciences current issue, 2015

Antigen-specific CD4+ T cells are implicated in the autoimmune disease systemic lupus erythematosus (SLE), but little is known about the peptide antigens that they recognize and their precise function in disease. We generated a series of MHC class II tetramers of I-Ek–containing peptides from the ...

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Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration [Immunology and Inflammation]

10.03.2015 | Jayendra Kumar Krishnaswamy; Arpita Singh; Uthaman Gowthaman; Renee Wu; Pavane Gorrepati; Manuela Sales Nascimento; ..., Proceedings of the National Academy of Sciences current issue, 2015

Dendritic cells (DCs) are the primary leukocytes responsible for priming T cells. To find and activate naïve T cells, DCs must migrate to lymph nodes, yet the cellular programs responsible for this key step remain unclear. DC migration to lymph nodes and the subsequent T-cell response are ...

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{beta}-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8+ T cells through regulation of IL-10 [Immunology and Inflammation]

03.03.2015 | Chunmei Fu; Xinjun Liang; Weiguo Cui; Julia L. Ober-Blöbaum; Joseph Vazzana; Protul A. Shrikant; Kelvin P. Lee; Björ ..., Proceedings of the National Academy of Sciences current issue, 2015

Recent studies have demonstrated that β-catenin in DCs serves as a key mediator in promoting both CD4+ and CD8+ T-cell tolerance, although how β-catenin exerts its functions remains incompletely understood. Here we report that activation of β-catenin in DCs inhibits cross-priming of CD8+ T cells ...

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Dendritic cell SIRT1-HIF1{alpha} axis programs the differentiation of CD4+ T cells through IL-12 and TGF-{beta}1 [Immunology and Inflammation]

03.03.2015 | Guangwei Liu; Yujing Bi; Lixiang Xue; Yan Zhang; Hui Yang; Xi Chen; Yun Lu; Zhengguo Zhang; Huanrong Liu; Xiao Wang; ..., Proceedings of the National Academy of Sciences current issue, 2015

The differentiation of naive CD4+ T cells into distinct lineages plays critical roles in mediating adaptive immunity or maintaining immune tolerance. In addition to being a first line of defense, the innate immune system also actively instructs adaptive immunity through antigen presentation and ...

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Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK [Immunology and Inflammation]

03.03.2015 | Idit Sagiv-Barfi; Holbrook E. K. Kohrt; Debra K. Czerwinski; Patrick P. Ng; Betty Y. Chang; Ronald Levy, Proceedings of the National Academy of Sciences current issue, 2015

Monoclonal antibodies can block cellular interactions that negatively regulate T-cell immune responses, such as CD80/CTLA-4 and PD-1/PD1-L, amplifying preexisting immunity and thereby evoking antitumor immune responses. Ibrutinib, an approved therapy for B-cell malignancies, is a covalent ...

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