30.04.2013 | Catharina Ruppert; Katharina Deiss; Sebastian Herrmann; Marie Vidal; Mehmet Oezkur; Armin Gorski; Frank Weidemann; M ..., Proceedings of the National Academy of Sciences current issue, 2013

Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are central mediators of cardiac hypertrophy and are discussed as potential therapeutic targets. However, direct inhibition of ERK1/2 leads to exacerbated cardiomyocyte death and impaired heart function. We have previously identified ...

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30.04.2013 | Dong Fu; Kasturi Mitra; Prabuddha Sengupta; Michal Jarnik; Jennifer Lippincott-Schwartz; Irwin M. Arias, Proceedings of the National Academy of Sciences current issue, 2013

Cell polarization requires increased cellular energy and metabolic output, but how these energetic demands are met by polarizing cells is unclear. To address these issues, we investigated the roles of mitochondrial bioenergetics and autophagy during cell polarization of hepatocytes cultured ...

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23.04.2013 | Yuanyan Wei; Yizhou Jiang; Fei Zou; Yingchao Liu; Shanshan Wang; Nuo Xu; Wenlong Xu; Chunhong Cui; Yang Xing; Ying L ..., Proceedings of the National Academy of Sciences current issue, 2013

The biological significance of a known normal and cancer stem cell marker CD133 remains elusive. We now demonstrate that the phosphorylation of tyrosine-828 residue in CD133 C-terminal cytoplasmic domain mediates direct interaction between CD133 and phosphoinositide 3-kinase (PI3K) 85 kDa ...

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16.04.2013 | Ji Young Kim; Tania Valencia; Shadi Abu-Baker; Juan Linares; Sang Jun Lee; Tomoko Yajima; Jing Chen; Alexey Eroshkin ..., Proceedings of the National Academy of Sciences current issue, 2013

Studies showing reduced PKCζ expression or enzymatic activity in different types of human cancers support the clinical relevance of PKCζ as a tumor suppressor. However, the in vivo role of PKCζ and its mechanisms of action in prostate cancer remain unclear. Here we demonstrate that the ...

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16.04.2013 | Kim M. Brown; Jon P. Day; Elaine Huston; Bastian Zimmermann; Kornelia Hampel; Frank Christian; David Romano; Selim T ..., Proceedings of the National Academy of Sciences current issue, 2013

V-raf-1 murine leukemia viral oncogene homolog 1 (Raf-1) is a key activator of the ERK pathway and is a target for cross-regulation of this pathway by the cAMP signaling system. The cAMP-activated protein kinase, PKA, inhibits Raf-1 by phosphorylation on S259. Here, we show that the ...

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09.04.2013 | Akira Maeda; Makoto Okazaki; David M. Baron; Thomas Dean; Ashok Khatri; Mathew Mahon; Hiroko Segawa; Abdul B. Abou-S ..., Proceedings of the National Academy of Sciences current issue, 2013

Agonist-induced phosphorylation of the parathyroid hormone (PTH) receptor 1 (PTHR1) regulates receptor signaling in vitro, but the role of this phosphorylation in vivo is uncertain. We investigated this role by injecting “knock-in” mice expressing a phosphorylation-deficient (PD) PTHR1 with ...

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02.04.2013 | Yi Zhang; Liuh-Yow Chen; Xin Han; Wei Xie; Hyeung Kim; Dong Yang; Dan Liu; Zhou Songyang, Proceedings of the National Academy of Sciences current issue, 2013

Telomere maintenance is essential for organisms with linear chromosomes and is carried out by telomerase during cell cycle. The precise mechanism by which cell cycle controls telomeric access of telomerase and telomere elongation in mammals remains largely unknown. Previous work has ...

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05.03.2013 | Kazuhisa Kohda; Wataru Kakegawa; Shinji Matsuda; Tadashi Yamamoto; Hisashi Hirano; Michisuke Yuzaki, Proceedings of the National Academy of Sciences current issue, 2013

Long-term depression (LTD) commonly affects learning and memory in various brain regions. Although cerebellar LTD absolutely requires the δ2 glutamate receptor (GluD2) that is expressed in Purkinje cells, LTD in other brain regions does not; why and how cerebellar LTD is regulated by GluD2 ...

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26.02.2013 | Brooke M. Emerling; Cyril H. Benes; George Poulogiannis; Eric L. Bell; Kevin Courtney; Hui Liu; Rayman Choo-Wing; Ga ..., Proceedings of the National Academy of Sciences current issue, 2013

CUB domain-containing protein 1 (CDCP1) is a transmembrane protein that is highly expressed in stem cells and frequently overexpressed and tyrosine-phosphorylated in cancer. CDCP1 promotes cancer cell metastasis. However, the mechanisms that regulate CDCP1 are not well-defined. Here we show ...

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19.02.2013 | Jessica A. J. Liu; Ming-Hoi Wu; Carol H. Yan; Bolton K. H. Chau; Henry So; Alvis Ng; Alan Chan; Kathryn S. E. Cheah; ..., Proceedings of the National Academy of Sciences current issue, 2013

Coordination of neural crest cell (NCC) induction and delamination is orchestrated by several transcription factors. Among these, Sry-related HMG box-9 (Sox9) and Snail2 have been implicated in both the induction of NCC identity and, together with phoshorylation, NCC delamination. How ...

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