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887 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Transcriptomics of critical period of visual cortical plasticity in mice [Neuroscience]

30.06.2015 | Jamie Benoit; Albert E. Ayoub; Pasko Rakic, Proceedings of the National Academy of Sciences current issue, 2015

In contrast to the prenatal development of the cerebral cortex, when cell production, migration, and layer formation dominate, development after birth involves more subtle processes, such as activity-dependent plasticity that includes refinement of synaptic connectivity by its stabilization and ...

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Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis [Medical Sciences]

30.06.2015 | T. S. Karin Eisinger-Mathason; Vera Mucaj; Kevin M. Biju; Michael S. Nakazawa; Mercy Gohil; Timothy P. Cash; Sam S. ..., Proceedings of the National Academy of Sciences current issue, 2015

Genetic aberrations responsible for soft-tissue sarcoma formation in adults are largely unknown, with targeted therapies sorely needed for this complex and heterogeneous family of diseases. Here we report that that the Hippo pathway is deregulated in many soft-tissue sarcomas, resulting in ...

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Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation [Biochemistry]

23.06.2015 | Yusuke Ohno; Shota Nakamichi; Aya Ohkuni; Nozomi Kamiyama; Ayano Naoe; Hisashi Tsujimura; Urara Yokose; Kazumitsu Su ..., Proceedings of the National Academy of Sciences current issue, 2015

A skin permeability barrier is essential for terrestrial animals, and its impairment causes several cutaneous disorders such as ichthyosis and atopic dermatitis. Although acylceramide is an important lipid for the skin permeability barrier, details of its production have yet to be determined, ...

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Late Oligocene-early Miocene birth of the Taklimakan Desert [Earth, Atmospheric, and Planetary Sciences]

23.06.2015 | Hongbo Zheng; Xiaochun Wei; Ryuji Tada; Peter D. Clift; Bin Wang; Fred Jourdan; Ping Wang; Mengying He, Proceedings of the National Academy of Sciences current issue, 2015

As the world’s second largest sand sea and one of the most important dust sources to the global aerosol system, the formation of the Taklimakan Desert marks a major environmental event in central Asia during the Cenozoic. Determining when and how the desert formed holds the key to better ...

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Production of extremely low volatile organic compounds from biogenic emissions: Measured yields and atmospheric implications [Earth, Atmospheric, and Planetary Sciences]

09.06.2015 | Tuija Jokinen; Torsten Berndt; Risto Makkonen; Veli-Matti Kerminen; Heikki Junninen; Pauli Paasonen; Frank Stratmann ..., Proceedings of the National Academy of Sciences current issue, 2015

Oxidation products of monoterpenes and isoprene have a major influence on the global secondary organic aerosol (SOA) burden and the production of atmospheric nanoparticles and cloud condensation nuclei (CCN). Here, we investigate the formation of extremely low volatility organic compounds (ELVOC) ...

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Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation [Medical Sciences]

09.06.2015 | Jinjiang Fan; Enrico Campioli; Andrew Midzak; Martine Culty; Vassilios Papadopoulos, Proceedings of the National Academy of Sciences current issue, 2015

Translocator protein (TSPO) is a key member of the mitochondrial cholesterol transport complex in steroidogenic tissues. To assess the function of TSPO, we generated two lines of Cre-mediated Tspo conditional knockout (cKO) mice. First, gonadal somatic cell-targeting Amhr2-Cre mice were crossed ...

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Colloidal test bed for universal dynamics of phase transitions [Physics]

02.06.2015 | Adolfo del Campo, Proceedings of the National Academy of Sciences current issue, 2015

Early insight on the critical dynamics of phase transitions arose in a cosmological setting in an effort to understand the origin of structure formation in the early Universe. Kibble pointed out that in a spontaneous symmetry breaking scenario, when a system is driven across a phase transition ...

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Reply to Li et al.: Insufficient evidence for the contribution of regional transport to severe haze formation in Beijing [Physical Sciences]

26.05.2015 | Renyi Zhang; Song Guo; Misti Levy Zamora; Min Hu, Proceedings of the National Academy of Sciences current issue, 2015

Contrary to the finding by Guo et al. (1), Li et al. argue that regional transport of fine particulate matter (PM2.5) represents the major cause for severe haze formation in Beijing (2). We noticed that the letter by Li et al. contains numerous nonscientific and unsubstantiated arguments: for ...

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Thermodynamics of formation of coffinite, USiO4 [Chemistry]

26.05.2015 | Xiaofeng Guo; Stéphanie Szenknect; Adel Mesbah; Sabrina Labs; Nicolas Clavier; Christophe Poinssot; Sergey V. Ushako ..., Proceedings of the National Academy of Sciences current issue, 2015

Coffinite, USiO4, is an important U(IV) mineral, but its thermodynamic properties are not well-constrained. In this work, two different coffinite samples were synthesized under hydrothermal conditions and purified from a mixture of products. The enthalpy of formation was obtained by ...

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A natural experiment of social network formation and dynamics [Statistics]

26.05.2015 | Tuan Q. Phan; Edoardo M. Airoldi, Proceedings of the National Academy of Sciences current issue, 2015

Social networks affect many aspects of life, including the spread of diseases, the diffusion of information, the workers' productivity, and consumers' behavior. Little is known, however, about how these networks form and change. Estimating causal effects and mechanisms that drive social network ...

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