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785 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Structural basis of cellular dNTP regulation by SAMHD1 [Biochemistry]

14.10.2014 | Xiaoyun Ji; Chenxiang Tang; Qi Zhao; Wei Wang; Yong Xiong, Proceedings of the National Academy of Sciences current issue, 2014

The sterile alpha motif and HD domain-containing protein 1 (SAMHD1), a dNTPase, prevents the infection of nondividing cells by retroviruses, including HIV, by depleting the cellular dNTP pool available for viral reverse transcription. SAMHD1 is a major regulator of cellular dNTP levels in ...

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Basis for substrate recognition and distinction by matrix metalloproteinases [Biochemistry]

07.10.2014 | Boris I. Ratnikov; Piotr Cieplak; Kosi Gramatikoff; James Pierce; Alexey Eroshkin; Yoshinobu Igarashi; Marat Kazanov ..., Proceedings of the National Academy of Sciences current issue, 2014

Genomic sequencing and structural genomics produced a vast amount of sequence and structural data, creating an opportunity for structure–function analysis in silico [Radivojac P, et al. (2013) Nat Methods 10(3):221–227]. Unfortunately, only a few large experimental datasets exist to serve as ...

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Single-molecule investigation of G-quadruplex folds of the human telomere sequence in a protein nanocavity [Biochemistry]

07.10.2014 | Na An; Aaron M. Fleming; Eric G. Middleton; Cynthia J. Burrows, Proceedings of the National Academy of Sciences current issue, 2014

Human telomeric DNA consists of tandem repeats of the sequence 5′-TTAGGG-3′ that can fold into various G-quadruplexes, including the hybrid, basket, and propeller folds. In this report, we demonstrate use of the α-hemolysin ion channel to analyze these subtle topological changes at a nanometer ...

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Ribosome-induced tuning of GTP hydrolysis by a translational GTPase [Biochemistry]

07.10.2014 | Cristina Maracci; Frank Peske; Ev Dannies; Corinna Pohl; Marina V. Rodnina, Proceedings of the National Academy of Sciences current issue, 2014

GTP hydrolysis by elongation factor Tu (EF-Tu), a translational GTPase that delivers aminoacyl-tRNAs to the ribosome, plays a crucial role in decoding and translational fidelity. The basic reaction mechanism and the way the ribosome contributes to catalysis are a matter of debate. Here we use ...

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Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1 [Biochemistry]

07.10.2014 | Non Miyata; Janos Steffen; Meghan E. Johnson; Sonia Fargue; Christopher J. Danpure; Carla M. Koehler, Proceedings of the National Academy of Sciences current issue, 2014

Primary hyperoxaluria 1 (PH1; Online Mendelian Inheritance in Man no. 259900), a typically lethal biochemical disorder, may be caused by the AGTP11LG170R allele in which the alanine:glyoxylate aminotransferase (AGT) enzyme is mistargeted from peroxisomes to mitochondria. AGT contains a C-terminal ...

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Molecular mechanics of 30S subunit head rotation [Biochemistry]

16.09.2014 | Srividya Mohan; John Paul Donohue; Harry F. Noller, Proceedings of the National Academy of Sciences current issue, 2014

During ribosomal translocation, a process central to the elongation phase of protein synthesis, movement of mRNA and tRNAs requires large-scale rotation of the head domain of the small (30S) subunit of the ribosome. It has generally been accepted that the head rotates by pivoting around the neck ...

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Structural insight into the molecular mechanism of allosteric activation of human cystathionine {beta}-synthase by S-adenosylmethionine [Biochemistry]

16.09.2014 | June Ereño-Orbea; Tomas Majtan; Iker Oyenarte; Jan P. Kraus; Luis Alfonso Martínez-Cruz, Proceedings of the National Academy of Sciences current issue, 2014

Cystathionine β-synthase (CBS) is a heme-dependent and pyridoxal-5′-phosphate–dependent protein that controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S. Deficiency of CBS activity causes homocystinuria, the most frequent disorder of sulfur amino ...

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Remodeling of a delivery complex allows ClpS-mediated degradation of N-degron substrates [Biochemistry]

16.09.2014 | Izarys Rivera-Rivera; Giselle Román-Hernández; Robert T. Sauer; Tania A. Baker, Proceedings of the National Academy of Sciences current issue, 2014

The ClpS adaptor collaborates with the AAA+ ClpAP protease to recognize and degrade N-degron substrates. ClpS binds the substrate N-degron and assembles into a high-affinity ClpS-substrate-ClpA complex, but how the N-degron is transferred from ClpS to the axial pore of the AAA+ ClpA unfoldase to ...

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Ligand- and mutation-induced conformational selection in the CCR5 chemokine G protein-coupled receptor [Biochemistry]

09.09.2014 | Ravinder Abrol; Bartosz Trzaskowski; William A. Goddard III; Alexandre Nesterov; Ivan Olave; Christopher Irons, Proceedings of the National Academy of Sciences current issue, 2014

We predicted the structural basis for pleiotropic signaling of the C-C chemokine type 5 (CCR5) G protein-coupled receptor (GPCR) by predicting the binding of several ligands to the lower-energy conformations of the CCR5 receptor and 11 mutants. For each case, we predicted the ∼20 most stable ...

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Structural basis for the fast self-cleavage reaction catalyzed by the twister ribozyme [Biochemistry]

09.09.2014 | Daniel Eiler; Jimin Wang; Thomas A. Steitz, Proceedings of the National Academy of Sciences current issue, 2014

Twister is a recently discovered RNA motif that is estimated to have one of the fastest known catalytic rates of any naturally occurring small self-cleaving ribozyme. We determined the 4.1-Å resolution crystal structure of a twister sequence from an organism that has not been cultured in ...

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