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847 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Towards link predictability of complex networks [Applied Physical Sciences]

24.02.2015 | Linyuan Lü; Liming Pan; Tao Zhou; Yi-Cheng Zhang; H. Eugene Stanley, Proceedings of the National Academy of Sciences current issue, 2015

The organization of real networks usually embodies both regularities and irregularities, and, in principle, the former can be modeled. The extent to which the formation of a network can be explained coincides with our ability to predict missing links. To understand network organization, we should ...

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Structures of the G{beta}-CCT and PhLP1-G{beta}-CCT complexes reveal a mechanism for G-protein {beta}-subunit folding and G{beta}{gamma} dimer assembly [Biochemistry]

24.02.2015 | Rebecca L. Plimpton; Jorge Cuéllar; Chun Wan J. Lai; Takuma Aoba; Aman Makaju; Sarah Franklin; Andrew D. Mathis; Joh ..., Proceedings of the National Academy of Sciences current issue, 2015

G-protein signaling depends on the ability of the individual subunits of the G-protein heterotrimer to assemble into a functional complex. Formation of the G-protein βγ (Gβγ) dimer is particularly challenging because it is an obligate dimer in which the individual subunits are unstable on their ...

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C-terminal sequence of amyloid-resistant type F apolipoprotein A-II inhibits amyloid fibril formation of apolipoprotein A-II in mice [Biochemistry]

24.02.2015 | Jinko Sawashita; Beiru Zhang; Kazuhiro Hasegawa; Masayuki Mori; Hironobu Naiki; Fuyuki Kametani; Keiichi Higuchi, Proceedings of the National Academy of Sciences current issue, 2015

In murine senile amyloidosis, misfolded serum apolipoprotein (apo) A-II deposits as amyloid fibrils (AApoAII) in a process associated with aging. Mouse strains carrying type C apoA-II (APOA2C) protein exhibit a high incidence of severe systemic amyloidosis. Previously, we showed that N- and ...

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The SWI/SNF chromatin remodeling complex regulates germinal center formation by repressing Blimp-1 expression [Immunology and Inflammation]

17.02.2015 | Jinwook Choi; Shin Jeon; Seungjin Choi; Kyungsoo Park; Rho Hyun Seong, Proceedings of the National Academy of Sciences current issue, 2015

Germinal center (GC) reaction is crucial in adaptive immune responses. The formation of GC is coordinated by the expression of specific genes including Blimp-1 and Bcl-6. Although gene expression is critically influenced by the status of chromatin structure, little is known about the role of ...

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Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate [Genetics]

17.02.2015 | Simon Fortier; Tara MacRae; Mélanie Bilodeau; Tobias Sargeant; Guy Sauvageau, Proceedings of the National Academy of Sciences current issue, 2015

In a functional genomics screen of mouse embryonic stem cells (ESCs) with nested hemizygous chromosomal deletions, we reveal that ribosomal protein (RP) genes are the most significant haploinsufficient determinants for embryoid body (EB) formation. Hemizygocity for three RP genes (Rps5, Rps14, or ...

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An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin [Microbiology]

17.02.2015 | Kristin R. Wade; Eileen M. Hotze; Michael J. Kuiper; Craig J. Morton; Michael W. Parker; Rodney K. Tweten, Proceedings of the National Academy of Sciences current issue, 2015

β-Barrel pore-forming toxins (βPFTs) form an obligatory oligomeric prepore intermediate before the formation of the β-barrel pore. The molecular components that control the critical prepore-to-pore transition remain unknown for βPFTs. Using the archetype βPFT perfringolysin O, we show that E183 ...

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Sulfur-cycling fossil bacteria from the 1.8-Ga Duck Creek Formation provide promising evidence of evolution's null hypothesis [Earth, Atmospheric, and Planetary Sciences]

17.02.2015 | J. William Schopf; Anatoliy B. Kudryavtsev; Malcolm R. Walter; Martin J. Van Kranendonk; Kenneth H. Williford; Reinh ..., Proceedings of the National Academy of Sciences current issue, 2015

The recent discovery of a deep-water sulfur-cycling microbial biota in the ∼2.3-Ga Western Australian Turee Creek Group opened a new window to life's early history. We now report a second such subseafloor-inhabiting community from the Western Australian ∼1.8-Ga Duck Creek Formation. ...

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A conserved amphipathic helix is required for membrane tubule formation by Yop1p [Biochemistry]

17.02.2015 | Jacob P. Brady; Jolyon K. Claridge; Peter G. Smith; Jason R. Schnell, Proceedings of the National Academy of Sciences current issue, 2015

The integral membrane proteins of the DP1 (deleted in polyposis) and reticulon families are responsible for maintaining the high membrane curvature required for both smooth endoplasmic reticulum (ER) tubules and the edges of ER sheets, and mutations in these proteins lead to motor neuron ...

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Matching times of leading and following suggest cooperation through direct reciprocity during V-formation flight in ibis [Evolution]

17.02.2015 | Bernhard Voelkl; Steven J. Portugal; Markus Unsöld; James R. Usherwood; Alan M. Wilson; Johannes Fritz, Proceedings of the National Academy of Sciences current issue, 2015

One conspicuous feature of several larger bird species is their annual migration in V-shaped or echelon formation. When birds are flying in these formations, energy savings can be achieved by using the aerodynamic up-wash produced by the preceding bird. As the leading bird in a formation cannot ...

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Differential RNA-seq of Vibrio cholerae identifies the VqmR small RNA as a regulator of biofilm formation [Microbiology]

17.02.2015 | Kai Papenfort; Konrad U. Förstner; Jian-Ping Cong; Cynthia M. Sharma; Bonnie L. Bassler, Proceedings of the National Academy of Sciences current issue, 2015

Quorum sensing (QS) is a process of cell-to-cell communication that enables bacteria to transition between individual and collective lifestyles. QS controls virulence and biofilm formation in Vibrio cholerae, the causative agent of cholera disease. Differential RNA sequencing (RNA-seq) of ...

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