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896 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Correction for Thompson et al., Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye [Correction]

21.07.2015 | Proceedings of the National Academy of Sciences current issue, 2015

MEDICAL SCIENCES Correction for “Identification of hydroxyapatite spherules provides new insight into subretinal pigment epithelial deposit formation in the aging eye,” by Richard B. Thompson, Valentina Reffatto, Jacob G. Bundy, Elod Kortvely, Jane M. Flinn, Antonio Lanzirotti, Emrys A. Jones, ...

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Tracing the ingredients for a habitable earth from interstellar space through planet formation [Earth, Atmospheric, and Planetary Sciences]

21.07.2015 | Edwin A. Bergin; Geoffrey A. Blake; Fred Ciesla; Marc M. Hirschmann; Jie Li, Proceedings of the National Academy of Sciences current issue, 2015

We use the C/N ratio as a monitor of the delivery of key ingredients of life to nascent terrestrial worlds. Total elemental C and N contents, and their ratio, are examined for the interstellar medium, comets, chondritic meteorites, and terrestrial planets; we include an updated estimate for the ...

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Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision [Biophysics and Computational Biology]

21.07.2015 | Marcelo Boareto; Mohit Kumar Jolly; Eshel Ben-Jacob; José N. Onuchic, Proceedings of the National Academy of Sciences current issue, 2015

Angiogenesis is critical during development, wound repair, and cancer progression. During angiogenesis, some endothelial cells adopt a tip phenotype to lead the formation of new branching vessels; the trailing stalk cells proliferate to develop the vessel. Notch and VEGF signaling mediate the ...

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Stem cells are units of natural selection for tissue formation, for germline development, and in cancer development [Colloquium Paper]

21.07.2015 | Irving L. Weissman, Proceedings of the National Academy of Sciences current issue, 2015

It is obvious that natural selection operates at the level of individuals and collections of individuals. Nearly two decades ago we showed that in multi-individual colonies of protochordate colonial tunicates sharing a blood circulation, there exists an exchange of somatic stem cells and germline ...

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Small GTP-binding protein Ran is regulated by posttranslational lysine acetylation [Biochemistry]

14.07.2015 | Susanne de Boor; Philipp Knyphausen; Nora Kuhlmann; Sarah Wroblowski; Julian Brenig; Lukas Scislowski; Linda Baldus; ..., Proceedings of the National Academy of Sciences current issue, 2015

Ran is a small GTP-binding protein of the Ras superfamily regulating fundamental cellular processes: nucleo-cytoplasmic transport, nuclear envelope formation and mitotic spindle assembly. An intracellular Ran•GTP/Ran•GDP gradient created by the distinct subcellular localization of its regulators ...

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Cortical instability drives periodic supracellular actin pattern formation in epithelial tubes [Applied Physical Sciences]

14.07.2015 | Edouard Hannezo; Bo Dong; Pierre Recho; Jean-François Joanny; Shigeo Hayashi, Proceedings of the National Academy of Sciences current issue, 2015

An essential question of morphogenesis is how patterns arise without preexisting positional information, as inspired by Turing. In the past few years, cytoskeletal flows in the cell cortex have been identified as a key mechanism of molecular patterning at the subcellular level. Theoretical and in ...

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The maize disease resistance gene Htn1 against northern corn leaf blight encodes a wall-associated receptor-like kinase [Plant Biology]

14.07.2015 | Severine Hurni; Daniela Scheuermann; Simon G. Krattinger; Bettina Kessel; Thomas Wicker; Gerhard Herren; Mirjam N. F ..., Proceedings of the National Academy of Sciences current issue, 2015

Northern corn leaf blight (NCLB) caused by the hemibiotrophic fungus Exserohilum turcicum is an important foliar disease of maize that is mainly controlled by growing resistant maize cultivars. The Htn1 locus confers quantitative and partial NCLB resistance by delaying the onset of lesion ...

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Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase {beta} in vivo [Biochemistry]

14.07.2015 | Jason L. Quiñones; Upasna Thapar; Kefei Yu; Qingming Fang; Robert William Sobol; Bruce Demple, Proceedings of the National Academy of Sciences current issue, 2015

Free radical attack on the C1′ position of DNA deoxyribose generates the oxidized abasic (AP) site 2-deoxyribonolactone (dL). Upon encountering dL, AP lyase enzymes such as DNA polymerase β (Polβ) form dead-end, covalent intermediates in vitro during attempted DNA repair. However, the conditions ...

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DC-SIGN activation mediates the differential effects of SAP and CRP on the innate immune system and inhibits fibrosis in mice [Immunology and Inflammation]

07.07.2015 | Nehemiah Cox; Darrell Pilling; Richard H. Gomer, Proceedings of the National Academy of Sciences current issue, 2015

Fibrosis is caused by scar tissue formation in internal organs and is associated with 45% of deaths in the United States. Two closely related human serum proteins, serum amyloid P (SAP) and C-reactive protein (CRP), strongly affect fibrosis. In multiple animal models, and in Phase 1 and Phase 2 ...

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Transcriptomics of critical period of visual cortical plasticity in mice [Neuroscience]

30.06.2015 | Jamie Benoit; Albert E. Ayoub; Pasko Rakic, Proceedings of the National Academy of Sciences current issue, 2015

In contrast to the prenatal development of the cerebral cortex, when cell production, migration, and layer formation dominate, development after birth involves more subtle processes, such as activity-dependent plasticity that includes refinement of synaptic connectivity by its stabilization and ...

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