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755 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Learning-induced neural plasticity of speech processing before birth [Psychological and Cognitive Sciences]

10.09.2013 | Eino Partanen; Teija Kujala; Risto Näätänen; Auli Liitola; Anke Sambeth; Minna Huotilainen, Proceedings of the National Academy of Sciences current issue, 2013

Learning, the foundation of adaptive and intelligent behavior, is based on plastic changes in neural assemblies, reflected by the modulation of electric brain responses. In infancy, auditory learning implicates the formation and strengthening of neural long-term memory traces, improving ...

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Correction for Tonthat et al., SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid [Correction]

10.09.2013 | Proceedings of the National Academy of Sciences current issue, 2013

BIOCHEMISTRY Correction for “SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid,” by Nam K. Tonthat, Sara L. Milam, Nagababu Chinnam, Travis Whitfill, William Margolin, and Maria A. Schumacher, which appeared in issue 26, June 25, 2013 of Proc ...

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Anion translocation through an Slc26 transporter mediates lumen expansion during tubulogenesis [Developmental Biology]

10.09.2013 | Wei Deng; Florian Nies; Anja Feuer; Ivana Bočina; Dominik Oliver; Di Jiang, Proceedings of the National Academy of Sciences current issue, 2013

Lumen formation is a critical event in biological tube formation, yet its molecular mechanisms remain poorly understood. Specifically, how lumen expansion is coordinated with other processes of tubulogenesis is not well known, and the role of membrane transporters in tubulogenesis during ...

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Surface chemistry allows for abiotic precipitation of dolomite at low temperature [Microbiology]

03.09.2013 | Jennifer A. Roberts; Paul A. Kenward; David A. Fowle; Robert H. Goldstein; Luis A. González; David S. Moore, Proceedings of the National Academy of Sciences current issue, 2013

Although the mineral dolomite is abundant in ancient low-temperature sedimentary systems, it is scarce in modern systems below 50 °C. Chemical mechanism(s) enhancing its formation remain an enigma because abiotic dolomite has been challenging to synthesize at low temperature in laboratory ...

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Pulsed hydrogen-deuterium exchange mass spectrometry probes conformational changes in amyloid beta (A{beta}) peptide aggregation [Chemistry]

03.09.2013 | Ying Zhang; Don L. Rempel; Jun Zhang; Anuj K. Sharma; Liviu M. Mirica; Michael L. Gross, Proceedings of the National Academy of Sciences current issue, 2013

Probing the conformational changes of amyloid beta (Aβ) peptide aggregation is challenging owing to the vast heterogeneity of the resulting soluble aggregates. To investigate the formation of these aggregates in solution, we designed an MS-based biophysical approach and applied it to the ...

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Dirigent domain-containing protein is part of the machinery required for formation of the lignin-based Casparian strip in the root [Plant Biology]

27.08.2013 | Prashant S. Hosmani; Takehiro Kamiya; John Danku; Sadaf Naseer; Niko Geldner; Mary Lou Guerinot; David E. Salt, Proceedings of the National Academy of Sciences current issue, 2013

The endodermis acts as a “second skin” in plant roots by providing the cellular control necessary for the selective entry of water and solutes into the vascular system. To enable such control, Casparian strips span the cell wall of adjacent endodermal cells to form a tight junction that blocks ...

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Metalloproteases meprin {alpha} and meprin {beta} are C- and N-procollagen proteinases important for collagen assembly and tensile strength [Biochemistry]

27.08.2013 | Claudia Broder; Philipp Arnold; Sandrine Vadon-Le Goff; Moritz A. Konerding; Kerstin Bahr; Stefan Müller; Christophe ..., Proceedings of the National Academy of Sciences current issue, 2013

Type I fibrillar collagen is the most abundant protein in the human body, crucial for the formation and strength of bones, skin, and tendon. Proteolytic enzymes are essential for initiation of the assembly of collagen fibrils by cleaving off the propeptides. We report that Mep1a−/− and Mep1b−/− ...

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R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation [Medical Sciences]

20.08.2013 | Weston T. Powell; Rochelle L. Coulson; Michael L. Gonzales; Florence K. Crary; Spencer S. Wong; Sarrita Adams; Rober ..., Proceedings of the National Academy of Sciences current issue, 2013

Prader–Willi syndrome (PWS) and Angelman syndrome (AS) are oppositely imprinted autism-spectrum disorders with known genetic bases, but complex epigenetic mechanisms underlie their pathogenesis. The PWS/AS locus on 15q11–q13 is regulated by an imprinting control region that is maternally ...

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On-chip phenotypic analysis of inflammatory monocytes in atherogenesis and myocardial infarction [Medical Sciences]

20.08.2013 | Greg A. Foster; R. Michael Gower; Kimber L. Stanhope; Peter J. Havel; Scott I. Simon; Ehrin J. Armstrong, Proceedings of the National Academy of Sciences current issue, 2013

Monocyte recruitment to inflamed arterial endothelium initiates plaque formation and drives progression of atherosclerosis. Three distinct monocyte subsets are detected in circulation (CD14++CD16−, CD14++CD16+, and CD14+CD16++), and each may play distinct roles during atherogenesis and myocardial ...

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Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis [Microbiology]

13.08.2013 | Ahmed Fazly; Charu Jain; Amie C. Dehner; Luca Issi; Elizabeth A. Lilly; Akbar Ali; Hong Cao; Paul L. Fidel, Jr.; Ree ..., Proceedings of the National Academy of Sciences current issue, 2013

Infection by pathogenic fungi, such as Candida albicans, begins with adhesion to host cells or implanted medical devices followed by biofilm formation. By high-throughput phenotypic screening of small molecules, we identified compounds that inhibit adhesion of C. albicans to polystyrene. Our lead ...

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