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883 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Plasmodium falciparum chloroquine resistance transporter is a H+-coupled polyspecific nutrient and drug exporter [Biochemistry]

17.03.2015 | Narinobu Juge; Sawako Moriyama; Takaaki Miyaji; Mamiyo Kawakami; Haruka Iwai; Tomoya Fukui; Nathan Nelson; Hiroshi O ..., Proceedings of the National Academy of Sciences current issue, 2015

Extrusion of chloroquine (CQ) from digestive vacuoles through the Plasmodium falciparum CQ resistance transporter (PfCRT) is essential to establish CQ resistance of the malaria parasite. However, the physiological relevance of PfCRT and how CQ-resistant PfCRT gains the ability to transport CQ ...

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Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH [Biochemistry]

17.03.2015 | Shangyu Dang; Shenjie Wu; Jiawei Wang; Hongbo Li; Min Huang; Wei He; Yue-Ming Li; Catherine C. L. Wong; Yigong Shi, Proceedings of the National Academy of Sciences current issue, 2015

Aberrant cleavage of amyloid precursor protein (APP) by γ-secretase contributes to the development of Alzheimer’s disease. More than 200 disease-derived mutations have been identified in presenilin (the catalytic subunit of γ-secretase), making modulation of γ-secretase activity a potentially ...

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Myosin VI deafness mutation prevents the initiation of processive runs on actin [Biochemistry]

17.03.2015 | Olena Pylypenko; Lin Song; Ai Shima; Zhaohui Yang; Anne M. Houdusse; H. Lee Sweeney, Proceedings of the National Academy of Sciences current issue, 2015

Mutations in the reverse-direction myosin, myosin VI, are associated with deafness in humans and mice. A myosin VI deafness mutation, D179Y, which is in the transducer of the motor, uncoupled the release of the ATP hydrolysis product, inorganic phosphate (Pi), from dependency on actin binding and ...

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Rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo [Biochemistry]

17.03.2015 | Tsz-Leung To; Beverly J. Piggott; Kalpana Makhijani; Dan Yu; Yuh Nung Jan; Xiaokun Shu, Proceedings of the National Academy of Sciences current issue, 2015

Fluorescence resonance energy transfer-based reporters have been widely used in imaging cell signaling; however, their in vivo application has been handicapped because of poor signal. Although fluorogenic reporters overcome this problem, no such reporter of proteases has been demonstrated for in ...

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Selective molecular transport through the protein shell of a bacterial microcompartment organelle [Biochemistry]

10.03.2015 | Chiranjit Chowdhury; Sunny Chun; Allan Pang; Michael R. Sawaya; Sharmistha Sinha; Todd O. Yeates; Thomas A. Bobik, Proceedings of the National Academy of Sciences current issue, 2015

Bacterial microcompartments are widespread prokaryotic organelles that have important and diverse roles ranging from carbon fixation to enteric pathogenesis. Current models for microcompartment function propose that their outer protein shell is selectively permeable to small molecules, but ...

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Rational design of a split-Cas9 enzyme complex [Biochemistry]

10.03.2015 | Addison V. Wright; Samuel H. Sternberg; David W. Taylor; Brett T. Staahl; Jorge A. Bardales; Jack E. Kornfeld; Jenni ..., Proceedings of the National Academy of Sciences current issue, 2015

Cas9, an RNA-guided DNA endonuclease found in clustered regularly interspaced short palindromic repeats (CRISPR) bacterial immune systems, is a versatile tool for genome editing, transcriptional regulation, and cellular imaging applications. Structures of Streptococcus pyogenes Cas9 alone or ...

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ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis [Biochemistry]

03.03.2015 | Wen-Wei Tsai; Shigenobu Matsumura; Weiyi Liu; Naomi G. Phillips; Tim Sonntag; Ergeng Hao; Soon Lee; Tsonwin Hai; Mar ..., Proceedings of the National Academy of Sciences current issue, 2015

Increases in circulating glucagon during fasting maintain glucose balance by stimulating hepatic gluconeogenesis. Acute ethanol intoxication promotes fasting hypoglycemia through an increase in hepatic NADH, which inhibits hepatic gluconeogenesis by reducing the conversion of lactate to pyruvate. ...

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Cell-specific proteomic analysis in Caenorhabditis elegans [Biochemistry]

03.03.2015 | Kai P. Yuet; Meenakshi K. Doma; John T. Ngo; Michael J. Sweredoski; Robert L. J. Graham; Annie Moradian; Sonja Hess; ..., Proceedings of the National Academy of Sciences current issue, 2015

Proteomic analysis of rare cells in heterogeneous environments presents difficult challenges. Systematic methods are needed to enrich, identify, and quantify proteins expressed in specific cells in complex biological systems including multicellular plants and animals. Here, we have engineered a ...

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In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly [Biochemistry]

03.03.2015 | Yi-Ling Du; Lona M. Alkhalaf; Katherine S. Ryan, Proceedings of the National Academy of Sciences current issue, 2015

The bacterial tryptophanyl–tRNA synthetase inhibitor indolmycin features a unique oxazolinone heterocycle whose biogenetic origins have remained obscure for over 50 years. Here we identify and characterize the indolmycin biosynthetic pathway, using systematic in vivo gene inactivation, in vitro ...

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Profile of Sabeeha Merchant [Profiles]

03.03.2015 | Tinsley H. Davis, Proceedings of the National Academy of Sciences current issue, 2015

Organic molecules dominate the biological world, yet many of life’s critical molecular reactions depend on metals for catalysis. Sabeeha Merchant, a professor of biochemistry at the University of California, Los Angeles (UCLA), studies how cells keep track of crucial trace nutrients like iron and ...

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