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844 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Stable, uncleaved HIV-1 envelope glycoprotein gp140 forms a tightly folded trimer with a native-like structure [Biochemistry]

30.12.2014 | James M. Kovacs; Erik Noeldeke; Heather Jiwon Ha; Hanqin Peng; Sophia Rits-Volloch; Stephen C. Harrison; Bing Chen, Proceedings of the National Academy of Sciences current issue, 2014

The HIV-1 envelope spike [trimeric (gp160)3, cleaved to (gp120/gp41)3] is the mediator of viral entry and the principal target of humoral immune response to the virus. Production of a recombinant preparation that represents the functional spike poses a challenge for vaccine development, because ...

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Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif [Biochemistry]

30.12.2014 | Lanfeng Wang; Oliver Limbo; Jia Fei; Lu Chen; Bong Kim; Jie Luo; Jenny Chong; Ronald C. Conaway; Joan W. Conaway; Je ..., Proceedings of the National Academy of Sciences current issue, 2014

CSB/ERCC6 (Cockayne syndrome B protein/excision repair cross-complementation group 6), a member of a subfamily of SWI2/SNF2 (SWItch/sucrose nonfermentable)-related chromatin remodelers, plays crucial roles in gene expression and the maintenance of genome integrity. Here, we report the mechanism ...

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A divergent Pumilio repeat protein family for pre-rRNA processing and mRNA localization [Biochemistry]

30.12.2014 | Chen Qiu; Kathleen L. McCann; Robert N. Wine; Susan J. Baserga; Traci M. Tanaka Hall, Proceedings of the National Academy of Sciences current issue, 2014

Pumilio/feminization of XX and XO animals (fem)-3 mRNA-binding factor (PUF) proteins bind sequence specifically to mRNA targets using a single-stranded RNA-binding domain comprising eight Pumilio (PUM) repeats. PUM repeats have now been identified in proteins that function in pre-rRNA processing, ...

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Allosteric activation of ADAMTS13 by von Willebrand factor [Biochemistry]

30.12.2014 | Joshua Muia; Jian Zhu; Garima Gupta; Sandra L. Haberichter; Kenneth D. Friedman; Hendrik B. Feys; Louis Deforche; Ka ..., Proceedings of the National Academy of Sciences current issue, 2014

The metalloprotease ADAMTS13 cleaves von Willebrand factor (VWF) within endovascular platelet aggregates, and ADAMTS13 deficiency causes fatal microvascular thrombosis. The proximal metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains of ADAMTS13 ...

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Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation [Biochemistry]

30.12.2014 | Puneet Anand; Alfred Hausladen; Ya-Juan Wang; Guo-Fang Zhang; Colin Stomberski; Henri Brunengraber; Douglas T. Hess; ..., Proceedings of the National Academy of Sciences current issue, 2014

Coenzyme A (CoA) mediates thiol-based acyl-group transfer (acetylation and palmitoylation). However, a role for CoA in the thiol-based transfer of NO groups (S-nitrosylation) has not been considered. Here we describe protein S-nitrosylation in yeast (heretofore unknown) that is mediated by ...

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Conformational activation of ADAMTS13 [Biochemistry]

30.12.2014 | Kieron South; Brenda M. Luken; James T. B. Crawley; Rebecca Phillips; Mari Thomas; Richard F. Collins; Louis Deforch ..., Proceedings of the National Academy of Sciences current issue, 2014

A disintegrin and metalloprotease with thrombospondin motifs 13 (ADAMTS13) is a metalloprotease that regulates von Willebrand factor (VWF) function. ADAMTS13-mediated proteolysis is determined by conformational changes in VWF, but also may depend on its own conformational activation. Kinetic ...

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Structure of a pantothenate transporter and implications for ECF module sharing and energy coupling of group II ECF transporters [Biochemistry]

30.12.2014 | Minhua Zhang; Zhihao Bao; Qin Zhao; Hui Guo; Ke Xu; Chengcheng Wang; Peng Zhang, Proceedings of the National Academy of Sciences current issue, 2014

Energy-coupling factor (ECF) transporters are a unique group of ATP-binding cassette (ABC) transporters responsible for micronutrient uptake from the environment. Each ECF transporter is composed of an S component (or EcfS protein) and T/A/A′ components (or EcfT/A/A′ proteins; ECF module). Among ...

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A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1 [Biochemistry]

30.12.2014 | T. Justin Rettenmaier; Jack D. Sadowsky; Nathan D. Thomsen; Steven C. Chen; Allison K. Doak; Michelle R. Arkin; Jame ..., Proceedings of the National Academy of Sciences current issue, 2014

There is great interest in developing selective protein kinase inhibitors by targeting allosteric sites, but these sites often involve protein–protein or protein–peptide interfaces that are very challenging to target with small molecules. Here we present a systematic approach to targeting a ...

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Outward-facing conformers of LacY stabilized by nanobodies [Biochemistry]

30.12.2014 | Irina Smirnova; Vladimir Kasho; Xiaoxu Jiang; Els Pardon; Jan Steyaert; H. Ronald Kaback, Proceedings of the National Academy of Sciences current issue, 2014

The lactose permease of Escherichia coli (LacY), a highly dynamic polytopic membrane protein, catalyzes stoichiometric galactoside/H+ symport by an alternating access mechanism and exhibits multiple conformations, the distribution of which is altered by sugar binding. We have developed ...

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Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes [Biochemistry]

23.12.2014 | Juliette Létoquart; Emmeline Huvelle; Ludivine Wacheul; Gabrielle Bourgeois; Christiane Zorbas; Marc Graille; Valéri ..., Proceedings of the National Academy of Sciences current issue, 2014

The eukaryotic small ribosomal subunit carries only four ribosomal (r) RNA methylated bases, all close to important functional sites. N7-methylguanosine (m7G) introduced at position 1575 on 18S rRNA by Bud23–Trm112 is at a ridge forming a steric block between P- and E-site tRNAs. Here we report ...

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