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1.111 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Kinetic selection vs. free energy of DNA base pairing in control of polymerase fidelity [Biochemistry]

19.04.2016 | Keriann Oertell; Emily M. Harcourt; Michael G. Mohsen; John Petruska; Eric T. Kool; Myron F. Goodman, Proceedings of the National Academy of Sciences current issue, 2016

What is the free energy source enabling high-fidelity DNA polymerases (pols) to favor incorporation of correct over incorrect base pairs by 103- to 104-fold, corresponding to free energy differences of ΔΔGinc ∼ 5.5–7 kcal/mol? Standard ΔΔG° values (∼0.3 kcal/mol) calculated from melting ...

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Individual variability in human blood metabolites identifies age-related differences [Biochemistry]

19.04.2016 | Romanas Chaleckis; Itsuo Murakami; Junko Takada; Hiroshi Kondoh; Mitsuhiro Yanagida, Proceedings of the National Academy of Sciences current issue, 2016

Metabolites present in human blood document individual physiological states influenced by genetic, epigenetic, and lifestyle factors. Using high-resolution liquid chromatography-mass spectrometry (LC-MS), we performed nontargeted, quantitative metabolomics analysis in blood of 15 young (29 ± 4 y ...

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Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function [Biochemistry]

19.04.2016 | Sushabhan Sadhukhan; Xiaojing Liu; Dongryeol Ryu; Ornella D. Nelson; John A. Stupinski; Zhi Li; Wei Chen; Sheng Zhan ..., Proceedings of the National Academy of Sciences current issue, 2016

Cellular metabolites, such as acyl-CoA, can modify proteins, leading to protein posttranslational modifications (PTMs). One such PTM is lysine succinylation, which is regulated by sirtuin 5 (SIRT5). Although numerous proteins are modified by lysine succinylation, the physiological significance of ...

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Mechanism for accurate, protein-assisted DNA annealing by Deinococcus radiodurans DdrB [Biochemistry]

19.04.2016 | Seiji N. Sugiman-Marangos; Yoni M. Weiss; Murray S. Junop, Proceedings of the National Academy of Sciences current issue, 2016

Accurate pairing of DNA strands is essential for repair of DNA double-strand breaks (DSBs). How cells achieve accurate annealing when large regions of single-strand DNA are unpaired has remained unclear despite many efforts focused on understanding proteins, which mediate this process. Here we ...

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Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNF{alpha}/NF-{kappa}B response [Biochemistry]

19.04.2016 | Anja Reintjes; Julian E. Fuchs; Leopold Kremser; Herbert H. Lindner; Klaus R. Liedl; Lukas A. Huber; Taras Valovka, Proceedings of the National Academy of Sciences current issue, 2016

Nuclear factor kappa B (NF-κB) is an inducible transcription factor that plays critical roles in immune and stress responses and is often implicated in pathologies, including chronic inflammation and cancer. Although much has been learned about NF-κB–activating pathways, the specific repression ...

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Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe [Biochemistry]

19.04.2016 | Rahul Jaiswal; Malay Choudhury; Shamsu Zaman; Samarendra Singh; Vishaka Santosh; Deepak Bastia; Carlos R. Escalante, Proceedings of the National Academy of Sciences current issue, 2016

Reb1 of Schizosaccharomyces pombe represents a family of multifunctional proteins that bind to specific terminator sites (Ter) and cause polar termination of transcription catalyzed by RNA polymerase I (pol I) and arrest of replication forks approaching the Ter sites from the opposite direction. ...

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Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions [Biochemistry]

19.04.2016 | Mira Sohn; Pavlina Ivanova; H. Alex Brown; Daniel J. Toth; Peter Varnai; Yeun Ju Kim; Tamas Balla, Proceedings of the National Academy of Sciences current issue, 2016

Lenz-Majewski syndrome (LMS) is a rare disease characterized by complex craniofacial, dental, cutaneous, and limb abnormalities combined with intellectual disability. Mutations in the PTDSS1 gene coding one of the phosphatidylserine (PS) synthase enzymes, PSS1, were described as causative in LMS ...

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Correction for Fukuda et al., Redox-coupled proton transfer mechanism in nitrite reductase revealed by femtosecond crystallography [Corrections]

12.04.2016 | Proceedings of the National Academy of Sciences current issue, 2016

BIOCHEMISTRY Correction for “Redox-coupled proton transfer mechanism in nitrite reductase revealed by femtosecond crystallography,” by Yohta Fukuda, Ka Man Tse, Takanori Nakane, Toru Nakatsu, Mamoru Suzuki, Michihiro Sugahara, Shigeyuki Inoue, Tetsuya Masuda, Fumiaki Yumoto, Naohiro Matsugaki, ...

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Structures of E. coli {sigma}S-transcription initiation complexes provide new insights into polymerase mechanism [Biochemistry]

12.04.2016 | Bin Liu; Yuhong Zuo; Thomas A. Steitz, Proceedings of the National Academy of Sciences current issue, 2016

In bacteria, multiple σ factors compete to associate with the RNA polymerase (RNAP) core enzyme to form a holoenzyme that is required for promoter recognition. During transcription initiation RNAP remains associated with the upstream promoter DNA via sequence-specific interactions between the σ ...

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Structural basis of rifampin inactivation by rifampin phosphotransferase [Biochemistry]

05.04.2016 | Xiaofeng Qi; Wei Lin; Miaolian Ma; Chengyuan Wang; Yang He; Nisha He; Jing Gao; Hu Zhou; Youli Xiao; Yong Wang; Peng ..., Proceedings of the National Academy of Sciences current issue, 2016

Rifampin (RIF) is a first-line drug used for the treatment of tuberculosis and other bacterial infections. Various RIF resistance mechanisms have been reported, and recently an RIF-inactivation enzyme, RIF phosphotransferase (RPH), was reported to phosphorylate RIF at its C21 hydroxyl at the cost ...

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