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737 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains [Biochemistry]

10.09.2013 | Fern Sha; Emel Basak Gencer; Sandrine Georgeon; Akiko Koide; Norihisa Yasui; Shohei Koide; Oliver Hantschel, Proceedings of the National Academy of Sciences current issue, 2013

The dysregulated tyrosine kinase BCR-ABL causes chronic myelogenous leukemia in humans and forms a large multiprotein complex that includes the Src-homology 2 (SH2) domain-containing phosphatase 2 (SHP2). The expression of SHP2 is necessary for BCR-ABL-dependent oncogenic transformation, but the ...

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Protoribosome by quantum kernel energy method [Biochemistry]

10.09.2013 | Lulu Huang; Miri Krupkin; Anat Bashan; Ada Yonath; Lou Massa, Proceedings of the National Academy of Sciences current issue, 2013

Experimental evidence suggests the existence of an RNA molecular prebiotic entity, called by us the “protoribosome,” which may have evolved in the RNA world before evolution of the genetic code and proteins. This vestige of the RNA world, which possesses all of the capabilities required for ...

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Illuminating the black box of B12 biosynthesis [Biochemistry]

10.09.2013 | Harry A. Dailey, Proceedings of the National Academy of Sciences current issue, 2013

Tetrapyrroles are nearly ubiquitous in nature as participants in a wide variety of biological reactions that are central to life, such as electron transfer, gas binding, and one-carbon metabolism (1, 2). Because of their diverse colors—for example the greens of plant chlorophylls, reds of blood, ...

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Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12) [Biochemistry]

10.09.2013 | Simon J. Moore; Andrew D. Lawrence; Rebekka Biedendieck; Evelyne Deery; Stefanie Frank; Mark J. Howard; Stephen E. J ..., Proceedings of the National Academy of Sciences current issue, 2013

It has been known for the past 20 years that two pathways exist in nature for the de novo biosynthesis of the coenzyme form of vitamin B12, adenosylcobalamin, representing aerobic and anaerobic routes. In contrast to the aerobic pathway, the anaerobic route has remained enigmatic because many of ...

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H3R42me2a is a histone modification with positive transcriptional effects [Biochemistry]

10.09.2013 | Fabio Casadio; Xiangdong Lu; Samuel B. Pollock; Gary LeRoy; Benjamin A. Garcia; Tom W. Muir; Robert G. Roeder; C. Da ..., Proceedings of the National Academy of Sciences current issue, 2013

Histone posttranslational modification leads to downstream effects indirectly by allowing or preventing docking of effector molecules, or directly by changing the intrinsic biophysical properties of local chromatin. To date, little has been done to study posttranslational modifications that lie ...

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Structural insights into the interaction of IL-33 with its receptors [Biochemistry]

10.09.2013 | Xi Liu; Michal Hammel; Yanfeng He; John A. Tainer; U-Ser Jeng; Linqi Zhang; Shuying Wang; Xinquan Wang, Proceedings of the National Academy of Sciences current issue, 2013

Interleukin (IL)-33 is an important member of the IL-1 family that has pleiotropic activities in innate and adaptive immune responses in host defense and disease. It signals through its ligand-binding primary receptor ST2 and IL-1 receptor accessory protein (IL-1RAcP), both of which are members ...

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Correction for Tonthat et al., SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid [Correction]

10.09.2013 | Proceedings of the National Academy of Sciences current issue, 2013

BIOCHEMISTRY Correction for “SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid,” by Nam K. Tonthat, Sara L. Milam, Nagababu Chinnam, Travis Whitfill, William Margolin, and Maria A. Schumacher, which appeared in issue 26, June 25, 2013 of Proc ...

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Glycosylated linkers in multimodular lignocellulose-degrading enzymes dynamically bind to cellulose [Biochemistry]

03.09.2013 | Christina M. Payne; Michael G. Resch; Liqun Chen; Michael F. Crowley; Michael E. Himmel; Larry E. Taylor II; Mats Sa ..., Proceedings of the National Academy of Sciences current issue, 2013

Plant cell-wall polysaccharides represent a vast source of food in nature. To depolymerize polysaccharides to soluble sugars, many organisms use multifunctional enzyme mixtures consisting of glycoside hydrolases, lytic polysaccharide mono-oxygenases, polysaccharide lyases, and carbohydrate ...

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Human {alpha}-l-iduronidase uses its own N-glycan as a substrate-binding and catalytic module [Biochemistry]

03.09.2013 | Nobuo Maita; Takahiro Tsukimura; Takako Taniguchi; Seiji Saito; Kazuki Ohno; Hisaaki Taniguchi; Hitoshi Sakuraba, Proceedings of the National Academy of Sciences current issue, 2013

N-glycosylation is a major posttranslational modification that endows proteins with various functions. It is established that N-glycans are essential for the correct folding and stability of some enzymes; however, the actual effects of N-glycans on their activities are poorly understood. Here, we ...

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A flexible polyglutamine hinge opens new doors for understanding huntingtin function [Biochemistry]

03.09.2013 | Flaviano Giorgini, Proceedings of the National Academy of Sciences current issue, 2013

It has been 20 y since the gene responsible for Huntington disease—a fatal neurodegenerative disorder—was identified by an intensive international collaborative effort (1). Although the features of the gene offered few clues to its normal function, the cloning of the IT15 gene immediately ...

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