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946 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Discovering the first tyrosine kinase [Biochemistry]

30.06.2015 | Tony Hunter, Proceedings of the National Academy of Sciences current issue, 2015

In the middle of the 20th century, animal tumor viruses were heralded as possible models for understanding human cancer. By the mid-1970s, the molecular basis by which tumor viruses transform cells into a malignant state was beginning to emerge as the first viral genomic sequences were reported ...

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Mediation of donor-acceptor distance in an enzymatic methyl transfer reaction [Biochemistry]

30.06.2015 | Jianyu Zhang; Heather J. Kulik; Todd J. Martinez; Judith P. Klinman, Proceedings of the National Academy of Sciences current issue, 2015

Enzymatic methyl transfer, catalyzed by catechol-O-methyltransferase (COMT), is investigated using binding isotope effects (BIEs), time-resolved fluorescence lifetimes, Stokes shifts, and extended graphics processing unit (GPU)-based quantum mechanics/molecular mechanics (QM/MM) approaches. The ...

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A universal entropy-driven mechanism for thioredoxin-target recognition [Biochemistry]

30.06.2015 | Prakash B. Palde; Kate S. Carroll, Proceedings of the National Academy of Sciences current issue, 2015

Cysteine residues in cytosolic proteins are maintained in their reduced state, but can undergo oxidation owing to posttranslational modification during redox signaling or under conditions of oxidative stress. In large part, the reduction of oxidized protein cysteines is mediated by a small 12-kDa ...

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Empirical inference of circuitry and plasticity in a kinase signaling network [Biochemistry]

23.06.2015 | Edmund H. Wilkes; Camille Terfve; John G. Gribben; Julio Saez-Rodriguez; Pedro Rodriguez Cutillas, Proceedings of the National Academy of Sciences current issue, 2015

Our understanding of physiology and disease is hampered by the difficulty of measuring the circuitry and plasticity of signaling networks that regulate cell biology, and how these relate to phenotypes. Here, using mass spectrometry-based phosphoproteomics, we systematically characterized the ...

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Regulation by a chaperone improves substrate selectivity during cotranslational protein targeting [Biochemistry]

23.06.2015 | Aileen Ariosa; Jae Ho Lee; Shuai Wang; Ishu Saraogi; Shu-ou Shan, Proceedings of the National Academy of Sciences current issue, 2015

The ribosome exit site is a crowded environment where numerous factors contact nascent polypeptides to influence their folding, localization, and quality control. Timely and accurate selection of nascent polypeptides into the correct pathway is essential for proper protein biogenesis. To ...

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Cytochrome cbb3 of Thioalkalivibrio is a Na+-pumping cytochrome oxidase [Biochemistry]

23.06.2015 | Maria S. Muntyan; Dmitry A. Cherepanov; Anssi M. Malinen; Dmitry A. Bloch; Dimitry Y. Sorokin; Inna I. Severina; Tat ..., Proceedings of the National Academy of Sciences current issue, 2015

Cytochrome c oxidases (Coxs) are the basic energy transducers in the respiratory chain of the majority of aerobic organisms. Coxs studied to date are redox-driven proton-pumping enzymes belonging to one of three subfamilies: A-, B-, and C-type oxidases. The C-type oxidases (cbb3 cytochromes), ...

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Phosphoregulatory protein 14-3-3 facilitates SAC1 transport from the endoplasmic reticulum [Biochemistry]

23.06.2015 | Kanika Bajaj Pahuja; Jinzhi Wang; Anastasia Blagoveshchenskaya; Lillian Lim; M. S. Madhusudhan; Peter Mayinger; Rand ..., Proceedings of the National Academy of Sciences current issue, 2015

Most secretory cargo proteins in eukaryotes are synthesized in the endoplasmic reticulum and actively exported in membrane-bound vesicles that are formed by the cytosolic coat protein complex II (COPII). COPII proteins are assisted by a variety of cargo-specific adaptor proteins required for the ...

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Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90 [Biochemistry]

23.06.2015 | Edgar E. Boczek; Lasse G. Reefschläger; Marco Dehling; Tobias J. Struller; Elisabeth Häusler; Andreas Seidl; Ville R ..., Proceedings of the National Academy of Sciences current issue, 2015

Hsp90 is a molecular chaperone involved in the activation of numerous client proteins, including many kinases. The most stringent kinase client is the oncogenic kinase v-Src. To elucidate how Hsp90 chaperones kinases, we reconstituted v-Src kinase chaperoning in vitro and show that its activation ...

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Structural basis of a Ni acquisition cycle for [NiFe] hydrogenase by Ni-metallochaperone HypA and its enhancer [Biochemistry]

23.06.2015 | Satoshi Watanabe; Takumi Kawashima; Yuichi Nishitani; Tamotsu Kanai; Takehiko Wada; Kenji Inaba; Haruyuki Atomi; Tad ..., Proceedings of the National Academy of Sciences current issue, 2015

The Ni atom at the catalytic center of [NiFe] hydrogenases is incorporated by a Ni-metallochaperone, HypA, and a GTPase/ATPase, HypB. We report the crystal structures of the transient complex formed between HypA and ATPase-type HypB (HypBAT) with Ni ions. Transient association between HypA and ...

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Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly [Biochemistry]

23.06.2015 | Andrew P. AhYoung; Jiansen Jiang; Jiang Zhang; Xuan Khoi Dang; Joseph A. Loo; Z. Hong Zhou; Pascal F. Egea, Proceedings of the National Academy of Sciences current issue, 2015

Membrane contact sites (MCS) between organelles are proposed as nexuses for the exchange of lipids, small molecules, and other signals crucial to cellular function and homeostasis. Various protein complexes, such as the endoplasmic reticulum-mitochondrial encounter structure (ERMES), function as ...

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