Meine Merkliste
my.bionity.com  
Login  

855 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

rss
mit folgenden Suchkriterien:

Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation [Biophysics and Computational Biology]

24.03.2015 | Jonggul Kim; Larry R. Masterson; Alessandro Cembran; Raffaello Verardi; Lei Shi; Jiali Gao; Susan S. Taylor; Gianlui ..., Proceedings of the National Academy of Sciences current issue, 2015

The dynamic interplay between kinases and substrates is crucial for the formation of catalytically committed complexes that enable phosphoryl transfer. However, a clear understanding on how substrates modulate kinase structural dynamics to control catalytic efficiency is still missing. Here, we ...

mehr

Lrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption [Medical Sciences]

17.03.2015 | Lei Xiong; Ji-Ung Jung; Haitao Wu; Wen-Fang Xia; Jin-Xiu Pan; Chengyong Shen; Lin Mei; Wen-Cheng Xiong, Proceedings of the National Academy of Sciences current issue, 2015

Bone mass is maintained by balanced activity of osteoblasts and osteoclasts. Lrp4 (low-density lipoprotein receptor related protein 4) is a member of the LDL receptor family, whose mutations have been identified in patients with high–bone-mass disorders, such as sclerosteosis and van Buchem ...

mehr

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation [Neuroscience]

17.03.2015 | Wuyang Wang; Qiong Gao; Meimei Yang; Xiaoli Zhang; Lu Yu; Maria Lawas; Xinran Li; Marthe Bryant-Genevier; Noel T. So ..., Proceedings of the National Academy of Sciences current issue, 2015

Upon nutrient starvation, autophagy digests unwanted cellular components to generate catabolites that are required for housekeeping biosynthesis processes. A complete execution of autophagy demands an enhancement in lysosome function and biogenesis to match the increase in autophagosome ...

mehr

Sequential de novo centromere formation and inactivation on a chromosomal fragment in maize [Genetics]

17.03.2015 | Yalin Liu; Handong Su; Junling Pang; Zhi Gao; Xiu-Jie Wang; James A. Birchler; Fangpu Han, Proceedings of the National Academy of Sciences current issue, 2015

The ability of centromeres to alternate between active and inactive states indicates significant epigenetic aspects controlling centromere assembly and function. In maize (Zea mays), misdivision of the B chromosome centromere on a translocation with the short arm of chromosome 9 (TB-9Sb) can ...

mehr

Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation [Biochemistry]

17.03.2015 | Sho W. Suzuki; Hayashi Yamamoto; Yu Oikawa; Chika Kondo-Kakuta; Yayoi Kimura; Hisashi Hirano; Yoshinori Ohsumi, Proceedings of the National Academy of Sciences current issue, 2015

During autophagosome formation, autophagosome-related (Atg) proteins are recruited hierarchically to organize the preautophagosomal structure (PAS). Atg13, which plays a central role in the initial step of PAS formation, consists of two structural regions, the N-terminal HORMA (from Hop1, Rev7, ...

mehr

Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen [Genetics]

17.03.2015 | Braham Dhillon; Nicolas Feau; Andrea L. Aerts; Stéphanie Beauseigle; Louis Bernier; Alex Copeland; Adam Foster; Navd ..., Proceedings of the National Academy of Sciences current issue, 2015

Some of the most damaging tree pathogens can attack woody stems, causing lesions (cankers) that may be lethal. To identify the genomic determinants of wood colonization leading to canker formation, we sequenced the genomes of the poplar canker pathogen, Mycosphaerella populorum, and the closely ...

mehr

Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2 [Medical Sciences]

10.03.2015 | Shurei Sugita; Yoko Hosaka; Keita Okada; Daisuke Mori; Fumiko Yano; Hiroshi Kobayashi; Yuki Taniguchi; Yoshifumi Mor ..., Proceedings of the National Academy of Sciences current issue, 2015

Notch signaling modulates skeletal formation and pathogenesis of osteoarthritis (OA) through induction of catabolic factors. Here we examined roles of Hes1, a transcription factor and important target of Notch signaling, in these processes. SRY-box containing gene 9 (Sox9)-Cre mice were mated ...

mehr

Conductance enlargement in picoscale electroburnt graphene nanojunctions [Applied Physical Sciences]

03.03.2015 | Hatef Sadeghi; Jan A. Mol; Chit Siong Lau; G. Andrew D. Briggs; Jamie Warner; Colin J. Lambert, Proceedings of the National Academy of Sciences current issue, 2015

Provided the electrical properties of electroburnt graphene junctions can be understood and controlled, they have the potential to underpin the development of a wide range of future sub-10-nm electrical devices. We examine both theoretically and experimentally the electrical conductance of ...

mehr

Towards link predictability of complex networks [Applied Physical Sciences]

24.02.2015 | Linyuan Lü; Liming Pan; Tao Zhou; Yi-Cheng Zhang; H. Eugene Stanley, Proceedings of the National Academy of Sciences current issue, 2015

The organization of real networks usually embodies both regularities and irregularities, and, in principle, the former can be modeled. The extent to which the formation of a network can be explained coincides with our ability to predict missing links. To understand network organization, we should ...

mehr

Structures of the G{beta}-CCT and PhLP1-G{beta}-CCT complexes reveal a mechanism for G-protein {beta}-subunit folding and G{beta}{gamma} dimer assembly [Biochemistry]

24.02.2015 | Rebecca L. Plimpton; Jorge Cuéllar; Chun Wan J. Lai; Takuma Aoba; Aman Makaju; Sarah Franklin; Andrew D. Mathis; Joh ..., Proceedings of the National Academy of Sciences current issue, 2015

G-protein signaling depends on the ability of the individual subunits of the G-protein heterotrimer to assemble into a functional complex. Formation of the G-protein βγ (Gβγ) dimer is particularly challenging because it is an obligate dimer in which the individual subunits are unstable on their ...

mehr

Seite 1 von 86
Suche per e-Mail abonnieren

Sie erhalten passend zu Ihrer Suche die neusten Suchergebnisse per E-Mail. Dieser Service ist für Sie kostenlos und kann jederzeit abbestellt werden.

Ihr Bowser ist nicht aktuell. Microsoft Internet Explorer 6.0 unterstützt einige Funktionen auf Chemie.DE nicht.