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865 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum [Biochemistry]

17.02.2015 | Filipa Teixeira; Helena Castro; Tânia Cruz; Eric Tse; Philipp Koldewey; Daniel R. Southworth; Ana M. Tomás; Ursula Jakob, Proceedings of the National Academy of Sciences current issue, 2015

Cytosolic eukaryotic 2-Cys-peroxiredoxins have been widely reported to act as dual-function proteins, either detoxifying reactive oxygen species or acting as chaperones to prevent protein aggregation. Several stimuli, including peroxide-mediated sulfinic acid formation at the active site ...

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Structural basis for transcription reactivation by RapA [Biochemistry]

17.02.2015 | Bin Liu; Yuhong Zuo; Thomas A. Steitz, Proceedings of the National Academy of Sciences current issue, 2015

RNA polymerase (RNAP) loses activity during transcription as it stalls at various inactive states due to erratic translocation. Reactivation of these stalled RNAPs is essential for efficient RNA synthesis. Here we report a 4.7-Å resolution crystal structure of the Escherichia coli RNAP core ...

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Distinct activation of an E2 ubiquitin-conjugating enzyme by its cognate E3 ligases [Biochemistry]

17.02.2015 | Itamar Cohen; Reuven Wiener; Yuval Reiss; Tommer Ravid, Proceedings of the National Academy of Sciences current issue, 2015

A significant portion of ubiquitin (Ub)-dependent cellular protein quality control takes place at the endoplasmic reticulum (ER) in a process termed “ER-associated degradation” (ERAD). Yeast ERAD employs two integral ER membrane E3 Ub ligases: Hrd1 (also termed “Der3”) and Doa10, which recognize ...

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A conserved amphipathic helix is required for membrane tubule formation by Yop1p [Biochemistry]

17.02.2015 | Jacob P. Brady; Jolyon K. Claridge; Peter G. Smith; Jason R. Schnell, Proceedings of the National Academy of Sciences current issue, 2015

The integral membrane proteins of the DP1 (deleted in polyposis) and reticulon families are responsible for maintaining the high membrane curvature required for both smooth endoplasmic reticulum (ER) tubules and the edges of ER sheets, and mutations in these proteins lead to motor neuron ...

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Inhibition of the {beta}-barrel assembly machine by a peptide that binds BamD [Biochemistry]

17.02.2015 | Christine L. Hagan; Joseph S. Wzorek; Daniel Kahne, Proceedings of the National Academy of Sciences current issue, 2015

The protein complex that assembles integral membrane β-barrel proteins in the outer membranes of Gram-negative bacteria is an attractive target in the development of new antibiotics. This complex, the β-barrel assembly machine (Bam), contains two essential proteins, BamA and BamD. We have ...

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Distinct pathways of RNA polymerase regulation by a phage-encoded factor [Biochemistry]

17.02.2015 | Daria Esyunina; Evgeny Klimuk; Konstantin Severinov; Andrey Kulbachinskiy, Proceedings of the National Academy of Sciences current issue, 2015

Transcription antitermination is a common strategy of gene expression regulation, but only a few transcription antitermination factors have been studied in detail. Here, we dissect the transcription antitermination mechanism of Xanthomonas oryzae virus Xp10 protein p7, which binds host RNA ...

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A CaMKII/PDE4D negative feedback regulates cAMP signaling [Biochemistry]

17.02.2015 | Delphine Mika; Wito Richter; Marco Conti, Proceedings of the National Academy of Sciences current issue, 2015

cAMP production and protein kinase A (PKA) are the most widely studied steps in β-adrenergic receptor (βAR) signaling in the heart; however, the multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII) is also activated in response to βAR stimulation and is involved in the regulation ...

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Specialized insulin is used for chemical warfare by fish-hunting cone snails [Biochemistry]

10.02.2015 | Helena Safavi-Hemami; Joanna Gajewiak; Santhosh Karanth; Samuel D. Robinson; Beatrix Ueberheide; Adam D. Douglass; A ..., Proceedings of the National Academy of Sciences current issue, 2015

More than 100 species of venomous cone snails (genus Conus) are highly effective predators of fish. The vast majority of venom components identified and functionally characterized to date are neurotoxins specifically targeted to receptors, ion channels, and transporters in the nervous system of ...

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Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase [Biochemistry]

10.02.2015 | Christopher N. Batuello; Paula M. Hauck; Jaimie M. Gendron; Jason A. Lehman; Lindsey D. Mayo, Proceedings of the National Academy of Sciences current issue, 2015

Murine double minute-2 protein (Mdm2) is a multifaceted phosphorylated protein that plays a role in regulating numerous proteins including the tumor suppressor protein p53. Mdm2 binds to and is involved in conjugating either ubiquitin or Nedd8 (Neural precursor cell expressed, developmentally ...

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Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices [Biochemistry]

10.02.2015 | Elizaveta S. Leshchiner; Andrey Parkhitko; Gregory H. Bird; James Luccarelli; Joseph A. Bellairs; Silvia Escudero; K ..., Proceedings of the National Academy of Sciences current issue, 2015

Activating mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) underlie the pathogenesis and chemoresistance of ∼30% of all human tumors, yet the development of high-affinity inhibitors that target the broad range of KRAS mutants remains a formidable challenge. Here, we report the ...

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