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610 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution [Immunology and Inflammation]

26.01.2016 | Yun-Hee Youm; Tamas L. Horvath; David J. Mangelsdorf; Steven A. Kliewer; Vishwa Deep Dixit, Proceedings of the National Academy of Sciences current issue, 2016

Age-related thymic degeneration is associated with loss of naïve T cells, restriction of peripheral T-cell diversity, and reduced healthspan due to lower immune competence. The mechanistic basis of age-related thymic demise is unclear, but prior evidence suggests that caloric restriction (CR) can ...


Imaging of the cross-presenting dendritic cell subsets in the skin-draining lymph node [Immunology and Inflammation]

26.01.2016 | Masahiro Kitano; Chihiro Yamazaki; Akiko Takumi; Takashi Ikeno; Hiroaki Hemmi; Noriko Takahashi; Kanako Shimizu; Sco ..., Proceedings of the National Academy of Sciences current issue, 2016

Dendritic cells (DCs) are antigen-presenting cells specialized for activating T cells to elicit effector T-cell functions. Cross-presenting DCs are a DC subset capable of presenting antigens to CD8+ T cells and play critical roles in cytotoxic T-cell–mediated immune responses to microorganisms ...


Surface expression, peptide repertoire, and thermostability of chicken class I molecules correlate with peptide transporter specificity [Immunology and Inflammation]

19.01.2016 | Clive A. Tregaskes; Michael Harrison; Anna K. Sowa; Andy van Hateren; Lawrence G. Hunt; Olli Vainio; Jim Kaufman, Proceedings of the National Academy of Sciences current issue, 2016

The chicken major histocompatibility complex (MHC) has strong genetic associations with resistance and susceptibility to certain infectious pathogens. The cell surface expression level of MHC class I molecules varies as much as 10-fold between chicken haplotypes and is inversely correlated with ...


Cytokine Diedel and a viral homologue suppress the IMD pathway in Drosophila [Immunology and Inflammation]

19.01.2016 | Olivier Lamiable; Christine Kellenberger; Cordula Kemp; Laurent Troxler; Nadège Pelte; Michael Boutros; Joao Trindad ..., Proceedings of the National Academy of Sciences current issue, 2016

Viruses are obligatory intracellular parasites that suffer strong evolutionary pressure from the host immune system. Rapidly evolving viral genomes can adapt to this pressure by acquiring genes that counteract host defense mechanisms. For example, many vertebrate DNA viruses have hijacked ...


Human autoreactive T cells recognize CD1b and phospholipids [Immunology and Inflammation]

12.01.2016 | Ildiko Van Rhijn; Twan van Berlo; Tamara Hilmenyuk; Tan-Yun Cheng; Benjamin J. Wolf; Raju V. V. Tatituri; Adam P. Ul ..., Proceedings of the National Academy of Sciences current issue, 2016

In contrast with the common detection of T cells that recognize MHC, CD1a, CD1c, or CD1d proteins, CD1b autoreactive T cells have been difficult to isolate in humans. Here we report the development of polyvalent complexes of CD1b proteins and carbohydrate backbones (dextramers) and their use in ...


IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo [Immunology and Inflammation]

12.01.2016 | Omar I. Vivar; Giulia Masi; Jean-Marie Carpier; Joao G. Magalhaes; Donatella Galgano; Gregory J. Pazour; Sebastian A ..., Proceedings of the National Academy of Sciences current issue, 2016

Biogenesis of the immune synapse at the interface between antigen-presenting cells and T cells assembles and organizes a large number of membrane proteins required for effective signaling through the T-cell receptor. We showed previously that the intraflagellar transport protein 20 (IFT20), a ...


Phospholipid signals of microbial infection for the human immune system [Immunology and Inflammation]

12.01.2016 | Mitchell Kronenberg; Meng Zhao, Proceedings of the National Academy of Sciences current issue, 2016

The immune system must defend the body from pathogens while avoiding self-reactivity leading to autoimmune disease. This discrimination depends upon distinguishing molecular structures that are autologous, or self, from those structures that are nonself. Although self–nonself discrimination is a ...


Deubiquitinase CYLD acts as a negative regulator for bacterium NTHi-induced inflammation by suppressing K63-linked ubiquitination of MyD88 [Immunology and Inflammation]

12.01.2016 | Byung-Cheol Lee; Masanori Miyata; Jae Hyang Lim; Jian-Dong Li, Proceedings of the National Academy of Sciences current issue, 2016

Myeloid differentiation factor 88 (MyD88) acts as a crucial adaptor molecule for Toll-like receptors (TLRs) and interleukin (IL)-1 receptor signaling. In contrast to the well-studied positive regulation of MyD88 signaling, how MyD88 signaling is negatively regulated still remains largely unknown. ...


Mesenchymal stem/stromal cells precondition lung monocytes/macrophages to produce tolerance against allo- and autoimmunity in the eye [Immunology and Inflammation]

05.01.2016 | Jung Hwa Ko; Hyun Ju Lee; Hyun Jeong Jeong; Mee Kum Kim; Won Ryang Wee; Sun-ok Yoon; Hosoon Choi; Darwin J. Prockop; ..., Proceedings of the National Academy of Sciences current issue, 2016

Intravenously administered mesenchymal stem/stromal cells (MSCs) engraft only transiently in recipients, but confer long-term therapeutic benefits in patients with immune disorders. This suggests that MSCs induce immune tolerance by long-lasting effects on the recipient immune regulatory system. ...


Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1 [Immunology and Inflammation]

29.12.2015 | Tina El Rayes; Raúl Catena; Sharrell Lee; Marcin Stawowczyk; Natasha Joshi; Claudia Fischbach; Charles A. Powell; An ..., Proceedings of the National Academy of Sciences current issue, 2015

Inflammation is inextricably associated with primary tumor progression. However, the contribution of inflammation to tumor outgrowth in metastatic organs has remained underexplored. Here, we show that extrinsic inflammation in the lungs leads to the recruitment of bone marrow-derived neutrophils, ...


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