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800 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Self-assembled MmsF proteinosomes control magnetite nanoparticle formation in vitro [Chemistry]

11.11.2014 | Andrea E. Rawlings; Jonathan P. Bramble; Robyn Walker; Jennifer Bain; Johanna M. Galloway; Sarah S. Staniland, Proceedings of the National Academy of Sciences current issue, 2014

Magnetotactic bacteria synthesize highly uniform intracellular magnetite nanoparticles through the action of several key biomineralization proteins. These proteins are present in a unique lipid-bound organelle (the magnetosome) that functions as a nanosized reactor in which the particle is ...

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p100/I{kappa}B{delta} sequesters and inhibits NF-{kappa}B through kappaBsome formation [Biochemistry]

11.11.2014 | Zhihua Tao; Amanda Fusco; De-Bin Huang; Kushol Gupta; Daniel Young Kim; Carl F. Ware; Gregory D. Van Duyne; Gourisan ..., Proceedings of the National Academy of Sciences current issue, 2014

Degradation of I kappaB (κB) inhibitors is critical to activation of dimeric transcription factors of the NF-κB family. There are two types of IκB inhibitors: the prototypical IκBs (IκBα, IκBβ, and IκBε), which form low-molecular-weight (MW) IκB:NF-κB complexes that are highly stable, and the ...

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Direct in situ observations of single Fe atom catalytic processes and anomalous diffusion at graphene edges [Chemistry]

04.11.2014 | Jiong Zhao; Qingming Deng; Stanislav M. Avdoshenko; Lei Fu; Jürgen Eckert; Mark H. Rümmeli, Proceedings of the National Academy of Sciences current issue, 2014

Single-atom catalysts are of great interest because of their high efficiency. In the case of chemically deposited sp2 carbon, the implementation of a single transition metal atom for growth can provide crucial insight into the formation mechanisms of graphene and carbon nanotubes. This knowledge ...

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Constraints on the magnitude and rate of CO2 dissolution at Bravo Dome natural gas field [Earth, Atmospheric, and Planetary Sciences]

28.10.2014 | Kiran J. Sathaye; Marc A. Hesse; Martin Cassidy; Daniel F. Stockli, Proceedings of the National Academy of Sciences current issue, 2014

The injection of carbon dioxide (CO2) captured at large point sources into deep saline aquifers can significantly reduce anthropogenic CO2 emissions from fossil fuels. Dissolution of the injected CO2 into the formation brine is a trapping mechanism that helps to ensure the long-term security of ...

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Dynamical facilitation governs glassy dynamics in suspensions of colloidal ellipsoids [Physics]

28.10.2014 | Chandan K. Mishra; K. Hima Nagamanasa; Rajesh Ganapathy; A. K. Sood; Shreyas Gokhale, Proceedings of the National Academy of Sciences current issue, 2014

One of the greatest challenges in contemporary condensed matter physics is to ascertain whether the formation of glasses from liquids is fundamentally thermodynamic or dynamic in origin. Although the thermodynamic paradigm has dominated theoretical research for decades, the purely kinetic ...

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Highly cooperative stress relaxation in two-dimensional soft colloidal crystals [Physics]

28.10.2014 | Berend van der Meer; Weikai Qi; Remco G. Fokkink; Jasper van der Gucht; Marjolein Dijkstra; Joris Sprakel, Proceedings of the National Academy of Sciences current issue, 2014

Stress relaxation in crystalline solids is mediated by the formation and diffusion of defects. Although it is well established how externally generated stresses relax, through the proliferation and motion of dislocations in the lattice, it remains relatively unknown how crystals cope with ...

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Neutral molecular cluster formation of sulfuric acid-dimethylamine observed in real time under atmospheric conditions [Environmental Sciences]

21.10.2014 | Andreas Kürten; Tuija Jokinen; Mario Simon; Mikko Sipilä; Nina Sarnela; Heikki Junninen; Alexey Adamov; João Almeida ..., Proceedings of the National Academy of Sciences current issue, 2014

For atmospheric sulfuric acid (SA) concentrations the presence of dimethylamine (DMA) at mixing ratios of several parts per trillion by volume can explain observed boundary layer new particle formation rates. However, the concentration and molecular composition of the neutral (uncharged) clusters ...

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Visualization and quantification of nascent RAD51 filament formation at single-monomer resolution [Biophysics and Computational Biology]

21.10.2014 | Andrea Candelli; Jan Thomas Holthausen; Martin Depken; Ineke Brouwer; Mariëlla A. M. Franker; Margherita Marchetti; ..., Proceedings of the National Academy of Sciences current issue, 2014

During recombinational repair of double-stranded DNA breaks, RAD51 recombinase assembles as a nucleoprotein filament around single-stranded DNA to form a catalytically proficient structure able to promote homology recognition and strand exchange. Mediators and accessory factors guide the action ...

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Species formation by host shifting in avian malaria parasites [Evolution]

14.10.2014 | Robert E. Ricklefs; Diana C. Outlaw; Maria Svensson-Coelho; Matthew C. I. Medeiros; Vincenzo A. Ellis; Steven Latta, Proceedings of the National Academy of Sciences current issue, 2014

The malaria parasites (Apicomplexa: Haemosporida) of birds are believed to have diversified across the avian host phylogeny well after the origin of most major host lineages. Although many symbionts with direct transmission codiversify with their hosts, mechanisms of species formation in ...

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Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages [Microbiology]

07.10.2014 | Shiho Suzuki; Hitomi Mimuro; Minsoo Kim; Michinaga Ogawa; Hiroshi Ashida; Takahito Toyotome; Luigi Franchi; Masato S ..., Proceedings of the National Academy of Sciences current issue, 2014

When nucleotide-binding oligomerization domain–like receptors (NLRs) sense cytosolic-invading bacteria, they induce the formation of inflammasomes and initiate an innate immune response. In quiescent cells, inflammasome activity is tightly regulated to prevent excess inflammation and cell death. ...

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